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A1XQV4

- TPM3_PIG

UniProt

A1XQV4 - TPM3_PIG

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Protein

Tropomyosin alpha-3 chain

Gene
TPM3
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments By similarity.

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomyosin alpha-3 chain
Alternative name(s):
Gamma-tropomyosin
Tropomyosin-3
Gene namesi
Name:TPM3
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284Tropomyosin alpha-3 chainPRO_0000289990Add
BLAST

Proteomic databases

PaxDbiA1XQV4.
PRIDEiA1XQV4.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain. Binds to TMOD1 By similarity.

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000006988.

Structurei

3D structure databases

ProteinModelPortaliA1XQV4.
SMRiA1XQV4. Positions 1-284.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1 – 284284 By similarityAdd
BLAST

Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Sequence similaritiesi

Belongs to the tropomyosin family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG304012.
HOGENOMiHOG000231521.
HOVERGENiHBG107404.

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1XQV4-1 [UniParc]FASTAAdd to Basket

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MEAIKKKMQM LKLDKENALD RAEQAEAEQK QAEERSKQLE DELAAMQKKL    50
KGTEDELDKY SEALKDAQEK LELAEKKAAD AEAEVASLNR RIQLVEEELD 100
RAQERLATAL QKLEEAEKAA DESERGMKVI ENRALKDEEK MELQEIQLKE 150
AKHIAEEADR KYEEVARKLV IIEGDLERTE ERAELAEFKC FELEEELKNV 200
TNNLKFLEAQ AEKYFQKKDK YEEEIKILTD KLKEAETRAE FAERSVAKLE 250
KTIDDLEDEL YAQKLKYKAI SEELDHALND MTSI 284
Length:284
Mass (Da):33,058
Last modified:February 6, 2007 - v1
Checksum:iD976F4916D301198
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ629176 mRNA. Translation: ABK55660.1.
UniGeneiSsc.51787.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ629176 mRNA. Translation: ABK55660.1 .
UniGenei Ssc.51787.

3D structure databases

ProteinModelPortali A1XQV4.
SMRi A1XQV4. Positions 1-284.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000006988.

Proteomic databases

PaxDbi A1XQV4.
PRIDEi A1XQV4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG304012.
HOGENOMi HOG000231521.
HOVERGENi HBG107404.

Family and domain databases

InterProi IPR000533. Tropomyosin.
[Graphical view ]
Pfami PF00261. Tropomyosin. 1 hit.
[Graphical view ]
PRINTSi PR00194. TROPOMYOSIN.
PROSITEi PS00326. TROPOMYOSIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Generation and analysis of cDNA sequences derived from a porcine skeletal muscle library."
    Cai G., Chen Y., Wang C., Li J., Peng G., Zhang H.
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Longissimus dorsi muscle.

Entry informationi

Entry nameiTPM3_PIG
AccessioniPrimary (citable) accession number: A1XQV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: February 6, 2007
Last modified: November 13, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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