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Protein

Protein clueless

Gene

clu

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.UniRule annotation1 Publication

GO - Molecular functioni

  • mRNA binding Source: FlyBase
  • ribosome binding Source: FlyBase

GO - Biological processi

  • asymmetric neuroblast division Source: FlyBase
  • intracellular distribution of mitochondria Source: InterPro
  • mitochondrion localization Source: FlyBase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein cluelessUniRule annotation
Alternative name(s):
Clustered mitochondria protein homologUniRule annotation
Gene namesi
Name:cluUniRule annotation
ORF Names:CG8443
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0034087 clu

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Causes mitochondria to cluster within cells.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003663821 – 1448Protein cluelessAdd BLAST1448

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei270PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA1ZAB5
PRIDEiA1ZAB5

PTM databases

iPTMnetiA1ZAB5

Expressioni

Gene expression databases

BgeeiFBgn0034087
GenevisibleiA1ZAB5 DM

Interactioni

Protein-protein interaction databases

BioGridi62513, 25 interactors
IntActiA1ZAB5, 6 interactors
MINTiA1ZAB5
STRINGi7227.FBpp0086380

Structurei

3D structure databases

ProteinModelPortaliA1ZAB5
SMRiA1ZAB5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini424 – 666CluPROSITE-ProRule annotationAdd BLAST243

Sequence similaritiesi

Belongs to the CLU family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1839 Eukaryota
ENOG410XQUQ LUCA
InParanoidiA1ZAB5
KOiK03255
OMAiQIFVYNN
OrthoDBiEOG091G00TP
PhylomeDBiA1ZAB5

Family and domain databases

CDDicd15466 CLU-central, 1 hit
Gene3Di1.25.40.10, 1 hit
3.30.2280.10, 1 hit
HAMAPiMF_03013 CLU, 1 hit
InterProiView protein in InterPro
IPR027523 CLU
IPR033646 CLU-central
IPR025697 CLU_dom
IPR028275 CLU_N
IPR007967 GSKIP_dom
IPR023231 GSKIP_dom_sf
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF13236 CLU, 1 hit
PF15044 CLU_N, 1 hit
PF05303 DUF727, 1 hit
PF12807 eIF3_p135, 1 hit
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS51823 CLU, 1 hit

Sequencei

Sequence statusi: Complete.

A1ZAB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALETEAKNS NATATGDATA TATKASGKAK ENNNTAGGKK NLNPNSNQQN
60 70 80 90 100
SNQNLVNGNG TAADGPAAKK KGKKNRNKSP TEPTTEAVLS NGHAEKPTVV
110 120 130 140 150
DAVEDNADTN ANVEKPQEGG APDAEADGDD IDLDALQDIG ITVNISSPGA
160 170 180 190 200
DLLCVQLSSM ELVQEIHQLL MDREETCHRT CFSLQLDNVT LDNFAELKSI
210 220 230 240 250
NNLEQGSTIK VVEEPYTMRE ARIHVRHVRD LLKNLDPADA YNGIDCTSLT
260 270 280 290 300
YLNTITQGDL LDKKRTRPDS VDCTPPEYVT PGVSDPPILP LHPNVKNAKG
310 320 330 340 350
PQALKVLTTS AWNPPPGPRK LHGDLMYLYV VTMEDKRFHI SACSKGFFIN
360 370 380 390 400
QSTDDTFNPK PDNPSHLSHS LIDLLSHISP SFRRAFQTIQ KRRTMRHAFE
410 420 430 440 450
RVATPYQVYQ WAAPILEHTV DAIRAEDAFS SKLGYEEHIP GQTRDWNEEL
460 470 480 490 500
QTTRELPRKT LPERLLRERA IFKVHGDFVT AATRGAMAVI DGNVLAINPG
510 520 530 540 550
EDTKMQMFIW NNIFFSMGFD VRDHYKELGG DAAAFVAPRY DLHGVRVYNA
560 570 580 590 600
VDIEGLYTLG TVVVDYRGYR VTAQSIIPGI LEREQEQSVV YGSIDFGKTV
610 620 630 640 650
LSHPKYLELL RQAGKHLKIL PHVVLNERDE PVELCSSVEC KGIIGNDGRH
660 670 680 690 700
YILDLLRTFP PDVNFLKLQD VQLSKELVDM GFPIEHRHKL CCLRQELLEA
710 720 730 740 750
FIEDRHVNFI RIAAARLQQL TTIKQSEKSE ANPVPALEGA EAASKVNGAE
760 770 780 790 800
KPDDKEKKNE EEEKKERSTS GEARAAAIVN AIREAQSNVA TSNEVQAAEV
810 820 830 840 850
VKRACAAVGS LKEKEFDFRF NPDVFSPGIR HADGEEGTSL AKQKVLVQEA
860 870 880 890 900
AEFLVLKQIP AFIKEHMSHS SSPIDGQSLT ESLHSHGINV RYLGKVIKIL
910 920 930 940 950
SQMPRMDYLH RIAVLELIVR ATKHIYYTYM QNTEPLHLSA AISHFLNCLL
960 970 980 990 1000
TNGPVNPAVS SEEAHKKRGN GGKHNKHKSS KGGKGQQQQQ TTGNQNGSSS
1010 1020 1030 1040 1050
GSSNSSSASD WTLMTPRSLW QQIRKEAKVY WDWELDCDSI ETAVSKYGIL
1060 1070 1080 1090 1100
RISLMRAFCL KVGIQVLLRE YNFESKHKPT FGDDDIVNVF PIVKHISPRA
1110 1120 1130 1140 1150
TDAYNFYTTG QAKIQQGLFK EGYELISGAL NLLNNVFGAL HQENGSCLRM
1160 1170 1180 1190 1200
LARLSYLLGD AQDALAIQQR AVIMSERVNG MDHPSTILEY THLSLYSFAN
1210 1220 1230 1240 1250
GHVGMSLKLL YRARYLMVLI CGEDHPEVAL IDSNISLILH ALGEYELSLR
1260 1270 1280 1290 1300
FIEHALKLNL KYFGDKDMHV ALSYHLMART QSCMGDFRSA LNNEKETYSF
1310 1320 1330 1340 1350
YKSQLGENHE KTRDSAECLR LLTQQAVLLQ RKMNDIYSSG KLTSDLPPIH
1360 1370 1380 1390 1400
ITPPSMGSVL DMLNTINGIL FVKISRKDIV KVRSEIEKHF KTDSTENEVN
1410 1420 1430 1440
DAINSIVAAA NNNGEAEDAV SKDIKEQPEA GKQLTNGDKA AATEATSS
Length:1,448
Mass (Da):160,852
Last modified:February 6, 2007 - v1
Checksum:iA9D1A150F6B8CBBB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti495Missing in AAR96136 (Ref. 3) Curated1
Sequence conflicti959V → L in AAR96136 (Ref. 3) Curated1
Sequence conflicti1061K → R in AAR96136 (Ref. 3) Curated1
Sequence conflicti1323T → A in AAR96136 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58047.1
BT011344 mRNA Translation: AAR96136.1
RefSeqiNP_611095.1, NM_137251.3
UniGeneiDm.7233

Genome annotation databases

EnsemblMetazoaiFBtr0087242; FBpp0086380; FBgn0034087
GeneIDi36793
KEGGidme:Dmel_CG8443
UCSCiCG8443-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiCLU_DROME
AccessioniPrimary (citable) accession number: A1ZAB5
Secondary accession number(s): Q6NNE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 6, 2007
Last modified: February 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health