Unreviewed, UniProtKB/TrEMBL A1ZAW0 (A1ZAW0_DROME)

Names and origin

Protein names

Submitted name:
    Dicer-2 EMBL AAF57830.2
    EC=3.1.26.3
    EC=3.6.1.3

Gene names

Name:	Dcr-2 FlyBase FBgn0034246
ORF Names:	Dmel_CG6493 EMBL AAF57830.2

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	1722 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Helicase RuleBase RU000452V3 Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	RNA interference, production of siRNA Inferred from direct assay. Source: FlyBase RNA interference, siRNA loading onto RISC Inferred from mutant phenotype. Source: FlyBase RNA interference, targeting of mRNA for destruction Inferred from mutant phenotype. Source: FlyBase chromatin silencing Inferred from mutant phenotype. Source: FlyBase defense response to virus Inferred from mutant phenotype. Source: FlyBase
Cellular component	cytoplasm Inferred from direct assay. Source: FlyBase nucleus Inferred from direct assay. Source: FlyBase
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro ATP-dependent helicase activity Inferred from electronic annotation. Source: InterPro ATPase activity, uncoupled Inferred from electronic annotation. Source: EC double-stranded RNA binding Inferred from electronic annotation. Source: InterPro ribonuclease III activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A1ZAW0-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 73755021033C399A	FASTA	1,722	197,765
	10 20 30 40 50 60 MEDVEIKPRG YQLRLVDHLT KSNGIVYLPT GSGKTFVAIL VLKRFSQDFD KPIESGGKRA 70 80 90 100 110 120 LFMCNTVELA RQQAMAVRRC TNFKVGFYVG EQGVDDWTRG MWSDEIKKNQ VLVGTAQVFL 130 140 150 160 170 180 DMVTQTYVAL SSLSVVIIDE CHHGTGHHPF REFMRLFTIA NQTKLPRVVG LTGVLIKGNE 190 200 210 220 230 240 ITNVATKLKE LEITYRGNII TVSDTKEMEN VMLYATKPTE VMVSFPHQEQ VLTVTRLISA 250 260 270 280 290 300 EIEKFYVSLD LMNIGVQPIR RSKSLQCLRD PSKKSFVKQL FNDFLYQMKE YGIYAASIAI 310 320 330 340 350 360 ISLIVEFDIK RRQAETLSVK LMHRTALTLC EKIRHLLVQK LQDMTYDDDD DNVNTEEVIM 370 380 390 400 410 420 NFSTPKVQRF LMSLKVSFAD KDPKDICCLV FVERRYTCKC IYGLLLNYIQ STPELRNVLT 430 440 450 460 470 480 PQFMVGRNNI SPDFESVLER KWQKSAIQQF RDGNANLMIC SSVLEEGIDV QACNHVFILD 490 500 510 520 530 540 PVKTFNMYVQ SKGRARTTEA KFVLFTADKE REKTIQQIYQ YRKAHNDIAE YLKDRVLEKT 550 560 570 580 590 600 EPELYEIKGH FQDDIDPFTN ENGAVLLPNN ALAILHRYCQ TIPTDAFGFV IPWFHVLQED 610 620 630 640 650 660 ERDRIFGVSA KGKHVISINM PVNCMLRDTI YSDPMDNVKT AKISAAFKAC KVLYSLGELN 670 680 690 700 710 720 ERFVPKTLKE RVASIADVHF EHWNKYGDSV TATVNKADKS KDRTYKTECP LEFYDALPRV 730 740 750 760 770 780 GEICYAYEIF LEPQFESCEY TEHMYLNLQT PRNYAILLRN KLPRLAEMPL FSNQGKLHVR 790 800 810 820 830 840 VANAPLEVII QNSEQLELLH QFHGMVFRDI LKIWHPFFVL DRRSKENSYL VVPLILGAGE 850 860 870 880 890 900 QKCFDWELMT NFRRLPQSHG SNVQQREQQP APRPEDFEGK IVTQWYANYD KPMLVTKVHR 910 920 930 940 950 960 ELTPLSYMEK NQQDKTYYEF TMSKYGNRIG DVVHKDKFMI EVRDLTEQLT FYVHNRGKFN 970 980 990 1000 1010 1020 AKSKAKMKVI LIPELCFNFN FPGDLWLKLI FLPSILNRMY FLLHAEALRK RFNTYLNLHL 1030 1040 1050 1060 1070 1080 LPFNGTDYMP RPLEIDYSLK RNVDPLGNVI PTEDIEEPKS LLEPMPTKSI EASVANLEIT 1090 1100 1110 1120 1130 1140 EFENPWQKYM EPVDLSRNLL STYPVELDYY YHFSVGNVCE MNEMDFEDKE YWAKNQFHMP 1150 1160 1170 1180 1190 1200 TGNIYGNRTP AKTNANVPAL MPSKPTVRGK VKPLLILQKT VSKEHITPAE QGEFLAAITA 1210 1220 1230 1240 1250 1260 SSAADVFDME RLEILGDSFL KLSATLYLAS KYSDWNEGTL TEVKSKLVSN RNLLFCLIDA 1270 1280 1290 1300 1310 1320 DIPKTLNTIQ FTPRYTWLPP GISLPHNVLA LWRENPEFAK IIGPHNLRDL ALGDEESLVK 1330 1340 1350 1360 1370 1380 GNCSDINYNR FVEGCRANGQ SFYAGADFSS EVNFCVGLVT IPNKVIADTL EALLGVIVKN 1390 1400 1410 1420 1430 1440 YGLQHAFKML EYFKICRADI DKPLTQLLNL ELGGKKMRAN VNTTEIDGFL INHYYLEKNL 1450 1460 1470 1480 1490 1500 GYTFKDRRYL LQALTHPSYP TNRITGSYQE LEFIGDAILD FLISAYIFEN NTKMNPGALT 1510 1520 1530 1540 1550 1560 DLRSALVNNT TLACICVRHR LHFFILAENA KLSEIISKFV NFQESQGHRV TNYVRILLEE 1570 1580 1590 1600 1610 1620 ADVQPTPLDL DDELDMTELP HANKCISQEA EKGVPPKGEF NMSTNVDVPK ALGDVLEALI 1630 1640 1650 1660 1670 1680 AAVYLDCRDL QRTWEVIFNL FEPELQEFTR KVPINHIRQL VEHKHAKPVF SSPIVEGETV 1690 1700 1710 1720 MVSCQFTCME KTIKVYGFGS NKDQAKLSAA KHALQQLSKC DA

