A1Z7C4 (A1Z7C4_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
CG33087 EMBL AAF59114.3

Gene names

Name:	LRP1 FlyBase FBgn0053087
ORF Names:	CG33087 FlyBase FBgn0053087, Dmel_CG33087 EMBL AAF59114.3

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	4699 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Cellular component	Membrane
Domain	EGF-like domain RuleBase RU000458 SAAS SAAS018097 Repeat SAAS SAAS011042 Transmembrane Transmembrane helix SAAS SAAS000033
PTM	Disulfide bond SAAS SAAS023415
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A1Z7C4 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 166D46B38C74A6BF	FASTA	4,699	524,928
	10 20 30 40 50 60 MQTVAETQMI EWLAACTSSF FLCILSDHYS VIYPIAGPCP ASYFTCNDGF CIPMRWKCDS 70 80 90 100 110 120 KADCPDMSDE GSECAPKCNE GQFRCGVSRH CIPNNWLCDG EFDCGKGDIS DELNCPNGDT 130 140 150 160 170 180 PKCRAFEGQC RNGDCLELSR FCDGRWDCDN DELQCDKQNA ACAALNCSFN CKLTPQGARC 190 200 210 220 230 240 YCPKDQVPES SNSTRCVDYD ECSEPGTCDQ VCRNTPGSYE CSCVSGYAKT KGNRCRAINV 250 260 270 280 290 300 PPTEPTTLIF LSRDGVQSVG TNGTEVIGPP GAKDNDKVTD KDGVGSEEEL LLSQPLRFVH 310 320 330 340 350 360 AFEVWHRNRT LCSLLFSWPE LQMRCQRVDD ARVNWTLPFS SFVSPQQFFT ELRLDWLSGN 370 380 390 400 410 420 WYLVSEDDGL VYLCTNAMTY CRVILQQVDP LSSLDLDPTK GFMFYTDWTP SLSRSLLDGS 430 440 450 460 470 480 NRTVLVTDQV YHPSSVTLDL ANELVYWIDI YKDEVNRVDY EGRNRWTLKR PLDSPVPLKT 490 500 510 520 530 540 IHAVEVFENS IYLAAWMDTA IVALDKFSLK THILQSNVSR GANLRIFHRQ KQPEVAHPCR 550 560 570 580 590 600 DNNAGCNQIC VPQWTKGFAS AKCMCTAGYK LHNQTTCLLS ALDKFLVYSD KHLARISGIP 610 620 630 640 650 660 LDTEQVQQLE QIGEQPDVMV PVYNVSKTLA IDVNVRGKAV FYVVADSGAS PFGNGEPSCS 670 680 690 700 710 720 IRSQSLNGSV SRLLAQGLKR VHAVAFDWIN DHLYWTSHKK MQVAPLRNLS KVLTFNTDCD 730 740 750 760 770 780 AMSLELDPTT GLLYWSQWES QSCEAGIYSS WMDGTHKELL AKGTSSMPMQ WPRSLDVDRR 790 800 810 820 830 840 TKELYWCDIR LSTIELMRLD GTGREVLFKS DQFHPYSIVQ NNGLIYWADN KNSTILRFHA 850 860 870 880 890 900 HQANLSSTFS STVHLQRTGR AADLRIFDIA SQPLPQTPSA CAQSKCPGMC LNTPKGAICR 910 920 930 940 950 960 CPDGFTLNGT GSHCIPQLAP SPIRPNCTSG YMCRSTRQCL DTKDMCDGFE DCEDGIDESS 970 980 990 1000 1010 1020 DPKGPCNVNT CDKTHNFVCN GRCYQRSLLC STIPYCSDGT DQANCHQNTC NSNEFTCHKS 1030 1040 1050 1060 1070 1080 GRCIQLTWVN DGVVDCGPDD DSDETSETIF ASKCPEFDCN NGRCRQFADV CDGIDNCGNN 1090 1100 1110 1120 1130 1140 ADEMECEQEC EHGEKYCRPI GCYGEMHMCD GIHDCLDFSD EANCNQTKSD NHPVTEWKEL 1150 1160 1170 1180 1190 1200 GECAPLEFAC MFPFECIPDF LRCDGISHCF DKTDEFNCTH INTTRFDMNE TVICEHPDRL 1210 1220 1230 1240 1250 1260 CGFSKQCVTV DQLCDGKNDC EDTTDEGFLC ADKLCDRGHE CSHRCHNTPE GYICSCPDHL 1270 1280 