ID   A1Z0P5_HHV1             Unreviewed;       904 AA.
AC   A1Z0P5;
DT   06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2007, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=Glycoprotein B {ECO:0000313|EMBL:ABM52970.1};
GN   Name=UL27 {ECO:0000313|EMBL:ABM52970.1};
OS   Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Orthoherpesviridae; Alphaherpesvirinae; Simplexvirus;
OC   Simplexvirus humanalpha1.
OX   NCBI_TaxID=10298 {ECO:0000313|EMBL:ABM52970.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:ABM52970.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=KOSc {ECO:0000313|EMBL:ABM52970.1};
RX   PubMed=17604805; DOI=10.1016/j.virol.2007.05.040;
RA   Ekblad M., Adamiak B., Bergefall K., Nenonen H., Roth A., Bergstrom T.,
RA   Ferro V., Trybala E.;
RT   "Molecular basis for resistance of herpes simplex virus type 1 mutants to
RT   the sulfated oligosaccharide inhibitor PI-88.";
RL   Virology 367:244-252(2007).
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DR   EMBL; EF157309; ABM52970.1; -; Genomic_DNA.
DR   GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-UniRule.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-UniRule.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.5.1890; -; 1.
DR   Gene3D; 2.30.29.100; -; 1.
DR   Gene3D; 2.30.30.1230; -; 1.
DR   Gene3D; 6.10.250.3280; -; 1.
DR   HAMAP; MF_04032; HSV_GB; 1.
DR   InterPro; IPR035377; Glycoprot_B_PH1.
DR   InterPro; IPR035381; Glycoprot_B_PH2.
DR   InterPro; IPR038631; Glycoprot_B_PH2_sf.
DR   InterPro; IPR000234; Herpes_Glycoprot_B.
DR   Pfam; PF17416; Glycoprot_B_PH1; 1.
DR   Pfam; PF17417; Glycoprot_B_PH2; 1.
DR   Pfam; PF00606; Glycoprotein_B; 1.
DR   SUPFAM; SSF161008; Viral glycoprotein ectodomain-like; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW   Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW   Host Golgi apparatus {ECO:0000256|ARBA:ARBA00022812};
KW   Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW   Viral envelope protein {ECO:0000256|ARBA:ARBA00022879};
KW   Virion {ECO:0000256|ARBA:ARBA00022844};
KW   Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT   TRANSMEM        752..771
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        777..798
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          153..364
FT                   /note="Herpesvirus Glycoprotein B PH-like"
FT                   /evidence="ECO:0000259|Pfam:PF17416"
FT   DOMAIN          366..463
FT                   /note="Herpesvirus Glycoprotein B PH-like"
FT                   /evidence="ECO:0000259|Pfam:PF17417"
FT   REGION          31..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          470..492
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          883..904
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   904 AA;  100311 MW;  B8FF576DF106A380 CRC64;
     MHQGAPSWGR RWFVVWALLG LTLGVLVASA APSSPGTPGV AAATQAANGG PANPAPPALG
     AAPTGDPKPK KNKKPKNPTP PRPAGDNATV AAGHATLREH LRDIKAENTD ANFYVCPPPT
     GATVVQFEQP RRCPTRPEGQ NYTEGIAVVF KENIAPYKFK ATMYYKDVTV SQVWFGHRYS
     QFMGIFEDRA PVPFEEVIDK INAKGVCRST AKYVRNNLET TAFHRDDHET DMELKPANAA
     TRTSRGWHTT DLKYNPSRVE AFHRYGTTVN CIVKEVDARS VYPYDEFVLA TGDFVYMSPF
     YGYREGSHTE HTSYAADRFK QVDGFYARDL TTKARATAPT TRNLLTTPKF TVAWDWVPKR
     PSVCTMTKWQ EVDEMLRSEY GGSFRFSSDA ISTTFTTNLT EYPLSRVDLG DCIGKDARDA
     MDRIFARRYN ATHIKVGQPQ YYLANGGFLI AYQPLLSNTL AELYVREHLR EQSRKPPNPT
     PPPPGASANA SVERIKTTSS IEFARLQFTY NHIQRHVNDM LGRVAIAWCE LQNHELTLWN
     EARKLNPNAI ASVTVGRRVS ARMLGDVMAV STCVPVAADN VIVQNSMRIS SRPGACYSRP
     LVSFRYEDQG PLVEGQLGEN NELRLTRDAI EPCTVGHRRY FTFGGGYVYF EEYAYSHQLS
     RADITTVSTF IDLNITMLED HEFVPLEVYT RHEIKDSGLL DYTEVQRRNQ LHDLRFADID
     TVIHADANAA MFAGLGAFFE GMGDLGRAVG KVVMGIVGGV VSAVSGVSSF MSNPFGALAV
     GLLVLAGLAA AFFAFRYVMR LQSNPMKALY PLTTKELKNP TNPDASGEGE EGGDFDEAKL
     AEAREMIRYM ALVSAMERTE HKAKKKGTSA LLSAKVTDMV MRKRRNTNYT QVPNKDGDAD
     EDDL
//