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Protein
Submitted name:

Eag-like K[+] channel

Gene

Elk

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. phosphorelay sensor kinase activity Source: InterPro
  2. voltage-gated cation channel activity Source: FlyBase
  3. voltage-gated potassium channel activity Source: FlyBase

GO - Biological processi

  1. potassium ion transmembrane transport Source: GO_Central
  2. potassium ion transport Source: FlyBase
  3. regulation of ion transmembrane transport Source: GOC
  4. regulation of membrane potential Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotation, TransferaseImported

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_180793. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Submitted name:
Eag-like K[+] channelImported (EC:2.7.3.-Imported)
Gene namesi
Name:ElkImported
Synonyms:elkImported
ORF Names:CG5076Imported, Dmel_CG5076Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0011589. Elk.

Subcellular locationi

GO - Cellular componenti

  1. voltage-gated potassium channel complex Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiA1ZB14.
PRIDEiA1ZB14.

Expressioni

Gene expression databases

BgeeiA1ZB14.

Interactioni

Protein-protein interaction databases

IntActiA1ZB14. 1 interaction.
STRINGi7227.FBpp0085981.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HP4X-ray2.00A/B11-136[»]
ProteinModelPortaliA1ZB14.
SMRiA1ZB14. Positions 11-135, 514-729.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains cyclic nucleotide-binding domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

eggNOGiCOG2202.
GeneTreeiENSGT00760000118772.
InParanoidiA1ZB14.
OMAiIAVKEYE.
OrthoDBiEOG7QG43V.
PhylomeDBiA1ZB14.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003950. K_chnl_volt-dep_ELK.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
PR01465. ELKCHANNEL.
SMARTiSM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1ZB14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPARKGLLAP QNTFLDTIAT RFDGTHSNFV LGNAQANGNP IVYCSDGFVD
60 70 80 90 100
LTGYSRAQIM QKGCSCHFLY GPDTKEEHKQ QIEKSLSNKM ELKLEVIFYK
110 120 130 140 150
KEGAPFWCLF DIVPIKNEKR DVVLFLASHK DITHTKMLEM NVNEECDSVF
160 170 180 190 200
ALTAALLGAR FRAGSNAGML GLGGLPGLGG PAASDGDTEA GEGNNLDVPA
210 220 230 240 250
GCNMGRRRSR AVLYQLSGHY KPEKGGVKTK LKLGNNFMHS TEAPFPEYKT
260 270 280 290 300
QSIKKSRLIL PHYGVFKGIW DWVILVATFY VALMVPYNAA FAKADRQTKV
310 320 330 340 350
SDVIVEALFI VDILLNFRTT FVSRKGEVVS NSKQIAINYL RGWFALDLLA
360 370 380 390 400
ALPFDHLYAS DLYDGEDSHI HLVKLTRLLR LARLLQKIDR YSQHTAMILT
410 420 430 440 450
LLMFSFTLAA HWLACIWYVI AVKEYEWFPE SNIGWLQLLA ERKNASVAIL
460 470 480 490 500
TTAETYSTAL YFTFTSLTSV GFGNVSANTT AEKVFTIIMM LIGALMHAVV
510 520 530 540 550
FGNVTAIIQR MYSRRSLYES KWRDLKDFVA LHNMPKELKQ RIEDYFQTSW
560 570 580 590 600
SLSHGIDIYE TLREFPEELR GDVSMHLHRE ILQLPIFEAA SQGCLKLLSL
610 620 630 640 650
HIKTNFCAPG EYLIHKGDAL NYIYYLCNGS MEVIKDDMVV AILGKGDLVG
660 670 680 690 700
SDINVHLVAT SNGQMTATTN SAGQDVVVRS SSDIKALTYC DLKCIHMGGL
710 720 730 740 750
VEVLRLYPEY QQQFANDIQH DLTCNLREGY ENQDSDIGPS FPLPSISEDD
760 770 780 790 800
ENREEAEEGG KGEKENGGGP PSGASPLHNI SNSPLHATRS PLLGMGSPRN
810 820 830 840 850
QRLHQRGRSL ITLRETNKRH RTLNAACSLD RGSFEEPEPL EEEQSSGGKR
860 870 880 890 900
PSLERLDSQV STLHQDVAQL SAEVRNAISA LQEMTFTSNA MTSHSSLKFP
910 920 930 940 950
PARSIPNISG VAGTRSGVAV EHGLMGGVLA AAELAAMQRS SSHPPEVWGR
960 970 980 990 1000
DVQLPTSNTA SSKAPSPVEP KKTMTSRSSQ TDFYRIDFPT FERFVLANPR
1010 1020 1030 1040 1050
LVLGLLGIEP AIKNEMDLLQ QKQTLQISPL NTIDECVSPS DHNLASSKER
1060 1070 1080 1090 1100
LITSSAVPTP GRIYPPLDDE NSNDFRWTMK HSASHHSCCK STDALLSPEE
1110 1120 1130 1140 1150
QPPISILPVD ATPAPSVQEV RSSKRSLRKS TSGSNSSLSS SSSSSNSCLV
1160 1170 1180 1190 1200
SQSTGNLTTT NASVHCSNSS QSVASVATTR RASWKLQHSR SGEYRRLSEA
1210 1220 1230 1240 1250
TAEYSPPAKT PLPVAGVSYG GDEEESVELL GPRRNSRPIL LGVSQNQGQG
1260 1270 1280
QAMNFRFSAG DADKLEKGLR GLPSTRSLRD PSSK
Length:1,284
Mass (Da):141,378
Last modified:February 6, 2007 - v1
Checksum:iC6EC31891E4B6D24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF57772.2.
RefSeqiNP_477009.1. NM_057661.3.

