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A1Z9P3 (SHRM_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein Shroom
Gene names
Name:Shroom
ORF Names:CG34379
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length1576 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in the assembly of microtubule arrays during cell elongation By similarity.

Subcellular location

Cytoplasmcytoskeleton. Note: Associates with cortical F-actin. Ref.6

Sequence similarities

Belongs to the shroom family.

Contains 1 ASD2 domain.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform D (identifier: A1Z9P3-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform F (identifier: A1Z9P3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2-10: KMRNHKENG → AQWFQWLNF
     11-917: Missing.
Note: No experimental confirmation available.
Isoform G (identifier: A1Z9P3-1)

The sequence of this isoform differs from the canonical sequence as follows:
     2-10: KMRNHKENG → VFGGKFRIR
     11-917: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15761576Protein Shroom
PRO_0000286069

Regions

Domain1305 – 1572268ASD2
Coiled coil1232 – 129665 Potential
Compositional bias34 – 314281Ser-rich
Compositional bias221 – 23515Asn-rich
Compositional bias707 – 896190Pro-rich

Amino acid modifications

Modified residue4041Phosphoserine Ref.7
Modified residue6671Phosphoserine Ref.7
Modified residue6681Phosphoserine Ref.7

Natural variations

Alternative sequence2 – 109KMRNHKENG → AQWFQWLNF in isoform F.
VSP_024971
Alternative sequence2 – 109KMRNHKENG → VFGGKFRIR in isoform G.
VSP_036999
Alternative sequence11 – 917907Missing in isoform F and isoform G.
VSP_037000

Secondary structure

....... 1576
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform D [UniParc].

Last modified May 5, 2009. Version 2.
Checksum: 52A7D124F9559D13

FASTA1,576172,713
        10         20         30         40         50         60 
MKMRNHKENG NGSEMGESTK SLAKMEPENN NKISVVSVSK LLLKDSNGAN SRSSNSNASF 

        70         80         90        100        110        120 
SSASVAGSVQ DDLPHHNSSS SQLGQQHGSS LDQCGLTQAG LEEYNNRSSS YYDQTAFHHQ 

       130        140        150        160        170        180 
KQPSYAQSEG YHSYVSSSDS TSATPFLDKL RQESDLLSRQ SHHWSENDLS SVCSNSVAPS 

       190        200        210        220        230        240 
PIPLLARQSH SHSHSHAHSH SNSHGHSHGH AHSASSSSSS NNNSNGSATN NNNNNSSEST 

       250        260        270        280        290        300 
SSTETLKWLG SMSDISEASH ATGYSAISES VSSSQRIVHS SRVPTPKRHH SESVLYLHNN 

       310        320        330        340        350        360 
EEQGDSSPTA SNSSQMMISE EANGEESPPS VQPLRIQHRH SPSYPPVHTS MVLHHFQQQQ 

       370        380        390        400        410        420 
QQQQDYQHPS RHHTNQSTLS TQSSLLELAS PTEKPRSLMG QSHSMGDLQQ KNPHQNPMLG 

       430        440        450        460        470        480 
RSAGQQHKSS ISVTISSSEA VVTIAPQPPA GKPSKLQLSL GKSEALSCST PNMGEQSPTN 

       490        500        510        520        530        540 
SIDSYRSNHR LFPVSTYTEP VHSNTSQYVQ HPKPQFSSGL HKSAKLPVIT PAGATVQPTW 

       550        560        570        580        590        600 
HSVAERINDF ERSQLGEPPK FAYLEPTKTH RLSNPALKAL QKNAVQSYVE RQQQQQKEEQ 

       610        620        630        640        650        660 
QLLRPHSQSY QACHVERKSL PNNLSPIMVG LPTGSNSAST RDCSSPTPPP PPRRSGSLLP 

       670        680        690        700        710        720 
NLLRRSSSAS DYAEFRELHQ AQGQVKGPSI RNISNAEKIS FNDCGMPPPP PPPRGRLAVP 

       730        740        750        760        770        780 
TRRTSSATEY APMRDKLLLQ QAAALAHQQH HPQQHRHAQP PHVPPERPPK HPNLRVPSPE 

       790        800        810        820        830        840 
LPPPPQSELD ISYTFDEPLP PPPPPEVLQP RPPPSPNRRN CFAGASTRRT TYEAPPPTAI 

       850        860        870        880        890        900 
VAAKVPPLVP KKPTSLQHKH LANGGGGSRK RPHHATPQPI LENVASPVAP PPPLLPRARS 

       910        920        930        940        950        960 
TAHDNVIASN LESNQQKRSN SKASYLPRQS LEKLNNTDPD HGIYKLTLTS NEDLVAHTKP 

       970        980        990       1000       1010       1020 
SYGVTGKLPN NLPDVLPLGV KLHQQPKLQP GSPNGDANVT LRYGSNNNLT GNSPTVAPPP 

