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A1YG32 (S38A2_PANPA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Sodium-coupled neutral amino acid transporter 2
Alternative name(s):
Amino acid transporter A2
Solute carrier family 38 member 2
System A amino acid transporter 2
System A transporter 1
System N amino acid transporter 2
Gene names
Name:SLC38A2
Synonyms:SNAT2
OrganismPan paniscus (Pygmy chimpanzee) (Bonobo)
Taxonomic identifier9597 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan

Protein attributes

Sequence length506 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta By similarity.

Enzyme regulation

Inhibited by N-methyl-D-glucamine and choline By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Note: Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes By similarity. Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal By similarity.

Post-translational modification

Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2 By similarity.

Sequence similarities

Belongs to the amino acid/polyamine transporter 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 506506Sodium-coupled neutral amino acid transporter 2
PRO_0000311371

Regions

Topological domain1 – 7676Cytoplasmic Potential
Transmembrane77 – 9721Helical; Potential
Topological domain98 – 1025Extracellular Potential
Transmembrane103 – 12321Helical; Potential
Topological domain124 – 15835Cytoplasmic Potential
Transmembrane159 – 17921Helical; Potential
Topological domain180 – 1889Extracellular Potential
Transmembrane189 – 20921Helical; Potential
Topological domain210 – 2178Cytoplasmic Potential
Transmembrane218 – 23821Helical; Potential
Topological domain239 – 29254Extracellular Potential
Transmembrane293 – 31321Helical; Potential
Topological domain314 – 32916Cytoplasmic Potential
Transmembrane330 – 35021Helical; Potential
Topological domain351 – 37121Extracellular Potential
Transmembrane372 – 39221Helical; Potential
Topological domain393 – 41321Cytoplasmic Potential
Transmembrane414 – 43421Helical; Potential
Topological domain435 – 4362Extracellular Potential
Transmembrane437 – 45721Helical; Potential
Topological domain458 – 47417Cytoplasmic Potential
Transmembrane475 – 49521Helical; Potential
Topological domain496 – 50611Extracellular Potential
Region1 – 9696Regulates protein turnover upon amino acid deprivation By similarity

Amino acid modifications

Modified residue121Phosphoserine By similarity
Modified residue221Phosphoserine By similarity
Modified residue411Phosphotyrosine By similarity
Modified residue551Phosphoserine By similarity
Glycosylation2581N-linked (GlcNAc...) Potential
Glycosylation2741N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
A1YG32 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 743D09A3C5DAF4A3

FASTA50656,053
        10         20         30         40         50         60 
MKKAEMGRFN ISPDEDSSSY SSNSDFNYSY PTKQAALKSH YADVDPENQN FLLESNLGKK 

        70         80         90        100        110        120 
KYETEFHPGT TSFGMSVFNL SNAIVGSGIL GLSYAMANTG IALFIILLTF VSIFSLYSVH 

       130        140        150        160        170        180 
LLLKTANEGG SLLYEQLGYK AFGLVGKLAA SGSITMQNIG AMSSYLFIVK YELPLVIQAL 

       190        200        210        220        230        240 
TNIEDKTGLW YLNGNYLVLL VSLVVILPLS LFRNLGYLGY TSGLSLLCMV FFLIVVICKK 

       250        260        270        280        290        300 
FQVPCPVEAA LIINETINTT LTQPTALVPA LSHNVTENDS CRPHYFIFNS QTVYAVPILI 

       310        320        330        340        350        360 
FSFVCHPAVL PIYEELKDRS RRRMMNVSKI SFFAMFLMYL LAALFGYLTF YEHVESELLH 

       370        380        390        400        410        420 
TYSSILGTDI LLLIVRLAVL MAVTLTVPVV IFPIRSSVTH LLCASKDFSW WRHSLITVSI 

       430        440        450        460        470        480 
LAFTNLLVIF VPTIRDIFGF IGASAASMLI FILPSAFYIK LVKKEPMKSV QKIGALFFLL 

       490        500 
SGVLVMTGSM ALIVLDWVHN APGGGH

« Hide

References

[1]"Positive selection in transcription factor genes on the human lineage."
Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		DQ977211 Genomic DNA. Translation: ABM54257.1.
RefSeqXP_003825811.1. XM_003825763.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100975486.
KEGGpps:100975486.

Organism-specific databases

CTD54407.

Phylogenomic databases

HOVERGENHBG059571.
KOK14207.

Family and domain databases

InterProIPR013057. AA_transpt_TM.
[Graphical view]
PfamPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameS38A2_PANPA
AccessionPrimary (citable) accession number: A1YG32
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: February 6, 2007
Last modified: March 6, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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