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A1XSY8

- EGR2_PIG

UniProt

A1XSY8 - EGR2_PIG

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Protein
E3 SUMO-protein ligase EGR2
Gene
EGR2
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. Binds to the promoter region of ERBB2 By similarity.
E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity By similarity.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri335 – 35925C2H2-type 1
Add
BLAST
Zinc fingeri365 – 38723C2H2-type 2
Add
BLAST
Zinc fingeri393 – 41523C2H2-type 3
Add
BLAST

GO - Molecular functioni

  1. chromatin binding Source: UniProtKB
  2. ligase activity Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
  4. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  5. transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  1. Schwann cell differentiation Source: Ensembl
  2. brain segmentation Source: Ensembl
  3. cellular response to organic substance Source: Ensembl
  4. facial nerve structural organization Source: Ensembl
  5. fat cell differentiation Source: Ensembl
  6. motor neuron axon guidance Source: Ensembl
  7. myelination Source: Ensembl
  8. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  9. positive regulation of transcription, DNA-templated Source: UniProtKB
  10. protein export from nucleus Source: UniProtKB
  11. protein sumoylation Source: UniProtKB-UniPathway
  12. regulation of ossification Source: Ensembl
  13. rhombomere 3 formation Source: Ensembl
  14. rhombomere 5 formation Source: Ensembl
  15. rhythmic behavior Source: Ensembl
  16. skeletal muscle cell differentiation Source: Ensembl
  17. transcription from RNA polymerase II promoter Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Activator, Ligase

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_225818. Transcriptional regulation of white adipocyte differentiation.
UniPathwayiUPA00886.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 SUMO-protein ligase EGR2 (EC:6.3.2.-)
Alternative name(s):
Early growth response protein 2
Short name:
EGR-2
Gene namesi
Name:EGR2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 14

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 471471E3 SUMO-protein ligase EGR2
PRO_0000296388Add
BLAST

Post-translational modificationi

Ubiquitinated by WWP2 leading to proteasomal degradation By similarity.

Keywords - PTMi

Ubl conjugation

Interactioni

Subunit structurei

Interacts with HCFC1. Interacts with WWP2. Interacts with CITED1. Interacts (via phosphorylated form) with SFN. Interacts with UBC9 By similarity.

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000010899.

Structurei

3D structure databases

ProteinModelPortaliA1XSY8.
SMRiA1XSY8. Positions 332-418.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi167 – 338172Pro-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00550000074455.
HOGENOMiHOG000036856.
HOVERGENiHBG003909.
KOiK12496.
OMAiNPEGVIN.
OrthoDBiEOG7Z69C7.
TreeFamiTF318980.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR021849. DUF3446.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF11928. DUF3446. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1XSY8-1 [UniParc]FASTAAdd to Basket

« Hide

MMTAKAVDKI PVTLSGFVHQ LSDNIYPVED LAATSVTIFP NAELGSPFDQ    50
MNGVAGDGMI NIDMTGEKRS LDLPYPSSFA PVSAPRNQTF TYMGKFSIDP 100
QYPGASCYPE GIINIVSAGI LQGVTSPAST TASSNVTSAS PNPLATGPLG 150
VCTMSQTQPD LDHLYSPPPP PPYSGCAGDL YQDPSAFLSA ATTSTSSSLA 200
YPPPPSYPSP KPATDPGLFP MIPDYPGFFP SQCQRDLHGT AGPDRKPFPC 250
PLDSLRVPPP LTPLSTIRNF TLGGPSAGTT GPGASGGSEG PRLPGSSAAA 300
AAAAYNPHHL PLRPILRPRK YPNRPSKTPV HERPYPCPAE GCDRRFSRSD 350
ELTRHIRIHT GHKPFQCRIC MRNFSRSDHL TTHIRTHTGE KPFACDYCGR 400
KFARSDERKR HTKIHLRQKE RKSSAPSSSV PAASTASCTG GAQPGGPLCS 450
SNSSTIGGGS LGPCSSRTRT P 471
Length:471
Mass (Da):49,911
Last modified:February 6, 2007 - v1
Checksum:i9C073404B9EB86A0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ665829 mRNA. Translation: ABG49107.1.
RefSeqiNP_001090957.1. NM_001097488.1.
UniGeneiSsc.51140.

Genome annotation databases

EnsembliENSSSCT00000011190; ENSSSCP00000010899; ENSSSCG00000010224.
GeneIDi100038004.
KEGGissc:100038004.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ665829 mRNA. Translation: ABG49107.1 .
RefSeqi NP_001090957.1. NM_001097488.1.
UniGenei Ssc.51140.

3D structure databases

ProteinModelPortali A1XSY8.
SMRi A1XSY8. Positions 332-418.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000010899.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSSSCT00000011190 ; ENSSSCP00000010899 ; ENSSSCG00000010224 .
GeneIDi 100038004.
KEGGi ssc:100038004.

Organism-specific databases

CTDi 1959.

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00550000074455.
HOGENOMi HOG000036856.
HOVERGENi HBG003909.
KOi K12496.
OMAi NPEGVIN.
OrthoDBi EOG7Z69C7.
TreeFami TF318980.

Enzyme and pathway databases

UniPathwayi UPA00886 .
Reactomei REACT_225818. Transcriptional regulation of white adipocyte differentiation.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
InterProi IPR021849. DUF3446.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF11928. DUF3446. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 3 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning, chromosome mapping and expression characteristics of porcine KLF4, KLF5, KLF7 and EGR2."
    Yang H.W., Yang Z.Q.
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiEGR2_PIG
AccessioniPrimary (citable) accession number: A1XSY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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