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A1YPR0 (ZBT7C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger and BTB domain-containing protein 7C
Alternative name(s):
Affected by papillomavirus DNA integration in ME180 cells protein 1
Short name=APM-1
Zinc finger and BTB domain-containing protein 36
Zinc finger protein 857C
Gene names
Name:ZBTB7C
Synonyms:APM1, ZBTB36, ZNF857C
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length619 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be a tumor suppressor gene. Ref.1

Tissue specificity

Detected in normal cervical keratinocytes, and in some cervical carcinoma cell lines. Ref.1

Sequence similarities

Contains 1 BTB (POZ) domain.

Contains 4 C2H2-type zinc fingers.

Ontologies

Keywords
   DiseaseTumor suppressor
   DomainRepeat
Zinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

nucleic acid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 619619Zinc finger and BTB domain-containing protein 7C
PRO_0000337869

Regions

Domain34 – 10168BTB
Zinc finger364 – 38623C2H2-type 1
Zinc finger392 – 41423C2H2-type 2
Zinc finger420 – 44223C2H2-type 3
Zinc finger448 – 47831C2H2-type 4; degenerate
Compositional bias125 – 16238Glu-rich
Compositional bias132 – 18251Asp-rich
Compositional bias298 – 32427Pro-rich

Sequences

Sequence LengthMass (Da)Tools
A1YPR0 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 73D82A34502B55BF

FASTA61969,017
        10         20         30         40         50         60 
MANDIDELIG IPFPNHSSEV LCSLNEQRHD GLLCDVLLVV QEQEYRTHRS VLAACSKYFK 

        70         80         90        100        110        120 
KLFTAGTLAS QPYVYEIDFV QPEALAAILE FAYTSTLTIT AGNVKHILNA ARMLEIQCIV 

       130        140        150        160        170        180 
NVCLEIMEPG GDGGEEDDKE DDDDDEDDDD EEDEEEEEEE EEDDDDDTED FADQENLPDP 

       190        200        210        220        230        240 
QDISCHQSPS KTDHLTEKAY SDTPRDFPDS FQAGSPGHLG VIRDFSIESL LRENLYPKAN 

       250        260        270        280        290        300 
IPDRRPSLSP FAPDFFPHLW PGDFGAFAQL PEQPMDSGPL DLVIKNRKIK EEEKEELPPP 

       310        320        330        340        350        360 
PPPPFPNDFF KDMFPDLPGG PLGPIKAEND YGAYLNFLSA THLGGLFPPW PLVEERKLKP 

       370        380        390        400        410        420 
KASQQCPICH KVIMGAGKLP RHMRTHTGEK PYMCTICEVR FTRQDKLKIH MRKHTGERPY 

       430        440        450        460        470        480 
LCIHCNAKFV HNYDLKNHMR IHTGVRPYQC EFCYKSFTRS DHLHRHIKRQ SCRMARPRRG 

       490        500        510        520        530        540 
RKPAAWRAAS LLFGPGGPAP DKAAFVMPPA LGEVGGHLGG AAVCLPGPSP AKHFLAAPKG 

       550        560        570        580        590        600 
ALSLQELERQ FEETQMKLFG RAQLEAERNA GGLLAFALAE NVAAARPYFP LPDPWAAGLA 

       610 
GLPGLAGLNH VASMSEANN 

« Hide

References

[1]"APM-1, a novel human gene, identified by aberrant co-transcription with papillomavirus oncogenes in a cervical carcinoma cell line, encodes a BTB/POZ-zinc finger protein with growth inhibitory activity."
Reuter S., Bartelmann M., Vogt M., Geisen C., Napierski I., Kahn T., Delius H., Lichter P., Weitz S., Korn B., Schwarz E.
EMBO J. 17:215-222(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
[2]"ZBTB7C."
Gilling M., Ullmann R., Kristoffersson U., Moller M., Friis-Henriksen K., Bugge M., Tumer Z., Tommerup N.
Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y14591 mRNA. Translation: CAA74933.1.
EF120357 mRNA. Translation: ABL98073.1.
CCDSCCDS32830.1.
RefSeqNP_001034449.1. NM_001039360.2.
XP_005258284.1. XM_005258227.1.
XP_005258286.1. XM_005258229.2.
XP_005258287.1. XM_005258230.2.
XP_006722480.1. XM_006722417.1.
XP_006722481.1. XM_006722418.1.
UniGeneHs.515388.
Hs.730374.
Hs.732162.

3D structure databases

ProteinModelPortalA1YPR0.
SMRA1YPR0. Positions 9-128, 352-466.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128390. 1 interaction.
IntActA1YPR0. 1 interaction.
MINTMINT-7944746.
STRING9606.ENSP00000328732.

PTM databases

PhosphoSiteA1YPR0.

Proteomic databases

PaxDbA1YPR0.
PRIDEA1YPR0.

Protocols and materials databases

DNASU201501.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000332053; ENSP00000328732; ENSG00000184828.
ENST00000535628; ENSP00000439781; ENSG00000184828.
ENST00000586438; ENSP00000468254; ENSG00000184828.
ENST00000588982; ENSP00000468782; ENSG00000184828.
ENST00000590800; ENSP00000467877; ENSG00000184828.
GeneID201501.
KEGGhsa:201501.
UCSCuc002ldb.3. human.

Organism-specific databases

CTD201501.
GeneCardsGC18M045553.
HGNCHGNC:31700. ZBTB7C.
HPAHPA014433.
neXtProtNX_A1YPR0.
PharmGKBPA134861865.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000059674.
HOVERGENHBG101042.
InParanoidA1YPR0.
KOK10494.
OMAMCTICEV.
OrthoDBEOG70W3D4.
PhylomeDBA1YPR0.
TreeFamTF331824.

Gene expression databases

ArrayExpressA1YPR0.
BgeeA1YPR0.
CleanExHS_ZBTB7C.
GenevestigatorA1YPR0.

Family and domain databases

Gene3D3.30.160.60. 4 hits.
3.30.710.10. 1 hit.
InterProIPR016024. ARM-type_fold.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF00651. BTB. 1 hit.
[Graphical view]
SMARTSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZBTB7C. human.
GenomeRNAi201501.
NextBio90152.
PROA1YPR0.

Entry information

Entry nameZBT7C_HUMAN
AccessionPrimary (citable) accession number: A1YPR0
Secondary accession number(s): O73453
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: February 6, 2007
Last modified: July 9, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM