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Protein

Palmitoyltransferase

Gene

CG17287

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.UniRule annotation

GO - Molecular functioni

  • protein-cysteine S-palmitoyltransferase activity Source: FlyBase

GO - Biological processi

  • protein palmitoylation Source: FlyBase

Keywordsi

Molecular functionAcyltransferaseUniRule annotationImported, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
PalmitoyltransferaseUniRule annotation (EC:2.3.1.225UniRule annotation)
Gene namesi
ORF Names:CG17287Imported, Dmel_CG17287Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0034202. CG17287.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei18 – 35HelicalUniRule annotationAdd BLAST18
Transmembranei47 – 69HelicalUniRule annotationAdd BLAST23
Transmembranei169 – 191HelicalUniRule annotationAdd BLAST23
Transmembranei211 – 233HelicalUniRule annotationAdd BLAST23

GO - Cellular componenti

  • endoplasmic reticulum Source: FlyBase
  • integral component of membrane Source: UniProtKB-KW

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiA1ZAR2.
PRIDEiA1ZAR2.

Expressioni

Gene expression databases

BgeeiFBgn0034202.
GenevisibleiA1ZAR2. DM.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0086152.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 244zf-DHHCInterPro annotationAdd BLAST120

Domaini

The DHHC domain is required for palmitoyltransferase activity.UniRule annotation

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG1315. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00850000132259.
InParanoidiA1ZAR2.
KOiK20028.
OMAiSRNRTTM.
OrthoDBiEOG091G0AXR.
PhylomeDBiA1ZAR2.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
IPR030293. ZDHHC15.
PANTHERiPTHR22883:SF162. PTHR22883:SF162. 1 hit.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.

Sequencei

Sequence statusi: Complete.

A1ZAR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCPIGEGHRR VPCCAVRWLP ALIILGFLVW SYHVFVYQIC IKKVSDYLTI
60 70 80 90 100
GLLLFFYHLL LFMFLWTWFR CIFVAPVRIP DQWKISPEDV DKLKRNDGIE
110 120 130 140 150
GASRVLNYAA RNLPIATCTI DGLVRYCKTC WIIKPDRAHH CRTCHMCVLK
160 170 180 190 200
MDHHCPWIVN CVHFHNFKYF ILFLFYAEVY CFYLFCVMVY DLYLICGFEV
210 220 230 240 250
TALKNQHSWN ILQYLVCILF NIFTVIMYTV SLLNVSRNRT TMESAYATYF
260 270 280 290 300
LLGGKNNNGF NLGYFVNFRD LYGDKWYLWP FPIFSSRGDG FSFPLAHDRL
310 320 330
KEVRTGNQKK DNQPTRTQMY KENMNRILGI HQPPFNEE
Length:338
Mass (Da):40,056
Last modified:February 6, 2007 - v1
Checksum:i7C94824B6F201E07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF57887.1.
RefSeqiNP_611197.1. NM_137353.2.
UniGeneiDm.28156.

Genome annotation databases

EnsemblMetazoaiFBtr0087000; FBpp0086152; FBgn0034202.
GeneIDi36939.
KEGGidme:Dmel_CG17287.
UCSCiCG17287-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF57887.1.
RefSeqiNP_611197.1. NM_137353.2.
UniGeneiDm.28156.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0086152.

Proteomic databases

PaxDbiA1ZAR2.
PRIDEiA1ZAR2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0087000; FBpp0086152; FBgn0034202.
GeneIDi36939.
KEGGidme:Dmel_CG17287.
UCSCiCG17287-RA. d. melanogaster.

Organism-specific databases

FlyBaseiFBgn0034202. CG17287.

Phylogenomic databases

eggNOGiKOG1315. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00850000132259.
InParanoidiA1ZAR2.
KOiK20028.
OMAiSRNRTTM.
OrthoDBiEOG091G0AXR.
PhylomeDBiA1ZAR2.

Miscellaneous databases

GenomeRNAii36939.

Gene expression databases

BgeeiFBgn0034202.
GenevisibleiA1ZAR2. DM.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
IPR030293. ZDHHC15.
PANTHERiPTHR22883:SF162. PTHR22883:SF162. 1 hit.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA1ZAR2_DROME
AccessioniPrimary (citable) accession number: A1ZAR2
Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: April 12, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.