References

[1]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Phosphoproteome analysis of Drosophila melanogaster embryos." Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P. J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE013599 Genomic DNA. Translation: AAF57830.2.
RefSeq	NP_523778.2.
UniGene	Dm.7764
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	A1ZAW0.
Genome annotation databases
Ensembl	FBgn0034246. Drosophila melanogaster. [Contig view]
GeneID	36993.
KEGG	dme:Dmel_CG6493.
Organism-specific databases
FlyBase	FBgn0034246. Dcr-2.
Phylogenomic databases
OMA	A1ZAW0. TNRITGS.
Family and domain databases
InterPro	IPR014001. DEAD-like_N. IPR005034. Dicer_dsRNA_binding_fold. IPR001650. DNA/RNA_helicase_C. IPR011545. DNA/RNA_helicase_DEAD/DEAH_N. IPR001159. Ds-RNA_bd. IPR014021. Helicase_SF1/SF2_ATP-bd. IPR003100. PAZ. IPR000999. RNase_III. [Graphical view]
Gene3D	G3DSA:1.10.1520.10. RNase_III. 2 hits.
Pfam	PF00270. DEAD. 1 hit. PF00035. dsrm. 1 hit. PF03368. dsRNA_bind. 1 hit. PF00271. Helicase_C. 1 hit. PF02170. PAZ. 1 hit. PF00636. Ribonuclease_3. 2 hits. [Graphical view]
SMART	SM00487. DEXDc. 1 hit. SM00358. DSRM. 1 hit. SM00490. HELICc. 1 hit. SM00535. RIBOc. 2 hits. [Graphical view]
PROSITE	PS51327. DICER_DSRBF. 1 hit. PS50137. DS_RBD. 1 hit. PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. PS50821. PAZ. 1 hit. PS50142. RNASE_3_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	801402.

Entry information

Entry name

A1ZAW0_DROME

Accession

Primary (citable) accession number: A1ZAW0

Entry history

Integrated into UniProtKB/TrEMBL:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	June 16, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)