Reviewed, UniProtKB/Swiss-Prot A1YGK7 (HXA7_PANPA)

Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A7

Gene names

Name:

HOXA7

Organism

Pan paniscus (Pygmy chimpanzee) (Bonobo)

Taxonomic identifier

9597 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan

Protein attributes

Sequence length	230 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 230	230	Homeobox protein Hox-A7		PRO_0000285420
Regions
	DNA binding	130 – 189	60	Homeobox
	Motif	119 – 124	6	Antp-type hexapeptide
	Compositional bias	157 – 160	4	Poly-Arg
	Compositional bias	196 – 199	4	Poly-Ala
	Compositional bias	214 – 230	17	Asp/Glu-rich (highly acidic)
	Compositional bias	223 – 230	8	Poly-Glu

Sequences

	Sequence		Length	Mass (Da)
	A1YGK7-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 1003B39E296223E1	FASTA	230	25,330
	10 20 30 40 50 60 MSSSYYVNAL FSKYTAGASL FQNAEPTSCS FAPNSQRSGY GAGAGAFAST VPGLYNVNSP 70 80 90 100 110 120 LYQSPFASGY GLGADAYGNL PCASYDQNIP GLCSDLAKGA CDKADEGALH GAAEANFRIY 130 140 150 160 170 180 PWMRSSGPDR KRGRQTYTRY QTLELEKEFH FNRYLTRRRR IEXXHALCLT ERQIXXWFQN 190 200 210 220 230 RRMKWKKEHK DDGPTAAAAP EGAVPSAAAT AAADKADEED DDEQEEDEEE

References

[1]	"Positive selection in transcription factor genes on the human lineage." Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ977296 Genomic DNA. Translation: ABM54432.1.
3D structure databases
SMR	A1YGK7. Positions 130-193.
ModBase	Search...
Phylogenomic databases
HOVERGEN	A1YGK7.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017995. Homeobox_antennapedia. IPR001827. Homeobox_Antennapedia_CS. IPR020479. Homeobox_region. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. False negative. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA7_PANPA

Accession

Primary (citable) accession number: A1YGK7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	February 6, 2007
Last modified:	November 24, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)