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Protein
Submitted name:

No child left behind

Gene

nclb

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • chromatin DNA binding Source: FlyBase

GO - Biological processi

  • germ cell development Source: FlyBase
  • male germ-line stem cell population maintenance Source: FlyBase
  • male gonad development Source: FlyBase
  • ovarian follicle cell development Source: FlyBase
  • ovarian fusome organization Source: FlyBase
  • regulation of gene expression Source: FlyBase

Enzyme and pathway databases

SignaLinkiA1Z8D0.

Names & Taxonomyi

Protein namesi
Submitted name:
No child left behindImported
Gene namesi
Name:nclbImported
ORF Names:CG6751Imported, Dmel_CG6751Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0263510. nclb.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: FlyBase

PTM / Processingi

Proteomic databases

PaxDbiA1Z8D0.
PRIDEiA1Z8D0.

Expressioni

Gene expression databases

BgeeiFBgn0263510.
GenevisibleiA1Z8D0. DM.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0087323.

Structurei

3D structure databases

ProteinModelPortaliA1Z8D0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini230 – 405WD_REPEATS_REGIONInterPro annotationAdd BLAST176
Repeati230 – 272WDPROSITE-ProRule annotationAdd BLAST43
Repeati363 – 405WDPROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

WD repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0270. Eukaryota.
ENOG410XT1V. LUCA.
InParanoidiA1Z8D0.
KOiK14791.
OMAiPLCVEWL.
OrthoDBiEOG091G07TA.
PhylomeDBiA1Z8D0.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
PfamiView protein in Pfam
PF00400. WD40. 2 hits.
SMARTiView protein in SMART
SM00320. WD40. 5 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

A1Z8D0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEGPPEPS IDFVPALCFV PRGVAKDRPD KIVLTQAELA RIIGDTQQEL
60 70 80 90 100
DEESDDDAEE GENAEEDQND MDVDDHADAN SENRDPQDEF QFQEYDNEAN
110 120 130 140 150
ANVTSLANIV DAGEQIPDED EDSEAEDEVI KPSDNLILVG HVQDDAASME
160 170 180 190 200
VWVFNQEEEA LYTHHDFLLP SFPLCIEWMN HDAGSEKAGN MCAIGCMDPI
210 220 230 240 250
ITVWDLDIQD AIEPTFKLGS KGSRKQNKEQ YGHKDAVLDL SWNTNFEHIL
260 270 280 290 300
ASGSVDQTVI LWDMDEGQPH TTITAFGKQI QSLEFHPQEA QSILTGCADG
310 320 330 340 350
YVRLFDCRDA EGVNSSSIEW KVDGEVEKVL WHPTQTDYFI VGTNDGTLHY
360 370 380 390 400
ADKRSPGQLL WSVKAHNEEI SGVCFNNQKP NLLTSTSTEG TLKVWNFDGT
410 420 430 440 450
EAKHVYEHEF NMGRLQCMRQ CPEDPYTLAF GGEKPPRCAI FNIKNSIAVR

RTFGIPDAE
Length:459
Mass (Da):51,391
Last modified:February 6, 2007 - v1
Checksum:i2FBA9D1149599D75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58738.1.
RefSeqiNP_610623.1. NM_136779.4.

Genome annotation databases

EnsemblMetazoaiFBtr0088228; FBpp0087323; FBgn0263510.
GeneIDi36150.
KEGGidme:Dmel_CG6751.
UCSCiCG6751-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58738.1.
RefSeqiNP_610623.1. NM_136779.4.

3D structure databases

ProteinModelPortaliA1Z8D0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0087323.

Proteomic databases

PaxDbiA1Z8D0.
PRIDEiA1Z8D0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0088228; FBpp0087323; FBgn0263510.
GeneIDi36150.
KEGGidme:Dmel_CG6751.
UCSCiCG6751-RA. d. melanogaster.

Organism-specific databases

CTDi36150.
FlyBaseiFBgn0263510. nclb.

Phylogenomic databases

eggNOGiKOG0270. Eukaryota.
ENOG410XT1V. LUCA.
InParanoidiA1Z8D0.
KOiK14791.
OMAiPLCVEWL.
OrthoDBiEOG091G07TA.
PhylomeDBiA1Z8D0.

Enzyme and pathway databases

SignaLinkiA1Z8D0.

Miscellaneous databases

GenomeRNAii36150.

Gene expression databases

BgeeiFBgn0263510.
GenevisibleiA1Z8D0. DM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
PfamiView protein in Pfam
PF00400. WD40. 2 hits.
SMARTiView protein in SMART
SM00320. WD40. 5 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA1Z8D0_DROME
AccessioniPrimary (citable) accession number: A1Z8D0
Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: June 7, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.