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Protein

Facilitated trehalose transporter Tret1-1

Gene

Tret1-1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Low-capacity facilitative transporter for trehalose. Does not transport maltose, sucrose or lactose. Mediates the bidirectional transfer of trehalose. Responsible for the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source, thereby regulating trehalose levels in the hemolymph.1 Publication

Kineticsi

  1. KM=10.94 mM for trehalose1 Publication

    GO - Molecular functioni

    GO - Biological processi

    • glucose import Source: GO_Central
    • hexose transmembrane transport Source: GO_Central
    • trehalose transport Source: UniProtKB
    Complete GO annotation...

    Keywords - Biological processi

    Sugar transport, Transport

    Enzyme and pathway databases

    ReactomeiR-DME-428790. Facilitative Na+-independent glucose transporters.
    R-DME-8856825. Cargo recognition for clathrin-mediated endocytosis.
    R-DME-8856828. Clathrin-mediated endocytosis.

    Protein family/group databases

    TCDBi2.A.1.1.99. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Facilitated trehalose transporter Tret1-11 Publication
    Short name:
    DmTret1-11 Publication
    Gene namesi
    Name:Tret1-1Imported
    ORF Names:CG30035
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    Proteomesi
    • UP000000803 Componenti: Chromosome 2R

    Organism-specific databases

    FlyBaseiFBgn0050035. Tret1-1.

    Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini1 – 392CytoplasmicSequence analysisAdd BLAST392
    Transmembranei393 – 413Helical; Name=1Sequence analysisAdd BLAST21
    Topological domaini414 – 440ExtracellularSequence analysisAdd BLAST27
    Transmembranei441 – 461Helical; Name=2Sequence analysisAdd BLAST21
    Topological domaini462 – 473CytoplasmicSequence analysisAdd BLAST12
    Transmembranei474 – 494Helical; Name=3Sequence analysisAdd BLAST21
    Topological domaini495 – 497ExtracellularSequence analysis3
    Transmembranei498 – 518Helical; Name=4Sequence analysisAdd BLAST21
    Topological domaini519 – 528CytoplasmicSequence analysis10
    Transmembranei529 – 549Helical; Name=5Sequence analysisAdd BLAST21
    Topological domaini550 – 552ExtracellularSequence analysis3
    Transmembranei553 – 573Helical; Name=6Sequence analysisAdd BLAST21
    Topological domaini574 – 636CytoplasmicSequence analysisAdd BLAST63
    Transmembranei637 – 657Helical; Name=7Sequence analysisAdd BLAST21
    Topological domaini658 – 673ExtracellularSequence analysisAdd BLAST16
    Transmembranei674 – 694Helical; Name=8Sequence analysisAdd BLAST21
    Topological domaini695 – 700CytoplasmicSequence analysis6
    Transmembranei701 – 721Helical; Name=9Sequence analysisAdd BLAST21
    Topological domaini722 – 740ExtracellularSequence analysisAdd BLAST19
    Transmembranei741 – 761Helical; Name=10Sequence analysisAdd BLAST21
    Topological domaini762 – 767CytoplasmicSequence analysis6
    Transmembranei768 – 788Helical; Name=11Sequence analysisAdd BLAST21
    Topological domaini789 – 801ExtracellularSequence analysisAdd BLAST13
    Transmembranei802 – 822Helical; Name=12Sequence analysisAdd BLAST21
    Topological domaini823 – 857CytoplasmicSequence analysisAdd BLAST35

    GO - Cellular componenti

    • integral component of plasma membrane Source: GO_Central
    • membrane Source: FlyBase
    • plasma membrane Source: UniProtKB
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00003955311 – 857Facilitated trehalose transporter Tret1-1Add BLAST857

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei248Phosphoserine1 Publication1
    Modified residuei249Phosphoserine1 Publication1
    Modified residuei250Phosphoserine1 Publication1
    Modified residuei320Phosphoserine1 Publication1
    Modified residuei322Phosphoserine1 Publication1
    Glycosylationi428N-linked (GlcNAc...)Sequence analysis1
    Glycosylationi550N-linked (GlcNAc...)Sequence analysis1
    Modified residuei845Phosphoserine1 Publication1
    Modified residuei846Phosphoserine1 Publication1
    Isoform B1 Publication (identifier: A1Z8N1-2)
    Modified residuei9Phosphothreonine1 Publication1
    Modified residuei12Phosphoserine1 Publication1

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiA1Z8N1.
    PRIDEiA1Z8N1.

