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A1YEQ3 (ZN449_GORGO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 449
Gene names
Name:ZNF449
OrganismGorilla gorilla gorilla (Lowland gorilla) [Reference proteome]
Taxonomic identifier9595 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla

Protein attributes

Sequence length518 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

May be involved in transcriptional regulation By similarity.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 7 C2H2-type zinc fingers.

Contains 1 SCAN box domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 518518Zinc finger protein 449
PRO_0000285474

Regions

Domain30 – 11283SCAN box
Zinc finger323 – 34523C2H2-type 1
Zinc finger351 – 37323C2H2-type 2
Zinc finger379 – 40123C2H2-type 3
Zinc finger407 – 42923C2H2-type 4
Zinc finger435 – 45723C2H2-type 5
Zinc finger463 – 48523C2H2-type 6
Zinc finger491 – 51323C2H2-type 7

Sequences

Sequence LengthMass (Da)Tools
A1YEQ3 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 4C670C337098A8B9

FASTA51859,962
        10         20         30         40         50         60 
MAVALGCAIQ ASLNQGSVFQ EYDTDCEVFR QRFRQFQYRE AAGPHEAFNK LWELCCQWLK 

        70         80         90        100        110        120 
PKMRSKEQIL ELLVLEQFLT ILPTEIETWV REHCPENRER VVSLIEDLQR ELEIPEQQVD 

       130        140        150        160        170        180 
MHDMLLEELA PVGTAHIPPT MHLESPALQV MGPAQEAPVT EAWIPQAGPP ELNYGATGEC 

       190        200        210        220        230        240 
QNFLDPGYPL PKLDMNFSLE NREEPWVKEL QDSKEMKQLL DSKIGFEIGI ENEEDTSKQK 

       250        260        270        280        290        300 
KMETMYPFIV TLEGNALQGP ILQKDYVQLE NQWETPPEDL QTDLAKLVDQ QNPTLGETPE 

       310        320        330        340        350        360 
NSNLEEPLNP KPHKKKSPGE KPHRCPQCGK CFARKSQLTG HQRIHSGEEP HKCPECGKRF 

       370        380        390        400        410        420 
LRSSDLYRHQ RLHTGERPYE CTVCKKRFTR RSHLIGHQRT HSEEETYKCL ECGKSFCHGS 

       430        440        450        460        470        480 
SLKRHLKTHT GEKPHRCHNC GKSFSRLTAL TLHQRTHTEE RPFKCNYCGK SFRQRPSLVI 

       490        500        510 
HLRIHTGEKP YKCTHCSKSF RQRAGLIMHQ VTHFRGLI 

« Hide

References

[1]"Positive selection in transcription factor genes on the human lineage."
Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ976438 Genomic DNA. Translation: ABM46621.1.
RefSeqXP_004064961.1. XM_004064913.1.

3D structure databases

ProteinModelPortalA1YEQ3.
SMRA1YEQ3. Positions 320-401.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGGOT00000000032; ENSGGOP00000000031; ENSGGOG00000000032.
GeneID101141177.
KEGGggo:101141177.

Organism-specific databases

CTD203523.

Phylogenomic databases

GeneTreeENSGT00730000110971.
HOVERGENHBG018163.
KOK09230.
OMAPWVKELQ.

Family and domain databases

Gene3D3.30.160.60. 7 hits.
InterProIPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF02023. SCAN. 1 hit.
[Graphical view]
SMARTSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMSSF47353. SSF47353. 1 hit.
PROSITEPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameZN449_GORGO
AccessionPrimary (citable) accession number: A1YEQ3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: February 6, 2007
Last modified: February 19, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families