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A1ZAX1 (EIF3C_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Eukaryotic translation initiation factor 3 subunit C
Short name=eIF3c
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 8
Gene names
Name:eIF3-S8
ORF Names:CG4954
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›

Protein attributes

Sequence length910 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. HAMAP-Rule MF_03002

Subunit structure

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix. Ref.5

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the eIF-3 subunit C family.

Contains 1 PCI domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 910910Eukaryotic translation initiation factor 3 subunit C HAMAP-Rule MF_03002
PRO_0000365388

Regions

Domain678 – 812135PCI

Amino acid modifications

Modified residue341Phosphoserine Ref.6
Modified residue1651Phosphoserine Ref.7
Modified residue1761Phosphoserine Ref.7
Modified residue1851Phosphoserine Ref.7

Experimental info

Sequence conflict2931K → N in AAM52637. Ref.3

Sequences

Sequence LengthMass (Da)Tools
A1ZAX1 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: FC05D6478712684A

FASTA910105,654
        10         20         30         40         50         60 
MSRFFANGSE SESESSEEEI QATNFNKASA FQFSDDEEEV KRVVRSTKEK RYENLTSIIK 

        70         80         90        100        110        120 
TIRNHKKIKD IPNTLSSFED LTRAYQKALP VISKEENGIT PRFYIRCLAE LEDFINEVWE 

       130        140        150        160        170        180 
DREGRKNLSK NNSKSLGTLR QKVRKYIKDF EDDLSRFREA PDQESEAEDE VVALESDGGD 

       190        200        210        220        230        240 
AGDDSDAGVK PTEAVPKAVK SAPAKAAPAD DDDSDDSIDW DSDSESETES SDDENQYQNM 

       250        260        270        280        290        300 
RERFLKRTTE KEEKDDDKRK DKRKEQKTKI RKRAEDDEDG EWETVVKGHV VEKPKMFEKD 

       310        320        330        340        350        360 
AEIDVPLVLA KLLEIMSARG KKRTDRRLQI DLLFELRDIS DQHNLGTAVS VKIHFNIISA 

       370        380        390        400        410        420 
IYDYNQKISE PMKLEHWALL LEVMQSMMKL LLANADIIMS ESVAEEHEEY ATSPFYVRGC 

       430        440        450        460        470        480 
PLAAVERLDD EFVKLLKECD PHSNDYVSRL KDEVNVVKTI ELVLQYFERS GTNNERCRIY 

       490        500        510        520        530        540 
LRKIEHLYYK FDPEVLKKKR GELPATTSTS VDVMDKLCKF IYAKDDTDRI RTRAILAHIY 

       550        560        570        580        590        600 
HHAMHDNWFQ ARDLVLMSHL QDNIDAADPA TRILYNRMMA NLGLCAFRQG NVKDAHHCLV 

       610        620        630        640        650        660 
DLMVTGKPKE LLAQGLLPQR QHERSAEQEK IEKQRQMPFH MHINLELLEC VYLVSAMLLE 

       670        680        690        700        710        720 
IPYIAAHEFD ARRRMISKTF YQQLRSSERQ SLVGPPESMR EHVVAAAKAM RCGNWQACAN 

       730        740        750        760        770        780 
FIVNKKMNTK VWDLFYESDR VREMLTKFIK EESLRTYLFT YSNVYTSISI PSLAQMYELP 

       790        800        810        820        830        840 
VPKVHSIISK MIINEELMAS LDDPSETVGM HRSEPSRLQA LAMQFVDKVT NLVDVNEKVF 

       850        860        870        880        890        900 
DMKQGNFFQR GNMGNRGDRG YNRNQNNQGG NWLGQRRDRN NRNRNQRGHH KNNQDRQQQQ 

       910 
QQQVQTIDEE

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[3]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Head.
[4]Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.
Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
[5]"The essential Drosophila ATP-binding cassette domain protein, pixie, binds the 40 S ribosome in an ATP-dependent manner and is required for translation initiation."
Andersen D.S., Leevers S.J.
J. Biol. Chem. 282:14752-14760(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PIX, ASSOCIATION WITH THE 40S RIBOSOME.
[6]"An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells."
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A., Eng J.K., Aebersold R., Tao W.A.
Mol. Biosyst. 3:275-286(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34, MASS SPECTROMETRY.
[7]"Phosphoproteome analysis of Drosophila melanogaster embryos."
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165; SER-176 AND SER-185, MASS SPECTROMETRY.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE013599 Genomic DNA. Translation: AAF57818.1.
AY122125 mRNA. Translation: AAM52637.1.
BT044242 mRNA. Translation: ACH92307.1.
RefSeqNP_611242.1. NM_137398.1.
UniGeneDm.7296.

3D structure databases

ProteinModelPortalA1ZAX1.
SMRA1ZAX1. Positions 742-815.
ModBaseSearch...

Protein-protein interaction databases

IntActA1ZAX1. 10 interactions.
STRING7227.FBpp0086013.

Proteomic databases

PaxDbA1ZAX1.
PRIDEA1ZAX1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0086836; FBpp0086013; FBgn0034258.
GeneID37005.
KEGGdme:Dmel_CG4954.
UCSCCG4954-RA. d. melanogaster.

Organism-specific databases

CTD37005.
FlyBaseFBgn0034258. eIF3-S8.

Phylogenomic databases

eggNOGNOG305883.
GeneTreeENSGT00390000017900.
InParanoidA1ZAX1.
KOK03252.
OMAESHITNY.
OrthoDBEOG4SQVBM.
PhylomeDBA1ZAX1.

Gene expression databases

BgeeA1ZAX1.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
HAMAPMF_03002. eIF3c.
InterProIPR008905. eIF3c_N.
IPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF05470. eIF-3c_N. 1 hit.
PF01399. PCI. 1 hit.
[Graphical view]
SMARTSM00088. PINT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSeIF3-S8. drosophila.
GenomeRNAi37005.
NextBio801456.

Entry information

Entry nameEIF3C_DROME
AccessionPrimary (citable) accession number: A1ZAX1
Secondary accession number(s): Q8MR49
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: February 6, 2007
Last modified: May 1, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Translation initiation factors

List of translation initiation factor entries

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents