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A1YPR0

- ZBT7C_HUMAN

UniProt

A1YPR0 - ZBT7C_HUMAN

Protein

Zinc finger and BTB domain-containing protein 7C

Gene

ZBTB7C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    May be a tumor suppressor gene.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri364 – 38623C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri392 – 41423C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri420 – 44223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri448 – 47831C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. nucleic acid binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger and BTB domain-containing protein 7C
    Alternative name(s):
    Affected by papillomavirus DNA integration in ME180 cells protein 1
    Short name:
    APM-1
    Zinc finger and BTB domain-containing protein 36
    Zinc finger protein 857C
    Gene namesi
    Name:ZBTB7C
    Synonyms:APM1, ZBTB36, ZNF857C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:31700. ZBTB7C.

    Pathology & Biotechi

    Keywords - Diseasei

    Tumor suppressor

    Organism-specific databases

    PharmGKBiPA134861865.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 619619Zinc finger and BTB domain-containing protein 7CPRO_0000337869Add
    BLAST

    Proteomic databases

    PaxDbiA1YPR0.
    PRIDEiA1YPR0.

    PTM databases

    PhosphoSiteiA1YPR0.

    Expressioni

    Tissue specificityi

    Detected in normal cervical keratinocytes, and in some cervical carcinoma cell lines.1 Publication

    Gene expression databases

    ArrayExpressiA1YPR0.
    BgeeiA1YPR0.
    CleanExiHS_ZBTB7C.
    GenevestigatoriA1YPR0.

    Organism-specific databases

    HPAiHPA014433.

    Interactioni

    Protein-protein interaction databases

    BioGridi128390. 1 interaction.
    IntActiA1YPR0. 1 interaction.
    MINTiMINT-7944746.
    STRINGi9606.ENSP00000328732.

    Structurei

    3D structure databases

    ProteinModelPortaliA1YPR0.
    SMRiA1YPR0. Positions 9-128, 352-466.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 10168BTBPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi125 – 16238Glu-richAdd
    BLAST
    Compositional biasi132 – 18251Asp-richAdd
    BLAST
    Compositional biasi298 – 32427Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
    Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri364 – 38623C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri392 – 41423C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri420 – 44223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri448 – 47831C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000059674.
    HOVERGENiHBG101042.
    InParanoidiA1YPR0.
    KOiK10494.
    OMAiMCTICEV.
    OrthoDBiEOG70W3D4.
    PhylomeDBiA1YPR0.
    TreeFamiTF331824.

    Family and domain databases

    Gene3Di3.30.160.60. 4 hits.
    3.30.710.10. 1 hit.
    InterProiIPR016024. ARM-type_fold.
    IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00651. BTB. 1 hit.
    [Graphical view]
    SMARTiSM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 4 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    SSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1YPR0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANDIDELIG IPFPNHSSEV LCSLNEQRHD GLLCDVLLVV QEQEYRTHRS    50
    VLAACSKYFK KLFTAGTLAS QPYVYEIDFV QPEALAAILE FAYTSTLTIT 100
    AGNVKHILNA ARMLEIQCIV NVCLEIMEPG GDGGEEDDKE DDDDDEDDDD 150
    EEDEEEEEEE EEDDDDDTED FADQENLPDP QDISCHQSPS KTDHLTEKAY 200
    SDTPRDFPDS FQAGSPGHLG VIRDFSIESL LRENLYPKAN IPDRRPSLSP 250
    FAPDFFPHLW PGDFGAFAQL PEQPMDSGPL DLVIKNRKIK EEEKEELPPP 300
    PPPPFPNDFF KDMFPDLPGG PLGPIKAEND YGAYLNFLSA THLGGLFPPW 350
    PLVEERKLKP KASQQCPICH KVIMGAGKLP RHMRTHTGEK PYMCTICEVR 400
    FTRQDKLKIH MRKHTGERPY LCIHCNAKFV HNYDLKNHMR IHTGVRPYQC 450
    EFCYKSFTRS DHLHRHIKRQ SCRMARPRRG RKPAAWRAAS LLFGPGGPAP 500
    DKAAFVMPPA LGEVGGHLGG AAVCLPGPSP AKHFLAAPKG ALSLQELERQ 550
    FEETQMKLFG RAQLEAERNA GGLLAFALAE NVAAARPYFP LPDPWAAGLA 600
    GLPGLAGLNH VASMSEANN 619
    Length:619
    Mass (Da):69,017
    Last modified:February 6, 2007 - v1
    Checksum:i73D82A34502B55BF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y14591 mRNA. Translation: CAA74933.1.
    EF120357 mRNA. Translation: ABL98073.1.
    CCDSiCCDS32830.1.
    RefSeqiNP_001034449.1. NM_001039360.2.
    XP_005258284.1. XM_005258227.1.
    XP_005258286.1. XM_005258229.2.
    XP_005258287.1. XM_005258230.2.
    XP_006722480.1. XM_006722417.1.
    XP_006722481.1. XM_006722418.1.
    UniGeneiHs.515388.
    Hs.730374.
    Hs.732162.

