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Protein

Protein fem-1 homolog B

Gene

Fem-1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein fem-1 homolog B
Alternative name(s):
dFEM-1
Gene namesi
Name:Fem-1
ORF Names:CG9025
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0034542. Fem-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 650650Protein fem-1 homolog BPRO_0000324541Add
BLAST

Proteomic databases

PaxDbiA1ZBY1.
PRIDEiA1ZBY1.

Expressioni

Tissue specificityi

Primarily detected in the embryonic central nervous system.1 Publication

Gene expression databases

BgeeiFBgn0034542.
ExpressionAtlasiA1ZBY1. differential.
GenevisibleiA1ZBY1. DM.

Interactioni

Subunit structurei

Component of some E3 ubiquitin-protein ligase complex.By similarity

Protein-protein interaction databases

BioGridi62993. 24 interactions.
STRINGi7227.FBpp0085558.

Structurei

3D structure databases

ProteinModelPortaliA1ZBY1.
SMRiA1ZBY1. Positions 23-275, 477-598.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati48 – 8033ANK 1Add
BLAST
Repeati90 – 12233ANK 2Add
BLAST
Repeati123 – 15533ANK 3Add
BLAST
Repeati156 – 18833ANK 4Add
BLAST
Repeati189 – 22133ANK 5Add
BLAST
Repeati222 – 24423ANK 6Add
BLAST
Repeati496 – 54348ANK 7Add
BLAST

Sequence similaritiesi

Belongs to the fem-1 family.Curated
Contains 7 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0508. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129781.
InParanoidiA1ZBY1.
KOiK10349.
OMAiERYRDSE.
OrthoDBiEOG091G03I9.
PhylomeDBiA1ZBY1.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 7 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform B (identifier: A1ZBY1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHAELYRTRK RWYESAWPGA GFWRGANDTL PVTNYITYPA NFDQPDGQSL
60 70 80 90 100
TPLTMAAMMG NVKFVKTLLS HYDVDLDREC NVIYDGMVVY GATALWVAAG
110 120 130 140 150
MGHLQIVKML VQAGAAINHN TKAQSSPLRA ACYEGRLDIV EFLIDNGADV
160 170 180 190 200
NATNLFNNNT LMIAAYKGHH LVVKTLLQNG SRANDQALCG ATALHYAAES
210 220 230 240 250
GHLDVVVALL DHGATLKKNE LGITPALQAA ERLHEDVLEA FIERPELMSL
260 270 280 290 300
EEQITALELL GATYANDKIK YDVNKAYGYL LRAMQLRYSN PRGVIRKRVQ
310 320 330 340 350
PTVPAYDNWL ETENLPELYA IKLNHHSIHM ESLAIRERIL GRNNPELPQA
360 370 380 390 400
IIYRGAVMAD QGRFYQCQVL WNYAIDLRMR NNVSVDRDLL RFAQLFAQIL
410 420 430 440 450
RVENHNLTLD HVLPVLAKCQ QEIENNKFKI KEAKPNACPS LWQDQNNQNC
460 470 480 490 500
ITALYLIKIV THLARRKKDQ NIDEEHIQQL FLVVRKFIQN DTRLQDGQTL
510 520 530 540 550
LHIAVNGVMP VDEFYTNEMC RFPCYATALV LVHCGASVVA VDSDRNTPLH
560 570 580 590 600
ILVTKVNTTQ DRQAEMARIL ELFVEAGAHL DAVNAAGQTA ATACKLPILA
610 620 630 640 650
NRLHAHQNAH TSLKCLAARS IATNRLNFKG LIPTQLEAFI QMHSVRKVLP
Note: No experimental confirmation available.
Length:650
Mass (Da):73,048
Last modified:February 6, 2007 - v1
Checksum:i20CF39D6EC4825C3
GO
Isoform A (identifier: A1ZBY1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-40: MHAELYRTRK...PVTNYITYPA → MDVDPAEEAP...RAVQTHLVNT

Note: No experimental confirmation available.
Show »
Length:702
Mass (Da):78,688
Checksum:iB1C2FD8FEAD7ABF1
GO

Sequence cautioni

The sequence AAM50903 differs from that shown. Reason: Frameshift at position 154. Curated
The sequence AAN71457 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4040MHAEL…ITYPA → MDVDPAEEAPLDEAHTSIYD GYPPDFGYFNMAHGMLVEIS EEIRAKFPHEPRLRFSQLNN LHLAARSGQMLSFVEILNSV SCRAVQTHLVNT in isoform A. 1 PublicationVSP_032268Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF57431.2.
AE013599 Genomic DNA. Translation: AAM68397.1.
AY119043 mRNA. Translation: AAM50903.1. Frameshift.
BT001702 mRNA. Translation: AAN71457.1. Different initiation.
RefSeqiNP_611508.1. NM_137664.3. [A1ZBY1-3]
NP_725993.1. NM_166408.2. [A1ZBY1-1]
UniGeneiDm.13937.

Genome annotation databases

EnsemblMetazoaiFBtr0086246; FBpp0085559; FBgn0034542. [A1ZBY1-1]
GeneIDi37344.
KEGGidme:Dmel_CG9025.
UCSCiCG9025-RA. d. melanogaster. [A1ZBY1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF57431.2.
AE013599 Genomic DNA. Translation: AAM68397.1.
AY119043 mRNA. Translation: AAM50903.1. Frameshift.
BT001702 mRNA. Translation: AAN71457.1. Different initiation.
RefSeqiNP_611508.1. NM_137664.3. [A1ZBY1-3]
NP_725993.1. NM_166408.2. [A1ZBY1-1]
UniGeneiDm.13937.

3D structure databases

ProteinModelPortaliA1ZBY1.
SMRiA1ZBY1. Positions 23-275, 477-598.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi62993. 24 interactions.
STRINGi7227.FBpp0085558.

Proteomic databases

PaxDbiA1ZBY1.
PRIDEiA1ZBY1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0086246; FBpp0085559; FBgn0034542. [A1ZBY1-1]
GeneIDi37344.
KEGGidme:Dmel_CG9025.
UCSCiCG9025-RA. d. melanogaster. [A1ZBY1-1]

Organism-specific databases

CTDi37344.
FlyBaseiFBgn0034542. Fem-1.

Phylogenomic databases

eggNOGiKOG0508. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129781.
InParanoidiA1ZBY1.
KOiK10349.
OMAiERYRDSE.
OrthoDBiEOG091G03I9.
PhylomeDBiA1ZBY1.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

GenomeRNAii37344.
PROiA1ZBY1.

Gene expression databases

BgeeiFBgn0034542.
ExpressionAtlasiA1ZBY1. differential.
GenevisibleiA1ZBY1. DM.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 7 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFEM1B_DROME
AccessioniPrimary (citable) accession number: A1ZBY1
Secondary accession number(s): A1ZBY0, Q8IGM5, Q8MS72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: February 6, 2007
Last modified: September 7, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.