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Protein

Rhomboid-like protein

Gene

rho-7

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • endopeptidase activity Source: FlyBase
  • serine-type endopeptidase activity Source: GO_Central

GO - Biological processi

  • mitochondrial fusion Source: FlyBase
  • protein processing Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, ProteaseUniRule annotation

Protein family/group databases

MEROPSiS54.A12.

Names & Taxonomyi

Protein namesi
Recommended name:
Rhomboid-like proteinUniRule annotation (EC:3.4.21.-UniRule annotation)
Gene namesi
Name:rho-7Imported
ORF Names:CG8972Imported, Dmel_CG8972Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0033672. rho-7.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei147 – 16418HelicalUniRule annotationAdd
BLAST
Transmembranei184 – 20320HelicalUniRule annotationAdd
BLAST
Transmembranei248 – 26619HelicalUniRule annotationAdd
BLAST
Transmembranei278 – 30629HelicalUniRule annotationAdd
BLAST
Transmembranei312 – 33322HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: GO_Central
  • mitochondrion Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiFBgn0033672.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0087151.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini185 – 329145RhomboidInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S54 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG2980. Eukaryota.
COG0705. LUCA.
GeneTreeiENSGT00390000013063.
KOiK09650.
OMAiYENTRSM.
OrthoDBiEOG091G0B3Z.
PhylomeDBiA1Z8R8.

Family and domain databases

Gene3Di1.20.1540.10. 1 hit.
InterProiIPR002610. Peptidase_S54_rhomboid.
IPR022764. Peptidase_S54_rhomboid_dom.
[Graphical view]
PANTHERiPTHR22936. PTHR22936. 1 hit.
PfamiPF01694. Rhomboid. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1Z8R8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMSRALCRS WLPQVARRCH ANVNVPILRI NSGHPAARSC RQIHSNRKQS
60 70 80 90 100
SNLKPTTGEP AAAEQNTPVP VNNVIKAVAF TGAFTVGCFA GATILEYENT
110 120 130 140 150
RSLILEKARQ ARFGWWQSRS LADRDYWTQI KQDIRRHWDS LTPGDKMFAP
160 170 180 190 200
ILLCNLVAFA MWRVPALKST MITYFTSNPA AKVVCWPMFL STFSHYSAMH
210 220 230 240 250
LFANMYVMHS FANAAAVSLG KEQFLAVYLS AGVFSSLMSV LYKAATSQAG
260 270 280 290 300
MSLGASGAIM TLLAYVCTQY PDTQLSILFL PALTFSAGAG IKVLMGIDFA
310 320 330 340 350
GVVMGWKFFD HAAHLGGAMF GIFWATYGAQ IWAKRIGLLN YYHDLRRTKQ

K
Length:351
Mass (Da):38,932
Last modified:February 6, 2007 - v1
Checksum:iCE9E774868BA30A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58598.1.
AE013599 Genomic DNA. Translation: AHN56122.1.
RefSeqiNP_001286324.1. NM_001299395.1.
NP_523704.1. NM_078980.4.

Genome annotation databases

EnsemblMetazoaiFBtr0088045; FBpp0087151; FBgn0033672.
FBtr0339555; FBpp0308636; FBgn0033672.
GeneIDi36281.
KEGGidme:Dmel_CG8972.
UCSCiCG8972-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58598.1.
AE013599 Genomic DNA. Translation: AHN56122.1.
RefSeqiNP_001286324.1. NM_001299395.1.
NP_523704.1. NM_078980.4.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0087151.

Protein family/group databases

MEROPSiS54.A12.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0088045; FBpp0087151; FBgn0033672.
FBtr0339555; FBpp0308636; FBgn0033672.
GeneIDi36281.
KEGGidme:Dmel_CG8972.
UCSCiCG8972-RA. d. melanogaster.

Organism-specific databases

CTDi36281.
FlyBaseiFBgn0033672. rho-7.

Phylogenomic databases

eggNOGiKOG2980. Eukaryota.
COG0705. LUCA.
GeneTreeiENSGT00390000013063.
KOiK09650.
OMAiYENTRSM.
OrthoDBiEOG091G0B3Z.
PhylomeDBiA1Z8R8.

Miscellaneous databases

GenomeRNAii36281.

Gene expression databases

BgeeiFBgn0033672.

Family and domain databases

Gene3Di1.20.1540.10. 1 hit.
InterProiIPR002610. Peptidase_S54_rhomboid.
IPR022764. Peptidase_S54_rhomboid_dom.
[Graphical view]
PANTHERiPTHR22936. PTHR22936. 1 hit.
PfamiPF01694. Rhomboid. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA1Z8R8_DROME
AccessioniPrimary (citable) accession number: A1Z8R8
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: September 7, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.