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A1XSY8 (EGR2_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
E3 SUMO-protein ligase EGR2

EC=6.3.2.-
Alternative name(s):
Early growth response protein 2
Short name=EGR-2
Gene names
Name:EGR2
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length471 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. Binds to the promoter region of ERBB2 By similarity.

E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity By similarity.

Pathway

Protein modification; protein sumoylation.

Subunit structure

Interacts with HCFC1. Interacts with WWP2. Interacts with CITED1. Interacts (via phosphorylated form) with SFN. Interacts with UBC9 By similarity.

Subcellular location

Nucleus By similarity.

Post-translational modification

Ubiquitinated by WWP2 leading to proteasomal degradation By similarity.

Sequence similarities

Belongs to the EGR C2H2-type zinc-finger protein family.

Contains 3 C2H2-type zinc fingers.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
Ubl conjugation pathway
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionActivator
Ligase
   PTMUbl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processSchwann cell differentiation

Inferred from electronic annotation. Source: Ensembl

brain segmentation

Inferred from electronic annotation. Source: Ensembl

cellular response to organic substance

Inferred from electronic annotation. Source: Ensembl

facial nerve structural organization

Inferred from electronic annotation. Source: Ensembl

fat cell differentiation

Inferred from electronic annotation. Source: Ensembl

motor neuron axon guidance

Inferred from electronic annotation. Source: Ensembl

myelination

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription, DNA-templated

Inferred from sequence or structural similarity. Source: UniProtKB

protein export from nucleus

Inferred from sequence or structural similarity. Source: UniProtKB

protein sumoylation

Inferred from electronic annotation. Source: UniProtKB-UniPathway

regulation of ossification

Inferred from electronic annotation. Source: Ensembl

rhombomere 3 formation

Inferred from electronic annotation. Source: Ensembl

rhombomere 5 formation

Inferred from electronic annotation. Source: Ensembl

rhythmic behavior

Inferred from electronic annotation. Source: Ensembl

skeletal muscle cell differentiation

Inferred from electronic annotation. Source: Ensembl

transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

nucleus

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionchromatin binding

Inferred from sequence or structural similarity. Source: UniProtKB

ligase activity

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding transcription factor activity

Inferred from sequence or structural similarity. Source: UniProtKB

transcription regulatory region DNA binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 471471E3 SUMO-protein ligase EGR2
PRO_0000296388

Regions

Zinc finger335 – 35925C2H2-type 1
Zinc finger365 – 38723C2H2-type 2
Zinc finger393 – 41523C2H2-type 3
Compositional bias167 – 338172Pro-rich

Sequences

Sequence LengthMass (Da)Tools
A1XSY8 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 9C073404B9EB86A0

FASTA47149,911
        10         20         30         40         50         60 
MMTAKAVDKI PVTLSGFVHQ LSDNIYPVED LAATSVTIFP NAELGSPFDQ MNGVAGDGMI 

        70         80         90        100        110        120 
NIDMTGEKRS LDLPYPSSFA PVSAPRNQTF TYMGKFSIDP QYPGASCYPE GIINIVSAGI 

       130        140        150        160        170        180 
LQGVTSPAST TASSNVTSAS PNPLATGPLG VCTMSQTQPD LDHLYSPPPP PPYSGCAGDL 

       190        200        210        220        230        240 
YQDPSAFLSA ATTSTSSSLA YPPPPSYPSP KPATDPGLFP MIPDYPGFFP SQCQRDLHGT 

       250        260        270        280        290        300 
AGPDRKPFPC PLDSLRVPPP LTPLSTIRNF TLGGPSAGTT GPGASGGSEG PRLPGSSAAA 

       310        320        330        340        350        360 
AAAAYNPHHL PLRPILRPRK YPNRPSKTPV HERPYPCPAE GCDRRFSRSD ELTRHIRIHT 

       370        380        390        400        410        420 
GHKPFQCRIC MRNFSRSDHL TTHIRTHTGE KPFACDYCGR KFARSDERKR HTKIHLRQKE 

       430        440        450        460        470 
RKSSAPSSSV PAASTASCTG GAQPGGPLCS SNSSTIGGGS LGPCSSRTRT P 

« Hide

References

[1]"Cloning, chromosome mapping and expression characteristics of porcine KLF4, KLF5, KLF7 and EGR2."
Yang H.W., Yang Z.Q.
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ665829 mRNA. Translation: ABG49107.1.
RefSeqNP_001090957.1. NM_001097488.1.
UniGeneSsc.51140.

3D structure databases

ProteinModelPortalA1XSY8.
SMRA1XSY8. Positions 332-418.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9823.ENSSSCP00000010899.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSSSCT00000011190; ENSSSCP00000010899; ENSSSCG00000010224.
GeneID100038004.
KEGGssc:100038004.

Organism-specific databases

CTD1959.

Phylogenomic databases

eggNOGCOG5048.
GeneTreeENSGT00550000074455.
HOGENOMHOG000036856.
HOVERGENHBG003909.
KOK12496.
OMANPEGVIN.
OrthoDBEOG7Z69C7.
TreeFamTF318980.

Enzyme and pathway databases

UniPathwayUPA00886.

Family and domain databases

Gene3D3.30.160.60. 3 hits.
InterProIPR021849. DUF3446.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF11928. DUF3446. 1 hit.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameEGR2_PIG
AccessionPrimary (citable) accession number: A1XSY8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: February 6, 2007
Last modified: February 19, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways