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Protein

Zinc finger and SCAN domain-containing protein 12

Gene

ZSCAN12

Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri274 – 29623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri302 – 32423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri330 – 35223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri358 – 38023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri386 – 40823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri414 – 43623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri442 – 46322C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri469 – 49123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri497 – 51923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri525 – 54723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri553 – 57826C2H2-type 11; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 12
Alternative name(s):
Zinc finger protein 96
Gene namesi
Name:ZSCAN12
Synonyms:ZNF96
OrganismiGorilla gorilla gorilla (Western lowland gorilla)
Taxonomic identifieri9595 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
ProteomesiUP000001519 Componenti: Chromosome 6

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 604604Zinc finger and SCAN domain-containing protein 12PRO_0000285482Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA1YEP8.
SMRiA1YEP8. Positions 38-131, 271-381, 383-564.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 12883SCAN boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri274 – 29623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri302 – 32423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri330 – 35223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri358 – 38023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri386 – 40823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri414 – 43623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri442 – 46322C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri469 – 49123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri497 – 51923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri525 – 54723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri553 – 57826C2H2-type 11; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00760000118881.
HOVERGENiHBG018163.
InParanoidiA1YEP8.
OMAiSLIPEWQ.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1YEP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTWAIQAH MDQNEPLEVK IEEEKYTTRQ DWDLRKNNTH SREVFRQYFR
60 70 80 90 100
QFCYQETSGP REALSRLREL CHQWLRPETH TKEQILELLV LEQFLTILPE
110 120 130 140 150
ELQAWVQEQH PESGEEVVTV LEDLERELDE PGEQVSVHTG EQEMFLQEMV
160 170 180 190 200
PLRKEGEPSM SLQSMKAQPK YESPELESQQ EQVLDVETGN EYGNLKQEVS
210 220 230 240 250
EEMEPHGNTS SKFENDMSKS ARCGETREPE EITEEPSACS REDKQPTCDE
260 270 280 290 300
NGVSLTENSD HTEHQRICPG EESYGCDDCG KAFSQHSYLI EHQRIHTGDR
310 320 330 340 350
PYKCEECGKA FRGRTVLIRH KIIHTGEKPY KCNECGKAFG RWSALNQHQR
360 370 380 390 400
LHTGEKHYHC NDCGKAFSQK AGLFHHIKIH TRDKPYQCTQ CNKSFSRRSI
410 420 430 440 450
LTQHQGVHTG AKPYECNECG KAFVYNSSLV SHQEIHHKEK CYQCKECGKS
460 470 480 490 500
FSQSGLIQHQ RIHTGEKPYK CDVCEKAFIQ RTSLTEHQRI HTGERPYKCD
510 520 530 540 550
KCGKAFTQRS VLTEHQRIHT GERPYKCDEC GNAFRGITSL IQHQRIHTGE
560 570 580 590 600
KPYQCDECGK AFRQRKKTSY KEILLKNHSE PQAGVNLLLS SLIPEWQSCF

RKDL
Length:604
Mass (Da):70,176
Last modified:February 6, 2007 - v1
Checksum:i3377BA01CDEC4406
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ976435 Genomic DNA. Translation: ABM46616.1.

Genome annotation databases

EnsembliENSGGOT00000034595; ENSGGOP00000020304; ENSGGOG00000026544.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ976435 Genomic DNA. Translation: ABM46616.1.

3D structure databases

ProteinModelPortaliA1YEP8.
SMRiA1YEP8. Positions 38-131, 271-381, 383-564.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGGOT00000034595; ENSGGOP00000020304; ENSGGOG00000026544.

Phylogenomic databases

GeneTreeiENSGT00760000118881.
HOVERGENiHBG018163.
InParanoidiA1YEP8.
OMAiSLIPEWQ.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Positive selection in transcription factor genes on the human lineage."
    Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiZSC12_GORGO
AccessioniPrimary (citable) accession number: A1YEP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: February 6, 2007
Last modified: July 22, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.