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A1ZB14

- A1ZB14_DROME

UniProt

A1ZB14 - A1ZB14_DROME

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Protein
Submitted name: Eag-like K[+] channel
Gene
Elk, elk, CG5076, Dmel_CG5076
Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. phosphorelay sensor kinase activity Source: InterPro
  2. voltage-gated potassium channel activity Source: FlyBase

GO - Biological processi

  1. potassium ion transmembrane transport Source: RefGenome
  2. potassium ion transport Source: FlyBase
  3. regulation of membrane potential Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotations, TransferaseImported

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_180793. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Submitted name:
Eag-like K[+] channelImported (EC:2.7.3.-Imported)
Gene namesi
Name:ElkImported
Synonyms:elkImported
ORF Names:CG5076Imported, Dmel_CG5076Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0011589. Elk.

Subcellular locationi

GO - Cellular componenti

  1. voltage-gated potassium channel complex Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiA1ZB14.
PRIDEiA1ZB14.

Expressioni

Gene expression databases

BgeeiA1ZB14.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0085981.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HP4X-ray2.00A/B11-136[»]
ProteinModelPortaliA1ZB14.
SMRiA1ZB14. Positions 11-135, 455-507, 514-729.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 263Sulfate bindingImported

Sequence similaritiesi

Contains cyclic nucleotide-binding domain.SAAS annotations

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

eggNOGiCOG2202.
GeneTreeiENSGT00680000099929.
InParanoidiA1ZB14.
OMAiIAVKEYE.
OrthoDBiEOG7QG43V.
PhylomeDBiA1ZB14.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003950. K_chnl_volt-dep_ELK.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
PR01465. ELKCHANNEL.
SMARTiSM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1ZB14-1 [UniParc]FASTAAdd to Basket

« Hide

MPARKGLLAP QNTFLDTIAT RFDGTHSNFV LGNAQANGNP IVYCSDGFVD     50
LTGYSRAQIM QKGCSCHFLY GPDTKEEHKQ QIEKSLSNKM ELKLEVIFYK 100
KEGAPFWCLF DIVPIKNEKR DVVLFLASHK DITHTKMLEM NVNEECDSVF 150
ALTAALLGAR FRAGSNAGML GLGGLPGLGG PAASDGDTEA GEGNNLDVPA 200
GCNMGRRRSR AVLYQLSGHY KPEKGGVKTK LKLGNNFMHS TEAPFPEYKT 250
QSIKKSRLIL PHYGVFKGIW DWVILVATFY VALMVPYNAA FAKADRQTKV 300
SDVIVEALFI VDILLNFRTT FVSRKGEVVS NSKQIAINYL RGWFALDLLA 350
ALPFDHLYAS DLYDGEDSHI HLVKLTRLLR LARLLQKIDR YSQHTAMILT 400
LLMFSFTLAA HWLACIWYVI AVKEYEWFPE SNIGWLQLLA ERKNASVAIL 450
TTAETYSTAL YFTFTSLTSV GFGNVSANTT AEKVFTIIMM LIGALMHAVV 500
FGNVTAIIQR MYSRRSLYES KWRDLKDFVA LHNMPKELKQ RIEDYFQTSW 550
SLSHGIDIYE TLREFPEELR GDVSMHLHRE ILQLPIFEAA SQGCLKLLSL 600
HIKTNFCAPG EYLIHKGDAL NYIYYLCNGS MEVIKDDMVV AILGKGDLVG 650
SDINVHLVAT SNGQMTATTN SAGQDVVVRS SSDIKALTYC DLKCIHMGGL 700
VEVLRLYPEY QQQFANDIQH DLTCNLREGY ENQDSDIGPS FPLPSISEDD 750
ENREEAEEGG KGEKENGGGP PSGASPLHNI SNSPLHATRS PLLGMGSPRN 800
QRLHQRGRSL ITLRETNKRH RTLNAACSLD RGSFEEPEPL EEEQSSGGKR 850
PSLERLDSQV STLHQDVAQL SAEVRNAISA LQEMTFTSNA MTSHSSLKFP 900
PARSIPNISG VAGTRSGVAV EHGLMGGVLA AAELAAMQRS SSHPPEVWGR 950
DVQLPTSNTA SSKAPSPVEP KKTMTSRSSQ TDFYRIDFPT FERFVLANPR 1000
LVLGLLGIEP AIKNEMDLLQ QKQTLQISPL NTIDECVSPS DHNLASSKER 1050
LITSSAVPTP GRIYPPLDDE NSNDFRWTMK HSASHHSCCK STDALLSPEE 1100
QPPISILPVD ATPAPSVQEV RSSKRSLRKS TSGSNSSLSS SSSSSNSCLV 1150
SQSTGNLTTT NASVHCSNSS QSVASVATTR RASWKLQHSR SGEYRRLSEA 1200
TAEYSPPAKT PLPVAGVSYG GDEEESVELL GPRRNSRPIL LGVSQNQGQG 1250
QAMNFRFSAG DADKLEKGLR GLPSTRSLRD PSSK 1284
Length:1,284
Mass (Da):141,378
Last modified:February 6, 2007 - v1
Checksum:iC6EC31891E4B6D24
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013599 Genomic DNA. Translation: AAF57772.2.
RefSeqiNP_477009.1. NM_057661.2.
UniGeneiDm.4335.

Genome annotation databases

EnsemblMetazoaiFBtr0086802; FBpp0085981; FBgn0011589.
GeneIDi37047.
KEGGidme:Dmel_CG5076.
UCSCiCG5076-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013599 Genomic DNA. Translation: AAF57772.2 .
RefSeqi NP_477009.1. NM_057661.2.
UniGenei Dm.4335.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4HP4 X-ray 2.00 A/B 11-136 [» ]
ProteinModelPortali A1ZB14.
SMRi A1ZB14. Positions 11-135, 455-507, 514-729.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7227.FBpp0085981.

Proteomic databases

PaxDbi A1ZB14.
PRIDEi A1ZB14.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0086802 ; FBpp0085981 ; FBgn0011589 .
GeneIDi 37047.
KEGGi dme:Dmel_CG5076.
UCSCi CG5076-RA. d. melanogaster.

Organism-specific databases

CTDi 37047.
FlyBasei FBgn0011589. Elk.

Phylogenomic databases

eggNOGi COG2202.
GeneTreei ENSGT00680000099929.
InParanoidi A1ZB14.
OMAi IAVKEYE.
OrthoDBi EOG7QG43V.
PhylomeDBi A1ZB14.

Enzyme and pathway databases

Reactomei REACT_180793. Voltage gated Potassium channels.

Miscellaneous databases

ChiTaRSi elk. drosophila.
GenomeRNAii 37047.
NextBioi 801691.

Gene expression databases

Bgeei A1ZB14.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003950. K_chnl_volt-dep_ELK.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view ]
PRINTSi PR01463. EAGCHANLFMLY.
PR01465. ELKCHANNEL.
SMARTi SM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsi TIGR00229. sensory_box. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  5. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  6. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  7. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  9. "Structural properties of PAS domains from the KCNH potassium channels."
    Adaixo R., Harley C.A., Castro-Rodrigues A.F., Morais-Cabral J.H.
    PLoS ONE 8:e59265-e59265(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 11-136.

Entry informationi

Entry nameiA1ZB14_DROME
AccessioniPrimary (citable) accession number: A1ZB14
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteome

External Data

Dasty 3

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