A1YPR0 (ZBT7C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger and BTB domain-containing protein 7C

Alternative name(s):
Affected by papillomavirus DNA integration in ME180 cells protein 1
Short name=APM-1
Zinc finger and BTB domain-containing protein 36
Zinc finger protein 857C

Gene names

Name:	ZBTB7C
Synonyms:	APM1, ZBTB36, ZNF857C

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	619 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be a tumor suppressor gene. Ref.1
Tissue specificity	Detected in normal cervical keratinocytes, and in some cervical carcinoma cell lines. Ref.1
Sequence similarities	Contains 1 BTB (POZ) domain. Contains 4 C2H2-type zinc fingers.

Ontologies

Keywords
Disease	Tumor suppressor
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	nucleic acid binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 619	619	Zinc finger and BTB domain-containing protein 7C		PRO_0000337869
Regions
	Domain	34 – 101	68	BTB
	Zinc finger	364 – 386	23	C2H2-type 1
	Zinc finger	392 – 414	23	C2H2-type 2
	Zinc finger	420 – 442	23	C2H2-type 3
	Zinc finger	448 – 478	31	C2H2-type 4; degenerate
	Compositional bias	125 – 162	38	Glu-rich
	Compositional bias	132 – 182	51	Asp-rich
	Compositional bias	298 – 324	27	Pro-rich
Amino acid modifications
	Modified residue	331	1	Phosphotyrosine Ref.3

Sequences

	Sequence		Length	Mass (Da)
	A1YPR0 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 73D82A34502B55BF	FASTA	619	69,017
	10 20 30 40 50 60 MANDIDELIG IPFPNHSSEV LCSLNEQRHD GLLCDVLLVV QEQEYRTHRS VLAACSKYFK 70 80 90 100 110 120 KLFTAGTLAS QPYVYEIDFV QPEALAAILE FAYTSTLTIT AGNVKHILNA ARMLEIQCIV 130 140 150 160 170 180 NVCLEIMEPG GDGGEEDDKE DDDDDEDDDD EEDEEEEEEE EEDDDDDTED FADQENLPDP 190 200 210 220 230 240 QDISCHQSPS KTDHLTEKAY SDTPRDFPDS FQAGSPGHLG VIRDFSIESL LRENLYPKAN 250 260 270 280 290 300 IPDRRPSLSP FAPDFFPHLW PGDFGAFAQL PEQPMDSGPL DLVIKNRKIK EEEKEELPPP 310 320 330 340 350 360 PPPPFPNDFF KDMFPDLPGG PLGPIKAEND YGAYLNFLSA THLGGLFPPW PLVEERKLKP 370 380 390 400 410 420 KASQQCPICH KVIMGAGKLP RHMRTHTGEK PYMCTICEVR FTRQDKLKIH MRKHTGERPY 430 440 450 460 470 480 LCIHCNAKFV HNYDLKNHMR IHTGVRPYQC EFCYKSFTRS DHLHRHIKRQ SCRMARPRRG 490 500 510 520 530 540 RKPAAWRAAS LLFGPGGPAP DKAAFVMPPA LGEVGGHLGG AAVCLPGPSP AKHFLAAPKG 550 560 570 580 590 600 ALSLQELERQ FEETQMKLFG RAQLEAERNA GGLLAFALAE NVAAARPYFP LPDPWAAGLA 610 GLPGLAGLNH VASMSEANN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"APM-1, a novel human gene, identified by aberrant co-transcription with papillomavirus oncogenes in a cervical carcinoma cell line, encodes a BTB/POZ-zinc finger protein with growth inhibitory activity." Reuter S., Bartelmann M., Vogt M., Geisen C., Napierski I., Kahn T., Delius H., Lichter P., Weitz S., Korn B., Schwarz E. EMBO J. 17:215-222(1998) [PubMed: 9427755] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
[2]	"ZBTB7C." Gilling M., Ullmann R., Kristoffersson U., Moller M., Friis-Henriksen K., Bugge M., Tumer Z., Tommerup N. Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. , Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J. Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-331, MASS SPECTROMETRY. Tissue: Lung carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y14591 mRNA. Translation: CAA74933.1. EF120357 mRNA. Translation: ABL98073.1.
IPI	IPI00719277.
RefSeq	NP_001034449.1. NM_001039360.2.
UniGene	Hs.515388.
3D structure databases
ProteinModelPortal	A1YPR0.
SMR	A1YPR0. Positions 9-128, 334-471.
ModBase	Search...
PTM databases
PhosphoSite	A1YPR0.
Proteomic databases
PRIDE	A1YPR0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000332053; ENSP00000328732; ENSG00000184828.
GeneID	201501.
KEGG	hsa:201501.
NMPDR	fig|9606.3.peg.15014.
UCSC	uc002lda.1. human.
Organism-specific databases
CTD	201501.
GeneCards	GC18M045553.
H-InvDB	HIX0039899.
HGNC	HGNC:31700. ZBTB7C.
HPA	HPA014433.
neXtProt	NX_A1YPR0.
PharmGKB	PA134861865.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG07137.
HOGENOM	HBG281041.
HOVERGEN	HBG101042.
InParanoid	A1YPR0.
OMA	EETQMKL.
OrthoDB	EOG4X6C8Q.
PhylomeDB	A1YPR0.
Gene expression databases
Bgee	A1YPR0.
CleanEx	HS_ZBTB7C.
Genevestigator	A1YPR0.
Family and domain databases
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.710.10. BTB/POZ_fold. 1 hit. G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 4 hits.
KO	K10494.
Pfam	PF00651. BTB. 1 hit. PF00096. zf-C2H2. 2 hits. [Graphical view]
SMART	SM00225. BTB. 1 hit. SM00355. ZnF_C2H2. 4 hits. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
PROSITE	PS50097. BTB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 3 hits. PS50157. ZINC_FINGER_C2H2_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	90152.

Entry information

Entry name

ZBT7C_HUMAN

Accession

Primary (citable) accession number: A1YPR0
Secondary accession number(s): O73453

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	February 6, 2007
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.