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Protein

Protein clueless

Gene

clu

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.UniRule annotation1 Publication

GO - Biological processi

  • asymmetric neuroblast division Source: FlyBase
  • intracellular distribution of mitochondria Source: InterPro
  • mitochondrion localization Source: FlyBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein cluelessUniRule annotation
Alternative name(s):
Clustered mitochondria protein homologUniRule annotation
Gene namesi
Name:cluUniRule annotation
ORF Names:CG8443
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0034087. clu.

Subcellular locationi

  • Cytoplasm UniRule annotation1 Publication

GO - Cellular componenti

  • cytoplasm Source: FlyBase
  • mitotic spindle Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Causes mitochondria to cluster within cells.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14481448Protein cluelessPRO_0000366382Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei270 – 2701PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA1ZAB5.
PRIDEiA1ZAB5.

PTM databases

iPTMnetiA1ZAB5.

Expressioni

Gene expression databases

BgeeiA1ZAB5.
GenevisibleiA1ZAB5. DM.

Interactioni

Protein-protein interaction databases

BioGridi62513. 5 interactions.
IntActiA1ZAB5. 6 interactions.
STRINGi7227.FBpp0086380.

Structurei

3D structure databases

ProteinModelPortaliA1ZAB5.
SMRiA1ZAB5. Positions 1116-1311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CLU family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1839. Eukaryota.
ENOG410XQUQ. LUCA.
GeneTreeiENSGT00390000012485.
InParanoidiA1ZAB5.
OMAiQFWESEL.
OrthoDBiEOG72RMX5.
PhylomeDBiA1ZAB5.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
HAMAPiMF_03013. CLU.
InterProiIPR027523. CLU.
IPR025697. CLU_dom.
IPR028275. CLU_N.
IPR007967. DUF727.
IPR023231. GSKIP_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF13236. CLU. 1 hit.
PF15044. CLU_N. 1 hit.
PF05303. DUF727. 1 hit.
PF13374. TPR_10. 1 hit.
[Graphical view]
SUPFAMiSSF103107. SSF103107. 1 hit.
SSF48452. SSF48452. 2 hits.

Sequencei

Sequence statusi: Complete.

A1ZAB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALETEAKNS NATATGDATA TATKASGKAK ENNNTAGGKK NLNPNSNQQN
60 70 80 90 100
SNQNLVNGNG TAADGPAAKK KGKKNRNKSP TEPTTEAVLS NGHAEKPTVV
110 120 130 140 150
DAVEDNADTN ANVEKPQEGG APDAEADGDD IDLDALQDIG ITVNISSPGA
160 170 180 190 200
DLLCVQLSSM ELVQEIHQLL MDREETCHRT CFSLQLDNVT LDNFAELKSI
210 220 230 240 250
NNLEQGSTIK VVEEPYTMRE ARIHVRHVRD LLKNLDPADA YNGIDCTSLT
260 270 280 290 300
YLNTITQGDL LDKKRTRPDS VDCTPPEYVT PGVSDPPILP LHPNVKNAKG
310 320 330 340 350
PQALKVLTTS AWNPPPGPRK LHGDLMYLYV VTMEDKRFHI SACSKGFFIN
360 370 380 390 400
QSTDDTFNPK PDNPSHLSHS LIDLLSHISP SFRRAFQTIQ KRRTMRHAFE
410 420 430 440 450
RVATPYQVYQ WAAPILEHTV DAIRAEDAFS SKLGYEEHIP GQTRDWNEEL
460 470 480 490 500
QTTRELPRKT LPERLLRERA IFKVHGDFVT AATRGAMAVI DGNVLAINPG
510 520 530 540 550
EDTKMQMFIW NNIFFSMGFD VRDHYKELGG DAAAFVAPRY DLHGVRVYNA
560 570 580 590 600
VDIEGLYTLG TVVVDYRGYR VTAQSIIPGI LEREQEQSVV YGSIDFGKTV
610 620 630 640 650
LSHPKYLELL RQAGKHLKIL PHVVLNERDE PVELCSSVEC KGIIGNDGRH
660 670 680 690 700
YILDLLRTFP PDVNFLKLQD VQLSKELVDM GFPIEHRHKL CCLRQELLEA
710 720 730 740 750
FIEDRHVNFI RIAAARLQQL TTIKQSEKSE ANPVPALEGA EAASKVNGAE
760 770 780 790 800
KPDDKEKKNE EEEKKERSTS GEARAAAIVN AIREAQSNVA TSNEVQAAEV
810 820 830 840 850
VKRACAAVGS LKEKEFDFRF NPDVFSPGIR HADGEEGTSL AKQKVLVQEA
860 870 880 890 900
AEFLVLKQIP AFIKEHMSHS SSPIDGQSLT ESLHSHGINV RYLGKVIKIL
910 920 930 940 950
SQMPRMDYLH RIAVLELIVR ATKHIYYTYM QNTEPLHLSA AISHFLNCLL
960 970 980 990 1000
TNGPVNPAVS SEEAHKKRGN GGKHNKHKSS KGGKGQQQQQ TTGNQNGSSS
1010 1020 1030 1040 1050
GSSNSSSASD WTLMTPRSLW QQIRKEAKVY WDWELDCDSI ETAVSKYGIL
1060 1070 1080 1090 1100
RISLMRAFCL KVGIQVLLRE YNFESKHKPT FGDDDIVNVF PIVKHISPRA
1110 1120 1130 1140 1150
TDAYNFYTTG QAKIQQGLFK EGYELISGAL NLLNNVFGAL HQENGSCLRM
1160 1170 1180 1190 1200
LARLSYLLGD AQDALAIQQR AVIMSERVNG MDHPSTILEY THLSLYSFAN
1210 1220 1230 1240 1250
GHVGMSLKLL YRARYLMVLI CGEDHPEVAL IDSNISLILH ALGEYELSLR
1260 1270 1280 1290 1300
FIEHALKLNL KYFGDKDMHV ALSYHLMART QSCMGDFRSA LNNEKETYSF
1310 1320 1330 1340 1350
YKSQLGENHE KTRDSAECLR LLTQQAVLLQ RKMNDIYSSG KLTSDLPPIH
1360 1370 1380 1390 1400
ITPPSMGSVL DMLNTINGIL FVKISRKDIV KVRSEIEKHF KTDSTENEVN
1410 1420 1430 1440
DAINSIVAAA NNNGEAEDAV SKDIKEQPEA GKQLTNGDKA AATEATSS
Length:1,448
Mass (Da):160,852
Last modified:February 6, 2007 - v1
Checksum:iA9D1A150F6B8CBBB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti495 – 4951Missing in AAR96136 (Ref. 3) Curated
Sequence conflicti959 – 9591V → L in AAR96136 (Ref. 3) Curated
Sequence conflicti1061 – 10611K → R in AAR96136 (Ref. 3) Curated
Sequence conflicti1323 – 13231T → A in AAR96136 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58047.1.
BT011344 mRNA. Translation: AAR96136.1.
RefSeqiNP_611095.1. NM_137251.3.
UniGeneiDm.7233.

