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Protein
Submitted name:

Rhomboid-7, isoform A

Gene

rho-7

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  • endopeptidase activity Source: FlyBase
  • serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  • mitochondrial fusion Source: FlyBase
  • protein processing Source: FlyBase

Keywordsi

Molecular functionHydrolaseImported

Enzyme and pathway databases

ReactomeiR-DME-8949664. Processing of SMDT1.

Protein family/group databases

MEROPSiS54.A12.

Names & Taxonomyi

Protein namesi
Submitted name:
Rhomboid-7, isoform AImported (EC:3.4.21.-Imported)
Submitted name:
Rhomboid-7, isoform BImported
Gene namesi
Name:rho-7Imported
ORF Names:CG8972Imported, Dmel_CG8972Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0033672. rho-7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei147 – 164HelicalSequence analysisAdd BLAST18
Transmembranei184 – 203HelicalSequence analysisAdd BLAST20
Transmembranei248 – 266HelicalSequence analysisAdd BLAST19
Transmembranei278 – 306HelicalSequence analysisAdd BLAST29
Transmembranei312 – 333HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrion Source: FlyBase

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiFBgn0033672.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0087151.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini185 – 330RhomboidInterPro annotationAdd BLAST146

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2980. Eukaryota.
COG0705. LUCA.
GeneTreeiENSGT00390000013063.
KOiK09650.
OMAiHEMRTNS.
OrthoDBiEOG091G0B3Z.

Family and domain databases

Gene3Di1.20.1540.10. 1 hit.
InterProiView protein in InterPro
IPR022764. Peptidase_S54_rhomboid_dom.
PfamiView protein in Pfam
PF01694. Rhomboid. 1 hit.
SUPFAMiSSF144091. SSF144091. 1 hit.

Sequencei

Sequence statusi: Complete.

A1Z8R8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMSRALCRS WLPQVARRCH ANVNVPILRI NSGHPAARSC RQIHSNRKQS
60 70 80 90 100
SNLKPTTGEP AAAEQNTPVP VNNVIKAVAF TGAFTVGCFA GATILEYENT
110 120 130 140 150
RSLILEKARQ ARFGWWQSRS LADRDYWTQI KQDIRRHWDS LTPGDKMFAP
160 170 180 190 200
ILLCNLVAFA MWRVPALKST MITYFTSNPA AKVVCWPMFL STFSHYSAMH
210 220 230 240 250
LFANMYVMHS FANAAAVSLG KEQFLAVYLS AGVFSSLMSV LYKAATSQAG
260 270 280 290 300
MSLGASGAIM TLLAYVCTQY PDTQLSILFL PALTFSAGAG IKVLMGIDFA
310 320 330 340 350
GVVMGWKFFD HAAHLGGAMF GIFWATYGAQ IWAKRIGLLN YYHDLRRTKQ

K
Length:351
Mass (Da):38,932
Last modified:February 6, 2007 - v1
Checksum:iCE9E774868BA30A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58598.1.
AE013599 Genomic DNA. Translation: AHN56122.1.
RefSeqiNP_001286324.1. NM_001299395.1.
NP_523704.1. NM_078980.4.

Genome annotation databases

EnsemblMetazoaiFBtr0088045; FBpp0087151; FBgn0033672.
FBtr0339555; FBpp0308636; FBgn0033672.
GeneIDi36281.
KEGGidme:Dmel_CG8972.
UCSCiCG8972-RA. d. melanogaster.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiA1Z8R8_DROME
AccessioniPrimary (citable) accession number: A1Z8R8
Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: July 5, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported