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A1XQU1

- PSB7_PIG

UniProt

A1XQU1 - PSB7_PIG

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Protein

Proteasome subunit beta type-7

Gene

PSMB7

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei44 – 441NucleophileBy similarity

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. proteolysis involved in cellular protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiREACT_191867. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
REACT_191871. Autodegradation of Cdh1 by Cdh1:APC/C.
REACT_191922. Separation of Sister Chromatids.
REACT_191925. APC/C:Cdc20 mediated degradation of Securin.
REACT_206004. Regulation of activated PAK-2p34 by proteasome mediated degradation.
REACT_206046. Asymmetric localization of PCP proteins.
REACT_206188. degradation of AXIN.
REACT_206688. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
REACT_207460. degradation of DVL.
REACT_208372. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_209467. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_211902. ER-Phagosome pathway.
REACT_215406. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_217391. Activation of NF-kappaB in B cells.
REACT_220527. Autodegradation of the E3 ubiquitin ligase COP1.
REACT_222346. Regulation of ornithine decarboxylase (ODC).
REACT_224565. Orc1 removal from chromatin.
REACT_226086. CDT1 association with the CDC6:ORC:origin complex.
REACT_227771. CDK-mediated phosphorylation and removal of Cdc6.
REACT_235846. Ubiquitin-dependent degradation of Cyclin D1.
REACT_240161. Hh ligand biogenesis disease.
REACT_247813. Hedgehog ligand biogenesis.
REACT_269574. Degradation of GLI1 by the proteasome.
REACT_270268. GLI3 is processed to GLI3R by the proteasome.
REACT_271421. Degradation of GLI2 by the proteasome.

Protein family/group databases

MEROPSiT01.A02.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta type-7 (EC:3.4.25.1)
Gene namesi
Name:PSMB7
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 1

Subcellular locationi

Cytoplasm PROSITE-ProRule annotation. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: Ensembl
  3. microtubule cytoskeleton Source: Ensembl
  4. nucleus Source: UniProtKB-KW
  5. proteasome core complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 4343Removed in mature formBy similarityPRO_0000311176Add
BLAST
Chaini44 – 277234Proteasome subunit beta type-7PRO_0000311177Add
BLAST

Keywords - PTMi

Zymogen

Proteomic databases

PaxDbiA1XQU1.
PRIDEiA1XQU1.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. This subunit can be displaced by the equivalent immune-specific subunit PSMB10 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000005987.

Structurei

3D structure databases

ProteinModelPortaliA1XQU1.
SMRiA1XQU1. Positions 44-263.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0638.
GeneTreeiENSGT00510000046533.
HOGENOMiHOG000182856.
HOVERGENiHBG093416.
InParanoidiA1XQU1.
KOiK02739.
OMAiQIWCAGA.
OrthoDBiEOG7CRTQJ.
TreeFamiTF106222.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR024689. Proteasome_bsu_C.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF12465. Pr_beta_C. 1 hit.
PF00227. Proteasome. 1 hit.
[Graphical view]
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1XQU1-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MAAVSVYERP VGGFSFDNCR RNAILEADFA KKGYKLPTAR KTGTTIAGVV
60 70 80 90 100
YKDGIVLGAD TRATEGMVVA DKNCSKIHFI SPNIYCCGAG TAADTDMTTQ
110 120 130 140 150
LISSNLELHS LSTGRLPRVV TANRMLKQML FRYQGYIGAA LVLGGVDVTG
160 170 180 190 200
PHLYSIYPHG STDKLPYVTM GSGSLAAMAV FEDKFRPEME EEEAKQLVSE
210 220 230 240 250
AIAAGIFNDL GSGSNIDLCV ISKSKLDFLR PYSVPNKKGT RFGRYRCEKG
260 270
TTAVLTEKVT ALDIEVLEET VQTMDTS
Length:277
Mass (Da):29,980
Last modified:November 13, 2007 - v2
Checksum:iD8DFC5B018F6F287
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti229 – 2291L → F in ABK55647. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009124 Genomic DNA. Translation: BAF45330.1.
DQ629163 mRNA. Translation: ABK55647.1.
RefSeqiNP_001090945.1. NM_001097476.2.
UniGeneiSsc.16968.

