A1Z6W3 (PRIC1_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein prickle

Alternative name(s):
Protein spiny legs

Gene names

Name:	pk
ORF Names:	CG11084

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	1299 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts in a planar cell polarity (PCP) complex; polarization along the apical/basal axis of epithelial cells. Correct expression of the alternative isoforms is required for PCP signaling in imaginal disks. PCP signaling in the wing disk requires the receptor fz and the cytoplasmic proteins dsh and pk. These act in a feedback loop leading to activation of the jnk cascade and subsequent polarized arrangement of hairs and bristles. Dgo and pk compete with one another for dsh binding, thereby modulating fz dsh activity and ensuring tight control over fz PCP signaling. Vang, stan and pk function together to regulate the establishment of tissue polarity in the adult eye. Ref.4 Ref.6 Ref.7
Subunit structure	Interacts with dsh; PET and LIM domains interact with dsh DEP domain, in wing cells. Interacts with Vang in photoreceptor cells. Ref.4 Ref.5 Ref.6 Ref.7
Subcellular location	Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note: Localized to the proximal wing cell boundary where fz and dsh localization is antagonized by binding the dsh DEP domain and preventing dsh cortical localization. Localization to the anterior photoreceptor cell membrane. Ref.4 Ref.5 Ref.6 Ref.7
Tissue specificity	Expressed in the wing, leg and eye imaginal disks. Expressed within the photoreceptors of the eye. Ref.1 Ref.4 Ref.6 Ref.7
Developmental stage	Expressed both maternally and zygotically. Isoform B is expressed in embryos only. Isoform A and isoform C are expressed in embryos and pupae. Ref.1
Disruption phenotype	Flies exhibit aberrant hair and bristle orientation on the wings and aberrant ommatidial arrangement in the compound eye. Ref.4 Ref.6 Ref.7
Sequence similarities	Belongs to the prickle / espinas / testin family. Contains 3 LIM zinc-binding domains. Contains 1 PET domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	LIM domain Repeat
Ligand	Metal-binding Zinc
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anterior/posterior axis specification Inferred from mutant phenotype Ref.4. Source: UniProtKB establishment of imaginal disc-derived wing hair orientation Inferred from mutant phenotype PubMed 21379328. Source: FlyBase establishment of ommatidial planar polarity Inferred from mutant phenotype PubMed 7555730. Source: FlyBase establishment of protein localization Traceable author statement PubMed 12414186. Source: FlyBase maintenance of protein location Traceable author statement PubMed 12414186. Source: FlyBase
Cellular_component	cytoplasm Traceable author statement PubMed 12414186. Source: FlyBase plasma membrane Inferred from direct assay Ref.4. Source: UniProtKB
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform C Ref.2 (identifier: A1Z6W3-1)

Also known as: sple;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform A Ref.2 (identifier: A1Z6W3-2)

Also known as: pk;

The sequence of this isoform differs from the canonical sequence as follows:
     2-13: SSLSTGGGAGGS → DTPNQMPVELER
     14-349: Missing.

Isoform B Ref.2 (identifier: A1Z6W3-3)

Also known as: pkM;

The sequence of this isoform differs from the canonical sequence as follows:
     2-80: SSLSTGGGAG...RQLYSKAAAQ → NDSTDNLHAD...KAIIKSAEVR
     81-349: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1299	1299	Protein prickle		PRO_0000288834
Regions
	Domain	515 – 623	109	PET
	Domain	622 – 686	65	LIM zinc-binding 1
	Domain	687 – 747	61	LIM zinc-binding 2
	Domain	748 – 810	63	LIM zinc-binding 3
	Compositional bias	245 – 292	48	Pro-rich
	Compositional bias	412 – 490	79	Pro-rich
	Compositional bias	857 – 877	21	Gln-rich
	Compositional bias	1157 – 1249	93	Ser-rich
Natural variations
	Alternative sequence	2 – 80	79	SSLST…KAAAQ → NDSTDNLHADCDGRVSNNNN GNSNTNDGPNNDGDSDEEVI EGMALLEGNYQVLRQWVPPA PNYWDAPPKAIIKSAEVR in isoform B. Ref.1		VSP_052412
	Alternative sequence	2 – 13	12	SSLST…GAGGS → DTPNQMPVELER in isoform A. Ref.1		VSP_052413
	Alternative sequence	14 – 349	336	Missing in isoform A. Ref.1		VSP_052414
	Alternative sequence	81 – 349	269	Missing in isoform B. Ref.1		VSP_052415
Experimental info
	Sequence conflict	175 – 177	3	ESS → VSN in CAB57345. Ref.1
	Sequence conflict	188	1	V → A in CAB57345. Ref.1
	Sequence conflict	279	1	Q → P in CAB57345. Ref.1
	Sequence conflict	715	1	A → G in CAB57344. Ref.1
	Sequence conflict	715	1	A → G in CAB57345. Ref.1
	Sequence conflict	715	1	A → G in CAB99211. Ref.1
	Sequence conflict	746	1	A → G in CAB57344. Ref.1
	Sequence conflict	746	1	A → G in CAB57345. Ref.1
	Sequence conflict	746	1	A → G in CAB99211. Ref.1
	Sequence conflict	755	1	A → G in CAB57344. Ref.1
	Sequence conflict	755	1	A → G in CAB57345. Ref.1
	Sequence conflict	755	1	A → G in CAB99211. Ref.1
	Sequence conflict	797	1	A → G in CAB57344. Ref.1
	Sequence conflict	797	1	A → G in CAB57345. Ref.1
	Sequence conflict	797	1	A → G in CAB99211. Ref.1
	Sequence conflict	830	1	R → G in CAB57344. Ref.1
	Sequence conflict	830	1	R → G in CAB57345. Ref.1
	Sequence conflict	830	1	R → G in CAB99211. Ref.1
	Sequence conflict	970	1	S → P in CAB57344. Ref.1
	Sequence conflict	970	1	S → P in CAB57345. Ref.1
	Sequence conflict	970	1	S → P in CAB99211. Ref.1
	Sequence conflict	1029	1	L → V in CAB57344. Ref.1
	Sequence conflict	1029	1	L → V in CAB57345. Ref.1
	Sequence conflict	1029	1	L → V in CAB99211. Ref.1
	Sequence conflict	1134	1	G → S in CAB57344. Ref.1
	Sequence conflict	1134	1	G → S in CAB57345. Ref.1
	Sequence conflict	1134	1	G → S in CAB99211. Ref.1
	Sequence conflict	1231	1	E → K in CAB57344. Ref.1
	Sequence conflict	1231	1	E → K in CAB57345. Ref.1
	Sequence conflict	1231	1	E → K in CAB99211. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform C (sple) [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 8BFAF1F75F352485	FASTA	1,299	140,722
