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Protein
Submitted name:

Pleiomorphic adenoma gene-like protein 1

Gene

PLAGL1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Pleiomorphic adenoma gene-like protein 1Imported
Submitted name:
Zinc finger protein PLAGL1Imported
Gene namesi
Name:PLAGL1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:9046. PLAGL1.

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33379.

PTM / Processingi

Proteomic databases

PaxDbiA1YLA1.

Expressioni

Gene expression databases

ExpressionAtlasiA1YLA1. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000346810.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 3128C2H2-typeInterPro annotationAdd
BLAST
Domaini32 – 6130C2H2-typeInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00390000013640.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR027770. PLAGL1.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PTHR10032:SF227. PTHR10032:SF227. 1 hit.
PfamiPF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

A1YLA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATFPCQLCG KTFLTLEKFT IHNYSHSRER PYKCVQPDCG KAFVSRYKLM
60
RHMATHSPQK SHQC
Length:64
Mass (Da):7,506
Last modified:February 6, 2007 - v1
Checksum:i9B6414824E8204E9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei64 – 641Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031390 Genomic DNA. No translation available.
AL049844 Genomic DNA. No translation available.
AL109755 Genomic DNA. No translation available.
KF458320 Genomic DNA. No translation available.
EF100438 mRNA. Translation: ABM54075.1.
EF100442 mRNA. Translation: ABM54079.1.
EF100445 mRNA. Translation: ABM54082.1.
EF100446 mRNA. Translation: ABM54083.1.
EF100447 mRNA. Translation: ABM54084.1.
EF100448 mRNA. Translation: ABM54085.1.
EF100449 mRNA. Translation: ABM54086.1.
EF100450 mRNA. Translation: ABM54087.1.
EF100452 mRNA. Translation: ABM54089.1.
RefSeqiNP_001074420.1. NM_001080951.2.
NP_001074421.1. NM_001080952.2.
NP_001074422.1. NM_001080953.2.
NP_001074423.1. NM_001080954.2.
NP_001275971.1. NM_001289042.1.
NP_001275972.1. NM_001289043.1.
NP_001275973.1. NM_001289044.1.
NP_001275976.1. NM_001289047.1.
NP_001275977.1. NM_001289048.1.
NP_001275978.1. NM_001289049.1.
NP_001304086.1. NM_001317157.1.
NP_001304088.1. NM_001317159.1.
NP_006709.2. NM_006718.4.
UniGeneiHs.743225.

Genome annotation databases

EnsembliENST00000629195; ENSP00000486763; ENSG00000118495.
GeneIDi5325.
UCSCiuc063rzx.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031390 Genomic DNA. No translation available.
AL049844 Genomic DNA. No translation available.
AL109755 Genomic DNA. No translation available.
KF458320 Genomic DNA. No translation available.
EF100438 mRNA. Translation: ABM54075.1.
EF100442 mRNA. Translation: ABM54079.1.
EF100445 mRNA. Translation: ABM54082.1.
EF100446 mRNA. Translation: ABM54083.1.
EF100447 mRNA. Translation: ABM54084.1.
EF100448 mRNA. Translation: ABM54085.1.
EF100449 mRNA. Translation: ABM54086.1.
EF100450 mRNA. Translation: ABM54087.1.
EF100452 mRNA. Translation: ABM54089.1.
RefSeqiNP_001074420.1. NM_001080951.2.
NP_001074421.1. NM_001080952.2.
NP_001074422.1. NM_001080953.2.
NP_001074423.1. NM_001080954.2.
NP_001275971.1. NM_001289042.1.
NP_001275972.1. NM_001289043.1.
NP_001275973.1. NM_001289044.1.
NP_001275976.1. NM_001289047.1.
NP_001275977.1. NM_001289048.1.
NP_001275978.1. NM_001289049.1.
NP_001304086.1. NM_001317157.1.
NP_001304088.1. NM_001317159.1.
NP_006709.2. NM_006718.4.
UniGeneiHs.743225.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000346810.

Proteomic databases

PaxDbiA1YLA1.

Protocols and materials databases

DNASUi5325.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000629195; ENSP00000486763; ENSG00000118495.
GeneIDi5325.
UCSCiuc063rzx.1. human.

Organism-specific databases

CTDi5325.
HGNCiHGNC:9046. PLAGL1.
PharmGKBiPA33379.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00390000013640.

Miscellaneous databases

ChiTaRSiPLAGL1. human.
GenomeRNAii5325.
NextBioi20600.

Gene expression databases

ExpressionAtlasiA1YLA1. baseline and differential.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR027770. PLAGL1.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PTHR10032:SF227. PTHR10032:SF227. 1 hit.
PfamiPF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Tissue-specific imprinting of the ZAC/PLAGL1 tumour suppressor gene results from variable utilization of monoallelic and biallelic promoters."
    Valleley E.M., Cordery S.F., Bonthron D.T.
    Hum. Mol. Genet. 16:972-981(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Ensembl
    Submitted (APR-2015) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiA1YLA1_HUMAN
AccessioniPrimary (citable) accession number: A1YLA1
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: May 11, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.