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Protein
Submitted name:

Hypocretin (orexin) receptor 2

Gene

hcrtr2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cellular response to hormone stimulus Source: GO_Central
  • circadian behavior Source: ZFIN
  • circadian sleep/wake cycle process Source: InterPro
  • feeding behavior Source: GO_Central
  • melatonin metabolic process Source: ZFIN
  • regulation of circadian sleep/wake cycle, sleep Source: ZFIN
  • response to peptide Source: GO_Central

Keywordsi

Molecular functionReceptorImported

Enzyme and pathway databases

ReactomeiR-DRE-389397. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
R-DRE-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Submitted name:
Hypocretin (orexin) receptor 2Imported
Submitted name:
Hypocretin receptorImported
Gene namesi
Name:hcrtr2Imported
Synonyms:hcrtrImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 13

Organism-specific databases

ZFINiZDB-GENE-070228-3. hcrtr2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei55 – 80HelicalSequence analysisAdd BLAST26
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Transmembranei132 – 151HelicalSequence analysisAdd BLAST20
Transmembranei172 – 190HelicalSequence analysisAdd BLAST19
Transmembranei222 – 244HelicalSequence analysisAdd BLAST23
Transmembranei305 – 323HelicalSequence analysisAdd BLAST19
Transmembranei343 – 367HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSDARG00000023722.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000029101.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 364G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST294

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00900000140797.
HOGENOMiHOG000230498.
HOVERGENiHBG101173.
KOiK04239.
OMAiHWLIYAN.
OrthoDBiEOG091G0ZDG.
TreeFamiTF315303.

Family and domain databases

CDDicd15208. 7tmA_OXR. 1 hit.
InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000204. Orexin_rcpt.
IPR004060. Orexin_rcpt_2.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PF03827. Orexin_rec2. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR01522. OREXIN2R.
PR01064. OREXINR.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A1YQE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGISVQRAC NSCFTSAQHL NSSADTISHS HAENEDDELL KYIWREYLHP
60 70 80 90 100
KQYEWVLIAG YILVFLVSLV GNTLVCFAVW KNHHMRTVTN YFIVNLSFAD
110 120 130 140 150
ILVTITCLPA SLVVDITETW FFGQTLCKIL PYLQTISVSV SVLTLSCIAQ
160 170 180 190 200
DRWYAICHPL KFKSTAKRAR KSIVLIWLVS CIMMIPQAVV MESSSLMPEL
210 220 230 240 250
TNKTSLFTVC DEQWPDEIYP KVYHTCFFIV TYFAPLCLMV LAYIQICHKL
260 270 280 290 300
WCQQIPGSSS VLQRQWKSLQ CSAHAVGSGE SVKVRTSTVS AEAKQVKARR
310 320 330 340 350
KTARMLMVVL FVFALCYLPI SILNIMKRVF GAFKNTGNRE TVYAWFTFSH
360 370 380 390 400
WLIYANSAAN PIIYNFLSGK FREEFKAAFI CQCSGRGETH KQRARGRTST
410 420
DSRKSLSTQV NNLDNISRIS DQAV
Length:424
Mass (Da):48,201
Last modified:February 6, 2007 - v1
Checksum:i7033870D2E7C02A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT009597 Genomic DNA. No translation available.
EF122429 mRNA. Translation: ABL96925.1.
RefSeqiNP_001073337.1. NM_001079868.1.
UniGeneiDr.110329.

Genome annotation databases

EnsembliENSDART00000038434; ENSDARP00000029101; ENSDARG00000023722.
GeneIDi561260.
KEGGidre:561260.

Similar proteinsi

Entry informationi

Entry nameiA1YQE3_DANRE
AccessioniPrimary (citable) accession number: A1YQE3
Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: October 25, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported