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A1XQU1

- PSB7_PIG

UniProt

A1XQU1 - PSB7_PIG

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Protein
Proteasome subunit beta type-7
Gene
PSMB7
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity.

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei44 – 441Nucleophile By similarity

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. proteolysis involved in cellular protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiREACT_191867. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
REACT_191871. Autodegradation of Cdh1 by Cdh1:APC/C.
REACT_191922. Separation of Sister Chromatids.
REACT_191925. APC/C:Cdc20 mediated degradation of Securin.
REACT_206004. Regulation of activated PAK-2p34 by proteasome mediated degradation.
REACT_206046. Asymmetric localization of PCP proteins.
REACT_206188. degradation of AXIN.
REACT_206688. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
REACT_207460. degradation of DVL.
REACT_208372. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_209467. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_211902. ER-Phagosome pathway.
REACT_215406. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_217391. Activation of NF-kappaB in B cells.
REACT_220527. Autodegradation of the E3 ubiquitin ligase COP1.
REACT_222346. Regulation of ornithine decarboxylase (ODC).
REACT_224565. Orc1 removal from chromatin.
REACT_226086. CDT1 association with the CDC6:ORC:origin complex.
REACT_227771. CDK-mediated phosphorylation and removal of Cdc6.

Protein family/group databases

MEROPSiT01.011.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta type-7 (EC:3.4.25.1)
Gene namesi
Name:PSMB7
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 1

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
  3. proteasome core complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 4343Removed in mature form By similarity
PRO_0000311176Add
BLAST
Chaini44 – 277234Proteasome subunit beta type-7
PRO_0000311177Add
BLAST

Keywords - PTMi

Zymogen

Proteomic databases

PaxDbiA1XQU1.
PRIDEiA1XQU1.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. This subunit can be displaced by the equivalent immune-specific subunit PSMB10 By similarity.

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000005987.

Structurei

3D structure databases

ProteinModelPortaliA1XQU1.
SMRiA1XQU1. Positions 44-263.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.

Phylogenomic databases

eggNOGiCOG0638.
GeneTreeiENSGT00510000046533.
HOGENOMiHOG000182856.
HOVERGENiHBG093416.
KOiK02739.
OMAiQIWCAGA.
OrthoDBiEOG7CRTQJ.
TreeFamiTF106222.