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A1XQV4 (TPM3_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tropomyosin alpha-3 chain
Alternative name(s):
Gamma-tropomyosin
Tropomyosin-3
Gene names
Name:TPM3
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length284 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments By similarity.

Subunit structure

Heterodimer of an alpha and a beta chain. Binds to TMOD1 By similarity.

Subcellular location

Cytoplasmcytoskeleton By similarity.

Domain

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Sequence similarities

Belongs to the tropomyosin family.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   DomainCoiled coil
   LigandActin-binding
   Molecular functionMuscle protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

cytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 284284Tropomyosin alpha-3 chain
PRO_0000289990

Regions

Coiled coil1 – 284284 By similarity

Sequences

Sequence LengthMass (Da)Tools
A1XQV4 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: D976F4916D301198

FASTA28433,058
        10         20         30         40         50         60 
MEAIKKKMQM LKLDKENALD RAEQAEAEQK QAEERSKQLE DELAAMQKKL KGTEDELDKY 

        70         80         90        100        110        120 
SEALKDAQEK LELAEKKAAD AEAEVASLNR RIQLVEEELD RAQERLATAL QKLEEAEKAA 

       130        140        150        160        170        180 
DESERGMKVI ENRALKDEEK MELQEIQLKE AKHIAEEADR KYEEVARKLV IIEGDLERTE 

       190        200        210        220        230        240 
ERAELAEFKC FELEEELKNV TNNLKFLEAQ AEKYFQKKDK YEEEIKILTD KLKEAETRAE 

       250        260        270        280 
FAERSVAKLE KTIDDLEDEL YAQKLKYKAI SEELDHALND MTSI 

« Hide

References

[1]"Generation and analysis of cDNA sequences derived from a porcine skeletal muscle library."
Cai G., Chen Y., Wang C., Li J., Peng G., Zhang H.
Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Longissimus dorsi muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ629176 mRNA. Translation: ABK55660.1.
UniGeneSsc.51787.

3D structure databases

ProteinModelPortalA1XQV4.
SMRA1XQV4. Positions 1-284.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9823.ENSSSCP00000006988.

Proteomic databases

PaxDbA1XQV4.
PRIDEA1XQV4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG304012.
HOGENOMHOG000231521.
HOVERGENHBG107404.

Family and domain databases

InterProIPR000533. Tropomyosin.
[Graphical view]
PfamPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSPR00194. TROPOMYOSIN.
PROSITEPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTPM3_PIG
AccessionPrimary (citable) accession number: A1XQV4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: February 6, 2007
Last modified: November 13, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families