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A1XQU1 (PSB7_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteasome subunit beta type-7

EC=3.4.25.1
Gene names
Name:PSMB7
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity.

Catalytic activity

Cleavage of peptide bonds with very broad specificity.

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. This subunit can be displaced by the equivalent immune-specific subunit PSMB10 By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the peptidase T1B family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide1 – 4343Removed in mature form By similarity
PRO_0000311176
Chain44 – 277234Proteasome subunit beta type-7
PRO_0000311177

Sites

Active site441Nucleophile By similarity

Experimental info

Sequence conflict2291L → F in ABK55647. Ref.2

Sequences

Sequence LengthMass (Da)Tools
A1XQU1 [UniParc].

Last modified November 13, 2007. Version 2.
Checksum: D8DFC5B018F6F287

FASTA27729,980
        10         20         30         40         50         60 
MAAVSVYERP VGGFSFDNCR RNAILEADFA KKGYKLPTAR KTGTTIAGVV YKDGIVLGAD 

        70         80         90        100        110        120 
TRATEGMVVA DKNCSKIHFI SPNIYCCGAG TAADTDMTTQ LISSNLELHS LSTGRLPRVV 

       130        140        150        160        170        180 
TANRMLKQML FRYQGYIGAA LVLGGVDVTG PHLYSIYPHG STDKLPYVTM GSGSLAAMAV 

       190        200        210        220        230        240 
FEDKFRPEME EEEAKQLVSE AIAAGIFNDL GSGSNIDLCV ISKSKLDFLR PYSVPNKKGT 

       250        260        270 
RFGRYRCEKG TTAVLTEKVT ALDIEVLEET VQTMDTS 

« Hide

References

« Hide 'large scale' references
[1]"Fine mapping of a swine quantitative trait locus for number of vertebrae and analysis of an orphan nuclear receptor, germ cell nuclear factor (NR6A1)."
Mikawa S., Morozumi T., Shimanuki S., Hayashi T., Uenishi H., Domukai M., Okumura N., Awata T.
Genome Res. 17:586-593(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Large white X Duroc.
[2]"Generation and analysis of cDNA sequences derived from a porcine skeletal muscle library."
Cai G., Chen Y., Wang C., Li J., Peng G., Zhang H.
Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Longissimus dorsi muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP009124 Genomic DNA. Translation: BAF45330.1.
DQ629163 mRNA. Translation: ABK55647.1.
RefSeqNP_001090945.1. NM_001097476.2.
UniGeneSsc.16968.

3D structure databases

ProteinModelPortalA1XQU1.
SMRA1XQU1. Positions 44-263.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9823.ENSSSCP00000005987.

Protein family/group databases

MEROPST01.011.

Proteomic databases

PaxDbA1XQU1.
PRIDEA1XQU1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSSSCT00000006146; ENSSSCP00000005987; ENSSSCG00000005590.
GeneID100037992.
KEGGssc:100037992.

Organism-specific databases

CTD5695.

Phylogenomic databases

eggNOGCOG0638.
GeneTreeENSGT00510000046533.
HOGENOMHOG000182856.
HOVERGENHBG093416.
KOK02739.
OMAQIWCAGA.
OrthoDBEOG7CRTQJ.
TreeFamTF106222.

Family and domain databases

Gene3D3.60.20.10. 1 hit.
InterProIPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR024689. Proteasome_bsu_C.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamPF12465. Pr_beta_C. 1 hit.
PF00227. Proteasome. 1 hit.
[Graphical view]
PRINTSPR00141. PROTEASOME.
SUPFAMSSF56235. SSF56235. 1 hit.
PROSITEPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePSB7_PIG
AccessionPrimary (citable) accession number: A1XQU1
Secondary accession number(s): A2BD06
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: June 11, 2014
This is version 52 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries