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Protein

Zinc finger protein 449

Gene

ZNF449

Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri323 – 34523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri351 – 37323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri379 – 40123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri407 – 42923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri435 – 45723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri463 – 48523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri491 – 51323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 449
Gene namesi
Name:ZNF449
OrganismiGorilla gorilla gorilla (Western lowland gorilla)
Taxonomic identifieri9595 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
ProteomesiUP000001519: Chromosome X

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518Zinc finger protein 449PRO_0000285474Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA1YEQ3.
SMRiA1YEQ3. Positions 320-401.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 11283SCAN boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri323 – 34523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri351 – 37323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri379 – 40123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri407 – 42923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri435 – 45723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri463 – 48523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri491 – 51323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00730000110971.
HOVERGENiHBG018163.
InParanoidiA1YEQ3.
KOiK09230.
OMAiPVAEAWI.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1YEQ3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVALGCAIQ ASLNQGSVFQ EYDTDCEVFR QRFRQFQYRE AAGPHEAFNK
60 70 80 90 100
LWELCCQWLK PKMRSKEQIL ELLVLEQFLT ILPTEIETWV REHCPENRER
110 120 130 140 150
VVSLIEDLQR ELEIPEQQVD MHDMLLEELA PVGTAHIPPT MHLESPALQV
160 170 180 190 200
MGPAQEAPVT EAWIPQAGPP ELNYGATGEC QNFLDPGYPL PKLDMNFSLE
210 220 230 240 250
NREEPWVKEL QDSKEMKQLL DSKIGFEIGI ENEEDTSKQK KMETMYPFIV
260 270 280 290 300
TLEGNALQGP ILQKDYVQLE NQWETPPEDL QTDLAKLVDQ QNPTLGETPE
310 320 330 340 350
NSNLEEPLNP KPHKKKSPGE KPHRCPQCGK CFARKSQLTG HQRIHSGEEP
360 370 380 390 400
HKCPECGKRF LRSSDLYRHQ RLHTGERPYE CTVCKKRFTR RSHLIGHQRT
410 420 430 440 450
HSEEETYKCL ECGKSFCHGS SLKRHLKTHT GEKPHRCHNC GKSFSRLTAL
460 470 480 490 500
TLHQRTHTEE RPFKCNYCGK SFRQRPSLVI HLRIHTGEKP YKCTHCSKSF
510
RQRAGLIMHQ VTHFRGLI
Length:518
Mass (Da):59,962
Last modified:February 6, 2007 - v1
Checksum:i4C670C337098A8B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ976438 Genomic DNA. Translation: ABM46621.1.
RefSeqiXP_004064961.1. XM_004064913.1.

Genome annotation databases

EnsembliENSGGOT00000000032; ENSGGOP00000000031; ENSGGOG00000000032.
GeneIDi101141177.
KEGGiggo:101141177.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ976438 Genomic DNA. Translation: ABM46621.1.
RefSeqiXP_004064961.1. XM_004064913.1.

3D structure databases

ProteinModelPortaliA1YEQ3.
SMRiA1YEQ3. Positions 320-401.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGGOT00000000032; ENSGGOP00000000031; ENSGGOG00000000032.
GeneIDi101141177.
KEGGiggo:101141177.

Organism-specific databases

CTDi203523.

Phylogenomic databases

GeneTreeiENSGT00730000110971.
HOVERGENiHBG018163.
InParanoidiA1YEQ3.
KOiK09230.
OMAiPVAEAWI.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Positive selection in transcription factor genes on the human lineage."
    Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiZN449_GORGO
AccessioniPrimary (citable) accession number: A1YEQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: February 6, 2007
Last modified: February 4, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.