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Protein

Zinc finger and BTB domain-containing protein 7C

Gene

ZBTB7C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be a tumor suppressor gene.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri364 – 38623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri420 – 44223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri448 – 47831C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. nucleic acid binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 7C
Alternative name(s):
Affected by papillomavirus DNA integration in ME180 cells protein 1
Short name:
APM-1
Zinc finger and BTB domain-containing protein 36
Zinc finger protein 857C
Gene namesi
Name:ZBTB7C
Synonyms:APM1, ZBTB36, ZNF857C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:31700. ZBTB7C.

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

PharmGKBiPA134861865.

Polymorphism and mutation databases

BioMutaiZBTB7C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 619619Zinc finger and BTB domain-containing protein 7CPRO_0000337869Add
BLAST

Proteomic databases

MaxQBiA1YPR0.
PaxDbiA1YPR0.
PRIDEiA1YPR0.

PTM databases

PhosphoSiteiA1YPR0.

Expressioni

Tissue specificityi

Detected in normal cervical keratinocytes, and in some cervical carcinoma cell lines.1 Publication

Gene expression databases

BgeeiA1YPR0.
CleanExiHS_ZBTB7C.
ExpressionAtlasiA1YPR0. baseline and differential.
GenevestigatoriA1YPR0.

Organism-specific databases

HPAiHPA014433.

Interactioni

Protein-protein interaction databases

BioGridi128390. 1 interaction.
IntActiA1YPR0. 1 interaction.
MINTiMINT-7944746.
STRINGi9606.ENSP00000328732.

Structurei

3D structure databases

ProteinModelPortaliA1YPR0.
SMRiA1YPR0. Positions 9-128, 350-466.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 10168BTBPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi125 – 16238Glu-richAdd
BLAST
Compositional biasi132 – 18251Asp-richAdd
BLAST
Compositional biasi298 – 32427Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri364 – 38623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri420 – 44223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri448 – 47831C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000059674.
HOVERGENiHBG101042.
InParanoidiA1YPR0.
KOiK10494.
OMAiISCHQSP.
OrthoDBiEOG70W3D4.
PhylomeDBiA1YPR0.
TreeFamiTF331824.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR016024. ARM-type_fold.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1YPR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANDIDELIG IPFPNHSSEV LCSLNEQRHD GLLCDVLLVV QEQEYRTHRS
60 70 80 90 100
VLAACSKYFK KLFTAGTLAS QPYVYEIDFV QPEALAAILE FAYTSTLTIT
110 120 130 140 150
AGNVKHILNA ARMLEIQCIV NVCLEIMEPG GDGGEEDDKE DDDDDEDDDD
160 170 180 190 200
EEDEEEEEEE EEDDDDDTED FADQENLPDP QDISCHQSPS KTDHLTEKAY
210 220 230 240 250
SDTPRDFPDS FQAGSPGHLG VIRDFSIESL LRENLYPKAN IPDRRPSLSP
260 270 280 290 300
FAPDFFPHLW PGDFGAFAQL PEQPMDSGPL DLVIKNRKIK EEEKEELPPP
310 320 330 340 350
PPPPFPNDFF KDMFPDLPGG PLGPIKAEND YGAYLNFLSA THLGGLFPPW
360 370 380 390 400
PLVEERKLKP KASQQCPICH KVIMGAGKLP RHMRTHTGEK PYMCTICEVR
410 420 430 440 450
FTRQDKLKIH MRKHTGERPY LCIHCNAKFV HNYDLKNHMR IHTGVRPYQC
460 470 480 490 500
EFCYKSFTRS DHLHRHIKRQ SCRMARPRRG RKPAAWRAAS LLFGPGGPAP
510 520 530 540 550
DKAAFVMPPA LGEVGGHLGG AAVCLPGPSP AKHFLAAPKG ALSLQELERQ
560 570 580 590 600
FEETQMKLFG RAQLEAERNA GGLLAFALAE NVAAARPYFP LPDPWAAGLA
610
GLPGLAGLNH VASMSEANN
Length:619
Mass (Da):69,017
Last modified:February 6, 2007 - v1
Checksum:i73D82A34502B55BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14591 mRNA. Translation: CAA74933.1.
EF120357 mRNA. Translation: ABL98073.1.
CCDSiCCDS32830.1.
RefSeqiNP_001034449.1. NM_001039360.2.
XP_005258284.1. XM_005258227.2.
XP_005258286.1. XM_005258229.3.
UniGeneiHs.515388.
Hs.730374.
Hs.732162.

