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A1YEP8 (ZSC12_GORGO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger and SCAN domain-containing protein 12
Alternative name(s):
Zinc finger protein 96
Gene names
Name:ZSCAN12
Synonyms:ZNF96
OrganismGorilla gorilla gorilla (Lowland gorilla) [Reference proteome]
Taxonomic identifier9595 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla

Protein attributes

Sequence length604 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 11 C2H2-type zinc fingers.

Contains 1 SCAN box domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 604604Zinc finger and SCAN domain-containing protein 12
PRO_0000285482

Regions

Domain46 – 12883SCAN box
Zinc finger274 – 29623C2H2-type 1
Zinc finger302 – 32423C2H2-type 2
Zinc finger330 – 35223C2H2-type 3
Zinc finger358 – 38023C2H2-type 4
Zinc finger386 – 40823C2H2-type 5
Zinc finger414 – 43623C2H2-type 6
Zinc finger442 – 46322C2H2-type 7
Zinc finger469 – 49123C2H2-type 8
Zinc finger497 – 51923C2H2-type 9
Zinc finger525 – 54723C2H2-type 10
Zinc finger553 – 57826C2H2-type 11; degenerate

Sequences

Sequence LengthMass (Da)Tools
A1YEP8 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 3377BA01CDEC4406

FASTA60470,176
        10         20         30         40         50         60 
MASTWAIQAH MDQNEPLEVK IEEEKYTTRQ DWDLRKNNTH SREVFRQYFR QFCYQETSGP 

        70         80         90        100        110        120 
REALSRLREL CHQWLRPETH TKEQILELLV LEQFLTILPE ELQAWVQEQH PESGEEVVTV 

       130        140        150        160        170        180 
LEDLERELDE PGEQVSVHTG EQEMFLQEMV PLRKEGEPSM SLQSMKAQPK YESPELESQQ 

       190        200        210        220        230        240 
EQVLDVETGN EYGNLKQEVS EEMEPHGNTS SKFENDMSKS ARCGETREPE EITEEPSACS 

       250        260        270        280        290        300 
REDKQPTCDE NGVSLTENSD HTEHQRICPG EESYGCDDCG KAFSQHSYLI EHQRIHTGDR 

       310        320        330        340        350        360 
PYKCEECGKA FRGRTVLIRH KIIHTGEKPY KCNECGKAFG RWSALNQHQR LHTGEKHYHC 

       370        380        390        400        410        420 
NDCGKAFSQK AGLFHHIKIH TRDKPYQCTQ CNKSFSRRSI LTQHQGVHTG AKPYECNECG 

       430        440        450        460        470        480 
KAFVYNSSLV SHQEIHHKEK CYQCKECGKS FSQSGLIQHQ RIHTGEKPYK CDVCEKAFIQ 

       490        500        510        520        530        540 
RTSLTEHQRI HTGERPYKCD KCGKAFTQRS VLTEHQRIHT GERPYKCDEC GNAFRGITSL 

       550        560        570        580        590        600 
IQHQRIHTGE KPYQCDECGK AFRQRKKTSY KEILLKNHSE PQAGVNLLLS SLIPEWQSCF 


RKDL 

« Hide

References

[1]"Positive selection in transcription factor genes on the human lineage."
Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ976435 Genomic DNA. Translation: ABM46616.1.

3D structure databases

ProteinModelPortalA1YEP8.
SMRA1YEP8. Positions 38-131, 271-381, 383-564.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGGOT00000034595; ENSGGOP00000020304; ENSGGOG00000026544.

Phylogenomic databases

GeneTreeENSGT00750000117455.
HOVERGENHBG018163.
OMAGKAFGRW.

Family and domain databases

Gene3D3.30.160.60. 11 hits.
InterProIPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF02023. SCAN. 1 hit.
[Graphical view]
SMARTSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMSSF47353. SSF47353. 1 hit.
PROSITEPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameZSC12_GORGO
AccessionPrimary (citable) accession number: A1YEP8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: February 6, 2007
Last modified: April 16, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families