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Protein
Submitted name:

Eag-like K[+] channel, isoform A

Gene

Elk

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • potassium ion transport Source: FlyBase
  • regulation of glucose metabolic process Source: FlyBase
  • regulation of membrane potential Source: GO_Central

Keywordsi

Molecular functionIon channel, Potassium channelSAAS annotation, TransferaseImported, Voltage-gated channelSAAS annotation
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-DME-1296072. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Submitted name:
Eag-like K[+] channel, isoform AImported (EC:2.7.3.-Imported)
Gene namesi
Name:ElkImported
Synonyms:elkImported
ORF Names:CG5076Imported, Dmel_CG5076Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0011589. Elk.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Transmembranei396 – 420HelicalSequence analysisAdd BLAST25
Transmembranei484 – 508HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiA1ZB14.
PRIDEiA1ZB14.

Expressioni

Gene expression databases

BgeeiFBgn0011589.
ExpressionAtlasiA1ZB14. differential.
GenevisibleiA1ZB14. DM.

Interactioni

Protein-protein interaction databases

IntActiA1ZB14. 1 interactor.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4HP4X-ray2.00A/B11-136[»]
ProteinModelPortaliA1ZB14.
SMRiA1ZB14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 89PASInterPro annotationAdd BLAST55
Domaini92 – 144PACInterPro annotationAdd BLAST53
Domaini586 – 650Cyclic nucleotide-bindingInterPro annotationAdd BLAST65

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0498. Eukaryota.
ENOG410XPSE. LUCA.
InParanoidiA1ZB14.
OMAiSHPPEVW.
OrthoDBiEOG091G0OXR.
PhylomeDBiA1ZB14.

Family and domain databases

CDDicd00038. CAP_ED. 1 hit.
cd00130. PAS. 1 hit.
Gene3Di2.60.120.10. 1 hit.
InterProiView protein in InterPro
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003950. K_chnl_volt-dep_ELK.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR035965. PAS-like_dom_sf.
IPR014710. RmlC-like_jellyroll.
PfamiView protein in Pfam
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
PRINTSiPR01463. EAGCHANLFMLY.
PR01465. ELKCHANNEL.
SMARTiView protein in SMART
SM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiView protein in PROSITE
PS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.

Sequencei

Sequence statusi: Complete.

A1ZB14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPARKGLLAP QNTFLDTIAT RFDGTHSNFV LGNAQANGNP IVYCSDGFVD
60 70 80 90 100
LTGYSRAQIM QKGCSCHFLY GPDTKEEHKQ QIEKSLSNKM ELKLEVIFYK
110 120 130 140 150
KEGAPFWCLF DIVPIKNEKR DVVLFLASHK DITHTKMLEM NVNEECDSVF
160 170 180 190 200
ALTAALLGAR FRAGSNAGML GLGGLPGLGG PAASDGDTEA GEGNNLDVPA
210 220 230 240 250
GCNMGRRRSR AVLYQLSGHY KPEKGGVKTK LKLGNNFMHS TEAPFPEYKT
260 270 280 290 300
QSIKKSRLIL PHYGVFKGIW DWVILVATFY VALMVPYNAA FAKADRQTKV
310 320 330 340 350
SDVIVEALFI VDILLNFRTT FVSRKGEVVS NSKQIAINYL RGWFALDLLA
360 370 380 390 400
ALPFDHLYAS DLYDGEDSHI HLVKLTRLLR LARLLQKIDR YSQHTAMILT
410 420 430 440 450
LLMFSFTLAA HWLACIWYVI AVKEYEWFPE SNIGWLQLLA ERKNASVAIL
460 470 480 490 500
TTAETYSTAL YFTFTSLTSV GFGNVSANTT AEKVFTIIMM LIGALMHAVV
510 520 530 540 550
FGNVTAIIQR MYSRRSLYES KWRDLKDFVA LHNMPKELKQ RIEDYFQTSW
560 570 580 590 600
SLSHGIDIYE TLREFPEELR GDVSMHLHRE ILQLPIFEAA SQGCLKLLSL
610 620 630 640 650
HIKTNFCAPG EYLIHKGDAL NYIYYLCNGS MEVIKDDMVV AILGKGDLVG
660 670 680 690 700
SDINVHLVAT SNGQMTATTN SAGQDVVVRS SSDIKALTYC DLKCIHMGGL
710 720 730 740 750
VEVLRLYPEY QQQFANDIQH DLTCNLREGY ENQDSDIGPS FPLPSISEDD
760 770 780 790 800
ENREEAEEGG KGEKENGGGP PSGASPLHNI SNSPLHATRS PLLGMGSPRN
810 820 830 840 850
QRLHQRGRSL ITLRETNKRH RTLNAACSLD RGSFEEPEPL EEEQSSGGKR
860 870 880 890 900
PSLERLDSQV STLHQDVAQL SAEVRNAISA LQEMTFTSNA MTSHSSLKFP
910 920 930 940 950
PARSIPNISG VAGTRSGVAV EHGLMGGVLA AAELAAMQRS SSHPPEVWGR
960 970 980 990 1000
DVQLPTSNTA SSKAPSPVEP KKTMTSRSSQ TDFYRIDFPT FERFVLANPR
1010 1020 1030 1040 1050
LVLGLLGIEP AIKNEMDLLQ QKQTLQISPL NTIDECVSPS DHNLASSKER
1060 1070 1080 1090 1100
LITSSAVPTP GRIYPPLDDE NSNDFRWTMK HSASHHSCCK STDALLSPEE
1110 1120 1130 1140 1150
QPPISILPVD ATPAPSVQEV RSSKRSLRKS TSGSNSSLSS SSSSSNSCLV
1160 1170 1180 1190 1200
SQSTGNLTTT NASVHCSNSS QSVASVATTR RASWKLQHSR SGEYRRLSEA
1210 1220 1230 1240 1250
TAEYSPPAKT PLPVAGVSYG GDEEESVELL GPRRNSRPIL LGVSQNQGQG
1260 1270 1280
QAMNFRFSAG DADKLEKGLR GLPSTRSLRD PSSK
Length:1,284
Mass (Da):141,378
Last modified:February 6, 2007 - v1
Checksum:iC6EC31891E4B6D24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF57772.2.
RefSeqiNP_477009.1. NM_057661.3.

Genome annotation databases

EnsemblMetazoaiFBtr0086802; FBpp0085981; FBgn0011589.
GeneIDi37047.
UCSCiCG5076-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiA1ZB14_DROME
AccessioniPrimary (citable) accession number: A1ZB14
Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: November 22, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported