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A1Z9P3

- SHRM_DROME

UniProt

A1Z9P3 - SHRM_DROME

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Protein

Protein Shroom

Gene

Shroom

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in the assembly of microtubule arrays during cell elongation.By similarity

GO - Molecular functioni

  1. actin binding Source: UniProtKB

GO - Biological processi

  1. cell migration Source: UniProtKB
  2. cell morphogenesis Source: FlyBase
  3. establishment of planar polarity of embryonic epithelium Source: FlyBase
  4. establishment or maintenance of actin cytoskeleton polarity Source: FlyBase
  5. melanosome organization Source: UniProtKB
  6. protein localization involved in establishment of planar polarity Source: FlyBase
  7. protein localization to adherens junction Source: FlyBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Shroom
Gene namesi
Name:Shroom
ORF Names:CG34379
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0085408. Shroom.

Subcellular locationi

Cytoplasmcytoskeleton 1 Publication
Note: Associates with cortical F-actin.

GO - Cellular componenti

  1. adherens junction Source: FlyBase
  2. cortical actin cytoskeleton Source: FlyBase
  3. cytoskeleton Source: UniProtKB
  4. microtubule Source: UniProtKB-KW
  5. plasma membrane Source: UniProtKB
  6. tight junction Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15761576Protein ShroomPRO_0000286069Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei404 – 4041Phosphoserine1 Publication
Modified residuei667 – 6671Phosphoserine1 Publication
Modified residuei668 – 6681Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiA1Z9P3.

Expressioni

Gene expression databases

BgeeiA1Z9P3.
ExpressionAtlasiA1Z9P3. differential.

Interactioni

Protein-protein interaction databases

BioGridi62342. 10 interactions.

Structurei

Secondary structure

1
1576
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1398 – 144548Combined sources
Helixi1448 – 152780Combined sources
Helixi1530 – 156738Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3THFX-ray2.70A/B1393-1576[»]
ProteinModelPortaliA1Z9P3.
SMRiA1Z9P3. Positions 1396-1570.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1305 – 1572268ASD2PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1232 – 129665Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi34 – 314281Ser-richAdd
BLAST
Compositional biasi221 – 23515Asn-richAdd
BLAST
Compositional biasi707 – 896190Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the shroom family.Curated
Contains 1 ASD2 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG72784.
GeneTreeiENSGT00530000063061.
InParanoidiA1Z9P3.
OMAiSSQRIVH.
OrthoDBiEOG7B05C7.
PhylomeDBiA1Z9P3.

Family and domain databases

InterProiIPR014799. ASD2.
IPR027685. Shroom_fam.
[Graphical view]
PANTHERiPTHR15012. PTHR15012. 1 hit.
PfamiPF08687. ASD2. 1 hit.
[Graphical view]
PROSITEiPS51307. ASD2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform D (identifier: A1Z9P3) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKMRNHKENG NGSEMGESTK SLAKMEPENN NKISVVSVSK LLLKDSNGAN
60 70 80 90 100
SRSSNSNASF SSASVAGSVQ DDLPHHNSSS SQLGQQHGSS LDQCGLTQAG
110 120 130 140 150
LEEYNNRSSS YYDQTAFHHQ KQPSYAQSEG YHSYVSSSDS TSATPFLDKL
160 170 180 190 200
RQESDLLSRQ SHHWSENDLS SVCSNSVAPS PIPLLARQSH SHSHSHAHSH
210 220 230 240 250
SNSHGHSHGH AHSASSSSSS NNNSNGSATN NNNNNSSEST SSTETLKWLG
260 270 280 290 300
SMSDISEASH ATGYSAISES VSSSQRIVHS SRVPTPKRHH SESVLYLHNN
310 320 330 340 350
EEQGDSSPTA SNSSQMMISE EANGEESPPS VQPLRIQHRH SPSYPPVHTS
360 370 380 390 400
MVLHHFQQQQ QQQQDYQHPS RHHTNQSTLS TQSSLLELAS PTEKPRSLMG
410 420 430 440 450
QSHSMGDLQQ KNPHQNPMLG RSAGQQHKSS ISVTISSSEA VVTIAPQPPA
460 470 480 490 500
GKPSKLQLSL GKSEALSCST PNMGEQSPTN SIDSYRSNHR LFPVSTYTEP
510 520 530 540 550
VHSNTSQYVQ HPKPQFSSGL HKSAKLPVIT PAGATVQPTW HSVAERINDF
560 570 580 590 600
ERSQLGEPPK FAYLEPTKTH RLSNPALKAL QKNAVQSYVE RQQQQQKEEQ
610 620 630 640 650
QLLRPHSQSY QACHVERKSL PNNLSPIMVG LPTGSNSAST RDCSSPTPPP
660 670 680 690 700
PPRRSGSLLP NLLRRSSSAS DYAEFRELHQ AQGQVKGPSI RNISNAEKIS
710 720 730 740 750
FNDCGMPPPP PPPRGRLAVP TRRTSSATEY APMRDKLLLQ QAAALAHQQH
760 770 780 790 800
HPQQHRHAQP PHVPPERPPK HPNLRVPSPE LPPPPQSELD ISYTFDEPLP
810 820 830 840 850
PPPPPEVLQP RPPPSPNRRN CFAGASTRRT TYEAPPPTAI VAAKVPPLVP
860 870 880 890 900
KKPTSLQHKH LANGGGGSRK RPHHATPQPI LENVASPVAP PPPLLPRARS
910 920 930 940 950
TAHDNVIASN LESNQQKRSN SKASYLPRQS LEKLNNTDPD HGIYKLTLTS
960 970 980 990 1000
NEDLVAHTKP SYGVTGKLPN NLPDVLPLGV KLHQQPKLQP GSPNGDANVT
1010 1020 1030 1040 1050
LRYGSNNNLT GNSPTVAPPP YYGGGQRYST PVLGQGYGKS SKPVTPQQYT
1060 1070 1080 1090 1100
RSQSYDVKHT SAVTMPTMSQ SHVDLKQAAH DLETTLEEVL PTATPTPTPT
1110 1120 1130 1140 1150
PTPTPPRLSP ASSHSDCSLS TSSLECTINP IATPIPKPEA HIFRAEVIST
1160 1170 1180 1190 1200
TLNTNPLTTP PKPAMNRQES LRENIEKITQ LQSVLMSAHL CDASLLGGYT
1210 1220 1230 1240 1250
TPLITSPTAS FANEPLMTPP LPPSPPPPLE PEEEEEQEEN DVHDKQPEIE
1260 1270 1280 1290 1300
ELQLMQRSEL VLMVNPKPST TDMACQTDEL EDRDTDLEAA REEHQTRTTL
1310 1320 1330 1340 1350
QPRQRQPIEL DYEQMSRELV KLLPPGDKIA DILTPKICKP TSQYVSNLYN
1360 1370 1380 1390 1400
PDVPLRLAKR DVGTSTLMRM KSITSSAEIR VVSVELQLAE PSEEPTNLIK
1410 1420 1430 1440 1450
QKMDELIKHL NQKIVSLKRE QQTISEECSA NDRLGQDLFA KLAEKVRPSE
1460 1470 1480 1490 1500
ASKFRTHVDA VGNITSLLLS LSERLAQTES SLETRQQERG ALESKRDLLY
1510 1520 1530 1540 1550
EQMEEAQRLK SDIERRGVSI AGLLAKNLSA DMCADYDYFI NMKAKLIADA
1560 1570
RDLAVRIKGS EEQLSSLSDA LVQSDC

Note: No experimental confirmation available.

Length:1,576
Mass (Da):172,713
Last modified:May 5, 2009 - v2
Checksum:i52A7D124F9559D13
GO
Isoform F (identifier: A1Z9P3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-10: KMRNHKENG → AQWFQWLNF
     11-917: Missing.

Note: No experimental confirmation available.

Show »
Length:669
Mass (Da):74,175
Checksum:iF22B2C2E0F946C2B
GO
Isoform G (identifier: A1Z9P3-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-10: KMRNHKENG → VFGGKFRIR
     11-917: Missing.

