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Protein

E3 SUMO-protein ligase EGR2

Gene

EGR2

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. Binds to the promoter region of ERBB2 (By similarity).By similarity
E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity.By similarity

Pathwayi: protein sumoylation

This protein is involved in the pathway protein sumoylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein sumoylation and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri335 – 359C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri365 – 387C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Ligase
Biological processTranscription, Transcription regulation, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00886.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 SUMO-protein ligase EGR2 (EC:6.3.2.-)
Alternative name(s):
Early growth response protein 2
Short name:
EGR-2
Gene namesi
Name:EGR2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 14

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002963881 – 471E3 SUMO-protein ligase EGR2Add BLAST471

Post-translational modificationi

Ubiquitinated by WWP2 leading to proteasomal degradation.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiA1XSY8.

Expressioni

Gene expression databases

BgeeiENSSSCG00000010224.

Interactioni

Subunit structurei

Interacts with HCFC1. Interacts with WWP2. Interacts with CITED1. Interacts (via phosphorylated form) with SFN. Interacts with UBC9 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000010899.

Structurei

3D structure databases

ProteinModelPortaliA1XSY8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi167 – 338Pro-richAdd BLAST172

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri335 – 359C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri365 – 387C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00550000074455.
HOGENOMiHOG000036856.
HOVERGENiHBG003909.
InParanoidiA1XSY8.
KOiK12496.
OMAiFPPQCQR.
OrthoDBiEOG091G06VX.
TreeFamiTF318980.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR021849. DUF3446.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF11928. DUF3446. 1 hit.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 3 hits.
SUPFAMiSSF57667. SSF57667. 2 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.

Sequencei

Sequence statusi: Complete.

A1XSY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTAKAVDKI PVTLSGFVHQ LSDNIYPVED LAATSVTIFP NAELGSPFDQ
60 70 80 90 100
MNGVAGDGMI NIDMTGEKRS LDLPYPSSFA PVSAPRNQTF TYMGKFSIDP
110 120 130 140 150
QYPGASCYPE GIINIVSAGI LQGVTSPAST TASSNVTSAS PNPLATGPLG
160 170 180 190 200
VCTMSQTQPD LDHLYSPPPP PPYSGCAGDL YQDPSAFLSA ATTSTSSSLA
210 220 230 240 250
YPPPPSYPSP KPATDPGLFP MIPDYPGFFP SQCQRDLHGT AGPDRKPFPC
260 270 280 290 300
PLDSLRVPPP LTPLSTIRNF TLGGPSAGTT GPGASGGSEG PRLPGSSAAA
310 320 330 340 350
AAAAYNPHHL PLRPILRPRK YPNRPSKTPV HERPYPCPAE GCDRRFSRSD
360 370 380 390 400
ELTRHIRIHT GHKPFQCRIC MRNFSRSDHL TTHIRTHTGE KPFACDYCGR
410 420 430 440 450
KFARSDERKR HTKIHLRQKE RKSSAPSSSV PAASTASCTG GAQPGGPLCS
460 470
SNSSTIGGGS LGPCSSRTRT P
Length:471
Mass (Da):49,911
Last modified:February 6, 2007 - v1
Checksum:i9C073404B9EB86A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ665829 mRNA. Translation: ABG49107.1.
RefSeqiNP_001090957.1. NM_001097488.1.
UniGeneiSsc.51140.

Genome annotation databases

EnsembliENSSSCT00000011190; ENSSSCP00000010899; ENSSSCG00000010224.
GeneIDi100038004.
KEGGissc:100038004.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiEGR2_PIG
AccessioniPrimary (citable) accession number: A1XSY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: February 6, 2007
Last modified: June 7, 2017
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families