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A1YG32

- S38A2_PANPA

UniProt

A1YG32 - S38A2_PANPA

Protein

Sodium-coupled neutral amino acid transporter 2

Gene

SLC38A2

Organism
Pan paniscus (Pygmy chimpanzee) (Bonobo)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta By similarity.By similarity

    Enzyme regulationi

    Inhibited by N-methyl-D-glucamine and choline.By similarity

    GO - Molecular functioni

    1. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. amino acid transport Source: UniProtKB-KW
    2. sodium ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Amino-acid transport, Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium-coupled neutral amino acid transporter 2
    Alternative name(s):
    Amino acid transporter A2
    Solute carrier family 38 member 2
    System A amino acid transporter 2
    System A transporter 1
    System N amino acid transporter 2
    Gene namesi
    Name:SLC38A2
    Synonyms:SNAT2
    OrganismiPan paniscus (Pygmy chimpanzee) (Bonobo)
    Taxonomic identifieri9597 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity
    Note: Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes. Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 506506Sodium-coupled neutral amino acid transporter 2PRO_0000311371Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei12 – 121PhosphoserineBy similarity
    Modified residuei22 – 221PhosphoserineBy similarity
    Modified residuei55 – 551PhosphoserineBy similarity
    Glycosylationi258 – 2581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein, Ubl conjugation

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7676CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini98 – 1025ExtracellularSequence Analysis
    Topological domaini124 – 15835CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini180 – 1889ExtracellularSequence Analysis
    Topological domaini210 – 2178CytoplasmicSequence Analysis
    Topological domaini239 – 29254ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini314 – 32916CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini351 – 37121ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini393 – 41321CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini435 – 4362ExtracellularSequence Analysis
    Topological domaini458 – 47417CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini496 – 50611ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei77 – 9721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei103 – 12321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei189 – 20921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei218 – 23821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei293 – 31321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei330 – 35021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei372 – 39221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei414 – 43421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei437 – 45721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei475 – 49521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 9696Regulates protein turnover upon amino acid deprivationBy similarityAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG059571.
    KOiK14207.

    Family and domain databases

    InterProiIPR013057. AA_transpt_TM.
    [Graphical view]
    PfamiPF01490. Aa_trans. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1YG32-1 [UniParc]FASTAAdd to Basket

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    MKKAEMGRFN ISPDEDSSSY SSNSDFNYSY PTKQAALKSH YADVDPENQN    50
    FLLESNLGKK KYETEFHPGT TSFGMSVFNL SNAIVGSGIL GLSYAMANTG 100
    IALFIILLTF VSIFSLYSVH LLLKTANEGG SLLYEQLGYK AFGLVGKLAA 150
    SGSITMQNIG AMSSYLFIVK YELPLVIQAL TNIEDKTGLW YLNGNYLVLL 200
    VSLVVILPLS LFRNLGYLGY TSGLSLLCMV FFLIVVICKK FQVPCPVEAA 250
    LIINETINTT LTQPTALVPA LSHNVTENDS CRPHYFIFNS QTVYAVPILI 300
    FSFVCHPAVL PIYEELKDRS RRRMMNVSKI SFFAMFLMYL LAALFGYLTF 350
    YEHVESELLH TYSSILGTDI LLLIVRLAVL MAVTLTVPVV IFPIRSSVTH 400
    LLCASKDFSW WRHSLITVSI LAFTNLLVIF VPTIRDIFGF IGASAASMLI 450
    FILPSAFYIK LVKKEPMKSV QKIGALFFLL SGVLVMTGSM ALIVLDWVHN 500
    APGGGH 506
    Length:506
    Mass (Da):56,053
    Last modified:February 6, 2007 - v1
    Checksum:i743D09A3C5DAF4A3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ977211 Genomic DNA. Translation: ABM54257.1.
    RefSeqiXP_003825811.1. XM_003825763.1.

    Genome annotation databases

    GeneIDi100975486.
    KEGGipps:100975486.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ977211 Genomic DNA. Translation: ABM54257.1 .
    RefSeqi XP_003825811.1. XM_003825763.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100975486.
    KEGGi pps:100975486.

    Organism-specific databases

    CTDi 54407.

    Phylogenomic databases

    HOVERGENi HBG059571.
    KOi K14207.

    Family and domain databases

    InterProi IPR013057. AA_transpt_TM.
    [Graphical view ]
    Pfami PF01490. Aa_trans. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Positive selection in transcription factor genes on the human lineage."
      Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiS38A2_PANPA
    AccessioniPrimary (citable) accession number: A1YG32
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3