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A1XQV4

- TPM3_PIG

UniProt

A1XQV4 - TPM3_PIG

Protein

Tropomyosin alpha-3 chain

Gene

TPM3

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments By similarity.By similarity

    Keywords - Molecular functioni

    Muscle protein

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tropomyosin alpha-3 chain
    Alternative name(s):
    Gamma-tropomyosin
    Tropomyosin-3
    Gene namesi
    Name:TPM3
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. cytoskeleton Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 284284Tropomyosin alpha-3 chainPRO_0000289990Add
    BLAST

    Proteomic databases

    PaxDbiA1XQV4.
    PRIDEiA1XQV4.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta chain. Binds to TMOD1 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000006988.

    Structurei

    3D structure databases

    ProteinModelPortaliA1XQV4.
    SMRiA1XQV4. Positions 1-284.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1 – 284284By similarityAdd
    BLAST

    Domaini

    The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

    Sequence similaritiesi

    Belongs to the tropomyosin family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG304012.
    HOGENOMiHOG000231521.
    HOVERGENiHBG107404.

    Family and domain databases

    InterProiIPR000533. Tropomyosin.
    [Graphical view]
    PfamiPF00261. Tropomyosin. 1 hit.
    [Graphical view]
    PRINTSiPR00194. TROPOMYOSIN.
    PROSITEiPS00326. TROPOMYOSIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1XQV4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEAIKKKMQM LKLDKENALD RAEQAEAEQK QAEERSKQLE DELAAMQKKL    50
    KGTEDELDKY SEALKDAQEK LELAEKKAAD AEAEVASLNR RIQLVEEELD 100
    RAQERLATAL QKLEEAEKAA DESERGMKVI ENRALKDEEK MELQEIQLKE 150
    AKHIAEEADR KYEEVARKLV IIEGDLERTE ERAELAEFKC FELEEELKNV 200
    TNNLKFLEAQ AEKYFQKKDK YEEEIKILTD KLKEAETRAE FAERSVAKLE 250
    KTIDDLEDEL YAQKLKYKAI SEELDHALND MTSI 284
    Length:284
    Mass (Da):33,058
    Last modified:February 6, 2007 - v1
    Checksum:iD976F4916D301198
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ629176 mRNA. Translation: ABK55660.1.
    UniGeneiSsc.51787.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ629176 mRNA. Translation: ABK55660.1 .
    UniGenei Ssc.51787.

    3D structure databases

    ProteinModelPortali A1XQV4.
    SMRi A1XQV4. Positions 1-284.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9823.ENSSSCP00000006988.

    Proteomic databases

    PaxDbi A1XQV4.
    PRIDEi A1XQV4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG304012.
    HOGENOMi HOG000231521.
    HOVERGENi HBG107404.

    Family and domain databases

    InterProi IPR000533. Tropomyosin.
    [Graphical view ]
    Pfami PF00261. Tropomyosin. 1 hit.
    [Graphical view ]
    PRINTSi PR00194. TROPOMYOSIN.
    PROSITEi PS00326. TROPOMYOSIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Generation and analysis of cDNA sequences derived from a porcine skeletal muscle library."
      Cai G., Chen Y., Wang C., Li J., Peng G., Zhang H.
      Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Longissimus dorsi muscle.

    Entry informationi

    Entry nameiTPM3_PIG
    AccessioniPrimary (citable) accession number: A1XQV4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 12, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3