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Protein

Eukaryotic translation initiation factor 3 subunit C

Gene

eIF3-S8

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.UniRule annotation

GO - Molecular functioni

  • translation initiation factor activity Source: FlyBase
  • translation initiation factor binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-72649. Translation initiation complex formation.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-DME-72702. Ribosomal scanning and start codon recognition.

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit CUniRule annotation
Short name:
eIF3cUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 8UniRule annotation
Gene namesi
Name:eIF3-S8UniRule annotation
ORF Names:CG4954
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0034258. eIF3-S8.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

  • cytosol Source: FlyBase
  • eukaryotic 43S preinitiation complex Source: UniProtKB-HAMAP
  • eukaryotic 48S preinitiation complex Source: UniProtKB-HAMAP
  • eukaryotic translation initiation factor 3 complex Source: FlyBase
  • mitochondrion Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003653881 – 910Eukaryotic translation initiation factor 3 subunit CAdd BLAST910

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34PhosphoserineUniRule annotation1 Publication1
Modified residuei165PhosphoserineUniRule annotation1 Publication1
Modified residuei176PhosphoserineUniRule annotation1 Publication1
Modified residuei185PhosphoserineUniRule annotation1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA1ZAX1.
PRIDEiA1ZAX1.

PTM databases

iPTMnetiA1ZAX1.

Expressioni

Gene expression databases

BgeeiFBgn0034258.
ExpressionAtlasiA1ZAX1. baseline.
GenevisibleiA1ZAX1. DM.

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix.UniRule annotation1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi62691. 18 interactors.
IntActiA1ZAX1. 14 interactors.
STRINGi7227.FBpp0086013.

Structurei

3D structure databases

ProteinModelPortaliA1ZAX1.
SMRiA1ZAX1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini678 – 812PCIUniRule annotationAdd BLAST135

Sequence similaritiesi

Belongs to the eIF-3 subunit C family.UniRule annotation
Contains 1 PCI domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG1076. Eukaryota.
ENOG410XRU3. LUCA.
GeneTreeiENSGT00390000017900.
InParanoidiA1ZAX1.
KOiK03252.
OMAiIIMSESV.
OrthoDBiEOG091G02A3.
PhylomeDBiA1ZAX1.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_03002. eIF3c. 1 hit.
InterProiIPR027516. EIF3C.
IPR008905. EIF3C_N_dom.
IPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05470. eIF-3c_N. 1 hit.
PF01399. PCI. 1 hit.
[Graphical view]
SMARTiSM00088. PINT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.

Sequencei

Sequence statusi: Complete.

