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Protein

Tropomyosin alpha-3 chain

Gene

TPM3

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Muscle protein

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomyosin alpha-3 chain
Alternative name(s):
Gamma-tropomyosin
Tropomyosin-3
Gene namesi
Name:TPM3
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002899901 – 284Tropomyosin alpha-3 chainAdd BLAST284

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei53PhosphothreonineBy similarity1
Modified residuei61PhosphoserineBy similarity1
Modified residuei87PhosphoserineBy similarity1
Modified residuei108PhosphothreonineBy similarity1
Modified residuei252PhosphothreonineBy similarity1
Modified residuei261PhosphotyrosineBy similarity1
Modified residuei271PhosphoserineBy similarity1
Modified residuei282PhosphothreonineBy similarity1
Modified residuei283PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PeptideAtlasiA1XQV4.
PRIDEiA1XQV4.

PTM databases

iPTMnetiA1XQV4.

Interactioni

Subunit structurei

Homodimer. Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain. Interacts with TMOD1.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA1XQV4.
SMRiA1XQV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 284By similarityAdd BLAST284

Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Sequence similaritiesi

Belongs to the tropomyosin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000231521.
HOVERGENiHBG107404.
InParanoidiA1XQV4.

Family and domain databases

InterProiView protein in InterPro
IPR000533. Tropomyosin.
PfamiView protein in Pfam
PF00261. Tropomyosin. 1 hit.
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiView protein in PROSITE
PS00326. TROPOMYOSIN. 1 hit.

Sequencei

Sequence statusi: Complete.

A1XQV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAIKKKMQM LKLDKENALD RAEQAEAEQK QAEERSKQLE DELAAMQKKL
60 70 80 90 100
KGTEDELDKY SEALKDAQEK LELAEKKAAD AEAEVASLNR RIQLVEEELD
110 120 130 140 150
RAQERLATAL QKLEEAEKAA DESERGMKVI ENRALKDEEK MELQEIQLKE
160 170 180 190 200
AKHIAEEADR KYEEVARKLV IIEGDLERTE ERAELAEFKC FELEEELKNV
210 220 230 240 250
TNNLKFLEAQ AEKYFQKKDK YEEEIKILTD KLKEAETRAE FAERSVAKLE
260 270 280
KTIDDLEDEL YAQKLKYKAI SEELDHALND MTSI
Length:284
Mass (Da):33,058
Last modified:February 6, 2007 - v1
Checksum:iD976F4916D301198
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ629176 mRNA. Translation: ABK55660.1.
RefSeqiNP_001302554.1. NM_001315625.1.
XP_003361668.3. XM_003361620.4.
UniGeneiSsc.51787.

Genome annotation databases

GeneIDi100620599.

Similar proteinsi

Entry informationi

Entry nameiTPM3_PIG
AccessioniPrimary (citable) accession number: A1XQV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: February 6, 2007
Last modified: October 25, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families