    PTM databases

    iPTMnetiA1Z8N1.

    Expressioni

    Gene expression databases

    BgeeiFBgn0050035.
    GenevisibleiA1Z8N1. DM.

    Interactioni

    Protein-protein interaction databases

    BioGridi62035. 3 interactors.
    IntActiA1Z8N1. 3 interactors.
    STRINGi7227.FBpp0087178.

    Structurei

    3D structure databases

    ProteinModelPortaliA1Z8N1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily. [View classification]Sequence analysis1 Publication

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG0254. Eukaryota.
    ENOG410XNQK. LUCA.
    GeneTreeiENSGT00850000132274.
    InParanoidiA1Z8N1.
    KOiK14258.
    OMAiGEDAEHK.
    OrthoDBiEOG091G1600.
    PhylomeDBiA1Z8N1.

    Family and domain databases

    CDDicd06174. MFS. 1 hit.
    InterProiIPR020846. MFS_dom.
    IPR005828. MFS_sugar_transport-like.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    PRINTSiPR00171. SUGRTRNSPORT.
    SUPFAMiSSF103473. SSF103473. 1 hit.
    TIGRFAMsiTIGR00879. SP. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 2 hits.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

    Isoform A1 Publication (identifier: A1Z8N1-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MSGRDNRGAG GGGGGHQPLS NAMGKLKEKL TRVGDELGYH RVESNLSTSN
    60 70 80 90 100
    TATSLDTILP EDPFLFPQVS PQRHPQNTVR TQRLLEDEPP LSFRPLLEDD
    110 120 130 140 150
    DINEPPTQQQ QRTPLRASGS LELTPLPPPP TSLEIREHRD RQQRGAQGDE
    160 170 180 190 200
    LQRSKQSLKG SRVSFERRDT GNSNTNSNKA AESSDEDSFE EKRTGFQQQK
    210 220 230 240 250
    ATSVDHKGIL KDLKHILAND NRRQFQAKKH VSLDVKGTRF LQDLLKESSS
    260 270 280 290 300
    EEEFHKTRRE FQGRKHQSLD PRVTFKLDKV LQGSSTDSDE EGEDAEHKRL
    310 320 330 340 350
    IHRPKDITKP VIIDLKDLES ESDEDFLTSR QHFQQQRSIS TDSRKSRRLY
    360 370 380 390 400
    EMDEMDNKRG ENIRHAVPFV RQITEDGKPK LEVYRPTTNP IYIWTQVLAA
    410 420 430 440 450
    LSVSLGSLVV GFVSAYTSPA LVSMTDRNIT SFEVTQDAGS WVGGIMPLAG
    460 470 480 490 500
    LAGGIAGGPL IEYLGRRNTI LATAVPFIVS SLLIACAVNV AMVLCGRFLA
    510 520 530 540 550
    GFCVGIASLS LPVYLGETVQ PEVRGTLGLL PTAFGNIGIL LCFVAGSFMN
    560 570 580 590 600
    WSMLAFLGAA LPVPFLILMF LIPETPRWFV GRGLEERARK ALKWLRGKEA
    610 620 630 640 650
    DVEPELKGLM RSQADADRQA SRNTMLELLK LNNLKPLSIS LGLMFFQQFS
    660 670 680 690 700
    GINAVIFYTV QIFKDAGSTI DGNLCTIIVG IVNFLATFIG IVLIDRAGRK
    710 720 730 740 750
    ILLYVSDIAM VLTLFVLGGF FYCKTYGPDV SHLGWLPLTC FVIYILGFSL
    760 770 780 790 800
    GFGPIPWLMM GEILPAKIRG SAASVATAFN WFCTFVVTKT FQDLTVAMGA
    810 820 830 840 850
    HGAFWLFGAI CFVGLFFVII YVPETQGKTL EDIERKMMGR VRRMSSVANI

    KPLSFNM
    Length:857
    Mass (Da):95,188
    Last modified:February 6, 2007 - v1
    Checksum:i8408E1191B8B7A5F
    GO
    Isoform B1 Publication (identifier: A1Z8N1-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-27: MSGRDNRGAGGGGGGHQPLSNAMGKLK → MKILMRADTHVSFSVPVEEPKAICTFS
         28-395: Missing.

