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A1XJK0

- TI224_ARATH

UniProt

A1XJK0 - TI224_ARATH

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Protein

Mitochondrial import inner membrane translocase subunit TIM22-4

Gene
TIM22-4, At1g18320, F15H18.28
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane By similarity.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit TIM22-4
Gene namesi
Name:TIM22-4
Ordered Locus Names:At1g18320
ORF Names:F15H18.28
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G18320.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4121Helical; Reviewed predictionAdd
BLAST
Transmembranei70 – 8819Helical; Reviewed predictionAdd
BLAST
Transmembranei97 – 11317Helical; Reviewed predictionAdd
BLAST
Transmembranei120 – 13718Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 142142Mitochondrial import inner membrane translocase subunit TIM22-4PRO_0000420937Add
BLAST

Proteomic databases

PaxDbiA1XJK0.

Expressioni

Gene expression databases

GenevestigatoriA1XJK0.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G10110.1-P.

Family & Domainsi

Sequence similaritiesi

Belongs to the Tim17/Tim22/Tim23 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5596.
HOGENOMiHOG000161169.
OMAiVIDPRIN.

Family and domain databases

InterProiIPR003397. Tim17/Tim22/Tim23/PMP24.
[Graphical view]
PfamiPF02466. Tim17. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1XJK0-1 [UniParc]FASTAAdd to Basket

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MPTIEEIRAQ EVWNNCAVRA VTSGVMGGGL GLMMGLFLGA LDNPITHDTM    50
TARQQFVFTA KQMGQRSWNS CKTFAVMGLV FSAAECIVEK ARAKHDTVNT 100
AIAGCVTGGS MSARGGPKAA CIGCAGFAIF SVLIEKFFDR HT 142
Length:142
Mass (Da):15,097
Last modified:March 6, 2013 - v3
Checksum:i49B954C61F4A5DB0
GO

Sequence cautioni

The sequence AY089200 differs from that shown. Reason: Frameshift at position 39.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC013354 Genomic DNA. No translation available.
CP002684 Genomic DNA. Translation: AEE29701.1.
AY089200 mRNA. No translation available.
RefSeqiNP_173268.3. NM_101690.3.
UniGeneiAt.41800.

Genome annotation databases

EnsemblPlantsiAT1G18320.1; AT1G18320.1; AT1G18320.
GeneIDi838412.
KEGGiath:AT1G18320.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC013354 Genomic DNA. No translation available.
CP002684 Genomic DNA. Translation: AEE29701.1 .
AY089200 mRNA. No translation available.
RefSeqi NP_173268.3. NM_101690.3.
UniGenei At.41800.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT3G10110.1-P.

Proteomic databases

PaxDbi A1XJK0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G18320.1 ; AT1G18320.1 ; AT1G18320 .
GeneIDi 838412.
KEGGi ath:AT1G18320.

Organism-specific databases

GeneFarmi 3097. 302.
TAIRi AT1G18320.

Phylogenomic databases

eggNOGi COG5596.
HOGENOMi HOG000161169.
OMAi VIDPRIN.

Gene expression databases

Genevestigatori A1XJK0.

Family and domain databases

InterProi IPR003397. Tim17/Tim22/Tim23/PMP24.
[Graphical view ]
Pfami PF02466. Tim17. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiTI224_ARATH
AccessioniPrimary (citable) accession number: A1XJK0
Secondary accession number(s): F4IAQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2013
Last sequence update: March 6, 2013
Last modified: May 14, 2014
This is version 41 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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