      1030       1040       1050       1060       1070       1080 
YYGGGQRYST PVLGQGYGKS SKPVTPQQYT RSQSYDVKHT SAVTMPTMSQ SHVDLKQAAH 

      1090       1100       1110       1120       1130       1140 
DLETTLEEVL PTATPTPTPT PTPTPPRLSP ASSHSDCSLS TSSLECTINP IATPIPKPEA 

      1150       1160       1170       1180       1190       1200 
HIFRAEVIST TLNTNPLTTP PKPAMNRQES LRENIEKITQ LQSVLMSAHL CDASLLGGYT 

      1210       1220       1230       1240       1250       1260 
TPLITSPTAS FANEPLMTPP LPPSPPPPLE PEEEEEQEEN DVHDKQPEIE ELQLMQRSEL 

      1270       1280       1290       1300       1310       1320 
VLMVNPKPST TDMACQTDEL EDRDTDLEAA REEHQTRTTL QPRQRQPIEL DYEQMSRELV 

      1330       1340       1350       1360       1370       1380 
KLLPPGDKIA DILTPKICKP TSQYVSNLYN PDVPLRLAKR DVGTSTLMRM KSITSSAEIR 

      1390       1400       1410       1420       1430       1440 
VVSVELQLAE PSEEPTNLIK QKMDELIKHL NQKIVSLKRE QQTISEECSA NDRLGQDLFA 

      1450       1460       1470       1480       1490       1500 
KLAEKVRPSE ASKFRTHVDA VGNITSLLLS LSERLAQTES SLETRQQERG ALESKRDLLY 

      1510       1520       1530       1540       1550       1560 
EQMEEAQRLK SDIERRGVSI AGLLAKNLSA DMCADYDYFI NMKAKLIADA RDLAVRIKGS 

      1570 
EEQLSSLSDA LVQSDC 

« Hide

Isoform F [UniParc].

Checksum: F22B2C2E0F946C2B
Show »

FASTA66974,175
Isoform G [UniParc].

Checksum: CC509350FB342EDE
Show »

FASTA66974,015

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
Strain: Berkeley.
[3]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM F).
Strain: Berkeley.
Tissue: Head.
[4]Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Celniker S.E.
Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM D).
Strain: Berkeley.
Tissue: Larva and Pupae.
[5]"A new standard nomenclature for proteins related to Apx and Shroom."
Hagens O., Ballabio A., Kalscheuer V., Kraehenbuhl J.-P., Schiaffino M.V., Smith P., Staub O., Hildebrand J.D., Wallingford J.B.
BMC Cell Biol. 7:18-18(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NOMENCLATURE.
[6]"Differential actin-dependent localization modulates the evolutionarily conserved activity of Shroom family proteins."
Dietz M.L., Bernaciak T.M., Vendetti F., Kielec J.M., Hildebrand J.D.
J. Biol. Chem. 281:20542-20554(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[7]"Phosphoproteome analysis of Drosophila melanogaster embryos."
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-404; SER-667 AND SER-668, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE013599 Genomic DNA. Translation: AAF58259.2.
AE013599 Genomic DNA. Translation: AAM70999.2.
AE013599 Genomic DNA. Translation: AAF58260.2.
AY069213 mRNA. Translation: AAL39358.1.
BT023900 mRNA. Translation: ABA81834.1.
RefSeqNP_001097307.1. NM_001103837.1. [A1Z9P3-3]
NP_610952.1. NM_137108.2. [A1Z9P3-2]
NP_725378.2. NM_166047.1. [A1Z9P3-1]
UniGeneDm.2231.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3THFX-ray2.70A/B1393-1576[»]
ProteinModelPortalA1Z9P3.
SMRA1Z9P3. Positions 1396-1570.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid62342. 10 interactions.

Proteomic databases

PRIDEA1Z9P3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0112614; FBpp0111526; FBgn0085408. [A1Z9P3-3]
GeneID36592.
KEGGdme:Dmel_CG34379.
UCSCCG34379-RD. d. melanogaster.

Organism-specific databases

CTD36592.
FlyBaseFBgn0085408. Shroom.

Phylogenomic databases

eggNOGNOG72784.
GeneTreeENSGT00530000063061.
InParanoidQ3KN39.
OMASSQRIVH.
OrthoDBEOG7B05C7.
PhylomeDBA1Z9P3.

Gene expression databases

BgeeA1Z9P3.

Family and domain databases

InterProIPR014799. ASD2.
IPR027685. Shroom_fam.
[Graphical view]
PANTHERPTHR15012. PTHR15012. 1 hit.
PfamPF08687. ASD2. 1 hit.
[Graphical view]
PROSITEPS51307. ASD2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi36592.
NextBio799392.

Entry information

Entry nameSHRM_DROME
AccessionPrimary (citable) accession number: A1Z9P3
Secondary accession number(s): A1Z9P2, Q3KN39, Q7K1B1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 5, 2009
Last modified: July 9, 2014
This is version 48 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase