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A1YEQ3

- ZN449_GORGO

UniProt

A1YEQ3 - ZN449_GORGO

Protein

Zinc finger protein 449

Gene

ZNF449

Organism
Gorilla gorilla gorilla (Lowland gorilla)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri323 – 34523C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri351 – 37323C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri379 – 40123C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri407 – 42923C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri435 – 45723C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri463 – 48523C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri491 – 51323C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 449
    Gene namesi
    Name:ZNF449
    OrganismiGorilla gorilla gorilla (Lowland gorilla)
    Taxonomic identifieri9595 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
    ProteomesiUP000001519: Chromosome X

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 518518Zinc finger protein 449PRO_0000285474Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliA1YEQ3.
    SMRiA1YEQ3. Positions 320-401.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 11283SCAN boxPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 SCAN box domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri323 – 34523C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri351 – 37323C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri379 – 40123C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri407 – 42923C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri435 – 45723C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri463 – 48523C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri491 – 51323C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    GeneTreeiENSGT00730000110971.
    HOVERGENiHBG018163.
    KOiK09230.
    OMAiPWVKELQ.

    Family and domain databases

    Gene3Di3.30.160.60. 7 hits.
    InterProiIPR008916. Retrov_capsid_C.
    IPR003309. Tscrpt_reg_SCAN.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF02023. SCAN. 1 hit.
    [Graphical view]
    SMARTiSM00431. SCAN. 1 hit.
    SM00355. ZnF_C2H2. 7 hits.
    [Graphical view]
    SUPFAMiSSF47353. SSF47353. 1 hit.
    PROSITEiPS50804. SCAN_BOX. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 7 hits.
    PS50157. ZINC_FINGER_C2H2_2. 7 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1YEQ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVALGCAIQ ASLNQGSVFQ EYDTDCEVFR QRFRQFQYRE AAGPHEAFNK    50
    LWELCCQWLK PKMRSKEQIL ELLVLEQFLT ILPTEIETWV REHCPENRER 100
    VVSLIEDLQR ELEIPEQQVD MHDMLLEELA PVGTAHIPPT MHLESPALQV 150
    MGPAQEAPVT EAWIPQAGPP ELNYGATGEC QNFLDPGYPL PKLDMNFSLE 200
    NREEPWVKEL QDSKEMKQLL DSKIGFEIGI ENEEDTSKQK KMETMYPFIV 250
    TLEGNALQGP ILQKDYVQLE NQWETPPEDL QTDLAKLVDQ QNPTLGETPE 300
    NSNLEEPLNP KPHKKKSPGE KPHRCPQCGK CFARKSQLTG HQRIHSGEEP 350
    HKCPECGKRF LRSSDLYRHQ RLHTGERPYE CTVCKKRFTR RSHLIGHQRT 400
    HSEEETYKCL ECGKSFCHGS SLKRHLKTHT GEKPHRCHNC GKSFSRLTAL 450
    TLHQRTHTEE RPFKCNYCGK SFRQRPSLVI HLRIHTGEKP YKCTHCSKSF 500
    RQRAGLIMHQ VTHFRGLI 518
    Length:518
    Mass (Da):59,962
    Last modified:February 6, 2007 - v1
    Checksum:i4C670C337098A8B9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ976438 Genomic DNA. Translation: ABM46621.1.
    RefSeqiXP_004064961.1. XM_004064913.1.

    Genome annotation databases

    EnsembliENSGGOT00000000032; ENSGGOP00000000031; ENSGGOG00000000032.
    GeneIDi101141177.
    KEGGiggo:101141177.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ976438 Genomic DNA. Translation: ABM46621.1 .
    RefSeqi XP_004064961.1. XM_004064913.1.

    3D structure databases

    ProteinModelPortali A1YEQ3.
    SMRi A1YEQ3. Positions 320-401.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGGOT00000000032 ; ENSGGOP00000000031 ; ENSGGOG00000000032 .
    GeneIDi 101141177.
    KEGGi ggo:101141177.

    Organism-specific databases

    CTDi 203523.

    Phylogenomic databases

    GeneTreei ENSGT00730000110971.
    HOVERGENi HBG018163.
    KOi K09230.
    OMAi PWVKELQ.

    Family and domain databases

    Gene3Di 3.30.160.60. 7 hits.
    InterProi IPR008916. Retrov_capsid_C.
    IPR003309. Tscrpt_reg_SCAN.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF02023. SCAN. 1 hit.
    [Graphical view ]
    SMARTi SM00431. SCAN. 1 hit.
    SM00355. ZnF_C2H2. 7 hits.
    [Graphical view ]
    SUPFAMi SSF47353. SSF47353. 1 hit.
    PROSITEi PS50804. SCAN_BOX. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 7 hits.
    PS50157. ZINC_FINGER_C2H2_2. 7 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Positive selection in transcription factor genes on the human lineage."
      Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiZN449_GORGO
    AccessioniPrimary (citable) accession number: A1YEQ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3