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A1ZB14

- A1ZB14_DROME

UniProt

A1ZB14 - A1ZB14_DROME

Protein
Submitted name:

Eag-like K[+] channel

Gene

Elk

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. phosphorelay sensor kinase activity Source: InterPro
    2. voltage-gated potassium channel activity Source: FlyBase

    GO - Biological processi

    1. potassium ion transmembrane transport Source: RefGenome
    2. potassium ion transport Source: FlyBase
    3. regulation of membrane potential Source: RefGenome

    Keywords - Molecular functioni

    Ion channelUniRule annotationSAAS annotation, TransferaseImported

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_180793. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Eag-like K[+] channelImported (EC:2.7.3.-Imported)
    Gene namesi
    Name:ElkImported
    Synonyms:elkImported
    ORF Names:CG5076Imported, Dmel_CG5076Imported
    OrganismiDrosophila melanogaster (Fruit fly)Imported
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2R

    Organism-specific databases

    FlyBaseiFBgn0011589. Elk.

    Subcellular locationi

    GO - Cellular componenti

    1. voltage-gated potassium channel complex Source: FlyBase

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Proteomic databases

    PaxDbiA1ZB14.
    PRIDEiA1ZB14.

    Expressioni

    Gene expression databases

    BgeeiA1ZB14.

    Interactioni

    Protein-protein interaction databases

    STRINGi7227.FBpp0085981.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4HP4X-ray2.00A/B11-136[»]
    ProteinModelPortaliA1ZB14.
    SMRiA1ZB14. Positions 11-135, 455-507, 514-729.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni24 – 263Sulfate bindingImported

    Sequence similaritiesi

    Contains cyclic nucleotide-binding domain.SAAS annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    eggNOGiCOG2202.
    GeneTreeiENSGT00680000099929.
    InParanoidiA1ZB14.
    OMAiIAVKEYE.
    OrthoDBiEOG7QG43V.
    PhylomeDBiA1ZB14.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    InterProiIPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR005821. Ion_trans_dom.
    IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
    IPR003950. K_chnl_volt-dep_ELK.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR000700. PAS-assoc_C.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF13426. PAS_9. 1 hit.
    [Graphical view]
    PRINTSiPR01463. EAGCHANLFMLY.
    PR01465. ELKCHANNEL.
    SMARTiSM00100. cNMP. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.
    SSF55785. SSF55785. 1 hit.
    TIGRFAMsiTIGR00229. sensory_box. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
    PS50113. PAC. 1 hit.
    PS50112. PAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1ZB14-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPARKGLLAP QNTFLDTIAT RFDGTHSNFV LGNAQANGNP IVYCSDGFVD     50
    LTGYSRAQIM QKGCSCHFLY GPDTKEEHKQ QIEKSLSNKM ELKLEVIFYK 100
    KEGAPFWCLF DIVPIKNEKR DVVLFLASHK DITHTKMLEM NVNEECDSVF 150
    ALTAALLGAR FRAGSNAGML GLGGLPGLGG PAASDGDTEA GEGNNLDVPA 200
    GCNMGRRRSR AVLYQLSGHY KPEKGGVKTK LKLGNNFMHS TEAPFPEYKT 250
    QSIKKSRLIL PHYGVFKGIW DWVILVATFY VALMVPYNAA FAKADRQTKV 300
    SDVIVEALFI VDILLNFRTT FVSRKGEVVS NSKQIAINYL RGWFALDLLA 350
    ALPFDHLYAS DLYDGEDSHI HLVKLTRLLR LARLLQKIDR YSQHTAMILT 400
    LLMFSFTLAA HWLACIWYVI AVKEYEWFPE SNIGWLQLLA ERKNASVAIL 450
    TTAETYSTAL YFTFTSLTSV GFGNVSANTT AEKVFTIIMM LIGALMHAVV 500
    FGNVTAIIQR MYSRRSLYES KWRDLKDFVA LHNMPKELKQ RIEDYFQTSW 550
    SLSHGIDIYE TLREFPEELR GDVSMHLHRE ILQLPIFEAA SQGCLKLLSL 600
    HIKTNFCAPG EYLIHKGDAL NYIYYLCNGS MEVIKDDMVV AILGKGDLVG 650
    SDINVHLVAT SNGQMTATTN SAGQDVVVRS SSDIKALTYC DLKCIHMGGL 700
    VEVLRLYPEY QQQFANDIQH DLTCNLREGY ENQDSDIGPS FPLPSISEDD 750
    ENREEAEEGG KGEKENGGGP PSGASPLHNI SNSPLHATRS PLLGMGSPRN 800
    QRLHQRGRSL ITLRETNKRH RTLNAACSLD RGSFEEPEPL EEEQSSGGKR 850
    PSLERLDSQV STLHQDVAQL SAEVRNAISA LQEMTFTSNA MTSHSSLKFP 900
    PARSIPNISG VAGTRSGVAV EHGLMGGVLA AAELAAMQRS SSHPPEVWGR 950
    DVQLPTSNTA SSKAPSPVEP KKTMTSRSSQ TDFYRIDFPT FERFVLANPR 1000
    LVLGLLGIEP AIKNEMDLLQ QKQTLQISPL NTIDECVSPS DHNLASSKER 1050
    LITSSAVPTP GRIYPPLDDE NSNDFRWTMK HSASHHSCCK STDALLSPEE 1100
    QPPISILPVD ATPAPSVQEV RSSKRSLRKS TSGSNSSLSS SSSSSNSCLV 1150
    SQSTGNLTTT NASVHCSNSS QSVASVATTR RASWKLQHSR SGEYRRLSEA 1200
    TAEYSPPAKT PLPVAGVSYG GDEEESVELL GPRRNSRPIL LGVSQNQGQG 1250
    QAMNFRFSAG DADKLEKGLR GLPSTRSLRD PSSK 1284
    Length:1,284
    Mass (Da):141,378
    Last modified:February 6, 2007 - v1
    Checksum:iC6EC31891E4B6D24
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013599 Genomic DNA. Translation: AAF57772.2.
    RefSeqiNP_477009.1. NM_057661.2.
    UniGeneiDm.4335.