Note: No experimental confirmation available.

Show »
Length:669
Mass (Da):74,015
Checksum:iCC509350FB342EDE
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2 – 109KMRNHKENG → AQWFQWLNF in isoform F. 1 PublicationVSP_024971
Alternative sequencei2 – 109KMRNHKENG → VFGGKFRIR in isoform G. CuratedVSP_036999
Alternative sequencei11 – 917907Missing in isoform F and isoform G. 1 PublicationVSP_037000Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013599 Genomic DNA. Translation: AAF58259.2.
AE013599 Genomic DNA. Translation: AAM70999.2.
AE013599 Genomic DNA. Translation: AAF58260.2.
AY069213 mRNA. Translation: AAL39358.1.
BT023900 mRNA. Translation: ABA81834.1.
RefSeqiNP_001097307.1. NM_001103837.2. [A1Z9P3-3]
NP_610952.1. NM_137108.3. [A1Z9P3-2]
NP_725378.2. NM_166047.2. [A1Z9P3-1]
UniGeneiDm.2231.

Genome annotation databases

EnsemblMetazoaiFBtr0112614; FBpp0111526; FBgn0085408. [A1Z9P3-3]
GeneIDi36592.
KEGGidme:Dmel_CG34379.
UCSCiCG34379-RD. d. melanogaster.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013599 Genomic DNA. Translation: AAF58259.2 .
AE013599 Genomic DNA. Translation: AAM70999.2 .
AE013599 Genomic DNA. Translation: AAF58260.2 .
AY069213 mRNA. Translation: AAL39358.1 .
BT023900 mRNA. Translation: ABA81834.1 .
RefSeqi NP_001097307.1. NM_001103837.2. [A1Z9P3-3 ]
NP_610952.1. NM_137108.3. [A1Z9P3-2 ]
NP_725378.2. NM_166047.2. [A1Z9P3-1 ]
UniGenei Dm.2231.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3THF X-ray 2.70 A/B 1393-1576 [» ]
ProteinModelPortali A1Z9P3.
SMRi A1Z9P3. Positions 1396-1570.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 62342. 10 interactions.

Proteomic databases

PRIDEi A1Z9P3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0112614 ; FBpp0111526 ; FBgn0085408 . [A1Z9P3-3 ]
GeneIDi 36592.
KEGGi dme:Dmel_CG34379.
UCSCi CG34379-RD. d. melanogaster.

Organism-specific databases

CTDi 36592.
FlyBasei FBgn0085408. Shroom.

Phylogenomic databases

eggNOGi NOG72784.
GeneTreei ENSGT00530000063061.
InParanoidi A1Z9P3.
OMAi SSQRIVH.
OrthoDBi EOG7B05C7.
PhylomeDBi A1Z9P3.

Miscellaneous databases

GenomeRNAii 36592.
NextBioi 799392.

Gene expression databases

Bgeei A1Z9P3.
ExpressionAtlasi A1Z9P3. differential.

Family and domain databases

InterProi IPR014799. ASD2.
IPR027685. Shroom_fam.
[Graphical view ]
PANTHERi PTHR15012. PTHR15012. 1 hit.
Pfami PF08687. ASD2. 1 hit.
[Graphical view ]
PROSITEi PS51307. ASD2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM F).
    Strain: Berkeley.
    Tissue: Head.
  4. Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Celniker S.E.
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM D).
    Strain: Berkeley.
    Tissue: Larva and Pupae.
  5. Cited for: NOMENCLATURE.
  6. "Differential actin-dependent localization modulates the evolutionarily conserved activity of Shroom family proteins."
    Dietz M.L., Bernaciak T.M., Vendetti F., Kielec J.M., Hildebrand J.D.
    J. Biol. Chem. 281:20542-20554(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  7. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-404; SER-667 AND SER-668, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiSHRM_DROME
AccessioniPrimary (citable) accession number: A1Z9P3
Secondary accession number(s): A1Z9P2, Q3KN39, Q7K1B1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3