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Protein

Mitochondrial import inner membrane translocase subunit TIM22-4

Gene

TIM22-4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit TIM22-4
Gene namesi
Name:TIM22-4
Ordered Locus Names:At1g18320
ORF Names:F15H18.28
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G18320.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4121HelicalSequence AnalysisAdd
BLAST
Transmembranei70 – 8819HelicalSequence AnalysisAdd
BLAST
Transmembranei97 – 11317HelicalSequence AnalysisAdd
BLAST
Transmembranei120 – 13718HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 142142Mitochondrial import inner membrane translocase subunit TIM22-4PRO_0000420937Add
BLAST

Proteomic databases

PaxDbiA1XJK0.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G18320.1.

Family & Domainsi

Sequence similaritiesi

Belongs to the Tim17/Tim22/Tim23 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5596.
HOGENOMiHOG000161169.
InParanoidiA1XJK0.
OMAiPIMQEEM.

Family and domain databases

InterProiIPR003397. Tim17/Tim22/Tim23/PMP24.
[Graphical view]
PfamiPF02466. Tim17. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1XJK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTIEEIRAQ EVWNNCAVRA VTSGVMGGGL GLMMGLFLGA LDNPITHDTM
60 70 80 90 100
TARQQFVFTA KQMGQRSWNS CKTFAVMGLV FSAAECIVEK ARAKHDTVNT
110 120 130 140
AIAGCVTGGS MSARGGPKAA CIGCAGFAIF SVLIEKFFDR HT
Length:142
Mass (Da):15,097
Last modified:March 6, 2013 - v3
Checksum:i49B954C61F4A5DB0
GO

Sequence cautioni

The sequence AY089200 differs from that shown. Reason: Frameshift at position 39. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013354 Genomic DNA. No translation available.
CP002684 Genomic DNA. Translation: AEE29701.1.
AY089200 mRNA. No translation available.
RefSeqiNP_173268.3. NM_101690.3.
UniGeneiAt.41800.

Genome annotation databases

EnsemblPlantsiAT1G18320.1; AT1G18320.1; AT1G18320.
GeneIDi838412.
KEGGiath:AT1G18320.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013354 Genomic DNA. No translation available.
CP002684 Genomic DNA. Translation: AEE29701.1.
AY089200 mRNA. No translation available.
RefSeqiNP_173268.3. NM_101690.3.
UniGeneiAt.41800.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G18320.1.

Proteomic databases

PaxDbiA1XJK0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G18320.1; AT1G18320.1; AT1G18320.
GeneIDi838412.
KEGGiath:AT1G18320.

Organism-specific databases

GeneFarmi3097. 302.
TAIRiAT1G18320.

Phylogenomic databases

eggNOGiCOG5596.
HOGENOMiHOG000161169.
InParanoidiA1XJK0.
OMAiPIMQEEM.

Miscellaneous databases

PROiA1XJK0.

Family and domain databases

InterProiIPR003397. Tim17/Tim22/Tim23/PMP24.
[Graphical view]
PfamiPF02466. Tim17. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiTI224_ARATH
AccessioniPrimary (citable) accession number: A1XJK0
Secondary accession number(s): F4IAQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2013
Last sequence update: March 6, 2013
Last modified: July 22, 2015
This is version 47 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.