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A1XSY8

- EGR2_PIG

UniProt

A1XSY8 - EGR2_PIG

Protein

E3 SUMO-protein ligase EGR2

Gene

EGR2

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. Binds to the promoter region of ERBB2 By similarity.By similarity
    E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity.By similarity

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri335 – 35925C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri365 – 38723C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri393 – 41523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: UniProtKB
    2. ligase activity Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW
    4. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    5. transcription regulatory region DNA binding Source: UniProtKB

    GO - Biological processi

    1. brain segmentation Source: Ensembl
    2. cellular response to organic substance Source: Ensembl
    3. facial nerve structural organization Source: Ensembl
    4. fat cell differentiation Source: Ensembl
    5. motor neuron axon guidance Source: Ensembl
    6. myelination Source: Ensembl
    7. positive regulation of transcription, DNA-templated Source: UniProtKB
    8. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    9. protein export from nucleus Source: UniProtKB
    10. protein sumoylation Source: UniProtKB-UniPathway
    11. regulation of ossification Source: Ensembl
    12. rhombomere 3 formation Source: Ensembl
    13. rhombomere 5 formation Source: Ensembl
    14. rhythmic behavior Source: Ensembl
    15. Schwann cell differentiation Source: Ensembl
    16. skeletal muscle cell differentiation Source: Ensembl
    17. transcription from RNA polymerase II promoter Source: Ensembl

    Keywords - Molecular functioni

    Activator, Ligase

    Keywords - Biological processi

    Transcription, Transcription regulation, Ubl conjugation pathway

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_225818. Transcriptional regulation of white adipocyte differentiation.
    UniPathwayiUPA00886.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    E3 SUMO-protein ligase EGR2 (EC:6.3.2.-)
    Alternative name(s):
    Early growth response protein 2
    Short name:
    EGR-2
    Gene namesi
    Name:EGR2
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Chromosome 14

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 471471E3 SUMO-protein ligase EGR2PRO_0000296388Add
    BLAST

    Post-translational modificationi

    Ubiquitinated by WWP2 leading to proteasomal degradation.By similarity

    Keywords - PTMi

    Ubl conjugation

    Interactioni

    Subunit structurei

    Interacts with HCFC1. Interacts with WWP2. Interacts with CITED1. Interacts (via phosphorylated form) with SFN. Interacts with UBC9 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000010899.

    Structurei

    3D structure databases

    ProteinModelPortaliA1XSY8.
    SMRiA1XSY8. Positions 332-418.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi167 – 338172Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri335 – 35925C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri365 – 38723C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri393 – 41523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    GeneTreeiENSGT00550000074455.
    HOGENOMiHOG000036856.
    HOVERGENiHBG003909.
    KOiK12496.
    OMAiNPEGVIN.
    OrthoDBiEOG7Z69C7.
    TreeFamiTF318980.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR021849. DUF3446.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF11928. DUF3446. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1XSY8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMTAKAVDKI PVTLSGFVHQ LSDNIYPVED LAATSVTIFP NAELGSPFDQ    50
    MNGVAGDGMI NIDMTGEKRS LDLPYPSSFA PVSAPRNQTF TYMGKFSIDP 100
    QYPGASCYPE GIINIVSAGI LQGVTSPAST TASSNVTSAS PNPLATGPLG 150
    VCTMSQTQPD LDHLYSPPPP PPYSGCAGDL YQDPSAFLSA ATTSTSSSLA 200
    YPPPPSYPSP KPATDPGLFP MIPDYPGFFP SQCQRDLHGT AGPDRKPFPC 250
    PLDSLRVPPP LTPLSTIRNF TLGGPSAGTT GPGASGGSEG PRLPGSSAAA 300
    AAAAYNPHHL PLRPILRPRK YPNRPSKTPV HERPYPCPAE GCDRRFSRSD 350
    ELTRHIRIHT GHKPFQCRIC MRNFSRSDHL TTHIRTHTGE KPFACDYCGR 400
    KFARSDERKR HTKIHLRQKE RKSSAPSSSV PAASTASCTG GAQPGGPLCS 450
    SNSSTIGGGS LGPCSSRTRT P 471
    Length:471
    Mass (Da):49,911
    Last modified:February 6, 2007 - v1
    Checksum:i9C073404B9EB86A0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ665829 mRNA. Translation: ABG49107.1.
    RefSeqiNP_001090957.1. NM_001097488.1.
    UniGeneiSsc.51140.

    Genome annotation databases

    EnsembliENSSSCT00000011190; ENSSSCP00000010899; ENSSSCG00000010224.
    GeneIDi100038004.
    KEGGissc:100038004.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ665829 mRNA. Translation: ABG49107.1 .
    RefSeqi NP_001090957.1. NM_001097488.1.
    UniGenei Ssc.51140.

    3D structure databases

    ProteinModelPortali A1XSY8.
    SMRi A1XSY8. Positions 332-418.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9823.ENSSSCP00000010899.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSSSCT00000011190 ; ENSSSCP00000010899 ; ENSSSCG00000010224 .
    GeneIDi 100038004.
    KEGGi ssc:100038004.

    Organism-specific databases

    CTDi 1959.

    Phylogenomic databases

    eggNOGi COG5048.
    GeneTreei ENSGT00550000074455.
    HOGENOMi HOG000036856.
    HOVERGENi HBG003909.
    KOi K12496.
    OMAi NPEGVIN.
    OrthoDBi EOG7Z69C7.
    TreeFami TF318980.

    Enzyme and pathway databases

    UniPathwayi UPA00886 .
    Reactomei REACT_225818. Transcriptional regulation of white adipocyte differentiation.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR021849. DUF3446.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF11928. DUF3446. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, chromosome mapping and expression characteristics of porcine KLF4, KLF5, KLF7 and EGR2."
      Yang H.W., Yang Z.Q.
      Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiEGR2_PIG
    AccessioniPrimary (citable) accession number: A1XSY8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3