Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A1Z6W3

- PRIC1_DROME

UniProt

A1Z6W3 - PRIC1_DROME

Protein

Protein prickle

Gene

pk

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Acts in a planar cell polarity (PCP) complex; polarization along the apical/basal axis of epithelial cells. Correct expression of the alternative isoforms is required for PCP signaling in imaginal disks. PCP signaling in the wing disk requires the receptor fz and the cytoplasmic proteins dsh and pk. These act in a feedback loop leading to activation of the jnk cascade and subsequent polarized arrangement of hairs and bristles. Dgo and pk compete with one another for dsh binding, thereby modulating fz dsh activity and ensuring tight control over fz PCP signaling. Vang, stan and pk function together to regulate the establishment of tissue polarity in the adult eye.3 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. anterior/posterior axis specification Source: UniProtKB
    2. establishment of imaginal disc-derived wing hair orientation Source: FlyBase
    3. establishment of ommatidial planar polarity Source: FlyBase
    4. establishment of planar polarity Source: UniProtKB
    5. establishment of protein localization Source: FlyBase
    6. establishment of tissue polarity Source: UniProtKB
    7. establishment or maintenance of cell polarity Source: FlyBase
    8. imaginal disc-derived leg joint morphogenesis Source: FlyBase
    9. maintenance of protein location Source: FlyBase
    10. morphogenesis of a polarized epithelium Source: FlyBase
    11. negative regulation of Notch signaling pathway Source: FlyBase
    12. protein localization Source: FlyBase

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_184330. Asymmetric localization of PCP proteins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein prickle
    Alternative name(s):
    Protein spiny legs
    Gene namesi
    Name:pkImported
    ORF Names:CG11084
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2R

    Organism-specific databases

    FlyBaseiFBgn0003090. pk.

    Subcellular locationi

    Cell membrane 4 Publications; Peripheral membrane protein 4 Publications; Cytoplasmic side 4 Publications
    Note: Localized to the proximal wing cell boundary where fz and dsh localization is antagonized by binding the dsh DEP domain and preventing dsh cortical localization. Localization to the anterior photoreceptor cell membrane.4 Publications

    GO - Cellular componenti

    1. cytoplasm Source: FlyBase
    2. membrane Source: FlyBase
    3. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Flies exhibit aberrant hair and bristle orientation on the wings and aberrant ommatidial arrangement in the compound eye.3 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12991299Protein pricklePRO_0000288834Add
    BLAST

    Proteomic databases

    PaxDbiA1Z6W3.
    PRIDEiA1Z6W3.

    Expressioni

    Tissue specificityi

    Expressed in the wing, leg and eye imaginal disks. Expressed within the photoreceptors of the eye.4 Publications

    Developmental stagei

    Expressed both maternally and zygotically. Isoform B is expressed in embryos only. Isoform A and isoform C are expressed in embryos and pupae.1 Publication

    Gene expression databases

    BgeeiA1Z6W3.

    Interactioni

    Subunit structurei

    Interacts with dsh; PET and LIM domains interact with dsh DEP domain, in wing cells. Interacts with Vang in photoreceptor cells.4 Publications

    Protein-protein interaction databases

    BioGridi69608. 8 interactions.
    DIPiDIP-59584N.
    IntActiA1Z6W3. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliA1Z6W3.
    SMRiA1Z6W3. Positions 624-805.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini515 – 623109PETPROSITE-ProRule annotationAdd
    BLAST
    Domaini622 – 68665LIM zinc-binding 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini687 – 74761LIM zinc-binding 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini748 – 81063LIM zinc-binding 3PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi245 – 29248Pro-richSequence AnalysisAdd
    BLAST
    Compositional biasi412 – 49079Pro-richSequence AnalysisAdd
    BLAST
    Compositional biasi857 – 87721Gln-richSequence AnalysisAdd
    BLAST
    Compositional biasi1157 – 124993Ser-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the prickle / espinas / testin family.Curated
    Contains 3 LIM zinc-binding domains.PROSITE-ProRule annotation
    Contains 1 PET domain.PROSITE-ProRule annotation

    Keywords - Domaini

    LIM domain, Repeat

    Phylogenomic databases

    eggNOGiNOG314122.
    GeneTreeiENSGT00550000074438.
    InParanoidiA1Z6W3.
    KOiK04511.
    OMAiWHATDEC.
    OrthoDBiEOG7P8P7M.
    PhylomeDBiA1Z6W3.

