A1Z6I7 (A1Z6I7_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Bub1-related kinase EMBL AAF57298.1
EC=2.7.11.- EMBL AAF57298.1

Gene names

Name:	BubR1 FlyBase FBgn0025458
Synonyms:	Bub1 FlyBase FBgn0025458
ORF Names:	Dmel_CG7838 EMBL AAF57298.1

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	1460 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the protein kinase superfamily. RuleBase RU000305

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000304 Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase RuleBase RU000305 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	mitotic cell cycle spindle assembly checkpoint Inferred from direct assay. Source: FlyBase mitotic spindle organization Inferred from mutant phenotype. Source: FlyBase regulation of exit from mitosis Inferred from mutant phenotype. Source: FlyBase regulation of mitotic prometaphase Inferred from mutant phenotype. Source: FlyBase regulation of mitotic sister chromatid separation Inferred from mutant phenotype. Source: FlyBase sister chromatid segregation Inferred from mutant phenotype. Source: FlyBase syncytial blastoderm mitotic cell cycle Inferred from mutant phenotype. Source: FlyBase
Cellular component	condensed chromosome outer kinetochore Non-traceable author statement. Source: FlyBase cytoplasm Inferred from direct assay. Source: FlyBase
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A1Z6I7 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 9DB083868A77263B	FASTA	1,460	165,061
	10 20 30 40 50 60 MDFDNAKENI QPLASGRNVS LLQASLSQDS THGQELLAQR KQMEEEVRTY KGADPLGAWY 70 80 90 100 110 120 TFICWIEQSY PAGGSGSGLQ TVLHQCLTKF EDDERYRQDK RLIKLFIKFM EKQKDKIEFY 130 140 150 160 170 180 QQMYNNGIGT MLADFYIAWA YSYDLSGNMR KADEIFRLGL ECRAEPLEDL KEAHHHFGYT 190 200 210 220 230 240 VGQRMLYSTG EEANAVNQEL NERRLALQSL HGRRQQISNS ITVGSIRTGA AVKSGLPGVV 250 260 270 280 290 300 QVEPSTTTSR RNVGRNVEVF NDENSEGNIP ISNSETEVKS SLRSIIDSAC SQENIKEPVA 310 320 330 340 350 360 WNKANAKRHK HGKIFGSNAS PDLGFDIHVD EQAMPPITNY ERRLEQPFRF PTNFVAKNRP 370 380 390 400 410 420 QEPWVTPVTI EDEPNASGLP CYNKCLLYPR PNIEFSPEEY RAYSFLKHRN PQHPFIHRND 430 440 450 460 470 480 DWWGTGRVIR GIRCYPNFAR YSKPQDLDEL DKFWKPPLVP GLQVVFDKIY NEVEQKEYQP 490 500 510 520 530 540 EELLAAKWME KRNVTVHGDF DMEETVCLPG NKMPRRKSFF PSSFRKSIMP RRVSSVQEED 550 560 570 580 590 600 EKKEDEATLI VKDIPSQVAP KIPESPCDQI DEPKIKIFED SGSPRDNFAV PAVPVPKIEI 610 620 630 640 650 660 YEDSEEPQPT PKTRPFYDGD ETCSTQMFNM FIKSQAVSTP KGTQKQAPSR QFGTVLKELP 670 680 690 700 710 720 LPEEAAHSVE SPVETRSPTL RKQLSTILET SEHGTQSLAT SGTTTKSTIT STSSPGSNAV 730 740 750 760 770 780 SKLGSKIEEN TPGQMRLQRV ISAGVSAVLS EPEKPGGDNF LRRELWEPNA PSVPMLKSLR 790 800 810 820 830 840 FQEDKTETIP RPLACFQEDK TETLPQMPIA LPENSMDHGS LGAENCFSAP QLPTLEDESD 850 860 870 880 890 900 LCGLFGKTPP KTNIFGSPKR NFDPTSQLFK STQGDRRSFA VTGNKLEAAP SISNLQDSFM 910 920 930 940 950 960 CDLSFVPETQ PEAVAKSGAI QKFDIFLDDT QPKLTKSKPV ALMVSSFDLD CTLPETQQVA 970 980 990 1000 1010 1020 IKEPGTQQEN IGHSHMIASF MKDCTEIGSC PSQMPASVVK TNISSTSNKI KFSNDSMSES 1030 1040 1050 1060 1070 1080 SRKAPVNENV GISKQPDEFF ELNAATEMFA TNISMIKNST LLIPNAKVAE ASELSIYYKT 1090 1100 1110 1120 1130 1140 TPLTPKQSHR SWSQSDLETP PRENFVHPTS NGDQTVLNET LADANKNPFN VELISSLLES 1150 1160 1170 1180 1190 1200 IDFSMYIEKL PHCQLVGHVK RLHPNTHLEV HNEKFEVSKM IGKGAYGSVY VGKHLKSGKK 1210 1220 1230 1240 1250 1260 VALKQERPTN YWEFYICLEI HSRLTSEQMI PSYAHIDYAL VGNNSSVYIS EFSDYGSLIG 1270 1280 1290 1300 1310 1320 VCNKVKSVTN RNMDEYVVMH LSCQMLDIVD HLHAMGIIHA DIKPDNFLLM KPICADPNEV 1330 1340 1350 1360 1370 1380 SLQLIDFGVS IDMKLFPDNQ TFNYVHHDDL FKCIEMRTGR PWTYQLDLYG LVSVMHVLLF 1390 1400 1410 1420 1430 1440 GRYMEVVQRS PSTIWMPKTN VPRYFQRTMW ENIFRTLLNI RDCRTMPNLQ QLRTQLKCAL 1450 1460 AEKEKYVAEA ISKFNTILQK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE013599 Genomic DNA. Translation: AAF57298.1.
RefSeq	NP_477382.1. NM_058034.3.
UniGene	Dm.6411.
3D structure databases
ProteinModelPortal	A1Z6I7.
SMR	A1Z6I7. Positions 38-195, 1125-1459.
ModBase	Search...
Protein-protein interaction databases
IntAct	A1Z6I7. 3 interactions.
STRING	A1Z6I7.
Proteomic databases
PRIDE	A1Z6I7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0086032; FBpp0085368; FBgn0025458.
GeneID	35522.
KEGG	dme:Dmel_CG7838.
UCSC	CG7838-RA. d. melanogaster.
Organism-specific databases
CTD	35522.
FlyBase	FBgn0025458. BubR1.
Phylogenomic databases
InParanoid	A1Z6I7.
OMA	RFQEDKT.
OrthoDB	EOG4C5B07.
PhylomeDB	A1Z6I7.
Gene expression databases
Bgee	A1Z6I7.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR013212. Mad3_BUB1_I. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_kinase-like_dom. IPR008271. Ser/Thr_kinase_AS. IPR015661. Ser/Thr_kinase_Bub1. [Graphical view]
KO	K02178.
PANTHER	PTHR14030. Bub1. 1 hit.
Pfam	PF08311. Mad3_BUB1_I. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00777. Mad3_BUB1_I. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS51489. BUB1_N. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	793831.

Entry information

Entry name

A1Z6I7_DROME

Accession

Primary (citable) accession number: A1Z6I7

Entry history

Integrated into UniProtKB/TrEMBL:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)