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Protein

Proteasome subunit beta type-7

Gene

PSMB7

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei44 – 441NucleophileBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiREACT_275353. Regulation of activated PAK-2p34 by proteasome mediated degradation.
REACT_278599. degradation of DVL.
REACT_284478. Degradation of GLI2 by the proteasome.
REACT_284724. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
REACT_287562. Separation of Sister Chromatids.
REACT_294188. degradation of AXIN.
REACT_295456. CDK-mediated phosphorylation and removal of Cdc6.
REACT_295928. Ubiquitin-dependent degradation of Cyclin D1.
REACT_296324. Autodegradation of Cdh1 by Cdh1:APC/C.
REACT_297542. Autodegradation of the E3 ubiquitin ligase COP1.
REACT_304542. Hedgehog ligand biogenesis.
REACT_306763. Orc1 removal from chromatin.
REACT_308441. GLI3 is processed to GLI3R by the proteasome.
REACT_309820. ER-Phagosome pathway.
REACT_313719. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_317060. SCF(Skp2)-mediated degradation of p27/p21.
REACT_317623. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_321411. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
REACT_322222. Regulation of ornithine decarboxylase (ODC).
REACT_324312. CDT1 association with the CDC6:ORC:origin complex.
REACT_330176. Activation of NF-kappaB in B cells.
REACT_333279. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_334169. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
REACT_334553. APC/C:Cdc20 mediated degradation of Securin.
REACT_346672. Asymmetric localization of PCP proteins.
REACT_359402. Degradation of GLI1 by the proteasome.
REACT_361274. Dectin-1 mediated noncanonical NF-kB signaling.

Protein family/group databases

MEROPSiT01.A02.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta type-7 (EC:3.4.25.1)
Gene namesi
Name:PSMB7
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm PROSITE-ProRule annotation
  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 4343Removed in mature formBy similarityPRO_0000311176Add
BLAST
Chaini44 – 277234Proteasome subunit beta type-7PRO_0000311177Add
BLAST

Keywords - PTMi

Zymogen

Proteomic databases

PaxDbiA1XQU1.
PRIDEiA1XQU1.

Expressioni

Gene expression databases

GenevisibleiA1XQU1. SS.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. This subunit can be displaced by the equivalent immune-specific subunit PSMB10 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000005987.

Structurei

3D structure databases

ProteinModelPortaliA1XQU1.
SMRiA1XQU1. Positions 44-263.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0638.
GeneTreeiENSGT00510000046533.
HOGENOMiHOG000182856.
HOVERGENiHBG093416.
InParanoidiA1XQU1.
KOiK02739.
OMAiRHQGHIG.
OrthoDBiEOG7CRTQJ.
TreeFamiTF106222.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR024689. Proteasome_bsu_C.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF12465. Pr_beta_C. 1 hit.
PF00227. Proteasome. 1 hit.
[Graphical view]
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1XQU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVSVYERP VGGFSFDNCR RNAILEADFA KKGYKLPTAR KTGTTIAGVV
60 70 80 90 100
YKDGIVLGAD TRATEGMVVA DKNCSKIHFI SPNIYCCGAG TAADTDMTTQ
110 120 130 140 150
LISSNLELHS LSTGRLPRVV TANRMLKQML FRYQGYIGAA LVLGGVDVTG
160 170 180 190 200
PHLYSIYPHG STDKLPYVTM GSGSLAAMAV FEDKFRPEME EEEAKQLVSE
210 220 230 240 250
AIAAGIFNDL GSGSNIDLCV ISKSKLDFLR PYSVPNKKGT RFGRYRCEKG
260 270
TTAVLTEKVT ALDIEVLEET VQTMDTS
Length:277
Mass (Da):29,980
Last modified:November 13, 2007 - v2
Checksum:iD8DFC5B018F6F287
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti229 – 2291L → F in ABK55647 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009124 Genomic DNA. Translation: BAF45330.1.
DQ629163 mRNA. Translation: ABK55647.1.
RefSeqiNP_001090945.1. NM_001097476.2.
UniGeneiSsc.16968.

