A1Z8Q7 (A1Z8Q7_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Microcephalin, isoform A EMBL AAF58607.3

Gene names

Name:	MCPH1 FlyBase FBgn0033664 FlyBase FBgn0260959
ORF Names:	Dmel_CG42572 EMBL AAF58607.3

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	779 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	embryo development Inferred from mutant phenotype. Source: FlyBase mitosis Inferred from mutant phenotype. Source: FlyBase mushroom body development Inferred from mutant phenotype. Source: FlyBase pole cell formation Inferred from mutant phenotype. Source: FlyBase
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A1Z8Q7 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 42B55EE0C9C67874	FASTA	779	86,189
	10 20 30 40 50 60 MSTNEPSITN KLRSLLLDDQ AARDRLMLKP ALAVSKAISQ HRSEFHQDEN EAGAEGSAAK 70 80 90 100 110 120 PDPPIGAATP TRQEGHWARL QQDLNSPNAA LRLRAIRALK SPTKSAYNTF DVPLAEQSII 130 140 150 160 170 180 TMEERNPQEP PSLPELLKDI VVYVEVRTGN DNRSEGVKSI IAKMGAQVKD RLTRTTTHVV 190 200 210 220 230 240 FKDGLLSTYK KATEWNIPVV SILWIEACKV QLKICDPKQF PISNIRMYEY PELFGKMPRV 250 260 270 280 290 300 KFMQPDSELN QRPRKRQGTP TSSKDNEPGS TNKRAQTGTP TTTTPKNDIS RFFRAINHNK 310 320 330 340 350 360 PSDDEAIESP ATKLLNRISS GCYTPLPAGG TPQLMGTNGS GDAVAQKVQA QKSLQFGEQT 370 380 390 400 410 420 DSNTPQAKPS STSRPRRSTV DPPPVMTPPV RTTRRRSCVA EISSPAATDT RMTRRRSSLL 430 440 450 460 470 480 TSTVIHEADP TQTAVAEPRM TRRRSSLLGI AKQAEETAQR QTIQPITEEL APVEENRNSI 490 500 510 520 530 540 IMAETNIINN TNCLEQSIEI TAVEAEASFK ADRRGTLYAS ELMDISSPRR RSVAKSSLEL 550 560 570 580 590 600 RQENLAPRAR QSLSNVTTQT SFLDVEQQVT PLFSSTRLPT GQTTGNRRRT IFNMDMDVIN 610 620 630 640 650 660 ESIERMNQSH RMSLALANKA ELGESCQVHE QEPPQAEPVP SQEPKRRRLF NPNDEVVISP 670 680 690 700 710 720 AMSNRKSRLS ITGSGSSSSV QKRRRSLATP AKSSSSELCA TTPLSKAVTN KEAEKSKSNT 730 740 750 760 770 EISEASLDAV PEVKKSTSNA GEENEKPKGK SRTRIRTLVH TNMHQEQINV IRKVGNTTE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE013599 Genomic DNA. Translation: AAF58607.3.
RefSeq	NP_725088.1. NM_165852.2.
UniGene	Dm.6585.
3D structure databases
ProteinModelPortal	A1Z8Q7.
SMR	A1Z8Q7. Positions 135-228.
ModBase	Search...
Protein-protein interaction databases
IntAct	A1Z8Q7. 3 interactions.
STRING	A1Z8Q7.
Proteomic databases
PRIDE	A1Z8Q7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0301428; FBpp0290643; FBgn0260959.
GeneID	36272.
KEGG	dme:Dmel_CG42572.
UCSC	CG8981-RA. d. melanogaster.
Organism-specific databases
CTD	79648.
FlyBase	FBgn0260959. MCPH1.
Phylogenomic databases
eggNOG	inNOG10311.
GeneTree	EMGT00050000014977.
InParanoid	A1Z8Q7.
OrthoDB	EOG4H9W1H.
Gene expression databases
Bgee	A1Z8Q7.
Family and domain databases
InterPro	IPR001357. BRCT. [Graphical view]
SMART	SM00292. BRCT. 1 hit. [Graphical view]
SUPFAM	SSF52113. BRCT. 1 hit.
PROSITE	PS50172. BRCT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	797665.

Entry information

Entry name

A1Z8Q7_DROME

Accession

Primary (citable) accession number: A1Z8Q7

Entry history

Integrated into UniProtKB/TrEMBL:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)