    Genome annotation databases

    EnsemblMetazoaiFBtr0086802; FBpp0085981; FBgn0011589.
    GeneIDi37047.
    KEGGidme:Dmel_CG5076.
    UCSCiCG5076-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013599 Genomic DNA. Translation: AAF57772.2 .
    RefSeqi NP_477009.1. NM_057661.2.
    UniGenei Dm.4335.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4HP4 X-ray 2.00 A/B 11-136 [» ]
    ProteinModelPortali A1ZB14.
    SMRi A1ZB14. Positions 11-135, 455-507, 514-729.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7227.FBpp0085981.

    Proteomic databases

    PaxDbi A1ZB14.
    PRIDEi A1ZB14.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0086802 ; FBpp0085981 ; FBgn0011589 .
    GeneIDi 37047.
    KEGGi dme:Dmel_CG5076.
    UCSCi CG5076-RA. d. melanogaster.

    Organism-specific databases

    CTDi 37047.
    FlyBasei FBgn0011589. Elk.

    Phylogenomic databases

    eggNOGi COG2202.
    GeneTreei ENSGT00680000099929.
    InParanoidi A1ZB14.
    OMAi IAVKEYE.
    OrthoDBi EOG7QG43V.
    PhylomeDBi A1ZB14.

    Enzyme and pathway databases

    Reactomei REACT_180793. Voltage gated Potassium channels.

    Miscellaneous databases

    ChiTaRSi elk. drosophila.
    GenomeRNAii 37047.
    NextBioi 801691.

    Gene expression databases

    Bgeei A1ZB14.

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    InterProi IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR005821. Ion_trans_dom.
    IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
    IPR003950. K_chnl_volt-dep_ELK.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR000700. PAS-assoc_C.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF13426. PAS_9. 1 hit.
    [Graphical view ]
    PRINTSi PR01463. EAGCHANLFMLY.
    PR01465. ELKCHANNEL.
    SMARTi SM00100. cNMP. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    SSF55785. SSF55785. 1 hit.
    TIGRFAMsi TIGR00229. sensory_box. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
    PS50113. PAC. 1 hit.
    PS50112. PAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    3. Cited for: GENOME REANNOTATION.
      Strain: BerkeleyImported.
    4. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
      Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
      Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    5. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
      Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
      Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    6. "Combined evidence annotation of transposable elements in genome sequences."
      Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
      PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    7. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
      Smith C.D., Shu S., Mungall C.J., Karpen G.H.
      Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    9. "Structural properties of PAS domains from the KCNH potassium channels."
      Adaixo R., Harley C.A., Castro-Rodrigues A.F., Morais-Cabral J.H.
      PLoS ONE 8:e59265-e59265(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 11-136.

    Entry informationi

    Entry nameiA1ZB14_DROME
    AccessioniPrimary (citable) accession number: A1ZB14
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 6, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3