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Protein
Submitted name:

Sin3A, isoform A

Gene

Sin3A

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • chromatin binding Source: FlyBase
  • protein heterodimerization activity Source: FlyBase
  • transcription cofactor activity Source: FlyBase

GO - Biological processi

  • dendrite morphogenesis Source: FlyBase
  • determination of adult lifespan Source: FlyBase
  • epithelial cell migration Source: FlyBase
  • larval somatic muscle development Source: FlyBase
  • muscle organ development Source: FlyBase
  • negative regulation of epithelial cell migration Source: FlyBase
  • negative regulation of transcription, DNA-templated Source: FlyBase
  • negative regulation of Wnt signaling pathway Source: FlyBase
  • neuron development Source: FlyBase
  • peripheral nervous system development Source: FlyBase
  • regulation of hemocyte proliferation Source: FlyBase
  • regulation of mitotic cell cycle Source: FlyBase
  • regulation of protein stability Source: FlyBase
  • wing disc development Source: FlyBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DME-400206. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).

Names & Taxonomyi

Protein namesi
Submitted name:
Sin3A, isoform AImported
Submitted name:
Sin3A, isoform FImported
Gene namesi
Name:Sin3AImported
ORF Names:CG8815Imported, Dmel_CG8815Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0022764. Sin3A.

Subcellular locationi

GO - Cellular componenti

  • chromatin Source: FlyBase
  • euchromatin Source: FlyBase
  • nucleus Source: FlyBase
  • polytene chromosome Source: FlyBase
  • Sin3 complex Source: FlyBase
  • Sin3-type complex Source: FlyBase
  • transcriptional repressor complex Source: FlyBase
Complete GO annotation...

Interactioni

GO - Molecular functioni

  • protein heterodimerization activity Source: FlyBase

Protein-protein interaction databases

STRINGi7227.FBpp0293225.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1032 – 1133102HDAC_interactInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG4204. Eukaryota.
COG5602. LUCA.
GeneTreeiENSGT00390000007239.
OrthoDBiEOG7SV0TV.

Family and domain databases

Gene3Di1.20.1160.11. 3 hits.
InterProiIPR013194. HDAC_interact_dom.
IPR003822. PAH.
IPR031693. Sin3_C.
[Graphical view]
PfamiPF02671. PAH. 3 hits.
PF08295. Sin3_corepress. 1 hit.
PF16879. Sin3a_C. 1 hit.
[Graphical view]
SMARTiSM00761. HDAC_interact. 1 hit.
[Graphical view]
SUPFAMiSSF47762. SSF47762. 3 hits.
PROSITEiPS51477. PAH. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1Z927-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKRTRVDEV QFGTRPVPQT SGGVGVGVVG VTGGGPTSGG GGTATVGVNT
60 70 80 90 100
TGVTIGTVVP SAHNATISGI GSIHHRILTP QHGGAQTIAY LPSTTPTATN
110 120 130 140 150
LKTTTSIVDS TTAGGPVGAG AQVAVGVGSA AGGGGVVVST GSTGTQTLQY
160 170 180 190 200
TTSYSVASIQ AGGTLKANTA DGANTVQIHV TGGGAANNPA SAQTVSSSSQ
210 220 230 240 250
TGTIRQRTIS GTQTVATAVG NLATISQQQP VQQSPLGKAQ TPPSSVVANS
260 270 280 290 300
IPVGGTTPPQ GQSGNATPRL KVEDALSYLD QVKYQYADQP QIYNNFLDIM
310 320 330 340 350
KEFKSHCIDT PGVIERVSTL FKGHTELIYG FNMFLPPGYK IEIHSDALGC
360 370 380 390 400
SVPVVSMPSP PGAPTSTGTV HMLTGNSSMS GAGHIAIKTT NAATLTPAAG
410 420 430 440 450
AGAAAAAAAV AQIQSAGAVN LMTHGGASLT QTTIHALQQA TPPQSQSPGG
460 470 480 490 500
GHVHVSVTNS TAANAVVPGQ PGISVSAHNV PQNYSRDRER ATITPTGQVA
510 520 530 540 550
GAAANVNASA SIVVGGPPTP NSLSELSPHG GAGGGPGAGA AQHNLHHIQQ
560 570 580 590 600
AHQSILLGET GQQNQPVEFN HAITYVNKIK NRFQNQPAKY KKFLEILHDY
610 620 630 640 650
QREQKVMKEG SLNQGKMLTE QEVYTQVAKL FGQDEDLLRE FGQFLPDATN
660 670 680 690 700
HQSGQYMSKS ASVHNDHGKR PTATLSGGAH ITMSSASPAP SGSPLHLGAT
710 720 730 740 750
TLPQIDKSAH AAAIGNLSAV NTSVSIKTYN NNQQQQNHVI GSGLNATRND
760 770 780 790 800
ILFEKDYHAG LQQQAHQRGA GVGGHHHLAG TAAGANIGRP GVGASVMVSY
810 820 830 840 850
DKEHRNNHHV QKYVGHAPNQ NLTHGHNAKK SPSYGIPSVI GSMPHISDNS
860 870 880 890 900
LDRSSPGISY ATPPLPSGPH GQHNSGSATR RPGDDSLVGH YASGAPPAKR
910 920 930 940 950
PKPYCRDVSF SEASSKCTIS DAAFFDKVRK ALRSPEVYDN FLRCLTLFNQ
960 970 980 990 1000
EIVSKTELLG LVSPFLMKFP DLLRWFTDFL GPPSGQPAGG LIDGMPLAAT
1010 1020 1030 1040 1050
QRQGGGSSNS SHDRGTSHQS AAEYVQDVDL SSCKRLGASY CALPQSTVPK
1060 1070 1080 1090 1100
KCSGRTALCR EVLNDKWVSF PTWASEDSTF VTSRKTQFEE TIYRTEDERF
1110 1120 1130 1140 1150
ELDLVIEVNS ATIRVLENLQ KKMSRMSTEE LSKFHLDDHL GGTSQTIHQR
1160 1170 1180 1190 1200
AIHRIYGDKS GEIITGMKKN PFVAVPIVLK RLKVKEEEWR EAQKTFNKQW
1210 1220 1230 1240 1250
REQNEKYYLK SLDHQAINFK PNDMKALRSK SLFNEIETLY DERHDQEDDA
1260 1270 1280 1290 1300
MEPFGPHLVL PYKDKTILDD AANLLIHHVK RQTGIQKQEK QKIKQIIRQF
1310 1320 1330 1340 1350
VPDLFFAPRQ PLSDDERDDA FPFLVDDNTK MDVDSPLGRT ESSTRNAKST
1360 1370 1380 1390 1400
PSESASPARS NASTSSVTPA GIKKETDDSK ATTGSFAPAS SATASSATPV
1410 1420 1430 1440 1450
DDATPSTSSA AAAASAASSS TVSGTEGKPK DDPLSSHKEE GAGSTSSGVA
1460 1470 1480 1490 1500
TSPRQAQDTA GAGVDVEIKL EHPADFSNPK LLPPHAHGQR EDESYTLFFA
1510 1520 1530 1540 1550
NNNWYLFLRL HAILCDRLHV MYERARLLAI EEERCRVNRR ESTATALRLK
1560 1570 1580 1590 1600
PKPEIQVEDY YPTFLDMLKN VLDGNMDSNT FEDTMREMFG IYAYISFTLD
1610 1620 1630 1640 1650
KVVSNAVRQL QYCVTERAAL DCVELFATEQ RRGCTGGFCR DAHKTFDREM
1660 1670 1680 1690 1700
SYQRKAESIL NEENCFKVYI YKIDCRVTIE LLDSEPEEVD KPAALKAQKF
1710 1720 1730 1740 1750
SKYVERLANP ALGGGGNTGR SDSALGNDSV VDGSDIKTEA DEDTAEHTQS
1760 1770
QQWTLLESEN EKYIWSSPLK IHVQSY
Length:1,776
Mass (Da):189,973
Last modified:February 6, 2007 - v1
Checksum:i484A4EDC25E0D4EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58488.2.
AE013599 Genomic DNA. Translation: ADV37160.1.
RefSeqiNP_001188913.1. NM_001201984.2.
NP_610799.2. NM_136955.4.
UniGeneiDm.4374.

Genome annotation databases

EnsemblMetazoaiFBtr0087888; FBpp0087001; FBgn0022764.
FBtr0303566; FBpp0292599; FBgn0022764.
GeneIDi36382.
UCSCiCG8815-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58488.2.
AE013599 Genomic DNA. Translation: ADV37160.1.
RefSeqiNP_001188913.1. NM_001201984.2.
NP_610799.2. NM_136955.4.
UniGeneiDm.4374.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0293225.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0087888; FBpp0087001; FBgn0022764.
FBtr0303566; FBpp0292599; FBgn0022764.
GeneIDi36382.
UCSCiCG8815-RA. d. melanogaster.

Organism-specific databases

CTDi25942.
FlyBaseiFBgn0022764. Sin3A.

Phylogenomic databases

eggNOGiKOG4204. Eukaryota.
COG5602. LUCA.
GeneTreeiENSGT00390000007239.
OrthoDBiEOG7SV0TV.

Enzyme and pathway databases

ReactomeiR-DME-400206. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).

Miscellaneous databases

ChiTaRSiSin3A. fly.
GenomeRNAii36382.

Family and domain databases

Gene3Di1.20.1160.11. 3 hits.
InterProiIPR013194. HDAC_interact_dom.
IPR003822. PAH.
IPR031693. Sin3_C.
[Graphical view]
PfamiPF02671. PAH. 3 hits.
PF08295. Sin3_corepress. 1 hit.
PF16879. Sin3a_C. 1 hit.
[Graphical view]
SMARTiSM00761. HDAC_interact. 1 hit.
[Graphical view]
SUPFAMiSSF47762. SSF47762. 3 hits.
PROSITEiPS51477. PAH. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  4. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  5. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  7. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  8. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  9. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  11. FlyBase
    Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiA1Z927_DROME
AccessioniPrimary (citable) accession number: A1Z927
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: July 6, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.