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A1XQU1

- PSB7_PIG

UniProt

A1XQU1 - PSB7_PIG

Protein

Proteasome subunit beta type-7

Gene

PSMB7

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 2 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity.By similarity

    Catalytic activityi

    Cleavage of peptide bonds with very broad specificity.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei44 – 441NucleophileBy similarity

    GO - Molecular functioni

    1. threonine-type endopeptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. proteolysis involved in cellular protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Threonine protease

    Enzyme and pathway databases

    ReactomeiREACT_191867. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
    REACT_191871. Autodegradation of Cdh1 by Cdh1:APC/C.
    REACT_191922. Separation of Sister Chromatids.
    REACT_191925. APC/C:Cdc20 mediated degradation of Securin.
    REACT_206004. Regulation of activated PAK-2p34 by proteasome mediated degradation.
    REACT_206046. Asymmetric localization of PCP proteins.
    REACT_206188. degradation of AXIN.
    REACT_206688. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
    REACT_207460. degradation of DVL.
    REACT_208372. Antigen processing: Ubiquitination & Proteasome degradation.
    REACT_209467. AUF1 (hnRNP D0) destabilizes mRNA.
    REACT_211902. ER-Phagosome pathway.
    REACT_215406. Cross-presentation of soluble exogenous antigens (endosomes).
    REACT_217391. Activation of NF-kappaB in B cells.
    REACT_220527. Autodegradation of the E3 ubiquitin ligase COP1.
    REACT_222346. Regulation of ornithine decarboxylase (ODC).
    REACT_224565. Orc1 removal from chromatin.
    REACT_226086. CDT1 association with the CDC6:ORC:origin complex.
    REACT_227771. CDK-mediated phosphorylation and removal of Cdc6.

    Protein family/group databases

    MEROPSiT01.011.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proteasome subunit beta type-7 (EC:3.4.25.1)
    Gene namesi
    Name:PSMB7
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Chromosome 1

    Subcellular locationi

    Cytoplasm PROSITE-ProRule annotation. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell
    3. proteasome core complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Proteasome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei1 – 4343Removed in mature formBy similarityPRO_0000311176Add
    BLAST
    Chaini44 – 277234Proteasome subunit beta type-7PRO_0000311177Add
    BLAST

    Keywords - PTMi

    Zymogen

    Proteomic databases

    PaxDbiA1XQU1.
    PRIDEiA1XQU1.

    Interactioni

    Subunit structurei

    The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. This subunit can be displaced by the equivalent immune-specific subunit PSMB10 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000005987.

    Structurei

    3D structure databases

    ProteinModelPortaliA1XQU1.
    SMRiA1XQU1. Positions 44-263.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase T1B family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0638.
    GeneTreeiENSGT00510000046533.
    HOGENOMiHOG000182856.
    HOVERGENiHBG093416.
    KOiK02739.
    OMAiQIWCAGA.
    OrthoDBiEOG7CRTQJ.
    TreeFamiTF106222.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    InterProiIPR029055. Ntn_hydrolases_N.
    IPR000243. Pept_T1A_subB.
    IPR024689. Proteasome_bsu_C.
    IPR016050. Proteasome_bsu_CS.
    IPR001353. Proteasome_sua/b.
    IPR023333. Proteasome_suB-type.
    [Graphical view]
    PfamiPF12465. Pr_beta_C. 1 hit.
    PF00227. Proteasome. 1 hit.
    [Graphical view]
    PRINTSiPR00141. PROTEASOME.
    SUPFAMiSSF56235. SSF56235. 1 hit.
    PROSITEiPS00854. PROTEASOME_BETA_1. 1 hit.
    PS51476. PROTEASOME_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A1XQU1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAVSVYERP VGGFSFDNCR RNAILEADFA KKGYKLPTAR KTGTTIAGVV    50
    YKDGIVLGAD TRATEGMVVA DKNCSKIHFI SPNIYCCGAG TAADTDMTTQ 100
    LISSNLELHS LSTGRLPRVV TANRMLKQML FRYQGYIGAA LVLGGVDVTG 150
    PHLYSIYPHG STDKLPYVTM GSGSLAAMAV FEDKFRPEME EEEAKQLVSE 200
    AIAAGIFNDL GSGSNIDLCV ISKSKLDFLR PYSVPNKKGT RFGRYRCEKG 250
    TTAVLTEKVT ALDIEVLEET VQTMDTS 277
    Length:277
    Mass (Da):29,980
    Last modified:November 13, 2007 - v2
    Checksum:iD8DFC5B018F6F287
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti229 – 2291L → F in ABK55647. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009124 Genomic DNA. Translation: BAF45330.1.
    DQ629163 mRNA. Translation: ABK55647.1.
    RefSeqiNP_001090945.1. NM_001097476.2.
    UniGeneiSsc.16968.

    Genome annotation databases

    EnsembliENSSSCT00000006146; ENSSSCP00000005987; ENSSSCG00000005590.
    GeneIDi100037992.
    KEGGissc:100037992.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009124 Genomic DNA. Translation: BAF45330.1 .
    DQ629163 mRNA. Translation: ABK55647.1 .
    RefSeqi NP_001090945.1. NM_001097476.2.
    UniGenei Ssc.16968.

    3D structure databases

    ProteinModelPortali A1XQU1.
    SMRi A1XQU1. Positions 44-263.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9823.ENSSSCP00000005987.

    Protein family/group databases

    MEROPSi T01.011.

    Proteomic databases

    PaxDbi A1XQU1.
    PRIDEi A1XQU1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSSSCT00000006146 ; ENSSSCP00000005987 ; ENSSSCG00000005590 .
    GeneIDi 100037992.
    KEGGi ssc:100037992.

    Organism-specific databases

    CTDi 5695.

    Phylogenomic databases

    eggNOGi COG0638.
    GeneTreei ENSGT00510000046533.
    HOGENOMi HOG000182856.
    HOVERGENi HBG093416.
    KOi K02739.
    OMAi QIWCAGA.
    OrthoDBi EOG7CRTQJ.
    TreeFami TF106222.

    Enzyme and pathway databases

    Reactomei REACT_191867. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
    REACT_191871. Autodegradation of Cdh1 by Cdh1:APC/C.
    REACT_191922. Separation of Sister Chromatids.
    REACT_191925. APC/C:Cdc20 mediated degradation of Securin.
    REACT_206004. Regulation of activated PAK-2p34 by proteasome mediated degradation.
    REACT_206046. Asymmetric localization of PCP proteins.
    REACT_206188. degradation of AXIN.
    REACT_206688. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
    REACT_207460. degradation of DVL.
    REACT_208372. Antigen processing: Ubiquitination & Proteasome degradation.
    REACT_209467. AUF1 (hnRNP D0) destabilizes mRNA.
    REACT_211902. ER-Phagosome pathway.
    REACT_215406. Cross-presentation of soluble exogenous antigens (endosomes).
    REACT_217391. Activation of NF-kappaB in B cells.
    REACT_220527. Autodegradation of the E3 ubiquitin ligase COP1.
    REACT_222346. Regulation of ornithine decarboxylase (ODC).
    REACT_224565. Orc1 removal from chromatin.
    REACT_226086. CDT1 association with the CDC6:ORC:origin complex.
    REACT_227771. CDK-mediated phosphorylation and removal of Cdc6.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    InterProi IPR029055. Ntn_hydrolases_N.
    IPR000243. Pept_T1A_subB.
    IPR024689. Proteasome_bsu_C.
    IPR016050. Proteasome_bsu_CS.
    IPR001353. Proteasome_sua/b.
    IPR023333. Proteasome_suB-type.
    [Graphical view ]
    Pfami PF12465. Pr_beta_C. 1 hit.
    PF00227. Proteasome. 1 hit.
    [Graphical view ]
    PRINTSi PR00141. PROTEASOME.
    SUPFAMi SSF56235. SSF56235. 1 hit.
    PROSITEi PS00854. PROTEASOME_BETA_1. 1 hit.
    PS51476. PROTEASOME_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Fine mapping of a swine quantitative trait locus for number of vertebrae and analysis of an orphan nuclear receptor, germ cell nuclear factor (NR6A1)."
      Mikawa S., Morozumi T., Shimanuki S., Hayashi T., Uenishi H., Domukai M., Okumura N., Awata T.
      Genome Res. 17:586-593(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Large white X Duroc.
    2. "Generation and analysis of cDNA sequences derived from a porcine skeletal muscle library."
      Cai G., Chen Y., Wang C., Li J., Peng G., Zhang H.
      Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Longissimus dorsi muscle.

    Entry informationi

    Entry nameiPSB7_PIG
    AccessioniPrimary (citable) accession number: A1XQU1
    Secondary accession number(s): A2BD06
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3