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Protein
Submitted name:

Hypocretin receptor

Gene

hcrtr2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cellular response to hormone stimulus Source: GO_Central
  • chemical synaptic transmission Source: GO_Central
  • circadian behavior Source: ZFIN
  • circadian sleep/wake cycle process Source: InterPro
  • feeding behavior Source: GO_Central
  • melatonin metabolic process Source: ZFIN
  • regulation of circadian sleep/wake cycle, sleep Source: ZFIN
  • response to peptide Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Enzyme and pathway databases

ReactomeiR-DRE-389397. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
R-DRE-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Submitted name:
Hypocretin receptorImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:hcrtr2Imported
Synonyms:hcrtrImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 13

Organism-specific databases

ZFINiZDB-GENE-070228-3. hcrtr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei55 – 8026HelicalSequence analysisAdd
BLAST
Transmembranei92 – 11221HelicalSequence analysisAdd
BLAST
Transmembranei132 – 15120HelicalSequence analysisAdd
BLAST
Transmembranei172 – 19019HelicalSequence analysisAdd
BLAST
Transmembranei222 – 24423HelicalSequence analysisAdd
BLAST
Transmembranei305 – 32319HelicalSequence analysisAdd
BLAST
Transmembranei343 – 36725HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSDARG00000023722.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000029101.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini71 – 364294G_PROTEIN_RECEP_F1_2InterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000230498.
HOVERGENiHBG101173.
KOiK04239.
OMAiNSIVVIW.
OrthoDBiEOG091G0ZDG.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000204. Orexin_rcpt.
IPR004060. Orexin_rcpt_2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF03827. Orexin_rec2. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01522. OREXIN2R.
PR01064. OREXINR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1YQE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGISVQRAC NSCFTSAQHL NSSADTISHS HAENEDDELL KYIWREYLHP
60 70 80 90 100
KQYEWVLIAG YILVFLVSLV GNTLVCFAVW KNHHMRTVTN YFIVNLSFAD
110 120 130 140 150
ILVTITCLPA SLVVDITETW FFGQTLCKIL PYLQTISVSV SVLTLSCIAQ
160 170 180 190 200
DRWYAICHPL KFKSTAKRAR KSIVLIWLVS CIMMIPQAVV MESSSLMPEL
210 220 230 240 250
TNKTSLFTVC DEQWPDEIYP KVYHTCFFIV TYFAPLCLMV LAYIQICHKL
260 270 280 290 300
WCQQIPGSSS VLQRQWKSLQ CSAHAVGSGE SVKVRTSTVS AEAKQVKARR
310 320 330 340 350
KTARMLMVVL FVFALCYLPI SILNIMKRVF GAFKNTGNRE TVYAWFTFSH
360 370 380 390 400
WLIYANSAAN PIIYNFLSGK FREEFKAAFI CQCSGRGETH KQRARGRTST
410 420
DSRKSLSTQV NNLDNISRIS DQAV
Length:424
Mass (Da):48,201
Last modified:February 6, 2007 - v1
Checksum:i7033870D2E7C02A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT009597 Genomic DNA. No translation available.
EF122429 mRNA. Translation: ABL96925.1.
RefSeqiNP_001073337.1. NM_001079868.1.
UniGeneiDr.110329.

Genome annotation databases

EnsembliENSDART00000038434; ENSDARP00000029101; ENSDARG00000023722.
GeneIDi561260.
KEGGidre:561260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT009597 Genomic DNA. No translation available.
EF122429 mRNA. Translation: ABL96925.1.
RefSeqiNP_001073337.1. NM_001079868.1.
UniGeneiDr.110329.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000029101.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000038434; ENSDARP00000029101; ENSDARG00000023722.
GeneIDi561260.
KEGGidre:561260.

Organism-specific databases

CTDi3062.
ZFINiZDB-GENE-070228-3. hcrtr2.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000230498.
HOVERGENiHBG101173.
KOiK04239.
OMAiNSIVVIW.
OrthoDBiEOG091G0ZDG.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiR-DRE-389397. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
R-DRE-416476. G alpha (q) signalling events.

Gene expression databases

BgeeiENSDARG00000023722.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000204. Orexin_rcpt.
IPR004060. Orexin_rcpt_2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF03827. Orexin_rec2. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01522. OREXIN2R.
PR01064. OREXINR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA1YQE3_DANRE
AccessioniPrimary (citable) accession number: A1YQE3
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: September 7, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.