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A1YEP8

- ZSC12_GORGO

UniProt

A1YEP8 - ZSC12_GORGO

Protein

Zinc finger and SCAN domain-containing protein 12

Gene

ZSCAN12

Organism
Gorilla gorilla gorilla (Lowland gorilla)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri274 – 29623C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri302 – 32423C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri330 – 35223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri358 – 38023C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri386 – 40823C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri414 – 43623C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri442 – 46322C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri469 – 49123C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri497 – 51923C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri525 – 54723C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri553 – 57826C2H2-type 11; degeneratePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger and SCAN domain-containing protein 12
    Alternative name(s):
    Zinc finger protein 96
    Gene namesi
    Name:ZSCAN12
    Synonyms:ZNF96
    OrganismiGorilla gorilla gorilla (Lowland gorilla)
    Taxonomic identifieri9595 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
    ProteomesiUP000001519: Chromosome 6

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 604604Zinc finger and SCAN domain-containing protein 12PRO_0000285482Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliA1YEP8.
    SMRiA1YEP8. Positions 38-131, 271-381, 383-564.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 12883SCAN boxPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 SCAN box domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri274 – 29623C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri302 – 32423C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri330 – 35223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri358 – 38023C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri386 – 40823C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri414 – 43623C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri442 – 46322C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri469 – 49123C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri497 – 51923C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri525 – 54723C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri553 – 57826C2H2-type 11; degeneratePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    GeneTreeiENSGT00750000117455.
    HOVERGENiHBG018163.
    OMAiGKAFGRW.

    Family and domain databases

    Gene3Di3.30.160.60. 11 hits.
    InterProiIPR008916. Retrov_capsid_C.
    IPR003309. Tscrpt_reg_SCAN.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF02023. SCAN. 1 hit.
    [Graphical view]
    SMARTiSM00431. SCAN. 1 hit.
    SM00355. ZnF_C2H2. 10 hits.
    [Graphical view]
    SUPFAMiSSF47353. SSF47353. 1 hit.
    PROSITEiPS50804. SCAN_BOX. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 9 hits.
    PS50157. ZINC_FINGER_C2H2_2. 11 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1YEP8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASTWAIQAH MDQNEPLEVK IEEEKYTTRQ DWDLRKNNTH SREVFRQYFR    50
    QFCYQETSGP REALSRLREL CHQWLRPETH TKEQILELLV LEQFLTILPE 100
    ELQAWVQEQH PESGEEVVTV LEDLERELDE PGEQVSVHTG EQEMFLQEMV 150
    PLRKEGEPSM SLQSMKAQPK YESPELESQQ EQVLDVETGN EYGNLKQEVS 200
    EEMEPHGNTS SKFENDMSKS ARCGETREPE EITEEPSACS REDKQPTCDE 250
    NGVSLTENSD HTEHQRICPG EESYGCDDCG KAFSQHSYLI EHQRIHTGDR 300
    PYKCEECGKA FRGRTVLIRH KIIHTGEKPY KCNECGKAFG RWSALNQHQR 350
    LHTGEKHYHC NDCGKAFSQK AGLFHHIKIH TRDKPYQCTQ CNKSFSRRSI 400
    LTQHQGVHTG AKPYECNECG KAFVYNSSLV SHQEIHHKEK CYQCKECGKS 450
    FSQSGLIQHQ RIHTGEKPYK CDVCEKAFIQ RTSLTEHQRI HTGERPYKCD 500
    KCGKAFTQRS VLTEHQRIHT GERPYKCDEC GNAFRGITSL IQHQRIHTGE 550
    KPYQCDECGK AFRQRKKTSY KEILLKNHSE PQAGVNLLLS SLIPEWQSCF 600
    RKDL 604
    Length:604
    Mass (Da):70,176
    Last modified:February 6, 2007 - v1
    Checksum:i3377BA01CDEC4406
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ976435 Genomic DNA. Translation: ABM46616.1.

    Genome annotation databases

    EnsembliENSGGOT00000034595; ENSGGOP00000020304; ENSGGOG00000026544.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ976435 Genomic DNA. Translation: ABM46616.1 .

    3D structure databases

    ProteinModelPortali A1YEP8.
    SMRi A1YEP8. Positions 38-131, 271-381, 383-564.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGGOT00000034595 ; ENSGGOP00000020304 ; ENSGGOG00000026544 .

    Phylogenomic databases

    GeneTreei ENSGT00750000117455.
    HOVERGENi HBG018163.
    OMAi GKAFGRW.

    Family and domain databases

    Gene3Di 3.30.160.60. 11 hits.
    InterProi IPR008916. Retrov_capsid_C.
    IPR003309. Tscrpt_reg_SCAN.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF02023. SCAN. 1 hit.
    [Graphical view ]
    SMARTi SM00431. SCAN. 1 hit.
    SM00355. ZnF_C2H2. 10 hits.
    [Graphical view ]
    SUPFAMi SSF47353. SSF47353. 1 hit.
    PROSITEi PS50804. SCAN_BOX. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 9 hits.
    PS50157. ZINC_FINGER_C2H2_2. 11 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Positive selection in transcription factor genes on the human lineage."
      Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiZSC12_GORGO
    AccessioniPrimary (citable) accession number: A1YEP8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3