A1XQV4 (TPM3_PIG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tropomyosin alpha-3 chain

Alternative name(s):
Gamma-tropomyosin
Tropomyosin-3

Gene names

Name:

TPM3

Organism

Sus scrofa (Pig) [Reference proteome]

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments By similarity.
Subunit structure	Heterodimer of an alpha and a beta chain. Binds to TMOD1 By similarity.
Subcellular location	Cytoplasm › cytoskeleton By similarity.
Domain	The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
Sequence similarities	Belongs to the tropomyosin family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Domain	Coiled coil
Ligand	Actin-binding
Molecular function	Muscle protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 284	284	Tropomyosin alpha-3 chain		PRO_0000289990
Regions
	Coiled coil	1 – 284	284	By similarity
Amino acid modifications
	Modified residue	283	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1XQV4 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: D976F4916D301198	FASTA	284	33,058
	10 20 30 40 50 60 MEAIKKKMQM LKLDKENALD RAEQAEAEQK QAEERSKQLE DELAAMQKKL KGTEDELDKY 70 80 90 100 110 120 SEALKDAQEK LELAEKKAAD AEAEVASLNR RIQLVEEELD RAQERLATAL QKLEEAEKAA 130 140 150 160 170 180 DESERGMKVI ENRALKDEEK MELQEIQLKE AKHIAEEADR KYEEVARKLV IIEGDLERTE 190 200 210 220 230 240 ERAELAEFKC FELEEELKNV TNNLKFLEAQ AEKYFQKKDK YEEEIKILTD KLKEAETRAE 250 260 270 280 FAERSVAKLE KTIDDLEDEL YAQKLKYKAI SEELDHALND MTSI

References

[1]	"Generation and analysis of cDNA sequences derived from a porcine skeletal muscle library." Cai G., Chen Y., Wang C., Li J., Peng G., Zhang H. Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Longissimus dorsi muscle.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ629176 mRNA. Translation: ABK55660.1.
UniGene	Ssc.51787.
3D structure databases
ProteinModelPortal	A1XQV4.
SMR	A1XQV4. Positions 1-284.
ModBase	Search...
Protein-protein interaction databases
STRING	9823.ENSSSCP00000006988.
Proteomic databases
PaxDb	A1XQV4.
PRIDE	A1XQV4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	NOG304012.
HOGENOM	HOG000231521.
HOVERGEN	HBG107404.
OrthoDB	EOG4TXBSM.
Family and domain databases
InterPro	IPR000533. Tropomyosin. [Graphical view]
Pfam	PF00261. Tropomyosin. 1 hit. [Graphical view]
PRINTS	PR00194. TROPOMYOSIN.
PROSITE	PS00326. TROPOMYOSIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TPM3_PIG

Accession

Primary (citable) accession number: A1XQV4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	February 6, 2007
Last modified:	April 3, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program