    Genome annotation databases

    EnsembliENST00000535628; ENSP00000439781; ENSG00000184828.
    ENST00000586438; ENSP00000468254; ENSG00000184828.
    ENST00000588982; ENSP00000468782; ENSG00000184828.
    ENST00000590800; ENSP00000467877; ENSG00000184828.
    GeneIDi201501.
    KEGGihsa:201501.
    UCSCiuc002ldb.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y14591 mRNA. Translation: CAA74933.1 .
    EF120357 mRNA. Translation: ABL98073.1 .
    CCDSi CCDS32830.1.
    RefSeqi NP_001034449.1. NM_001039360.2.
    XP_005258284.1. XM_005258227.1.
    XP_005258286.1. XM_005258229.2.
    XP_005258287.1. XM_005258230.2.
    XP_006722480.1. XM_006722417.1.
    XP_006722481.1. XM_006722418.1.
    UniGenei Hs.515388.
    Hs.730374.
    Hs.732162.

    3D structure databases

    ProteinModelPortali A1YPR0.
    SMRi A1YPR0. Positions 9-128, 352-466.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128390. 1 interaction.
    IntActi A1YPR0. 1 interaction.
    MINTi MINT-7944746.
    STRINGi 9606.ENSP00000328732.

    PTM databases

    PhosphoSitei A1YPR0.

    Proteomic databases

    PaxDbi A1YPR0.
    PRIDEi A1YPR0.

    Protocols and materials databases

    DNASUi 201501.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000535628 ; ENSP00000439781 ; ENSG00000184828 .
    ENST00000586438 ; ENSP00000468254 ; ENSG00000184828 .
    ENST00000588982 ; ENSP00000468782 ; ENSG00000184828 .
    ENST00000590800 ; ENSP00000467877 ; ENSG00000184828 .
    GeneIDi 201501.
    KEGGi hsa:201501.
    UCSCi uc002ldb.3. human.

    Organism-specific databases

    CTDi 201501.
    GeneCardsi GC18M045553.
    HGNCi HGNC:31700. ZBTB7C.
    HPAi HPA014433.
    neXtProti NX_A1YPR0.
    PharmGKBi PA134861865.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000059674.
    HOVERGENi HBG101042.
    InParanoidi A1YPR0.
    KOi K10494.
    OMAi MCTICEV.
    OrthoDBi EOG70W3D4.
    PhylomeDBi A1YPR0.
    TreeFami TF331824.

    Miscellaneous databases

    ChiTaRSi ZBTB7C. human.
    GenomeRNAii 201501.
    NextBioi 90152.
    PROi A1YPR0.

    Gene expression databases

    ArrayExpressi A1YPR0.
    Bgeei A1YPR0.
    CleanExi HS_ZBTB7C.
    Genevestigatori A1YPR0.

    Family and domain databases

    Gene3Di 3.30.160.60. 4 hits.
    3.30.710.10. 1 hit.
    InterProi IPR016024. ARM-type_fold.
    IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00651. BTB. 1 hit.
    [Graphical view ]
    SMARTi SM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 4 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "APM-1, a novel human gene, identified by aberrant co-transcription with papillomavirus oncogenes in a cervical carcinoma cell line, encodes a BTB/POZ-zinc finger protein with growth inhibitory activity."
      Reuter S., Bartelmann M., Vogt M., Geisen C., Napierski I., Kahn T., Delius H., Lichter P., Weitz S., Korn B., Schwarz E.
      EMBO J. 17:215-222(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    2. "ZBTB7C."
      Gilling M., Ullmann R., Kristoffersson U., Moller M., Friis-Henriksen K., Bugge M., Tumer Z., Tommerup N.
      Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiZBT7C_HUMAN
    AccessioniPrimary (citable) accession number: A1YPR0
    Secondary accession number(s): O73453
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3