Genome annotation databases

EnsembliENSSSCT00000006146; ENSSSCP00000005987; ENSSSCG00000005590.
GeneIDi100037992.
KEGGissc:100037992.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009124 Genomic DNA. Translation: BAF45330.1.
DQ629163 mRNA. Translation: ABK55647.1.
RefSeqiNP_001090945.1. NM_001097476.2.
UniGeneiSsc.16968.

3D structure databases

ProteinModelPortaliA1XQU1.
SMRiA1XQU1. Positions 44-263.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000005987.

Protein family/group databases

MEROPSiT01.A02.

Proteomic databases

PaxDbiA1XQU1.
PRIDEiA1XQU1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000006146; ENSSSCP00000005987; ENSSSCG00000005590.
GeneIDi100037992.
KEGGissc:100037992.

Organism-specific databases

CTDi5695.

Phylogenomic databases

eggNOGiCOG0638.
GeneTreeiENSGT00510000046533.
HOGENOMiHOG000182856.
HOVERGENiHBG093416.
InParanoidiA1XQU1.
KOiK02739.
OMAiRHQGHIG.
OrthoDBiEOG7CRTQJ.
TreeFamiTF106222.

Enzyme and pathway databases

ReactomeiREACT_275353. Regulation of activated PAK-2p34 by proteasome mediated degradation.
REACT_278599. degradation of DVL.
REACT_284478. Degradation of GLI2 by the proteasome.
REACT_284724. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
REACT_287562. Separation of Sister Chromatids.
REACT_294188. degradation of AXIN.
REACT_295456. CDK-mediated phosphorylation and removal of Cdc6.
REACT_295928. Ubiquitin-dependent degradation of Cyclin D1.
REACT_296324. Autodegradation of Cdh1 by Cdh1:APC/C.
REACT_297542. Autodegradation of the E3 ubiquitin ligase COP1.
REACT_304542. Hedgehog ligand biogenesis.
REACT_306763. Orc1 removal from chromatin.
REACT_308441. GLI3 is processed to GLI3R by the proteasome.
REACT_309820. ER-Phagosome pathway.
REACT_313719. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_317060. SCF(Skp2)-mediated degradation of p27/p21.
REACT_317623. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_321411. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
REACT_322222. Regulation of ornithine decarboxylase (ODC).
REACT_324312. CDT1 association with the CDC6:ORC:origin complex.
REACT_330176. Activation of NF-kappaB in B cells.
REACT_333279. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_334169. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
REACT_334553. APC/C:Cdc20 mediated degradation of Securin.
REACT_346672. Asymmetric localization of PCP proteins.
REACT_359402. Degradation of GLI1 by the proteasome.
REACT_361274. Dectin-1 mediated noncanonical NF-kB signaling.

Gene expression databases

GenevisibleiA1XQU1. SS.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR024689. Proteasome_bsu_C.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF12465. Pr_beta_C. 1 hit.
PF00227. Proteasome. 1 hit.
[Graphical view]
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Fine mapping of a swine quantitative trait locus for number of vertebrae and analysis of an orphan nuclear receptor, germ cell nuclear factor (NR6A1)."
    Mikawa S., Morozumi T., Shimanuki S., Hayashi T., Uenishi H., Domukai M., Okumura N., Awata T.
    Genome Res. 17:586-593(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Large white X Duroc.
  2. "Generation and analysis of cDNA sequences derived from a porcine skeletal muscle library."
    Cai G., Chen Y., Wang C., Li J., Peng G., Zhang H.
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Longissimus dorsi muscle.

Entry informationi

Entry nameiPSB7_PIG
AccessioniPrimary (citable) accession number: A1XQU1
Secondary accession number(s): A2BD06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: July 22, 2015
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.