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Protein

Eukaryotic translation initiation factor 3 subunit C

Gene

eIF3c

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.UniRule annotation

GO - Molecular functioni

  • translation initiation factor activity Source: FlyBase
  • translation initiation factor binding Source: GO_Central

GO - Biological processi

  • translational initiation Source: FlyBase

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-DME-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-72649 Translation initiation complex formation
R-DME-72689 Formation of a pool of free 40S subunits
R-DME-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-DME-72702 Ribosomal scanning and start codon recognition

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit CUniRule annotation
Short name:
eIF3cUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 8UniRule annotation
Gene namesi
Name:eIF3cUniRule annotation
Synonyms:eIF3-S8UniRule annotation
ORF Names:CG4954Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0034258 eIF3c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003653881 – 910Eukaryotic translation initiation factor 3 subunit CAdd BLAST910

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34PhosphoserineUniRule annotation1 Publication1
Modified residuei165PhosphoserineUniRule annotation1 Publication1
Modified residuei176PhosphoserineUniRule annotation1 Publication1
Modified residuei185PhosphoserineUniRule annotation1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA1ZAX1
PRIDEiA1ZAX1

PTM databases

iPTMnetiA1ZAX1

Expressioni

Gene expression databases

BgeeiFBgn0034258
ExpressionAtlasiA1ZAX1 baseline and differential
GenevisibleiA1ZAX1 DM

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix.UniRule annotation1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi62691, 29 interactors
IntActiA1ZAX1, 15 interactors
STRINGi7227.FBpp0086013

Structurei

3D structure databases

ProteinModelPortaliA1ZAX1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini639 – 815PCIPROSITE-ProRule annotationAdd BLAST177

Sequence similaritiesi

Belongs to the eIF-3 subunit C family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1076 Eukaryota
ENOG410XRU3 LUCA
GeneTreeiENSGT00390000017900
InParanoidiA1ZAX1
KOiK03252
OMAiVVMHRSE
OrthoDBiEOG091G02A3
PhylomeDBiA1ZAX1

Family and domain databases

HAMAPiMF_03002 eIF3c, 1 hit
InterProiView protein in InterPro
IPR027516 EIF3C
IPR008905 EIF3C_N_dom
IPR000717 PCI_dom
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF05470 eIF-3c_N, 1 hit
PF01399 PCI, 1 hit
SMARTiView protein in SMART
SM00088 PINT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequencei

Sequence statusi: Complete.

A1ZAX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRFFANGSE SESESSEEEI QATNFNKASA FQFSDDEEEV KRVVRSTKEK
60 70 80 90 100
RYENLTSIIK TIRNHKKIKD IPNTLSSFED LTRAYQKALP VISKEENGIT
110 120 130 140 150
PRFYIRCLAE LEDFINEVWE DREGRKNLSK NNSKSLGTLR QKVRKYIKDF
160 170 180 190 200
EDDLSRFREA PDQESEAEDE VVALESDGGD AGDDSDAGVK PTEAVPKAVK
210 220 230 240 250
SAPAKAAPAD DDDSDDSIDW DSDSESETES SDDENQYQNM RERFLKRTTE
260 270 280 290 300
KEEKDDDKRK DKRKEQKTKI RKRAEDDEDG EWETVVKGHV VEKPKMFEKD
310 320 330 340 350
AEIDVPLVLA KLLEIMSARG KKRTDRRLQI DLLFELRDIS DQHNLGTAVS
360 370 380 390 400
VKIHFNIISA IYDYNQKISE PMKLEHWALL LEVMQSMMKL LLANADIIMS
410 420 430 440 450
ESVAEEHEEY ATSPFYVRGC PLAAVERLDD EFVKLLKECD PHSNDYVSRL
460 470 480 490 500
KDEVNVVKTI ELVLQYFERS GTNNERCRIY LRKIEHLYYK FDPEVLKKKR
510 520 530 540 550
GELPATTSTS VDVMDKLCKF IYAKDDTDRI RTRAILAHIY HHAMHDNWFQ
560 570 580 590 600
ARDLVLMSHL QDNIDAADPA TRILYNRMMA NLGLCAFRQG NVKDAHHCLV
610 620 630 640 650
DLMVTGKPKE LLAQGLLPQR QHERSAEQEK IEKQRQMPFH MHINLELLEC
660 670 680 690 700
VYLVSAMLLE IPYIAAHEFD ARRRMISKTF YQQLRSSERQ SLVGPPESMR
710 720 730 740 750
EHVVAAAKAM RCGNWQACAN FIVNKKMNTK VWDLFYESDR VREMLTKFIK
760 770 780 790 800
EESLRTYLFT YSNVYTSISI PSLAQMYELP VPKVHSIISK MIINEELMAS
810 820 830 840 850
LDDPSETVGM HRSEPSRLQA LAMQFVDKVT NLVDVNEKVF DMKQGNFFQR
860 870 880 890 900
GNMGNRGDRG YNRNQNNQGG NWLGQRRDRN NRNRNQRGHH KNNQDRQQQQ
910
QQQVQTIDEE
Length:910
Mass (Da):105,654
Last modified:February 6, 2007 - v1
Checksum:iFC05D6478712684A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti293K → N in AAM52637 (PubMed:12537569).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF57818.1
AY122125 mRNA Translation: AAM52637.1
BT044242 mRNA Translation: ACH92307.1
RefSeqiNP_001286545.1, NM_001299616.1
NP_611242.1, NM_137398.2
UniGeneiDm.7296

Genome annotation databases

EnsemblMetazoaiFBtr0086836; FBpp0086013; FBgn0034258
FBtr0340269; FBpp0309235; FBgn0034258
GeneIDi37005
KEGGidme:Dmel_CG4954
UCSCiCG4954-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiEIF3C_DROME
AccessioniPrimary (citable) accession number: A1ZAX1
Secondary accession number(s): Q8MR49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: February 6, 2007
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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