Reviewed, UniProtKB/Swiss-Prot A1YL72 (ASIP_TRAAU)

Names and origin

Protein names

Recommended name:
    Agouti-signaling protein
      Short name=ASP
Alternative name(s):
    Agouti switch protein

Gene names

Name:

ASIP

Organism

Trachypithecus auratus (Javan langur)

Taxonomic identifier

222416 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Colobinae › Trachypithecus

Protein attributes

Sequence length	132 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) By similarity.
Subcellular location	Secreted By similarity.
Domain	The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin By similarity.
Sequence similarities	Contains 1 agouti domain.

Ontologies

Keywords
Cellular component	Secreted
Domain	Knottin Signal
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	hormone-mediated signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 132	110	Agouti-signaling protein		PRO_0000285061
Regions
	Domain	93 – 132	40	Agouti
	Compositional bias	57 – 86	30	Arg/Lys-rich (basic)
Amino acid modifications
	Glycosylation	39	1	N-linked (GlcNAc...) Potential
	Disulfide bond	93 ↔ 108		By similarity
	Disulfide bond	100 ↔ 114		By similarity
	Disulfide bond	107 ↔ 125		By similarity
	Disulfide bond	111 ↔ 132		By similarity
	Disulfide bond	116 ↔ 123		By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1YL72-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 373A273D6B667C80	FASTA	132	14,673
	10 20 30 40 50 60 MDVTRLLLAT LLVFLCFFTV YSHLPPEEKL RDDRSLRSNS SVNLLDFPSV SIVALNKKSK 70 80 90 100 110 120 QISRKEAEKK RSSKKEASMK KVAQPRTPLS APCVATRDSC KPPAPACCDP CASCQCRFFR 130 SACSCRVLSL NC

References

[1]	"Investigation of the role of the agouti signaling protein gene (ASIP) in coat color evolution in primates." Mundy N.I., Kelly J. Mamm. Genome 17:1205-1213(2006) [PubMed: 17143587] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	EF094489 Genomic DNA. Translation: ABL84287.1.
3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	A1YL72.
Family and domain databases
InterPro	IPR007733. Agouti. [Graphical view]
Gene3D	G3DSA:4.10.760.10. Agouti. 1 hit.
PANTHER	PTHR16551. Agouti. 1 hit.
Pfam	PF05039. Agouti. 1 hit. [Graphical view]
SMART	SM00792. Agouti. 1 hit. [Graphical view]
PROSITE	PS60024. AGOUTI_1. 1 hit. PS51150. AGOUTI_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASIP_TRAAU

Accession

Primary (citable) accession number: A1YL72

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	February 6, 2007
Last modified:	July 28, 2009
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)