	10 20 30 40 50 60 MSSLSTGGGA GGSSGGPGGA DAAAAPAAGQ ATVTATGNME PAMVPRTANL LACKQWWRVC 70 80 90 100 110 120 FLYGDQQKYY RQLYSKAAAQ RLADANQEPD NARDREYDTV DCDLIAGQLD AVEDADDGID 130 140 150 160 170 180 LGDHSSTPKG GATTAGRPLF PHSSSPRRSK KLLRSLRAHV RGEKLPKNDT TTANESSEVT 190 200 210 220 230 240 QRNARVTVLD DPFLFGIDAD HLGDLVVRGK RYSTLDATEN MARFYAEQEA TAQVLEIIEQ 250 260 270 280 290 300 EEESPEQEAP KPALPPKQKQ QRPVPPLPPP PANRVTQDQG TQPAAPQVPL QPLTAGDLQF 310 320 330 340 350 360 LNLSLRQRSL PRSMKPFKDA HDISFTFNEL DTSAEPEVAT GAAQQESNEP ISRTPLTQIS 370 380 390 400 410 420 YLQKIPTLPR HFSPSGQGLA TPPALGSGGM GLPSSSSASA LYAAQAAAGI LPTSPLPLQR 430 440 450 460 470 480 HQQYLPPHHQ QHPGAGMGPG PGSGAAAGPP LGPQYSPGCS ANPKYSNAQL PPPPHHHHQL 490 500 510 520 530 540 SPALSTPSPP SLLHHPAGGT SSASAHAPFL GGPHMDMQRQ SHSDDDSGCA LEEYTWVPPG 550 560 570 580 590 600 LRPDQVRLYF SQIPDDKVPY VNSPGEQYRV RQLLHQLPPH DNEVRYCHSL TDEERKELRL 610 620 630 640 650 660 FSTQRKRDAL GRGNVRQLMS ARPCDGCDDL ISTGDIAVFA TRLGPNASWH PACFACSVCR 670 680 690 700 710 720 ELLVDLIYFH RDGRMYCGRH HAETLKPRCS ACDEIILADE CTEAEGRAWH MNHFACHECD 730 740 750 760 770 780 KQLGGQRYIM REGKPYCLHC FDAMFAEYCD YCGEAIGVDQ GQMSHDGQHW HATDECFSCN 790 800 810 820 830 840 TCRCSLLGRA FLPRRGAIYC SIACSKGEPP TPSDSSGTGM YTTPTPPTQR VRPHPQAPLP 850 860 870 880 890 900 ARIPSSHASS SPPMSPQQQQ QHQATFNQAM YQMQSQQMEA AGGLVDQSKS YAASDSDAGV 910 920 930 940 950 960 VKDLEHGGHM GGGDLTDFSG GRASSTSQNL SPLNSPGDFQ PHFLPKPMEL QRDGVYNFNE 970 980 990 1000 1010 1020 MSSNLDAAWS AKPTNSYHLQ RQLLENPHTA SMPELAGKLV APPAHMQHLS QLHAVSSHQF 1030 1040 1050 1060 1070 1080 QQHEYADILH PPPPPPGEIP ELPTPNLSVA STALPPELMG SPTHSAGDRS LNTPMSTQSA 1090 1100 1110 1120 1130 1140 SHAPPHPVSI LSGASSSSPM SGEPAKKKGV RFEGIPDTLP RSRSYSGNGA GTSGGGERER 1150 1160 1170 1180 1190 1200 DRDKDKEGGG RHGHGHSSRR RRRRKSSSSS SHHRSGSGHR SHSTTRADTY APAQPLSSSY 1210 1220 1230 1240 1250 1260 QGPPSVLQAA NLVHESPSRQ QRERERERER EESEESDVCS TCSSSSSSSE DYMMMYQLPQ 1270 1280 1290 RRHYGGVRVS YVPNDALAYD RKRKPSELGG DKDKNCIIS
	Isoform A (pk) [UniParc]. Checksum: C01685B61EA4C367	FASTA	963	104,682
	10 20 30 40 50 60 MDTPNQMPVE LERPISRTPL TQISYLQKIP TLPRHFSPSG QGLATPPALG SGGMGLPSSS 70 80 90 100 110 120 SASALYAAQA AAGILPTSPL PLQRHQQYLP PHHQQHPGAG MGPGPGSGAA AGPPLGPQYS 130 140 150 160 170 180 PGCSANPKYS NAQLPPPPHH HHQLSPALST PSPPSLLHHP AGGTSSASAH APFLGGPHMD 190 200 210 220 230 240 MQRQSHSDDD SGCALEEYTW VPPGLRPDQV RLYFSQIPDD KVPYVNSPGE QYRVRQLLHQ 250 260 270 280 290 300 LPPHDNEVRY CHSLTDEERK ELRLFSTQRK RDALGRGNVR QLMSARPCDG CDDLISTGDI 310 320 330 340 350 360 AVFATRLGPN ASWHPACFAC SVCRELLVDL IYFHRDGRMY CGRHHAETLK PRCSACDEII 370 380 390 400 410 420 LADECTEAEG RAWHMNHFAC HECDKQLGGQ RYIMREGKPY CLHCFDAMFA EYCDYCGEAI 430 440 450 460 470 480 GVDQGQMSHD GQHWHATDEC FSCNTCRCSL LGRAFLPRRG AIYCSIACSK GEPPTPSDSS 490 500 510 520 530 540 GTGMYTTPTP PTQRVRPHPQ APLPARIPSS HASSSPPMSP