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Protein

Zinc finger protein 449

Gene

ZNF449

Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri323 – 345C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri351 – 373C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri379 – 401C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri407 – 429C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri435 – 457C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri463 – 485C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri491 – 513C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 449
Gene namesi
Name:ZNF449
OrganismiGorilla gorilla gorilla (Western lowland gorilla)
Taxonomic identifieri9595 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
Proteomesi
  • UP000001519 Componenti: Chromosome X

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002854741 – 518Zinc finger protein 449Add BLAST518

Expressioni

Gene expression databases

BgeeiENSGGOG00000000032.

Interactioni

Protein-protein interaction databases

STRINGi9593.ENSGGOP00000000031.

Structurei

3D structure databases

ProteinModelPortaliA1YEQ3.
SMRiA1YEQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 112SCAN boxPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri323 – 345C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri351 – 373C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri379 – 401C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri407 – 429C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri435 – 457C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri463 – 485C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri491 – 513C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00890000139469.
HOVERGENiHBG018163.
InParanoidiA1YEQ3.
KOiK09230.
OMAiPHKKKSP.
OrthoDBiEOG091G02KC.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF02023. SCAN. 1 hit.
SMARTiView protein in SMART
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
SUPFAMiSSF47353. SSF47353. 1 hit.
SSF57667. SSF57667. 4 hits.
PROSITEiView protein in PROSITE
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.

Sequencei

Sequence statusi: Complete.

A1YEQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVALGCAIQ ASLNQGSVFQ EYDTDCEVFR QRFRQFQYRE AAGPHEAFNK
60 70 80 90 100
LWELCCQWLK PKMRSKEQIL ELLVLEQFLT ILPTEIETWV REHCPENRER
110 120 130 140 150
VVSLIEDLQR ELEIPEQQVD MHDMLLEELA PVGTAHIPPT MHLESPALQV
160 170 180 190 200
MGPAQEAPVT EAWIPQAGPP ELNYGATGEC QNFLDPGYPL PKLDMNFSLE
210 220 230 240 250
NREEPWVKEL QDSKEMKQLL DSKIGFEIGI ENEEDTSKQK KMETMYPFIV
260 270 280 290 300
TLEGNALQGP ILQKDYVQLE NQWETPPEDL QTDLAKLVDQ QNPTLGETPE
310 320 330 340 350
NSNLEEPLNP KPHKKKSPGE KPHRCPQCGK CFARKSQLTG HQRIHSGEEP
360 370 380 390 400
HKCPECGKRF LRSSDLYRHQ RLHTGERPYE CTVCKKRFTR RSHLIGHQRT
410 420 430 440 450
HSEEETYKCL ECGKSFCHGS SLKRHLKTHT GEKPHRCHNC GKSFSRLTAL
460 470 480 490 500
TLHQRTHTEE RPFKCNYCGK SFRQRPSLVI HLRIHTGEKP YKCTHCSKSF
510
RQRAGLIMHQ VTHFRGLI
Length:518
Mass (Da):59,962
Last modified:February 6, 2007 - v1
Checksum:i4C670C337098A8B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ976438 Genomic DNA. Translation: ABM46621.1.
RefSeqiXP_004064961.1. XM_004064913.2.

Genome annotation databases

EnsembliENSGGOT00000000032; ENSGGOP00000000031; ENSGGOG00000000032.
GeneIDi101141177.
KEGGiggo:101141177.

Similar proteinsi

Entry informationi

Entry nameiZN449_GORGO
AccessioniPrimary (citable) accession number: A1YEQ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: February 6, 2007
Last modified: August 30, 2017
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families