1290 1300 1310 1320 YLQPNGKRCS MQHACDHWDT CSQVCESSGK GYDCRCLDGF DLGFDRFTCK STAPDEPYVI 1330 1340 1350 1360 1370 1380 FTNRQDIKGI NLKTLNVGNF YSSLRNIIAL DFLYNNESNV EIYWTDVIDD KIYRGHLVGE 1390 1400 1410 1420 1430 1440 SLRNVEAVIH SGLSTTEGLA VDWVGKNLYW IDSNLDQIEV AKLNGSFRRT LIAGNMESPR 1450 1460 1470 1480 1490 1500 AIALDPREGL LFWTDWDDNS PRIERASMSG DGRRMISTSW QLSAGWPNGL TLDYTQKRVY 1510 1520 1530 1540 1550 1560 WVDAKSDSIS STMYDGSEHH VVLRNKEILS HPFAISVFEN YVYWTDWRTT SVIRANKWNG 1570 1580 1590 1600 1610 1620 SDVQVLQRTQ SQPFGIQVLH SSRQPWDRNP CGENNGGCSH LCLLSGRGTF KCECPHVMRL 1630 1640 1650 1660 1670 1680 DPANERNCVP NEQVLLFVMV DEIRGIDLHQ PNHHTIPTIR QSPRRIDFLV DESRIFWSDI 1690 1700 1710 1720 1730 1740 QQNEISSAGI SNGLIEPIIN TNIEKPYGFA VDWIARNMYF SSGQIKCNIL ASNLKGEFAS 1750 1760 1770 1780 1790 1800 IIHEDLNMVD SIVLDPANGK MYWIHSASDG SMSQLEQSNL DGSSRSLIYQ HENNLQSLTM 1810 1820 1830 1840 1850 1860 DFDSQRLYYA YDNSGIAYYD IPRNETRKVL VASPITSISS LTVYNGTLYF PENIQSVIMQ 1870 1880 1890 1900 1910 1920 CEKEACSNMS YLRVNTKSIQ SMKMFYADAQ TGSNTCAEWA YRGGCQQLCL ATSSIDHVCR 1930 1940 1950 1960 1970 1980 CALGYDVEPN NPTGCVPRAE FIFYSIDVLQ GVEMIDPSEQ FDTPSPALVP ISRVSSASFI 1990 2000 2010 2020 2030 2040 DYLANTDTLY WGDNELGSIS RVKRDGTQRE TILEALNLVG YKQQDWLGGI AIDWVAGNIY 2050 2060 2070 2080 2090 2100 WSDTKRNIIE VARLDGSHRY VVVSNLEKPT ALAVDPLQGL LFYVTQQHIG RVGLDGSQPF 2110 2120 2130 2140 2150 2160 VLVNQTRANW AVGSLVLDIE ATKVYWCERY PDALMKVDYD GNLREQLLNE SLNNPVALAK 2170 2180 2190 2200 2210 2220 MGDYLYWAEN KYNEGIIRVA PLANLSQSKV VLQTEQDAIR DLKIYSKHLQ RGSNPCAHSN 2230 2240 2250 2260 2270 2280 GACEQLCLFN GTSAVCACAH SRLASDGYSC EPYENFLLFS YRSNIESIHM TDHADKNWPV 2290 2300 2310 2320 2330 2340 QMISNTSLMR NVIAITYNYE EQLVYYSDVQ LSTINQVHFN GTGHRVLLEQ QQRVEGLAYD 2350 2360 2370 2380 2390 2400 IVNEQLFWTS NNNATIRSVE LRHLSEHADQ NQVHVKKVLS LREDDKPRGI AVEPCLGMIY 2410 2420 2430 2440 2450 2460 WTNWNEGSPC IQRSYLTGYG TEVIIKTDIK MPNALTLDLE QQKLYWADAR LDKIERTNYD 2470 2480 2490 2500 2510 2520 GSNRVVLAHS TPKHAFAMAV YGDLLFWTDW VLHAVVRANK YTGTDVLFLR EHVTRPMGIV 2530 2540 2550 2560 2570 2580 AVQNTSINCD ANQCKILNGQ CEDVCILNKS GQATCHCTQG VLAPDGRRCI APVNTSCGLS 2590 2600 2610 2620 2630 2640 QYNCHSGECI PLELTCDNVT HCADGSDEFR SYCIFRQCPE THFMCQNHRC IPKEHKCDGE 2650 2660 2670 2680 2690 2700 QQCGDGSDET PLLCKCQSED IDMHPSNNNT KEMPDMFRCG SGECIPRKFL CDSLKDCRDF 2710 2720 2730 2740 2750 2760 SDEKMCAPIP CEKNDMTFVH CGNSTICIMP RWRCDGDPDC PDGTDELDCA NHTSLSCDPG 2770 2780 2790 2800 2810 2820 QFRCASGNCI AGSWHCDGEK DCPDGSDEIN CRTECRHNQF ACDKTCIPAS WQCDGKSDCE 2830 2840 2850 2860 2870 2880 DGSDEGPQCP NRPCRPHLFQ CKSSGRCIPQ KWVCDGEKDC PSGLGDEGSE DEGPQCGGVA 2890 