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A1ZAX1

- EIF3C_DROME

UniProt

A1ZAX1 - EIF3C_DROME

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Protein

Eukaryotic translation initiation factor 3 subunit C

Gene

eIF3-S8

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.

GO - Molecular functioni

  1. translation initiation factor activity Source: FlyBase

GO - Biological processi

  1. formation of translation preinitiation complex Source: UniProtKB-HAMAP
  2. regulation of translational initiation Source: UniProtKB-HAMAP
  3. translational initiation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

ReactomeiREACT_205240. Formation of a pool of free 40S subunits.
REACT_207008. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_207218. Translation initiation complex formation.
REACT_213100. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_215632. Ribosomal scanning and start codon recognition.
REACT_225982. Formation of the ternary complex, and subsequently, the 43S complex.

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit CUniRule annotation
Short name:
eIF3cUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 8UniRule annotation
Gene namesi
Name:eIF3-S8UniRule annotation
ORF Names:CG4954
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0034258. eIF3-S8.

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytosol Source: FlyBase
  2. eukaryotic 43S preinitiation complex Source: UniProtKB-HAMAP
  3. eukaryotic 48S preinitiation complex Source: UniProtKB-HAMAP
  4. eukaryotic translation initiation factor 3 complex Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 910910Eukaryotic translation initiation factor 3 subunit CPRO_0000365388Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341Phosphoserine1 PublicationUniRule annotation
Modified residuei165 – 1651Phosphoserine1 PublicationUniRule annotation
Modified residuei176 – 1761Phosphoserine1 PublicationUniRule annotation
Modified residuei185 – 1851Phosphoserine1 PublicationUniRule annotation

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA1ZAX1.
PRIDEiA1ZAX1.

Expressioni

Gene expression databases

BgeeiA1ZAX1.

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix.1 PublicationUniRule annotation

Protein-protein interaction databases

BioGridi62691. 16 interactions.
IntActiA1ZAX1. 11 interactions.
STRINGi7227.FBpp0086013.

Structurei

3D structure databases

ProteinModelPortaliA1ZAX1.
SMRiA1ZAX1. Positions 744-811.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini678 – 812135PCIUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the eIF-3 subunit C family.UniRule annotation
Contains 1 PCI domain.UniRule annotation

Phylogenomic databases

eggNOGiNOG305883.
GeneTreeiENSGT00390000017900.
InParanoidiA1ZAX1.
KOiK03252.
OMAiWKACKNF.
OrthoDBiEOG7DC23R.
PhylomeDBiA1ZAX1.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_03002. eIF3c.
InterProiIPR027516. EIF3C.
IPR008905. EIF3C_N_dom.
IPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05470. eIF-3c_N. 1 hit.
PF01399. PCI. 1 hit.
[Graphical view]
SMARTiSM00088. PINT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1ZAX1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRFFANGSE SESESSEEEI QATNFNKASA FQFSDDEEEV KRVVRSTKEK
60 70 80 90 100
RYENLTSIIK TIRNHKKIKD IPNTLSSFED LTRAYQKALP VISKEENGIT
110 120 130 140 150
PRFYIRCLAE LEDFINEVWE DREGRKNLSK NNSKSLGTLR QKVRKYIKDF
160 170 180 190 200
EDDLSRFREA PDQESEAEDE VVALESDGGD AGDDSDAGVK PTEAVPKAVK
210 220 230 240 250
SAPAKAAPAD DDDSDDSIDW DSDSESETES SDDENQYQNM RERFLKRTTE
260 270 280 290 300
KEEKDDDKRK DKRKEQKTKI RKRAEDDEDG EWETVVKGHV VEKPKMFEKD
310 320 330 340 350
AEIDVPLVLA KLLEIMSARG KKRTDRRLQI DLLFELRDIS DQHNLGTAVS
360 370 380 390 400
VKIHFNIISA IYDYNQKISE PMKLEHWALL LEVMQSMMKL LLANADIIMS
410 420 430 440 450
ESVAEEHEEY ATSPFYVRGC PLAAVERLDD EFVKLLKECD PHSNDYVSRL
460 470 480 490 500
KDEVNVVKTI ELVLQYFERS GTNNERCRIY LRKIEHLYYK FDPEVLKKKR
510 520 530 540 550
GELPATTSTS VDVMDKLCKF IYAKDDTDRI RTRAILAHIY HHAMHDNWFQ
560 570 580 590 600
ARDLVLMSHL QDNIDAADPA TRILYNRMMA NLGLCAFRQG NVKDAHHCLV
610 620 630 640 650
DLMVTGKPKE LLAQGLLPQR QHERSAEQEK IEKQRQMPFH MHINLELLEC
660 670 680 690 700
VYLVSAMLLE IPYIAAHEFD ARRRMISKTF YQQLRSSERQ SLVGPPESMR
710 720 730 740 750
EHVVAAAKAM RCGNWQACAN FIVNKKMNTK VWDLFYESDR VREMLTKFIK
760 770 780 790 800
EESLRTYLFT YSNVYTSISI PSLAQMYELP VPKVHSIISK MIINEELMAS
810 820 830 840 850
LDDPSETVGM HRSEPSRLQA LAMQFVDKVT NLVDVNEKVF DMKQGNFFQR
860 870 880 890 900
GNMGNRGDRG YNRNQNNQGG NWLGQRRDRN NRNRNQRGHH KNNQDRQQQQ
910
QQQVQTIDEE
Length:910
Mass (Da):105,654
Last modified:February 6, 2007 - v1
Checksum:iFC05D6478712684A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti293 – 2931K → N in AAM52637. (PubMed:12537569)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF57818.1.
AY122125 mRNA. Translation: AAM52637.1.
BT044242 mRNA. Translation: ACH92307.1.
RefSeqiNP_001286545.1. NM_001299616.1.
NP_611242.1. NM_137398.2.
UniGeneiDm.7296.