QQQQQHQATF NQAMYQMQSQ 550 560 570 580 590 600 QMEAAGGLVD QSKSYAASDS DAGVVKDLEH GGHMGGGDLT DFSGGRASST SQNLSPLNSP 610 620 630 640 650 660 GDFQPHFLPK PMELQRDGVY NFNEMSSNLD AAWSAKPTNS YHLQRQLLEN PHTASMPELA 670 680 690 700 710 720 GKLVAPPAHM QHLSQLHAVS SHQFQQHEYA DILHPPPPPP GEIPELPTPN LSVASTALPP 730 740 750 760 770 780 ELMGSPTHSA GDRSLNTPMS TQSASHAPPH PVSILSGASS SSPMSGEPAK KKGVRFEGIP 790 800 810 820 830 840 DTLPRSRSYS GNGAGTSGGG ERERDRDKDK EGGGRHGHGH SSRRRRRRKS SSSSSHHRSG 850 860 870 880 890 900 SGHRSHSTTR ADTYAPAQPL SSSYQGPPSV LQAANLVHES PSRQQRERER EREREESEES 910 920 930 940 950 960 DVCSTCSSSS SSSEDYMMMY QLPQRRHYGG VRVSYVPNDA LAYDRKRKPS ELGGDKDKNC IIS
	Isoform B (pkM) [UniParc]. Checksum: D532D80FFFDAC461	FASTA	1,029	111,765
	10 20 30 40 50 60 MNDSTDNLHA DCDGRVSNNN NGNSNTNDGP NNDGDSDEEV IEGMALLEGN YQVLRQWVPP 70 80 90 100 110 120 APNYWDAPPK AIIKSAEVRP ISRTPLTQIS YLQKIPTLPR HFSPSGQGLA TPPALGSGGM 130 140 150 160 170 180 GLPSSSSASA LYAAQAAAGI LPTSPLPLQR HQQYLPPHHQ QHPGAGMGPG PGSGAAAGPP 190 200 210 220 230 240 LGPQYSPGCS ANPKYSNAQL PPPPHHHHQL SPALSTPSPP SLLHHPAGGT SSASAHAPFL 250 260 270 280 290 300 GGPHMDMQRQ SHSDDDSGCA LEEYTWVPPG LRPDQVRLYF SQIPDDKVPY VNSPGEQYRV 310 320 330 340 350 360 RQLLHQLPPH DNEVRYCHSL TDEERKELRL FSTQRKRDAL GRGNVRQLMS ARPCDGCDDL 370 380 390 400 410 420 ISTGDIAVFA TRLGPNASWH PACFACSVCR ELLVDLIYFH RDGRMYCGRH HAETLKPRCS 430 440 450 460 470 480 ACDEIILADE CTEAEGRAWH MNHFACHECD KQLGGQRYIM REGKPYCLHC FDAMFAEYCD 490 500 510 520 530 540 YCGEAIGVDQ GQMSHDGQHW HATDECFSCN TCRCSLLGRA FLPRRGAIYC SIACSKGEPP 550 560 570 580 590 600 TPSDSSGTGM YTTPTPPTQR VRPHPQAPLP ARIPSSHASS SPPMSPQQQQ QHQATFNQAM 610 620 630 640 650 660 YQMQSQQMEA AGGLVDQSKS YAASDSDAGV VKDLEHGGHM GGGDLTDFSG GRASSTSQNL 670 680 690 700 710 720 SPLNSPGDFQ PHFLPKPMEL QRDGVYNFNE MSSNLDAAWS AKPTNSYHLQ RQLLENPHTA 730 740 750 760 770 780 SMPELAGKLV APPAHMQHLS QLHAVSSHQF QQHEYADILH PPPPPPGEIP ELPTPNLSVA 790 800 810 820 830 840 STALPPELMG SPTHSAGDRS LNTPMSTQSA SHAPPHPVSI LSGASSSSPM SGEPAKKKGV 850 860 870 880 890 900 RFEGIPDTLP RSRSYSGNGA GTSGGGERER DRDKDKEGGG RHGHGHSSRR RRRRKSSSSS 910 920 930 940 950 960 SHHRSGSGHR SHSTTRADTY APAQPLSSSY QGPPSVLQAA NLVHESPSRQ QRERERERER 970 980 990 1000 1010 1020 EESEESDVCS TCSSSSSSSE DYMMMYQLPQ RRHYGGVRVS YVPNDALAYD RKRKPSELGG DKDKNCIIS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The balance between isoforms of the prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs." Gubb D., Green C., Huen D., Coulson D., Johnson G., Tree D.R.P., Collier S., Roote J. Genes Dev. 13:2315-2327(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B AND C), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Strain: DP CN BW. Tissue: Embryo.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING. Strain: Berkeley.