    Family and domain databases

    Gene3Di2.10.110.10. 3 hits.
    InterProiIPR010442. PET_domain.
    IPR001781. Znf_LIM.
    [Graphical view]
    PfamiPF00412. LIM. 2 hits.
    PF06297. PET. 1 hit.
    [Graphical view]
    SMARTiSM00132. LIM. 3 hits.
    [Graphical view]
    PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 3 hits.
    PS51303. PET. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform C1 Publication (identifier: A1Z6W3-1) [UniParc]FASTAAdd to Basket

    Also known as: sple1 Publication

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSLSTGGGA GGSSGGPGGA DAAAAPAAGQ ATVTATGNME PAMVPRTANL     50
    LACKQWWRVC FLYGDQQKYY RQLYSKAAAQ RLADANQEPD NARDREYDTV 100
    DCDLIAGQLD AVEDADDGID LGDHSSTPKG GATTAGRPLF PHSSSPRRSK 150
    KLLRSLRAHV RGEKLPKNDT TTANESSEVT QRNARVTVLD DPFLFGIDAD 200
    HLGDLVVRGK RYSTLDATEN MARFYAEQEA TAQVLEIIEQ EEESPEQEAP 250
    KPALPPKQKQ QRPVPPLPPP PANRVTQDQG TQPAAPQVPL QPLTAGDLQF 300
    LNLSLRQRSL PRSMKPFKDA HDISFTFNEL DTSAEPEVAT GAAQQESNEP 350
    ISRTPLTQIS YLQKIPTLPR HFSPSGQGLA TPPALGSGGM GLPSSSSASA 400
    LYAAQAAAGI LPTSPLPLQR HQQYLPPHHQ QHPGAGMGPG PGSGAAAGPP 450
    LGPQYSPGCS ANPKYSNAQL PPPPHHHHQL SPALSTPSPP SLLHHPAGGT 500
    SSASAHAPFL GGPHMDMQRQ SHSDDDSGCA LEEYTWVPPG LRPDQVRLYF 550
    SQIPDDKVPY VNSPGEQYRV RQLLHQLPPH DNEVRYCHSL TDEERKELRL 600
    FSTQRKRDAL GRGNVRQLMS ARPCDGCDDL ISTGDIAVFA TRLGPNASWH 650
    PACFACSVCR ELLVDLIYFH RDGRMYCGRH HAETLKPRCS ACDEIILADE 700
    CTEAEGRAWH MNHFACHECD KQLGGQRYIM REGKPYCLHC FDAMFAEYCD 750
    YCGEAIGVDQ GQMSHDGQHW HATDECFSCN TCRCSLLGRA FLPRRGAIYC 800
    SIACSKGEPP TPSDSSGTGM YTTPTPPTQR VRPHPQAPLP ARIPSSHASS 850
    SPPMSPQQQQ QHQATFNQAM YQMQSQQMEA AGGLVDQSKS YAASDSDAGV 900
    VKDLEHGGHM GGGDLTDFSG GRASSTSQNL SPLNSPGDFQ PHFLPKPMEL 950
    QRDGVYNFNE MSSNLDAAWS AKPTNSYHLQ RQLLENPHTA SMPELAGKLV 1000
    APPAHMQHLS QLHAVSSHQF QQHEYADILH PPPPPPGEIP ELPTPNLSVA 1050
    STALPPELMG SPTHSAGDRS LNTPMSTQSA SHAPPHPVSI LSGASSSSPM 1100
    SGEPAKKKGV RFEGIPDTLP RSRSYSGNGA GTSGGGERER DRDKDKEGGG 1150
    RHGHGHSSRR RRRRKSSSSS SHHRSGSGHR SHSTTRADTY APAQPLSSSY 1200
    QGPPSVLQAA NLVHESPSRQ QRERERERER EESEESDVCS TCSSSSSSSE 1250
    DYMMMYQLPQ RRHYGGVRVS YVPNDALAYD RKRKPSELGG DKDKNCIIS 1299
    Length:1,299
    Mass (Da):140,722
    Last modified:February 6, 2007 - v1
    Checksum:i8BFAF1F75F352485
    GO
    Isoform A1 Publication (identifier: A1Z6W3-2) [UniParc]FASTAAdd to Basket

    Also known as: pk1 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         2-13: SSLSTGGGAGGS → DTPNQMPVELER
         14-349: Missing.

    Show »
    Length:963
    Mass (Da):104,682
    Checksum:iC01685B61EA4C367
    GO
    Isoform B1 Publication (identifier: A1Z6W3-3) [UniParc]FASTAAdd to Basket

    Also known as: pkM1 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         2-80: SSLSTGGGAG...RQLYSKAAAQ → NDSTDNLHAD...KAIIKSAEVR
         81-349: Missing.

    Show »
    Length:1,029
    Mass (Da):111,765
    Checksum:iD532D80FFFDAC461
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti175 – 1773ESS → VSN in CAB57345. (PubMed:10485852)Curated
    Sequence conflicti188 – 1881V → A in CAB57345. (PubMed:10485852)Curated
    Sequence conflicti279 – 2791Q → P in CAB57345. (PubMed:10485852)Curated
    Sequence conflicti715 – 7151A → G in CAB57344. (PubMed:10485852)Curated
    Sequence conflicti715 – 7151A → G in CAB57345. (PubMed:10485852)Curated
    Sequence conflicti715 – 7151A → G in CAB99211. (PubMed:10485852)Curated
    Sequence conflicti746 – 7461A → G in CAB57344. (PubMed:10485852)Curated
    Sequence conflicti746 – 7461A → G in CAB57345. (PubMed:10485852)Curated
    Sequence conflicti746 – 7461A → G in CAB99211. (PubMed:10485852)Curated
    Sequence conflicti755 – 7551A → G in CAB57344. (PubMed:10485852)Curated
    Sequence conflicti755 – 7551A → G in CAB57345. (PubMed:10485852)Curated
    Sequence conflicti755 – 7551A → G in CAB99211. (PubMed:10485852)Curated
    Sequence conflicti797 – 7971A → G in CAB57344. (PubMed:10485852)Curated
    Sequence conflicti797 – 7971A → G in CAB57345. (PubMed:10485852)Curated
    Sequence conflicti797 – 7971A → G in CAB99211. (PubMed:10485852)Curated
    Sequence conflicti830 – 8301R → G in CAB57344. (PubMed:10485852)Curated
    Sequence conflicti830 – 8301R → G in CAB57345. (PubMed:10485852)Curated
    Sequence conflicti830 – 8301R → G in CAB99211. (PubMed:10485852)Curated
    Sequence conflicti970 – 9701S → P in CAB57344. (PubMed:10485852)Curated
    Sequence conflicti970 – 9701S → P in CAB57345. (PubMed:10485852)Curated
    Sequence conflicti970 – 9701S → P in CAB99211. (PubMed:10485852)Curated
    Sequence conflicti1029 – 10291L → V in CAB57344. (PubMed:10485852)Curated
    Sequence conflicti1029 – 10291L → V in CAB57345. (PubMed:10485852)Curated
    Sequence conflicti1029 – 10291L → V in CAB99211. (PubMed:10485852)Curated
    Sequence conflicti1134 – 11341G → S in CAB57344. (PubMed:10485852)Curated
    Sequence conflicti1134 – 11341G → S in CAB57345. (PubMed:10485852)Curated
    Sequence conflicti1134 – 11341G → S in CAB99211. (PubMed:10485852)Curated
    Sequence conflicti1231 – 12311E → K in CAB57344. (PubMed:10485852)Curated
    Sequence conflicti1231 – 12311E → K in CAB57345. (PubMed:10485852)Curated
    Sequence conflicti1231 – 12311E → K in CAB99211. (PubMed:10485852)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei2 – 8079SSLST…KAAAQ → NDSTDNLHADCDGRVSNNNN GNSNTNDGPNNDGDSDEEVI EGMALLEGNYQVLRQWVPPA PNYWDAPPKAIIKSAEVR in isoform B. 1 PublicationVSP_052412Add
    BLAST
    Alternative sequencei2 – 1312SSLST…GAGGS → DTPNQMPVELER in isoform A. 1 PublicationVSP_052413Add
    BLAST
    Alternative sequencei14 – 349336Missing in isoform A. 1 PublicationVSP_052414Add
    BLAST
    Alternative sequencei81 – 349269Missing in isoform B. 1 PublicationVSP_052415Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ243708 mRNA. Translation: CAB57344.3.
    AJ243710 mRNA. Translation: CAB57345.3.
    AJ243709 mRNA. Translation: CAB99211.2.
    AE013599 Genomic DNA. Translation: AAF59281.2.
    AE013599 Genomic DNA. Translation: AAF59284.2.
    AE013599 Genomic DNA. Translation: AAM68908.1.
    RefSeqiNP_724534.1. NM_165508.2. [A1Z6W3-2]
    NP_724535.1. NM_165509.2. [A1Z6W3-3]
    NP_724538.1. NM_165512.2. [A1Z6W3-1]
    UniGeneiDm.3470.