Genome annotation databases

EnsemblMetazoaiFBtr0086802; FBpp0085981; FBgn0011589.
GeneIDi37047.
KEGGidme:Dmel_CG5076.
UCSCiCG5076-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF57772.2.
RefSeqiNP_477009.1. NM_057661.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HP4X-ray2.00A/B11-136[»]
ProteinModelPortaliA1ZB14.
SMRiA1ZB14. Positions 11-135, 514-729.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA1ZB14. 1 interaction.
STRINGi7227.FBpp0085981.

Proteomic databases

PaxDbiA1ZB14.
PRIDEiA1ZB14.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0086802; FBpp0085981; FBgn0011589.
GeneIDi37047.
KEGGidme:Dmel_CG5076.
UCSCiCG5076-RA. d. melanogaster.

Organism-specific databases

CTDi37047.
FlyBaseiFBgn0011589. Elk.

Phylogenomic databases

eggNOGiCOG2202.
GeneTreeiENSGT00760000118772.
InParanoidiA1ZB14.
OMAiIAVKEYE.
OrthoDBiEOG7QG43V.
PhylomeDBiA1ZB14.

Enzyme and pathway databases

ReactomeiREACT_180793. Voltage gated Potassium channels.

Miscellaneous databases

ChiTaRSielk. fly.
GenomeRNAii37047.
NextBioi801691.

Gene expression databases

BgeeiA1ZB14.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003950. K_chnl_volt-dep_ELK.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
PR01465. ELKCHANNEL.
SMARTiSM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  3. Cited for: GENOME REANNOTATION.
    Strain: BerkeleyImported.
  4. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  5. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  7. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  9. "Structural properties of PAS domains from the KCNH potassium channels."
    Adaixo R., Harley C.A., Castro-Rodrigues A.F., Morais-Cabral J.H.
    PLoS ONE 8:E59265-E59265(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 11-136.

Entry informationi

Entry nameiA1ZB14_DROME
AccessioniPrimary (citable) accession number: A1ZB14
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: March 4, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.