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Protein

Carboxylic ester hydrolase

Gene

Jhe

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  • carboxylic ester hydrolase activity Source: FlyBase
  • juvenile-hormone esterase activity Source: FlyBase

GO - Biological processi

  • behavioral response to ethanol Source: FlyBase
  • juvenile hormone catabolic process Source: FlyBase
  • male mating behavior Source: FlyBase

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported

Enzyme and pathway databases

BRENDAi3.1.1.59. 1994.

Protein family/group databases

ESTHERidrome-CG8425. Juvenile_hormone_esterase.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxylic ester hydrolaseUniRule annotation (EC:3.1.1.-UniRule annotation)
Gene namesi
Name:JheImported
ORF Names:CG8425Imported, Dmel_CG8425Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0010052. Jhe.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: FlyBase

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4265.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17UniRule annotationAdd BLAST17
ChainiPRO_500936589618 – 579Carboxylic ester hydrolaseUniRule annotationAdd BLAST562

Expressioni

Gene expression databases

BgeeiFBgn0010052.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0086362.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 522COesteraseInterPro annotationAdd BLAST485

Sequence similaritiesi

Belongs to the type-B carboxylesterase/lipase family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG1516. Eukaryota.
COG2272. LUCA.
GeneTreeiENSGT00680000100015.
KOiK01063.
OMAiYHEFANA.
OrthoDBiEOG091G05S3.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
PfamiView protein in Pfam
PF00135. COesterase. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiView protein in PROSITE
PS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A1ZA98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQQRMLQLL LLGQLLAGPG PFCAALATVD QLTVCPPSVG CLKGTNLQGY
60 70 80 90 100
QSERFEAFMG IPYALPPIGD LRFSNPKVMP KLLGMYDASA PKMDCIQKNY
110 120 130 140 150
LLPTPVVYGD EDCLYLNVYR PEIRKSALPV MVYIHGGGFF GGSAGPGVTG
160 170 180 190 200
PEYFMDSGEV ILVTMAYRLG PFGFLSTQDA VMSGNFGLKD QNLALRWVQR
210 220 230 240 250
NIRFFGGDPQ RVTIFGQSAG GVAAHMHLLS PRSHGLFHRV ISMSGTANVP
260 270 280 290 300
FAIAEQPLEQ ARLLAEFADV PDARNLSTVK LTKALRRINA TKLLNAGDGL
310 320 330 340 350
KYWDVDHMTN FRPVVEEGLE VDAFLNAHPM DMLAQGMPTS IPLLLGTVPG
360 370 380 390 400
EGAVRVVNIL GNETLRQSFN LRFDELLQEL LEFPASFSQD RREKMMDLLV
410 420 430 440 450
EVYFQGQHEV NELTVQGFMN LISDRGFKQP LYNTIHKNVC HTPNPVYLYS
460 470 480 490 500
FNYQGPLSYA SAYTSANVTG KYGVVHCDDL LYLFRSPLLF PDFQRNSTEA
510 520 530 540 550
KVIHSFVDYF VHFAKFGKPR NSESLTPCSI EVLQSRPDGI CDYHEFANAP
560 570
DAYQGFEVHV ASEFQTDRVN LWSHILNEK
Length:579
Mass (Da):64,509
Last modified:November 13, 2007 - v2
Checksum:i334E6C9685764CB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58061.3.
AE013599 Genomic DNA. Translation: ACZ94438.1.
AE013599 Genomic DNA. Translation: AHN56273.1.
RefSeqiNP_001163166.1. NM_001169695.2.
NP_001286476.1. NM_001299547.1.
NP_523758.3. NM_079034.5.

Genome annotation databases

EnsemblMetazoaiFBtr0087223; FBpp0086362; FBgn0010052.
FBtr0301751; FBpp0290965; FBgn0010052.
FBtr0340021; FBpp0309035; FBgn0010052.
GeneIDi36780.
KEGGidme:Dmel_CG8425.
UCSCiCG8425-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58061.3.
AE013599 Genomic DNA. Translation: ACZ94438.1.
AE013599 Genomic DNA. Translation: AHN56273.1.
RefSeqiNP_001163166.1. NM_001169695.2.
NP_001286476.1. NM_001299547.1.
NP_523758.3. NM_079034.5.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0086362.

Chemistry databases

ChEMBLiCHEMBL4265.

Protein family/group databases

ESTHERidrome-CG8425. Juvenile_hormone_esterase.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0087223; FBpp0086362; FBgn0010052.
FBtr0301751; FBpp0290965; FBgn0010052.
FBtr0340021; FBpp0309035; FBgn0010052.
GeneIDi36780.
KEGGidme:Dmel_CG8425.
UCSCiCG8425-RA. d. melanogaster.

Organism-specific databases

CTDi36780.
FlyBaseiFBgn0010052. Jhe.

Phylogenomic databases

eggNOGiKOG1516. Eukaryota.
COG2272. LUCA.
GeneTreeiENSGT00680000100015.
KOiK01063.
OMAiYHEFANA.
OrthoDBiEOG091G05S3.

Enzyme and pathway databases

BRENDAi3.1.1.59. 1994.

Miscellaneous databases

GenomeRNAii36780.

Gene expression databases

BgeeiFBgn0010052.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
PfamiView protein in Pfam
PF00135. COesterase. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiView protein in PROSITE
PS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA1ZA98_DROME
AccessioniPrimary (citable) accession number: A1ZA98
Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: November 13, 2007
Last modified: March 15, 2017
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.