Genome annotation databases

EnsembliENSSSCT00000006146; ENSSSCP00000005987; ENSSSCG00000005590.
GeneIDi100037992.
KEGGissc:100037992.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009124 Genomic DNA. Translation: BAF45330.1 .
DQ629163 mRNA. Translation: ABK55647.1 .
RefSeqi NP_001090945.1. NM_001097476.2.
UniGenei Ssc.16968.

3D structure databases

ProteinModelPortali A1XQU1.
SMRi A1XQU1. Positions 44-263.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000005987.

Protein family/group databases

MEROPSi T01.A02.

Proteomic databases

PaxDbi A1XQU1.
PRIDEi A1XQU1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSSSCT00000006146 ; ENSSSCP00000005987 ; ENSSSCG00000005590 .
GeneIDi 100037992.
KEGGi ssc:100037992.

Organism-specific databases

CTDi 5695.

Phylogenomic databases

eggNOGi COG0638.
GeneTreei ENSGT00510000046533.
HOGENOMi HOG000182856.
HOVERGENi HBG093416.
InParanoidi A1XQU1.
KOi K02739.
OMAi QIWCAGA.
OrthoDBi EOG7CRTQJ.
TreeFami TF106222.

Enzyme and pathway databases

Reactomei REACT_191867. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
REACT_191871. Autodegradation of Cdh1 by Cdh1:APC/C.
REACT_191922. Separation of Sister Chromatids.
REACT_191925. APC/C:Cdc20 mediated degradation of Securin.
REACT_206004. Regulation of activated PAK-2p34 by proteasome mediated degradation.
REACT_206046. Asymmetric localization of PCP proteins.
REACT_206188. degradation of AXIN.
REACT_206688. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
REACT_207460. degradation of DVL.
REACT_208372. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_209467. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_211902. ER-Phagosome pathway.
REACT_215406. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_217391. Activation of NF-kappaB in B cells.
REACT_220527. Autodegradation of the E3 ubiquitin ligase COP1.
REACT_222346. Regulation of ornithine decarboxylase (ODC).
REACT_224565. Orc1 removal from chromatin.
REACT_226086. CDT1 association with the CDC6:ORC:origin complex.
REACT_227771. CDK-mediated phosphorylation and removal of Cdc6.
REACT_235846. Ubiquitin-dependent degradation of Cyclin D1.
REACT_240161. Hh ligand biogenesis disease.
REACT_247813. Hedgehog ligand biogenesis.
REACT_269574. Degradation of GLI1 by the proteasome.
REACT_270268. GLI3 is processed to GLI3R by the proteasome.
REACT_271421. Degradation of GLI2 by the proteasome.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
InterProi IPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR024689. Proteasome_bsu_C.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view ]
Pfami PF12465. Pr_beta_C. 1 hit.
PF00227. Proteasome. 1 hit.
[Graphical view ]
PRINTSi PR00141. PROTEASOME.
SUPFAMi SSF56235. SSF56235. 1 hit.
PROSITEi PS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Fine mapping of a swine quantitative trait locus for number of vertebrae and analysis of an orphan nuclear receptor, germ cell nuclear factor (NR6A1)."
    Mikawa S., Morozumi T., Shimanuki S., Hayashi T., Uenishi H., Domukai M., Okumura N., Awata T.
    Genome Res. 17:586-593(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Large white X Duroc.
  2. "Generation and analysis of cDNA sequences derived from a porcine skeletal muscle library."
    Cai G., Chen Y., Wang C., Li J., Peng G., Zhang H.
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Longissimus dorsi muscle.

Entry informationi

Entry nameiPSB7_PIG
AccessioniPrimary (citable) accession number: A1XQU1
Secondary accession number(s): A2BD06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: November 26, 2014
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3