Genome annotation databases

EnsemblMetazoaiFBtr0086836; FBpp0086013; FBgn0034258.
GeneIDi37005.
KEGGidme:Dmel_CG4954.
UCSCiCG4954-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF57818.1 .
AY122125 mRNA. Translation: AAM52637.1 .
BT044242 mRNA. Translation: ACH92307.1 .
RefSeqi NP_001286545.1. NM_001299616.1.
NP_611242.1. NM_137398.2.
UniGenei Dm.7296.

3D structure databases

ProteinModelPortali A1ZAX1.
SMRi A1ZAX1. Positions 744-811.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 62691. 16 interactions.
IntActi A1ZAX1. 11 interactions.
STRINGi 7227.FBpp0086013.

Proteomic databases

PaxDbi A1ZAX1.
PRIDEi A1ZAX1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0086836 ; FBpp0086013 ; FBgn0034258 .
GeneIDi 37005.
KEGGi dme:Dmel_CG4954.
UCSCi CG4954-RA. d. melanogaster.

Organism-specific databases

CTDi 37005.
FlyBasei FBgn0034258. eIF3-S8.

Phylogenomic databases

eggNOGi NOG305883.
GeneTreei ENSGT00390000017900.
InParanoidi A1ZAX1.
KOi K03252.
OMAi WKACKNF.
OrthoDBi EOG7DC23R.
PhylomeDBi A1ZAX1.

Enzyme and pathway databases

Reactomei REACT_205240. Formation of a pool of free 40S subunits.
REACT_207008. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_207218. Translation initiation complex formation.
REACT_213100. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_215632. Ribosomal scanning and start codon recognition.
REACT_225982. Formation of the ternary complex, and subsequently, the 43S complex.

Miscellaneous databases

ChiTaRSi eIF3-S8. fly.
GenomeRNAii 37005.
NextBioi 801456.
PROi A1ZAX1.

Gene expression databases

Bgeei A1ZAX1.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
HAMAPi MF_03002. eIF3c.
InterProi IPR027516. EIF3C.
IPR008905. EIF3C_N_dom.
IPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF05470. eIF-3c_N. 1 hit.
PF01399. PCI. 1 hit.
[Graphical view ]
SMARTi SM00088. PINT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Head.
  4. Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.
    Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
  5. "The essential Drosophila ATP-binding cassette domain protein, pixie, binds the 40 S ribosome in an ATP-dependent manner and is required for translation initiation."
    Andersen D.S., Leevers S.J.
    J. Biol. Chem. 282:14752-14760(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PIX, ASSOCIATION WITH THE 40S RIBOSOME.
  6. "An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells."
    Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A., Eng J.K., Aebersold R., Tao W.A.
    Mol. Biosyst. 3:275-286(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34, IDENTIFICATION BY MASS SPECTROMETRY.
  7. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165; SER-176 AND SER-185, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiEIF3C_DROME
AccessioniPrimary (citable) accession number: A1ZAX1
Secondary accession number(s): Q8MR49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: February 6, 2007
Last modified: November 26, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Translation initiation factors
    List of translation initiation factor entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3