    Genome annotation databases

    EnsemblMetazoaiFBtr0089044; FBpp0088115; FBgn0003090. [A1Z6W3-1]
    GeneIDi45343.
    KEGGidme:Dmel_CG11084.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ243708 mRNA. Translation: CAB57344.3 .
    AJ243710 mRNA. Translation: CAB57345.3 .
    AJ243709 mRNA. Translation: CAB99211.2 .
    AE013599 Genomic DNA. Translation: AAF59281.2 .
    AE013599 Genomic DNA. Translation: AAF59284.2 .
    AE013599 Genomic DNA. Translation: AAM68908.1 .
    RefSeqi NP_724534.1. NM_165508.2. [A1Z6W3-2 ]
    NP_724535.1. NM_165509.2. [A1Z6W3-3 ]
    NP_724538.1. NM_165512.2. [A1Z6W3-1 ]
    UniGenei Dm.3470.

    3D structure databases

    ProteinModelPortali A1Z6W3.
    SMRi A1Z6W3. Positions 624-805.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 69608. 8 interactions.
    DIPi DIP-59584N.
    IntActi A1Z6W3. 2 interactions.

    Proteomic databases

    PaxDbi A1Z6W3.
    PRIDEi A1Z6W3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0089044 ; FBpp0088115 ; FBgn0003090 . [A1Z6W3-1 ]
    GeneIDi 45343.
    KEGGi dme:Dmel_CG11084.

    Organism-specific databases

    CTDi 18745.
    FlyBasei FBgn0003090. pk.

    Phylogenomic databases

    eggNOGi NOG314122.
    GeneTreei ENSGT00550000074438.
    InParanoidi A1Z6W3.
    KOi K04511.
    OMAi WHATDEC.
    OrthoDBi EOG7P8P7M.
    PhylomeDBi A1Z6W3.

    Enzyme and pathway databases

    Reactomei REACT_184330. Asymmetric localization of PCP proteins.

    Miscellaneous databases

    GenomeRNAii 45343.
    NextBioi 838057.

    Gene expression databases

    Bgeei A1Z6W3.

    Family and domain databases

    Gene3Di 2.10.110.10. 3 hits.
    InterProi IPR010442. PET_domain.
    IPR001781. Znf_LIM.
    [Graphical view ]
    Pfami PF00412. LIM. 2 hits.
    PF06297. PET. 1 hit.
    [Graphical view ]
    SMARTi SM00132. LIM. 3 hits.
    [Graphical view ]
    PROSITEi PS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 3 hits.
    PS51303. PET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The balance between isoforms of the prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs."
      Gubb D., Green C., Huen D., Coulson D., Johnson G., Tree D.R.P., Collier S., Roote J.
      Genes Dev. 13:2315-2327(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B AND C), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Strain: DP CN BW.
      Tissue: Embryo1 Publication.
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley1 Publication.
    3. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
      Strain: Berkeley.
    4. "Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling."
      Tree D.R.P., Shulman J.M., Rousset R., Scott M.P., Gubb D., Axelrod J.D.
      Cell 109:371-381(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH DSH, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    5. "Prickle and Strabismus form a functional complex to generate a correct axis during planar cell polarity signaling."
      Jenny A., Darken R.S., Wilson P.A., Mlodzik M.
      EMBO J. 22:4409-4420(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH VANG, SUBCELLULAR LOCATION.
    6. "Strabismus requires Flamingo and Prickle function to regulate tissue polarity in the Drosophila eye."
      Rawls A.S., Wolff T.
      Development 130:1877-1887(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH VANG, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    7. "Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding."
      Jenny A., Reynolds-Kenneally J., Das G., Burnett M., Mlodzik M.
      Nat. Cell Biol. 7:691-697(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH DSH, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiPRIC1_DROME
    AccessioniPrimary (citable) accession number: A1Z6W3
    Secondary accession number(s): A1Z6V4
    , A1Z6V8, Q9N9H6, Q9U5X0, Q9U5X1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3