A1ZAX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRFFANGSE SESESSEEEI QATNFNKASA FQFSDDEEEV KRVVRSTKEK
60 70 80 90 100
RYENLTSIIK TIRNHKKIKD IPNTLSSFED LTRAYQKALP VISKEENGIT
110 120 130 140 150
PRFYIRCLAE LEDFINEVWE DREGRKNLSK NNSKSLGTLR QKVRKYIKDF
160 170 180 190 200
EDDLSRFREA PDQESEAEDE VVALESDGGD AGDDSDAGVK PTEAVPKAVK
210 220 230 240 250
SAPAKAAPAD DDDSDDSIDW DSDSESETES SDDENQYQNM RERFLKRTTE
260 270 280 290 300
KEEKDDDKRK DKRKEQKTKI RKRAEDDEDG EWETVVKGHV VEKPKMFEKD
310 320 330 340 350
AEIDVPLVLA KLLEIMSARG KKRTDRRLQI DLLFELRDIS DQHNLGTAVS
360 370 380 390 400
VKIHFNIISA IYDYNQKISE PMKLEHWALL LEVMQSMMKL LLANADIIMS
410 420 430 440 450
ESVAEEHEEY ATSPFYVRGC PLAAVERLDD EFVKLLKECD PHSNDYVSRL
460 470 480 490 500
KDEVNVVKTI ELVLQYFERS GTNNERCRIY LRKIEHLYYK FDPEVLKKKR
510 520 530 540 550
GELPATTSTS VDVMDKLCKF IYAKDDTDRI RTRAILAHIY HHAMHDNWFQ
560 570 580 590 600
ARDLVLMSHL QDNIDAADPA TRILYNRMMA NLGLCAFRQG NVKDAHHCLV
610 620 630 640 650
DLMVTGKPKE LLAQGLLPQR QHERSAEQEK IEKQRQMPFH MHINLELLEC
660 670 680 690 700
VYLVSAMLLE IPYIAAHEFD ARRRMISKTF YQQLRSSERQ SLVGPPESMR
710 720 730 740 750
EHVVAAAKAM RCGNWQACAN FIVNKKMNTK VWDLFYESDR VREMLTKFIK
760 770 780 790 800
EESLRTYLFT YSNVYTSISI PSLAQMYELP VPKVHSIISK MIINEELMAS
810 820 830 840 850
LDDPSETVGM HRSEPSRLQA LAMQFVDKVT NLVDVNEKVF DMKQGNFFQR
860 870 880 890 900
GNMGNRGDRG YNRNQNNQGG NWLGQRRDRN NRNRNQRGHH KNNQDRQQQQ
910
QQQVQTIDEE
Length:910
Mass (Da):105,654
Last modified:February 6, 2007 - v1
Checksum:iFC05D6478712684A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti293K → N in AAM52637 (PubMed:12537569).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF57818.1.
AY122125 mRNA. Translation: AAM52637.1.
BT044242 mRNA. Translation: ACH92307.1.
RefSeqiNP_001286545.1. NM_001299616.1.
NP_611242.1. NM_137398.2.
UniGeneiDm.7296.

Genome annotation databases

EnsemblMetazoaiFBtr0086836; FBpp0086013; FBgn0034258.
FBtr0340269; FBpp0309235; FBgn0034258.
GeneIDi37005.
KEGGidme:Dmel_CG4954.
UCSCiCG4954-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF57818.1.
AY122125 mRNA. Translation: AAM52637.1.
BT044242 mRNA. Translation: ACH92307.1.
RefSeqiNP_001286545.1. NM_001299616.1.
NP_611242.1. NM_137398.2.
UniGeneiDm.7296.

3D structure databases

ProteinModelPortaliA1ZAX1.
SMRiA1ZAX1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi62691. 18 interactors.
IntActiA1ZAX1. 14 interactors.
STRINGi7227.FBpp0086013.

PTM databases

iPTMnetiA1ZAX1.

Proteomic databases

PaxDbiA1ZAX1.
PRIDEiA1ZAX1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0086836; FBpp0086013; FBgn0034258.
FBtr0340269; FBpp0309235; FBgn0034258.
GeneIDi37005.
KEGGidme:Dmel_CG4954.
UCSCiCG4954-RA. d. melanogaster.

Organism-specific databases

CTDi37005.
FlyBaseiFBgn0034258. eIF3-S8.

Phylogenomic databases

eggNOGiKOG1076. Eukaryota.
ENOG410XRU3. LUCA.
GeneTreeiENSGT00390000017900.
InParanoidiA1ZAX1.
KOiK03252.
OMAiIIMSESV.
OrthoDBiEOG091G02A3.
PhylomeDBiA1ZAX1.

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-72649. Translation initiation complex formation.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-DME-72702. Ribosomal scanning and start codon recognition.

Miscellaneous databases

ChiTaRSieIF3-S8. fly.
GenomeRNAii37005.
PROiA1ZAX1.

Gene expression databases

BgeeiFBgn0034258.
ExpressionAtlasiA1ZAX1. baseline.
GenevisibleiA1ZAX1. DM.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_03002. eIF3c. 1 hit.
InterProiIPR027516. EIF3C.
IPR008905. EIF3C_N_dom.
IPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05470. eIF-3c_N. 1 hit.
PF01399. PCI. 1 hit.
[Graphical view]
SMARTiSM00088. PINT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEIF3C_DROME
AccessioniPrimary (citable) accession number: A1ZAX1
Secondary accession number(s): Q8MR49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: February 6, 2007
Last modified: November 30, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Translation initiation factors
    List of translation initiation factor entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.