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Protein

Proteasome subunit beta type-7

Gene

PSMB7

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei44NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-SSC-1169091. Activation of NF-kappaB in B cells.
R-SSC-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-SSC-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-SSC-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-SSC-174154. APC/C:Cdc20 mediated degradation of Securin.
R-SSC-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-SSC-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-SSC-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-SSC-2467813. Separation of Sister Chromatids.
R-SSC-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-SSC-350562. Regulation of ornithine decarboxylase (ODC).
R-SSC-382556. ABC-family proteins mediated transport.
R-SSC-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-SSC-4608870. Asymmetric localization of PCP proteins.
R-SSC-4641257. Degradation of AXIN.
R-SSC-4641258. Degradation of DVL.
R-SSC-5358346. Hedgehog ligand biogenesis.
R-SSC-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-SSC-5610780. Degradation of GLI1 by the proteasome.
R-SSC-5610785. GLI3 is processed to GLI3R by the proteasome.
R-SSC-5658442. Regulation of RAS by GAPs.
R-SSC-5668541. TNFR2 non-canonical NF-kB pathway.
R-SSC-5676590. NIK-->noncanonical NF-kB signaling.
R-SSC-5687128. MAPK6/MAPK4 signaling.
R-SSC-5689603. UCH proteinases.
R-SSC-5689880. Ub-specific processing proteases.
R-SSC-6798695. Neutrophil degranulation.
R-SSC-68827. CDT1 association with the CDC6:ORC:origin complex.
R-SSC-68949. Orc1 removal from chromatin.
R-SSC-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-SSC-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-SSC-69481. G2/M Checkpoints.
R-SSC-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-SSC-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.
R-SSC-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-SSC-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Protein family/group databases

MEROPSiT01.A02.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta type-7 (EC:3.4.25.1)
Gene namesi
Name:PSMB7
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00003111761 – 43Removed in mature formBy similarityAdd BLAST43
ChainiPRO_000031117744 – 277Proteasome subunit beta type-7Add BLAST234

Keywords - PTMi

Zymogen

Proteomic databases

PaxDbiA1XQU1.
PeptideAtlasiA1XQU1.
PRIDEiA1XQU1.

Expressioni

Gene expression databases

BgeeiENSSSCG00000005590.
GenevisibleiA1XQU1. SS.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000005987.

Structurei

3D structure databases

ProteinModelPortaliA1XQU1.
SMRiA1XQU1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0173. Eukaryota.
COG0638. LUCA.
GeneTreeiENSGT00510000046533.
HOGENOMiHOG000182856.
HOVERGENiHBG093416.
InParanoidiA1XQU1.
KOiK02739.
OMAiPFSVPNK.
OrthoDBiEOG09020B3N.
TreeFamiTF106222.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiView protein in InterPro
IPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR024689. Proteasome_bsu_C.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
PfamiView protein in Pfam
PF12465. Pr_beta_C. 1 hit.
PF00227. Proteasome. 1 hit.
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiView protein in PROSITE
PS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1XQU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVSVYERP VGGFSFDNCR RNAILEADFA KKGYKLPTAR KTGTTIAGVV
60 70 80 90 100
YKDGIVLGAD TRATEGMVVA DKNCSKIHFI SPNIYCCGAG TAADTDMTTQ
110 120 130 140 150
LISSNLELHS LSTGRLPRVV TANRMLKQML FRYQGYIGAA LVLGGVDVTG
160 170 180 190 200
PHLYSIYPHG STDKLPYVTM GSGSLAAMAV FEDKFRPEME EEEAKQLVSE
210 220 230 240 250
AIAAGIFNDL GSGSNIDLCV ISKSKLDFLR PYSVPNKKGT RFGRYRCEKG
260 270
TTAVLTEKVT ALDIEVLEET VQTMDTS
Length:277
Mass (Da):29,980
Last modified:November 13, 2007 - v2
Checksum:iD8DFC5B018F6F287
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti229L → F in ABK55647 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009124 Genomic DNA. Translation: BAF45330.1.
DQ629163 mRNA. Translation: ABK55647.1.
RefSeqiNP_001090945.1. NM_001097476.2.
UniGeneiSsc.16968.

Genome annotation databases

EnsembliENSSSCT00000006146; ENSSSCP00000005987; ENSSSCG00000005590.
GeneIDi100037992.
KEGGissc:100037992.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009124 Genomic DNA. Translation: BAF45330.1.
DQ629163 mRNA. Translation: ABK55647.1.
RefSeqiNP_001090945.1. NM_001097476.2.
UniGeneiSsc.16968.

3D structure databases

ProteinModelPortaliA1XQU1.
SMRiA1XQU1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000005987.

Protein family/group databases

MEROPSiT01.A02.

Proteomic databases

PaxDbiA1XQU1.
PeptideAtlasiA1XQU1.
PRIDEiA1XQU1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000006146; ENSSSCP00000005987; ENSSSCG00000005590.
GeneIDi100037992.
KEGGissc:100037992.

Organism-specific databases

CTDi5695.

Phylogenomic databases

eggNOGiKOG0173. Eukaryota.
COG0638. LUCA.
GeneTreeiENSGT00510000046533.
HOGENOMiHOG000182856.
HOVERGENiHBG093416.
InParanoidiA1XQU1.
KOiK02739.
OMAiPFSVPNK.
OrthoDBiEOG09020B3N.
TreeFamiTF106222.

Enzyme and pathway databases

ReactomeiR-SSC-1169091. Activation of NF-kappaB in B cells.
R-SSC-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-SSC-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-SSC-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-SSC-174154. APC/C:Cdc20 mediated degradation of Securin.
R-SSC-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-SSC-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-SSC-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-SSC-2467813. Separation of Sister Chromatids.
R-SSC-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-SSC-350562. Regulation of ornithine decarboxylase (ODC).
R-SSC-382556. ABC-family proteins mediated transport.
R-SSC-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-SSC-4608870. Asymmetric localization of PCP proteins.
R-SSC-4641257. Degradation of AXIN.
R-SSC-4641258. Degradation of DVL.
R-SSC-5358346. Hedgehog ligand biogenesis.
R-SSC-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-SSC-5610780. Degradation of GLI1 by the proteasome.
R-SSC-5610785. GLI3 is processed to GLI3R by the proteasome.
R-SSC-5658442. Regulation of RAS by GAPs.
R-SSC-5668541. TNFR2 non-canonical NF-kB pathway.
R-SSC-5676590. NIK-->noncanonical NF-kB signaling.
R-SSC-5687128. MAPK6/MAPK4 signaling.
R-SSC-5689603. UCH proteinases.
R-SSC-5689880. Ub-specific processing proteases.
R-SSC-6798695. Neutrophil degranulation.
R-SSC-68827. CDT1 association with the CDC6:ORC:origin complex.
R-SSC-68949. Orc1 removal from chromatin.
R-SSC-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-SSC-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-SSC-69481. G2/M Checkpoints.
R-SSC-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-SSC-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.
R-SSC-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-SSC-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Gene expression databases

BgeeiENSSSCG00000005590.
GenevisibleiA1XQU1. SS.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiView protein in InterPro
IPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR024689. Proteasome_bsu_C.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
PfamiView protein in Pfam
PF12465. Pr_beta_C. 1 hit.
PF00227. Proteasome. 1 hit.
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiView protein in PROSITE
PS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPSB7_PIG
AccessioniPrimary (citable) accession number: A1XQU1
Secondary accession number(s): A2BD06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: February 15, 2017
This is version 73 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.