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A1YG32

- S38A2_PANPA

UniProt

A1YG32 - S38A2_PANPA

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Protein
Sodium-coupled neutral amino acid transporter 2
Gene
SLC38A2, SNAT2
Organism
Pan paniscus (Pygmy chimpanzee) (Bonobo)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta By similarity.

Enzyme regulationi

Inhibited by N-methyl-D-glucamine and choline By similarity.

GO - Molecular functioni

  1. symporter activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. amino acid transport Source: UniProtKB-KW
  2. sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-coupled neutral amino acid transporter 2
Alternative name(s):
Amino acid transporter A2
Solute carrier family 38 member 2
System A amino acid transporter 2
System A transporter 1
System N amino acid transporter 2
Gene namesi
Name:SLC38A2
Synonyms:SNAT2
OrganismiPan paniscus (Pygmy chimpanzee) (Bonobo)
Taxonomic identifieri9597 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan

Subcellular locationi

Cell membrane; Multi-pass membrane protein By similarity
Note: Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes By similarity. Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7676Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei77 – 9721Helical; Reviewed prediction
Add
BLAST
Topological domaini98 – 1025Extracellular Reviewed prediction
Transmembranei103 – 12321Helical; Reviewed prediction
Add
BLAST
Topological domaini124 – 15835Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei159 – 17921Helical; Reviewed prediction
Add
BLAST
Topological domaini180 – 1889Extracellular Reviewed prediction
Transmembranei189 – 20921Helical; Reviewed prediction
Add
BLAST
Topological domaini210 – 2178Cytoplasmic Reviewed prediction
Transmembranei218 – 23821Helical; Reviewed prediction
Add
BLAST
Topological domaini239 – 29254Extracellular Reviewed prediction
Add
BLAST
Transmembranei293 – 31321Helical; Reviewed prediction
Add
BLAST
Topological domaini314 – 32916Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei330 – 35021Helical; Reviewed prediction
Add
BLAST
Topological domaini351 – 37121Extracellular Reviewed prediction
Add
BLAST
Transmembranei372 – 39221Helical; Reviewed prediction
Add
BLAST
Topological domaini393 – 41321Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei414 – 43421Helical; Reviewed prediction
Add
BLAST
Topological domaini435 – 4362Extracellular Reviewed prediction
Transmembranei437 – 45721Helical; Reviewed prediction
Add
BLAST
Topological domaini458 – 47417Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei475 – 49521Helical; Reviewed prediction
Add
BLAST
Topological domaini496 – 50611Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506Sodium-coupled neutral amino acid transporter 2
PRO_0000311371Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei12 – 121Phosphoserine By similarity
Modified residuei22 – 221Phosphoserine By similarity
Modified residuei55 – 551Phosphoserine By similarity
Glycosylationi258 – 2581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi274 – 2741N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2 By similarity.

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9696Regulates protein turnover upon amino acid deprivation By similarity
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG059571.
KOiK14207.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1YG32-1 [UniParc]FASTAAdd to Basket

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MKKAEMGRFN ISPDEDSSSY SSNSDFNYSY PTKQAALKSH YADVDPENQN    50
FLLESNLGKK KYETEFHPGT TSFGMSVFNL SNAIVGSGIL GLSYAMANTG 100
IALFIILLTF VSIFSLYSVH LLLKTANEGG SLLYEQLGYK AFGLVGKLAA 150
SGSITMQNIG AMSSYLFIVK YELPLVIQAL TNIEDKTGLW YLNGNYLVLL 200
VSLVVILPLS LFRNLGYLGY TSGLSLLCMV FFLIVVICKK FQVPCPVEAA 250
LIINETINTT LTQPTALVPA LSHNVTENDS CRPHYFIFNS QTVYAVPILI 300
FSFVCHPAVL PIYEELKDRS RRRMMNVSKI SFFAMFLMYL LAALFGYLTF 350
YEHVESELLH TYSSILGTDI LLLIVRLAVL MAVTLTVPVV IFPIRSSVTH 400
LLCASKDFSW WRHSLITVSI LAFTNLLVIF VPTIRDIFGF IGASAASMLI 450
FILPSAFYIK LVKKEPMKSV QKIGALFFLL SGVLVMTGSM ALIVLDWVHN 500
APGGGH 506
Length:506
Mass (Da):56,053
Last modified:February 6, 2007 - v1
Checksum:i743D09A3C5DAF4A3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ977211 Genomic DNA. Translation: ABM54257.1.
RefSeqiXP_003825811.1. XM_003825763.1.

Genome annotation databases

GeneIDi100975486.
KEGGipps:100975486.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ977211 Genomic DNA. Translation: ABM54257.1 .
RefSeqi XP_003825811.1. XM_003825763.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100975486.
KEGGi pps:100975486.

Organism-specific databases

CTDi 54407.

Phylogenomic databases

HOVERGENi HBG059571.
KOi K14207.

Family and domain databases

InterProi IPR013057. AA_transpt_TM.
[Graphical view ]
Pfami PF01490. Aa_trans. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Positive selection in transcription factor genes on the human lineage."
    Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiS38A2_PANPA
AccessioniPrimary (citable) accession number: A1YG32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: February 6, 2007
Last modified: April 16, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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