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A1YEP8

- ZSC12_GORGO

UniProt

A1YEP8 - ZSC12_GORGO

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Protein
Zinc finger and SCAN domain-containing protein 12
Gene
ZSCAN12, ZNF96
Organism
Gorilla gorilla gorilla (Lowland gorilla)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri274 – 29623C2H2-type 1
Add
BLAST
Zinc fingeri302 – 32423C2H2-type 2
Add
BLAST
Zinc fingeri330 – 35223C2H2-type 3
Add
BLAST
Zinc fingeri358 – 38023C2H2-type 4
Add
BLAST
Zinc fingeri386 – 40823C2H2-type 5
Add
BLAST
Zinc fingeri414 – 43623C2H2-type 6
Add
BLAST
Zinc fingeri442 – 46322C2H2-type 7
Add
BLAST
Zinc fingeri469 – 49123C2H2-type 8
Add
BLAST
Zinc fingeri497 – 51923C2H2-type 9
Add
BLAST
Zinc fingeri525 – 54723C2H2-type 10
Add
BLAST
Zinc fingeri553 – 57826C2H2-type 11; degenerate
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 12
Alternative name(s):
Zinc finger protein 96
Gene namesi
Name:ZSCAN12
Synonyms:ZNF96
OrganismiGorilla gorilla gorilla (Lowland gorilla)
Taxonomic identifieri9595 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
ProteomesiUP000001519: Chromosome 6

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 604604Zinc finger and SCAN domain-containing protein 12
PRO_0000285482Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA1YEP8.
SMRiA1YEP8. Positions 38-131, 271-381, 383-564.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 12883SCAN box
Add
BLAST

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.
Contains 1 SCAN box domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00750000117455.
HOVERGENiHBG018163.
OMAiGKAFGRW.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1YEP8-1 [UniParc]FASTAAdd to Basket

« Hide

MASTWAIQAH MDQNEPLEVK IEEEKYTTRQ DWDLRKNNTH SREVFRQYFR    50
QFCYQETSGP REALSRLREL CHQWLRPETH TKEQILELLV LEQFLTILPE 100
ELQAWVQEQH PESGEEVVTV LEDLERELDE PGEQVSVHTG EQEMFLQEMV 150
PLRKEGEPSM SLQSMKAQPK YESPELESQQ EQVLDVETGN EYGNLKQEVS 200
EEMEPHGNTS SKFENDMSKS ARCGETREPE EITEEPSACS REDKQPTCDE 250
NGVSLTENSD HTEHQRICPG EESYGCDDCG KAFSQHSYLI EHQRIHTGDR 300
PYKCEECGKA FRGRTVLIRH KIIHTGEKPY KCNECGKAFG RWSALNQHQR 350
LHTGEKHYHC NDCGKAFSQK AGLFHHIKIH TRDKPYQCTQ CNKSFSRRSI 400
LTQHQGVHTG AKPYECNECG KAFVYNSSLV SHQEIHHKEK CYQCKECGKS 450
FSQSGLIQHQ RIHTGEKPYK CDVCEKAFIQ RTSLTEHQRI HTGERPYKCD 500
KCGKAFTQRS VLTEHQRIHT GERPYKCDEC GNAFRGITSL IQHQRIHTGE 550
KPYQCDECGK AFRQRKKTSY KEILLKNHSE PQAGVNLLLS SLIPEWQSCF 600
RKDL 604
Length:604
Mass (Da):70,176
Last modified:February 6, 2007 - v1
Checksum:i3377BA01CDEC4406
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ976435 Genomic DNA. Translation: ABM46616.1.

Genome annotation databases

EnsembliENSGGOT00000034595; ENSGGOP00000020304; ENSGGOG00000026544.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ976435 Genomic DNA. Translation: ABM46616.1 .

3D structure databases

ProteinModelPortali A1YEP8.
SMRi A1YEP8. Positions 38-131, 271-381, 383-564.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGGOT00000034595 ; ENSGGOP00000020304 ; ENSGGOG00000026544 .

Phylogenomic databases

GeneTreei ENSGT00750000117455.
HOVERGENi HBG018163.
OMAi GKAFGRW.

Family and domain databases

Gene3Di 3.30.160.60. 11 hits.
InterProi IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF02023. SCAN. 1 hit.
[Graphical view ]
SMARTi SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view ]
SUPFAMi SSF47353. SSF47353. 1 hit.
PROSITEi PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Positive selection in transcription factor genes on the human lineage."
    Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiZSC12_GORGO
AccessioniPrimary (citable) accession number: A1YEP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: February 6, 2007
Last modified: April 16, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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