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Protein

SH3 domain-containing protein Dlish

Gene

Dlish

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for the apical cell cortex localization, total cellular level and full activity of dachs.1 Publication

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 domain-containing protein DlishCurated
Alternative name(s):
Dachs ligand with SH3 domains1 Publication
Gene namesi
Name:Dlish1 Publication
ORF Names:CG10933Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0034264. CG10933.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Cytoplasmcell cortex 1 Publication

  • Note: Low levels are found diffusely in the cytoplasm with high levels concentrated at the subapical cell cortex.1 Publication

GO - Cellular componenti

  • apical cortex Source: UniProtKB
  • cytoplasm Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown results in reduced spacing between the anterior and posterior crossveins of the wing, reduced levels of subapical cortical dachs, increased levels of dachs throughout the cytoplasm, increased total cellular levels of dachs and suppression of the overgrowth and dachs up-regulation seen in ft mutants.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004388531 – 355SH3 domain-containing protein DlishAdd BLAST355

Post-translational modificationi

Palmitoylated by app.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiA1ZAY1.

Expressioni

Gene expression databases

BgeeiFBgn0034264.

Interactioni

Subunit structurei

Interacts with dachs (via C-terminus); the interaction is direct. Interacts (via N-terminus including SH3 domain 1) with palmitoyltransferase app; this leads to palmitoylation of Dlish by app. Also interacts with dco, ft, ft-regulated E3 ubiquitin ligase Fbxl7, F-box protein slmb and SCF E3 ubiquitin-protein ligase complex component Cul1.1 Publication

Structurei

3D structure databases

ProteinModelPortaliA1ZAY1.
SMRiA1ZAY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 117SH3 1PROSITE-ProRule annotationAdd BLAST61
Domaini183 – 243SH3 2PROSITE-ProRule annotationAdd BLAST61
Domaini287 – 352SH3 3PROSITE-ProRule annotationAdd BLAST66

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi248 – 277Gln-richPROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiENOG410IIV7. Eukaryota.
ENOG410XSY1. LUCA.
GeneTreeiENSGT00390000000504.
OMAiFLCPVRI.
OrthoDBiEOG091G0HCZ.
PhylomeDBiA1ZAY1.

Family and domain databases

InterProiView protein in InterPro
IPR001452. SH3_domain.
PfamiView protein in Pfam
PF00018. SH3_1. 1 hit.
PF14604. SH3_9. 1 hit.
SMARTiView protein in SMART
SM00326. SH3. 3 hits.
SUPFAMiSSF50044. SSF50044. 3 hits.
PROSITEiView protein in PROSITE
PS50002. SH3. 3 hits.

Sequencei

Sequence statusi: Complete.

A1ZAY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFLCPVRMR RDKKKATNAS IERDLPAVGV LGMGRITGSS SIETLVRVGI
60 70 80 90 100
EKEHGLSPDS KMVVLHDFTP CVDDELEVKR GQLVNILYRE NDWVYVIGQD
110 120 130 140 150
SRQEGFIPFS YCAPCNTQLA DLAVKKKLPR EQCPEQPIEE NIPLLGTDNK
160 170 180 190 200
LDVLCDETLN PGSANSIENT LLVEPECTPF VKEPSGRCIV LYTFIARDEN
210 220 230 240 250
DLSVERGEFV TVLNREDPDW FWIMRSDGQE GFVPASFIYP ADSVRVLQQQ
260 270 280 290 300
KATLNAMETI LQQGQQGQQS QQQQQPQLGL GTDDLRYHGT ELVMLYDYKA
310 320 330 340 350
QAPDDLYLSV RRGDWIYADL TNQTVDGWLW AYAPKTRKYG FIPKAYARPP

AMTSL
Length:355
Mass (Da):40,131
Last modified:February 6, 2007 - v1
Checksum:iC500D56CD93F467B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF57808.2.
BT099964 mRNA. Translation: ACX47665.1.
RefSeqiNP_611251.2. NM_137407.3.
UniGeneiDm.26280.

Genome annotation databases

EnsemblMetazoaiFBtr0086860; FBpp0086020; FBgn0034264.
GeneIDi37014.
KEGGidme:Dmel_CG10933.
UCSCiCG10933-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF57808.2.
BT099964 mRNA. Translation: ACX47665.1.
RefSeqiNP_611251.2. NM_137407.3.
UniGeneiDm.26280.

3D structure databases

ProteinModelPortaliA1ZAY1.
SMRiA1ZAY1.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiA1ZAY1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0086860; FBpp0086020; FBgn0034264.
GeneIDi37014.
KEGGidme:Dmel_CG10933.
UCSCiCG10933-RA. d. melanogaster.

Organism-specific databases

FlyBaseiFBgn0034264. CG10933.

Phylogenomic databases

eggNOGiENOG410IIV7. Eukaryota.
ENOG410XSY1. LUCA.
GeneTreeiENSGT00390000000504.
OMAiFLCPVRI.
OrthoDBiEOG091G0HCZ.
PhylomeDBiA1ZAY1.

Miscellaneous databases

GenomeRNAii37014.

Gene expression databases

BgeeiFBgn0034264.

Family and domain databases

InterProiView protein in InterPro
IPR001452. SH3_domain.
PfamiView protein in Pfam
PF00018. SH3_1. 1 hit.
PF14604. SH3_9. 1 hit.
SMARTiView protein in SMART
SM00326. SH3. 3 hits.
SUPFAMiSSF50044. SSF50044. 3 hits.
PROSITEiView protein in PROSITE
PS50002. SH3. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiDLISH_DROME
AccessioniPrimary (citable) accession number: A1ZAY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2017
Last sequence update: February 6, 2007
Last modified: April 12, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.