ID   ASIP_TRAAU              Reviewed;         132 AA.
AC   A1YL72;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   02-MAR-2010, entry version 17.
DE   RecName: Full=Agouti-signaling protein;
DE            Short=ASP;
DE   AltName: Full=Agouti switch protein;
DE   Flags: Precursor;
GN   Name=ASIP;
OS   Trachypithecus auratus (Javan langur).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Colobinae; Trachypithecus.
OX   NCBI_TaxID=222416;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=17143587; DOI=10.1007/s00335-006-0056-0;
RA   Mundy N.I., Kelly J.;
RT   "Investigation of the role of the agouti signaling protein gene (ASIP)
RT   in coat color evolution in primates.";
RL   Mamm. Genome 17:1205-1213(2006).
CC   -!- FUNCTION: Involved in the regulation of melanogenesis. The binding
CC       of ASP to MC1R precludes alpha-MSH initiated signaling and thus
CC       blocks production of cAMP, leading to a down-regulation of
CC       eumelanogenesis (brown/black pigment) and thus increasing
CC       synthesis of pheomelanin (yellow/red pigment) (By similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted (By similarity).
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin (By similarity).
CC   -!- SIMILARITY: Contains 1 agouti domain.
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DR   EMBL; EF094489; ABL84287.1; -; Genomic_DNA.
DR   HOVERGEN; HBG050593; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:InterPro.
DR   InterPro; IPR007733; Agouti.
DR   Gene3D; G3DSA:4.10.760.10; Agouti; 1.
DR   PANTHER; PTHR16551; Agouti; 1.
DR   Pfam; PF05039; Agouti; 1.
DR   SMART; SM00792; Agouti; 1.
DR   SUPFAM; SSF57055; Agouti; 1.
DR   PROSITE; PS60024; AGOUTI_1; 1.
DR   PROSITE; PS51150; AGOUTI_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Glycoprotein; Knottin; Secreted; Signal.
FT   SIGNAL        1     22       Potential.
FT   CHAIN        23    132       Agouti-signaling protein.
FT                                /FTId=PRO_0000285061.
FT   DOMAIN       93    132       Agouti.
FT   COMPBIAS     57     86       Arg/Lys-rich (basic).
FT   CARBOHYD     39     39       N-linked (GlcNAc...) (Potential).
FT   DISULFID     93    108       By similarity.
FT   DISULFID    100    114       By similarity.
FT   DISULFID    107    125       By similarity.
FT   DISULFID    111    132       By similarity.
FT   DISULFID    116    123       By similarity.
SQ   SEQUENCE   132 AA;  14673 MW;  373A273D6B667C80 CRC64;
     MDVTRLLLAT LLVFLCFFTV YSHLPPEEKL RDDRSLRSNS SVNLLDFPSV SIVALNKKSK
     QISRKEAEKK RSSKKEASMK KVAQPRTPLS APCVATRDSC KPPAPACCDP CASCQCRFFR
     SACSCRVLSL NC
//