2900 2910 2920 2930 2940 HIPDCPPPAH LCTSGLCIDS HYVCDGDEDC PGGDDEYEGC VPAFQPHSCP GGSLMHQCQD 2950 2960 2970 2980 2990 3000 GLCIFKNQTC DGKPDCGDGS DETSSLCAHT RGCNGTDDFR CKNGACIHAD LLCDRRNDCA 3010 3020 3030 3040 3050 3060 DFSDEELCNV NECLIPDICE HECEDKVVGY QCHCRPGYKV LPKSPHLCTD IDECDEQQPC 3070 3080 3090 3100 3110 3120 SQTCINTYGS YKCLCAKGYA LVDHHTCKAT SNVSMELIFS NRYYIRQVDM TGNGSILINE 3130 3140 3150 3160 3170 3180 LSNAVALDYD WDSQCLYWSD VTSTVGTIKR YCPKENKTQT LHQAMLKNPD GLAVDWVAKN 3190 3200 3210 3220 3230 3240 LYWCDKGLDT IEVSQLDGKY RKVLINEYLR EPRGIALHPY QQHIFWSDWG DSPHIGKAGM 3250 3260 3270 3280 3290 3300 DGSNPKMIIR DGLGWPNALT ISFETQQLFW GDAREDTISV SDLDGNHTRL LLARSINPLL 3310 3320 3330 3340 3350 3360 NLHHIFAIAV WEGHIYWSDW ETKSIEYCSI FNGQNCTTLI TTIHRPMDLR VFHPYRQQQP 3370 3380 3390 3400 3410 3420 MSGNPCLAAN CSTLCVLSPE EPYYKCMCPT NFILADDGRT CRANCTAAHF ECVNTYKCIP 3430 3440 3450 3460 3470 3480 FYWRCDTQDD CGDGSDEPET CPPFHCEPGQ YQCANKKCTH PSNLCDGINQ CGDGSDELNC 3490 3500 3510 3520 3530 3540 DKFTCFDNHM KCGATANSSA FCVDNVKRCD GVKDCPGGED ESACTPLVCK KDQFQCGNNR 3550 3560 3570 3580 3590 3600 CMPFVWVCDG DIDCPDKSDE ANCDNVSCGP NDFQCDSGRC IPLAWRCDDD HDCPNGEDEP 3610 3620 3630 3640 3650 3660 ASCFSSKATC DPTYFKCNNS KCIPGRWRCD YENDCGDGSD ELNCQMRNCS ESEFRCGTGK 3670 3680 3690 3700 3710 3720 CIKHNYRCDG EIHCDDNSDE INCNITCKEN QFKCAAFNTC INKQYKCDGD DDCPDGSDEV 3730 3740 3750 3760 3770 3780 NCTCHSDHFS CGNGKCIMSR WKCDGWDDCL DGSDESLETC AKTHCHANAF KCRNQLCVRN 3790 3800 3810 3820 3830 3840 SALCDGINDC GENEDESDAV CAALPKCRHD QFQCENDDCI SKAFRCDGQY NCVDGSDEMN 3850 3860 3870 3880 3890 3900 CQPPVCGFGS CSQICIEKKA GHYNCKCADG YHKGPEKNAT CLASGPDQIL LLASEQEFRF 3910 3920 3930 3940 3950 3960 ILPAKQEGTT VVGFFQTDSL KIDVFDILIR PKDTLLFWID SHHGKVHTMK IATPHVEGTG 3970 3980 3990 4000 4010 4020 VRVRRDLKEL TAFNIPELDD PKSLAVDWIS QRVYIIDSRH NQILATDIEG KKYISLVSTG 4030 4040 4050 4060 4070 4080 MNPTDIVLEP ESRIMIWSTL ENGILVASLD GSNKKSLVER DVGWPISLSM DYPTGRLYWA 4090 4100 4110 4120 4130 4140 DYRKGTIETC RLNGKDRNVV RRFGNREKPQ KIDVFEDYLY IKLYDQSIIK MNKFGNDNGT 4150 4160 4170 4180 4190 4200 YLLKGYRSSD IGILHPMKQN RNISNPCAKD PCKSSRALCI LSSESSVGYS CKCAEGYVMT 4210 4220 4230 4240 4250 4260 DDGVCKAHAD IPDYCPLQCN LGTCKIVDHV PKCICQPQFE GELCEHYRCS GYCQNYGVCS 4270 4280 4290 4300 4310 4320 VAPALPGSQE PPPLKCTCTA GWSGARCETS MPACQSRCHN GGSCLISETE GMKCSCPKMF 4330 4340 4350 4360 4370 4380 TGEQCEHCRN LTCENGGICR ETLTGTPQCE CPDGFTGKRC EIDECADFCK NGGSCVISTK 4390 4400 4410 4420 4430 4440 GQRQCKCPSG YFGEHCESNS CRDFCRNGGT CSERGGRLSC TCPPRYIGES CESDLCKTSS 4450 4460 4470 4480 4490 4500 PPHFCDNTKV PTRDPCTLMI CQNAGTCHII KGVALCNCTD QWNGDLCTLP