[4]	"Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling." Tree D.R.P., Shulman J.M., Rousset R., Scott M.P., Gubb D., Axelrod J.D. Cell 109:371-381(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH DSH, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
[5]	"Prickle and Strabismus form a functional complex to generate a correct axis during planar cell polarity signaling." Jenny A., Darken R.S., Wilson P.A., Mlodzik M. EMBO J. 22:4409-4420(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH VANG, SUBCELLULAR LOCATION.
[6]	"Strabismus requires Flamingo and Prickle function to regulate tissue polarity in the Drosophila eye." Rawls A.S., Wolff T. Development 130:1877-1887(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH VANG, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
[7]	"Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding." Jenny A., Reynolds-Kenneally J., Das G., Burnett M., Mlodzik M. Nat. Cell Biol. 7:691-697(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH DSH, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ243708 mRNA. Translation: CAB57344.3. AJ243710 mRNA. Translation: CAB57345.3. AJ243709 mRNA. Translation: CAB99211.2. AE013599 Genomic DNA. Translation: AAF59281.2. AE013599 Genomic DNA. Translation: AAF59284.2. AE013599 Genomic DNA. Translation: AAM68908.1.
RefSeq	NP_724534.1. NM_165508.2. NP_724535.1. NM_165509.2. NP_724538.1. NM_165512.2.
UniGene	Dm.3470.
3D structure databases
ProteinModelPortal	A1Z6W3.
SMR	A1Z6W3. Positions 624-806.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-59584N.
IntAct	A1Z6W3. 2 interactions.
Proteomic databases
PaxDb	A1Z6W3.
PRIDE	A1Z6W3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0089044; FBpp0088115; FBgn0003090.
GeneID	45343.
KEGG	dme:Dmel_CG11084.
Organism-specific databases
CTD	18745.
FlyBase	FBgn0003090. pk.
Phylogenomic databases
eggNOG	NOG314122.
GeneTree	ENSGT00550000074438.
InParanoid	A1Z6W3.
KO	K04511.
OMA	WHATDEC.
OrthoDB	EOG4T1G2F.
PhylomeDB	A1Z6W3.
Gene expression databases
Bgee	A1Z6W3.
Family and domain databases
Gene3D	2.10.110.10. 3 hits.
InterPro	IPR010442. PET_domain. IPR001781. Znf_LIM. [Graphical view]
Pfam	PF00412. LIM. 2 hits. PF06297. PET. 1 hit. [Graphical view]
SMART	SM00132. LIM. 3 hits. [Graphical view]
PROSITE	PS00478. LIM_DOMAIN_1. 2 hits. PS50023. LIM_DOMAIN_2. 3 hits. PS51303. PET. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	45343.
NextBio	838057.

Entry information

Entry name

PRIC1_DROME

Accession

Primary (citable) accession number: A1Z6W3
Secondary accession number(s): A1Z6V4 , A1Z6V8, Q9N9H6, Q9U5X0, Q9U5X1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	February 6, 2007
Last modified:	May 1, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project