Genome annotation databases

EnsemblMetazoaiFBtr0087242; FBpp0086380; FBgn0034087.
GeneIDi36793.
UCSCiCG8443-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58047.1.
BT011344 mRNA. Translation: AAR96136.1.
RefSeqiNP_611095.1. NM_137251.3.
UniGeneiDm.7233.

3D structure databases

ProteinModelPortaliA1ZAB5.
SMRiA1ZAB5. Positions 1116-1311.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi62513. 5 interactions.
IntActiA1ZAB5. 6 interactions.
STRINGi7227.FBpp0086380.

PTM databases

iPTMnetiA1ZAB5.

Proteomic databases

PaxDbiA1ZAB5.
PRIDEiA1ZAB5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0087242; FBpp0086380; FBgn0034087.
GeneIDi36793.
UCSCiCG8443-RA. d. melanogaster.

Organism-specific databases

CTDi1191.
FlyBaseiFBgn0034087. clu.

Phylogenomic databases

eggNOGiKOG1839. Eukaryota.
ENOG410XQUQ. LUCA.
GeneTreeiENSGT00390000012485.
InParanoidiA1ZAB5.
OMAiQFWESEL.
OrthoDBiEOG72RMX5.
PhylomeDBiA1ZAB5.

Miscellaneous databases

GenomeRNAii36793.
NextBioi800419.
PROiA1ZAB5.

Gene expression databases

BgeeiA1ZAB5.
GenevisibleiA1ZAB5. DM.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
HAMAPiMF_03013. CLU.
InterProiIPR027523. CLU.
IPR025697. CLU_dom.
IPR028275. CLU_N.
IPR007967. DUF727.
IPR023231. GSKIP_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF13236. CLU. 1 hit.
PF15044. CLU_N. 1 hit.
PF05303. DUF727. 1 hit.
PF13374. TPR_10. 1 hit.
[Graphical view]
SUPFAMiSSF103107. SSF103107. 1 hit.
SSF48452. SSF48452. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.
  4. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-270, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.
  5. "Clueless, a conserved Drosophila gene required for mitochondrial subcellular localization, interacts genetically with parkin."
    Cox R.T., Spradling A.C.
    Dis. Model. Mech. 2:490-499(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCLU_DROME
AccessioniPrimary (citable) accession number: A1ZAB5
Secondary accession number(s): Q6NNE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 6, 2007
Last modified: January 20, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.