VTDDNPCARY 4510 4520 4530 4540 4550 4560 CANGGVCHLD EYRLPHCSCI GEWQGNACEM PPHCVGGECN VCRPGSSINE CLCENNRVVP 4570 4580 4590 4600 4610 4620 CLSDSADALK EEQEPTESGG VFSVVVLVLA VILLVFALFA GAVYFLKKHR IAQPFSHARL 4630 4640 4650 4660 4670 4680 TDNVEIMLTN AMYRGDADEA PTFASEDDKG NFANPVYESM YADAIPEPVS TEITHSTAPD 4690 ERKGLLQHTH DENHTPDIL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE013599 Genomic DNA. Translation: AAF59114.3.
RefSeq	NP_788284.1. NM_176104.1.
UniGene	Dm.19876.
3D structure databases
ProteinModelPortal	A1Z7C4.
SMR	A1Z7C4. Positions 35-158, 166-239, 245-578, 890-915, 935-1630, 1663-1933, 1940-2571, 2576-2652, 2755-3403, 3567-4565.
ModBase	Search...
Protein-protein interaction databases
IntAct	A1Z7C4. 1 interaction.
STRING	A1Z7C4.
Proteomic databases
PRIDE	A1Z7C4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0088791; FBpp0087868; FBgn0053087.
GeneID	35799.
KEGG	dme:Dmel_CG33087.
NMPDR	fig|7227.3.peg.3843.
UCSC	CG33087-RC. d. melanogaster.
Organism-specific databases
CTD	4035.
FlyBase	FBgn0053087. LRP1.
Phylogenomic databases
eggNOG	inNOG07413.
GeneTree	EMGT00050000000208.
InParanoid	A1Z7C4.
OMA	DEEACGT.
OrthoDB	EOG46DJHJ.
PhylomeDB	A1Z7C4.
Gene expression databases
Bgee	A1Z7C4.
Family and domain databases
InterPro	IPR011042. 6-blade_b-propeller_TolB-like. IPR006209. EGF. IPR006210. EGF-like. IPR001881. EGF-like_Ca-bd. IPR013032. EGF-like_reg_CS. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR000742. EGF_3. IPR018097. EGF_Ca-bd_CS. IPR003645. Fol_N. IPR009030. Growth_fac_rcpt. IPR023415. LDLR_class-A_CS. IPR000033. LDLR_classB_rpt. IPR002172. LDrepeatLR_classA_rpt. [Graphical view]
Gene3D	G3DSA:2.120.10.30. 6-blade_b-propeller_TolB-like. 8 hits. G3DSA:4.10.400.10. LDL_rcpt_classA_cys-rich. 29 hits.
KO	K04550.
Pfam	PF00008. EGF. 1 hit. PF07645. EGF_CA. 2 hits. PF00057. Ldl_recept_a. 23 hits. PF00058. Ldl_recept_b. 6 hits. [Graphical view]
SMART	SM00181. EGF. 19 hits. SM00179. EGF_CA. 3 hits. SM00274. FOLN. 4 hits. SM00192. LDLa. 31 hits. SM00135. LY. 32 hits. [Graphical view]
SUPFAM	SSF57184. Grow_fac_recept. 3 hits. SSF57424. LDL_rcpt_classA_cys-rich. 26 hits.
PROSITE	PS00010. ASX_HYDROXYL. 4 hits. PS00022. EGF_1. 8 hits. PS01186. EGF_2. 9 hits. PS50026. EGF_3. 11 hits. PS01187. EGF_CA. 3 hits. PS01209. LDLRA_1. 22 hits. PS50068. LDLRA_2. 31 hits. PS51120. LDLRB. 33 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	795266.

Entry information

Entry name

A1Z7C4_DROME

Accession

Primary (citable) accession number: A1Z7C4

Entry history

Integrated into UniProtKB/TrEMBL:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)