    Show »
    Length:489
    Mass (Da):53,027
    Checksum:iD26436DAD69723C6
    GO

    Sequence cautioni

    The sequence AAO39469 differs from that shown. Reason: Frameshift at position 348.Curated
    The sequence AAO39469 differs from that shown. Reason: Erroneous termination at position 97. Translated as Leu.Curated

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_0395151 – 27MSGRD…MGKLK → MKILMRADTHVSFSVPVEEP KAICTFS in isoform B. 3 PublicationsAdd BLAST27
    Alternative sequenceiVSP_03951628 – 395Missing in isoform B. 3 PublicationsAdd BLAST368

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB369552 mRNA. Translation: BAF96746.1.
    AB369553 mRNA. Translation: BAF96747.1.
    AE013599 Genomic DNA. Translation: AAF58631.1.
    AE013599 Genomic DNA. Translation: AAF58632.2.
    BT003466 mRNA. Translation: AAO39469.1. Sequence problems.
    BT010286 mRNA. Translation: AAQ23604.1.
    RefSeqiNP_610693.1. NM_136849.2. [A1Z8N1-1]
    NP_725068.1. NM_165845.2. [A1Z8N1-2]
    UniGeneiDm.6727.

    Genome annotation databases

    EnsemblMetazoaiFBtr0088073; FBpp0087178; FBgn0050035. [A1Z8N1-1]
    GeneIDi36248.
    KEGGidme:Dmel_CG30035.
    UCSCiCG30035-RA. d. melanogaster. [A1Z8N1-1]
    CG30035-RB. d. melanogaster.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB369552 mRNA. Translation: BAF96746.1.
    AB369553 mRNA. Translation: BAF96747.1.
    AE013599 Genomic DNA. Translation: AAF58631.1.
    AE013599 Genomic DNA. Translation: AAF58632.2.
    BT003466 mRNA. Translation: AAO39469.1. Sequence problems.
    BT010286 mRNA. Translation: AAQ23604.1.
    RefSeqiNP_610693.1. NM_136849.2. [A1Z8N1-1]
    NP_725068.1. NM_165845.2. [A1Z8N1-2]
    UniGeneiDm.6727.

    3D structure databases

    ProteinModelPortaliA1Z8N1.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi62035. 3 interactors.
    IntActiA1Z8N1. 3 interactors.
    STRINGi7227.FBpp0087178.

    Protein family/group databases

    TCDBi2.A.1.1.99. the major facilitator superfamily (mfs).

    PTM databases

    iPTMnetiA1Z8N1.

    Proteomic databases

    PaxDbiA1Z8N1.
    PRIDEiA1Z8N1.

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblMetazoaiFBtr0088073; FBpp0087178; FBgn0050035. [A1Z8N1-1]
    GeneIDi36248.
    KEGGidme:Dmel_CG30035.
    UCSCiCG30035-RA. d. melanogaster. [A1Z8N1-1]
    CG30035-RB. d. melanogaster.

    Organism-specific databases

    CTDi36248.
    FlyBaseiFBgn0050035. Tret1-1.

    Phylogenomic databases

    eggNOGiKOG0254. Eukaryota.
    ENOG410XNQK. LUCA.
    GeneTreeiENSGT00850000132274.
    InParanoidiA1Z8N1.
    KOiK14258.
    OMAiGEDAEHK.
    OrthoDBiEOG091G1600.
    PhylomeDBiA1Z8N1.

    Enzyme and pathway databases

    ReactomeiR-DME-428790. Facilitative Na+-independent glucose transporters.
    R-DME-8856825. Cargo recognition for clathrin-mediated endocytosis.
    R-DME-8856828. Clathrin-mediated endocytosis.

    Miscellaneous databases

    GenomeRNAii36248.
    PROiA1Z8N1.

    Gene expression databases

    BgeeiFBgn0050035.
    GenevisibleiA1Z8N1. DM.

    Family and domain databases

    CDDicd06174. MFS. 1 hit.
    InterProiIPR020846. MFS_dom.
    IPR005828. MFS_sugar_transport-like.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    PRINTSiPR00171. SUGRTRNSPORT.
    SUPFAMiSSF103473. SSF103473. 1 hit.
    TIGRFAMsiTIGR00879. SP. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 2 hits.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Entry informationi

    Entry nameiTRE11_DROME
    AccessioniPrimary (citable) accession number: A1Z8N1
    Secondary accession number(s): A9ZSY5, Q6NQZ8, Q86P59
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 13, 2010
    Last sequence update: February 6, 2007
    Last modified: November 30, 2016
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.