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Protein
Submitted name:

Angiotensin I converting enzyme

Gene
N/A
Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Protein has several cofactor binding sites:
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

CarboxypeptidaseUniRule annotation, Hydrolase, MetalloproteaseUniRule annotation, Protease

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Protein family/group databases

MEROPSiM02.005.

Names & Taxonomyi

Protein namesi
Submitted name:
Angiotensin I converting enzymeImported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Keywords - PTMi

GlycoproteinUniRule annotation

Proteomic databases

PaxDbiA1YQ85.

Expressioni

Gene expression databases

GenevisibleiA1YQ85. SS.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000030627.

Structurei

3D structure databases

ProteinModelPortaliA1YQ85.
SMRiA1YQ85. Positions 34-644, 648-1225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M2 family.UniRule annotation

Phylogenomic databases

eggNOGiNOG71044.
HOGENOMiHOG000007838.
HOVERGENiHBG000264.
KOiK01283.

Family and domain databases

InterProiIPR001548. Peptidase_M2.
[Graphical view]
PANTHERiPTHR10514. PTHR10514. 1 hit.
PfamiPF01401. Peptidase_M2. 2 hits.
[Graphical view]
PRINTSiPR00791. PEPDIPTASEA.

Sequencei

Sequence statusi: Complete.

A1YQ85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAAPGRRWP WPPLLPLLLM LLLPPPPLPV ALALDSALQP GNFTADEAGA
60 70 80 90 100
EDFAQSFNSS SEQVLFQSTA ASWAHDTNIT EENARRQEEA ALISQEFSEV
110 120 130 140 150
WGQKAKALYD PIWQNFTSRT PRRIIGVVRT LGSANLPGKR QQYNSLLSNM
160 170 180 190 200
TRIYSTARVC FPNKTATCWS LDPELTNILA TSRSYTLLLY AWEGWHNAAG
210 220 230 240 250
IPLKPLYQDF TALSNEAYKQ DGFSDTGAYW RSLYDSPTFT EDLERLYHQL
260 270 280 290 300
EPLYLNLHAY VRRALHRQYG DRFINLRGPI PAHLLGNMWA QSWNNIYDMV
310 320 330 340 350
VPFPGKPSLD VTSAMVQKGW NVTHMFRVAE EFFTSLGLLP MPPEFWAESM
360 370 380 390 400
LEKPSDRREV VCHASAWDFY NRKDFRIKQC TQVTIDQLST VHHEMGHVQY
410 420 430 440 450
YLQYKDRHVS LRRGANPGFH EAIGDVLALS VSTPAHLHKI GLLDHVTSDW
460 470 480 490 500
ESDINYLLKM ALEKIAFLPF GYLVDQWRWG VFSGRTPPSL YNYDWWYLRT
510 520 530 540 550
KYQGVCPPVV RNETHFDAGA KYHVPNVTPY IRYFVSFILQ FQFHQALCKE
560 570 580 590 600
AGHQGPLHQC DIYQSTRAGA KLRAVLQAGF SRPWQEVLKD MVGSGALDAQ
610 620 630 640 650
PLLDYFQPVT QWLEEQNQRS GDILGWPEYQ WRPPMPDNYP EGIDLVSDEA
660 670 680 690 700
EASKFVEEYD RRSQVVLNEY AEANWDYNTN ITAEGSKRVL EKSTQMANHT
710 720 730 740 750
VKYGIWARKF DVANIQNFTL KRMIKKIQDL ERAALPFKEL EEYNQILLDM
760 770 780 790 800
ETAYSVASVC HANSTCLQLE PDLTNLMATS RSYEELLWAW KGWRDKVGRA
810 820 830 840 850
ILPYFPKYVE LTNKAARLNG YEDGGDAWRA AYEMPFLEQE LEQLFQELQP
860 870 880 890 900
LYLNLHAYVR RALHHHYGPE HINLEGPIPA HLLGNMWAQT WSNIYDLVVP
910 920 930 940 950
FPSASKMDAS EAMINQGWTP QRMFKEADNF FTSLGLLPVP PEFWNKSMLE
960 970 980 990 1000
KPTDGREVVC HASAWDFFNG KDFRIKQCTT VNMEDLVVAH HEMGHIQYFM
1010 1020 1030 1040 1050
QYKDLPVTFR EGANPGFHEA IGDVLVLSVS TPKHLRSINL LKSEDDGYEE
1060 1070 1080 1090 1100
DINFLMKMAL DKVAFVPFSY LVDQWRWRVF DRSITKENYN QEWWSLRLKY
1110 1120 1130 1140 1150
QGLCPPVARS QGDFDPGAKF HIPSSVPYIR YFVSFIIQFQ FHEALCQAAG
1160 1170 1180 1190 1200
HKGPLHKCDI YQSKEAGRRL ADAMKLGLSK PWPEAMQLIT GQPNVSASAM
1210 1220 1230 1240 1250
MTYFKPLLDW LVTENGRHGE KLGWPQYSWT PNSARLEGSF AGTGRVNFLG
1260 1270 1280 1290 1300
LNLEEQQARV GQWVLLFLGV TLLVATMGLT QRLFSIRHQI LRRTHRGPQF

GSEVELRHS
Length:1,309
Mass (Da):150,543
Last modified:February 6, 2007 - v1
Checksum:i09D9ACD74A715D59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF121312 mRNA. Translation: ABL73884.1.
RefSeqiNP_001077410.1. NM_001083941.1.
UniGeneiSsc.25769.

Genome annotation databases

GeneIDi613133.
KEGGissc:613133.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF121312 mRNA. Translation: ABL73884.1.
RefSeqiNP_001077410.1. NM_001083941.1.
UniGeneiSsc.25769.

3D structure databases

ProteinModelPortaliA1YQ85.
SMRiA1YQ85. Positions 34-644, 648-1225.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000030627.

Chemistry

BindingDBiA1YQ85.

Protein family/group databases

MEROPSiM02.005.

Proteomic databases

PaxDbiA1YQ85.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi613133.
KEGGissc:613133.

Organism-specific databases

CTDi1636.

Phylogenomic databases

eggNOGiNOG71044.
HOGENOMiHOG000007838.
HOVERGENiHBG000264.
KOiK01283.

Gene expression databases

GenevisibleiA1YQ85. SS.

Family and domain databases

InterProiIPR001548. Peptidase_M2.
[Graphical view]
PANTHERiPTHR10514. PTHR10514. 1 hit.
PfamiPF01401. Peptidase_M2. 2 hits.
[Graphical view]
PRINTSiPR00791. PEPDIPTASEA.
ProtoNetiSearch...

Publicationsi

  1. "Cloning of porcine kidney cDNA encoding an angiotensin I converting enzyme."
    Yoon J., Yoon J., Hong K.
    Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: KidneyImported.

Entry informationi

Entry nameiA1YQ85_PIG
AccessioniPrimary (citable) accession number: A1YQ85
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: June 24, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.