Genome annotation databases

EnsembliENST00000535628; ENSP00000439781; ENSG00000184828.
ENST00000586438; ENSP00000468254; ENSG00000184828.
ENST00000588982; ENSP00000468782; ENSG00000184828.
ENST00000590800; ENSP00000467877; ENSG00000184828.
GeneIDi201501.
KEGGihsa:201501.
UCSCiuc002ldb.3. human.

Polymorphism and mutation databases

BioMutaiZBTB7C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14591 mRNA. Translation: CAA74933.1.
EF120357 mRNA. Translation: ABL98073.1.
CCDSiCCDS32830.1.
RefSeqiNP_001034449.1. NM_001039360.2.
XP_005258284.1. XM_005258227.2.
XP_005258286.1. XM_005258229.3.
UniGeneiHs.515388.
Hs.730374.
Hs.732162.

3D structure databases

ProteinModelPortaliA1YPR0.
SMRiA1YPR0. Positions 9-128, 350-466.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128390. 1 interaction.
IntActiA1YPR0. 1 interaction.
MINTiMINT-7944746.
STRINGi9606.ENSP00000328732.

PTM databases

PhosphoSiteiA1YPR0.

Polymorphism and mutation databases

BioMutaiZBTB7C.

Proteomic databases

MaxQBiA1YPR0.
PaxDbiA1YPR0.
PRIDEiA1YPR0.

Protocols and materials databases

DNASUi201501.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000535628; ENSP00000439781; ENSG00000184828.
ENST00000586438; ENSP00000468254; ENSG00000184828.
ENST00000588982; ENSP00000468782; ENSG00000184828.
ENST00000590800; ENSP00000467877; ENSG00000184828.
GeneIDi201501.
KEGGihsa:201501.
UCSCiuc002ldb.3. human.

Organism-specific databases

CTDi201501.
GeneCardsiGC18M045553.
HGNCiHGNC:31700. ZBTB7C.
HPAiHPA014433.
neXtProtiNX_A1YPR0.
PharmGKBiPA134861865.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000059674.
HOVERGENiHBG101042.
InParanoidiA1YPR0.
KOiK10494.
OMAiISCHQSP.
OrthoDBiEOG70W3D4.
PhylomeDBiA1YPR0.
TreeFamiTF331824.

Miscellaneous databases

ChiTaRSiZBTB7C. human.
GenomeRNAii201501.
NextBioi90152.
PROiA1YPR0.

Gene expression databases

BgeeiA1YPR0.
CleanExiHS_ZBTB7C.
ExpressionAtlasiA1YPR0. baseline and differential.
GenevestigatoriA1YPR0.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR016024. ARM-type_fold.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "APM-1, a novel human gene, identified by aberrant co-transcription with papillomavirus oncogenes in a cervical carcinoma cell line, encodes a BTB/POZ-zinc finger protein with growth inhibitory activity."
    Reuter S., Bartelmann M., Vogt M., Geisen C., Napierski I., Kahn T., Delius H., Lichter P., Weitz S., Korn B., Schwarz E.
    EMBO J. 17:215-222(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  2. "ZBTB7C."
    Gilling M., Ullmann R., Kristoffersson U., Moller M., Friis-Henriksen K., Bugge M., Tumer Z., Tommerup N.
    Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiZBT7C_HUMAN
AccessioniPrimary (citable) accession number: A1YPR0
Secondary accession number(s): O73453
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: February 6, 2007
Last modified: April 29, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.