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Protein

E3 SUMO-protein ligase EGR2

Gene

EGR2

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. Binds to the promoter region of ERBB2 (By similarity).By similarity
E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity.By similarity

Pathway:iprotein sumoylation

This protein is involved in the pathway protein sumoylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein sumoylation and in Protein modification.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri335 – 35925C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri365 – 38723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri393 – 41523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Ligase

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00886.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 SUMO-protein ligase EGR2 (EC:6.3.2.-)
Alternative name(s):
Early growth response protein 2
Short name:
EGR-2
Gene namesi
Name:EGR2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227 Componenti: Chromosome 14

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 471471E3 SUMO-protein ligase EGR2PRO_0000296388Add
BLAST

Post-translational modificationi

Ubiquitinated by WWP2 leading to proteasomal degradation.By similarity

Keywords - PTMi

Ubl conjugation

Interactioni

Subunit structurei

Interacts with HCFC1. Interacts with WWP2. Interacts with CITED1. Interacts (via phosphorylated form) with SFN. Interacts with UBC9 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000010899.

Structurei

3D structure databases

ProteinModelPortaliA1XSY8.
SMRiA1XSY8. Positions 332-418.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi167 – 338172Pro-richAdd
BLAST

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri335 – 35925C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri365 – 38723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri393 – 41523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00550000074455.
HOGENOMiHOG000036856.
HOVERGENiHBG003909.
InParanoidiA1XSY8.
KOiK12496.
OMAiNPEGVIN.
OrthoDBiEOG7Z69C7.
TreeFamiTF318980.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR021849. DUF3446.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF11928. DUF3446. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1XSY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTAKAVDKI PVTLSGFVHQ LSDNIYPVED LAATSVTIFP NAELGSPFDQ
60 70 80 90 100
MNGVAGDGMI NIDMTGEKRS LDLPYPSSFA PVSAPRNQTF TYMGKFSIDP
110 120 130 140 150
QYPGASCYPE GIINIVSAGI LQGVTSPAST TASSNVTSAS PNPLATGPLG
160 170 180 190 200
VCTMSQTQPD LDHLYSPPPP PPYSGCAGDL YQDPSAFLSA ATTSTSSSLA
210 220 230 240 250
YPPPPSYPSP KPATDPGLFP MIPDYPGFFP SQCQRDLHGT AGPDRKPFPC
260 270 280 290 300
PLDSLRVPPP LTPLSTIRNF TLGGPSAGTT GPGASGGSEG PRLPGSSAAA
310 320 330 340 350
AAAAYNPHHL PLRPILRPRK YPNRPSKTPV HERPYPCPAE GCDRRFSRSD
360 370 380 390 400
ELTRHIRIHT GHKPFQCRIC MRNFSRSDHL TTHIRTHTGE KPFACDYCGR
410 420 430 440 450
KFARSDERKR HTKIHLRQKE RKSSAPSSSV PAASTASCTG GAQPGGPLCS
460 470
SNSSTIGGGS LGPCSSRTRT P
Length:471
Mass (Da):49,911
Last modified:February 6, 2007 - v1
Checksum:i9C073404B9EB86A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ665829 mRNA. Translation: ABG49107.1.
RefSeqiNP_001090957.1. NM_001097488.1.
UniGeneiSsc.51140.

Genome annotation databases

EnsembliENSSSCT00000011190; ENSSSCP00000010899; ENSSSCG00000010224.
GeneIDi100038004.
KEGGissc:100038004.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ665829 mRNA. Translation: ABG49107.1.
RefSeqiNP_001090957.1. NM_001097488.1.
UniGeneiSsc.51140.

3D structure databases

ProteinModelPortaliA1XSY8.
SMRiA1XSY8. Positions 332-418.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000010899.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000011190; ENSSSCP00000010899; ENSSSCG00000010224.
GeneIDi100038004.
KEGGissc:100038004.

Organism-specific databases

CTDi1959.

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00550000074455.
HOGENOMiHOG000036856.
HOVERGENiHBG003909.
InParanoidiA1XSY8.
KOiK12496.
OMAiNPEGVIN.
OrthoDBiEOG7Z69C7.
TreeFamiTF318980.

Enzyme and pathway databases

UniPathwayiUPA00886.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR021849. DUF3446.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF11928. DUF3446. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning, chromosome mapping and expression characteristics of porcine KLF4, KLF5, KLF7 and EGR2."
    Yang H.W., Yang Z.Q.
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiEGR2_PIG
AccessioniPrimary (citable) accession number: A1XSY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: February 6, 2007
Last modified: June 24, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.