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A1XJK0

- TI224_ARATH

UniProt

A1XJK0 - TI224_ARATH

Protein

Mitochondrial import inner membrane translocase subunit TIM22-4

Gene

TIM22-4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 3 (06 Mar 2013)
      Previous versions | rss
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    Functioni

    Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial import inner membrane translocase subunit TIM22-4
    Gene namesi
    Name:TIM22-4
    Ordered Locus Names:At1g18320
    ORF Names:F15H18.28
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G18320.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 142142Mitochondrial import inner membrane translocase subunit TIM22-4PRO_0000420937Add
    BLAST

    Proteomic databases

    PaxDbiA1XJK0.

    Expressioni

    Gene expression databases

    GenevestigatoriA1XJK0.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT3G10110.1-P.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei70 – 8819HelicalSequence AnalysisAdd
    BLAST
    Transmembranei97 – 11317HelicalSequence AnalysisAdd
    BLAST
    Transmembranei120 – 13718HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Tim17/Tim22/Tim23 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5596.
    HOGENOMiHOG000161169.
    OMAiVIDPRIN.

    Family and domain databases

    InterProiIPR003397. Tim17/Tim22/Tim23/PMP24.
    [Graphical view]
    PfamiPF02466. Tim17. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1XJK0-1 [UniParc]FASTAAdd to Basket

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    MPTIEEIRAQ EVWNNCAVRA VTSGVMGGGL GLMMGLFLGA LDNPITHDTM    50
    TARQQFVFTA KQMGQRSWNS CKTFAVMGLV FSAAECIVEK ARAKHDTVNT 100
    AIAGCVTGGS MSARGGPKAA CIGCAGFAIF SVLIEKFFDR HT 142
    Length:142
    Mass (Da):15,097
    Last modified:March 6, 2013 - v3
    Checksum:i49B954C61F4A5DB0
    GO

    Sequence cautioni

    The sequence AY089200 differs from that shown. Reason: Frameshift at position 39.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC013354 Genomic DNA. No translation available.
    CP002684 Genomic DNA. Translation: AEE29701.1.
    AY089200 mRNA. No translation available.
    RefSeqiNP_173268.3. NM_101690.3.
    UniGeneiAt.41800.

    Genome annotation databases

    EnsemblPlantsiAT1G18320.1; AT1G18320.1; AT1G18320.
    GeneIDi838412.
    KEGGiath:AT1G18320.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC013354 Genomic DNA. No translation available.
    CP002684 Genomic DNA. Translation: AEE29701.1 .
    AY089200 mRNA. No translation available.
    RefSeqi NP_173268.3. NM_101690.3.
    UniGenei At.41800.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT3G10110.1-P.

    Proteomic databases

    PaxDbi A1XJK0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G18320.1 ; AT1G18320.1 ; AT1G18320 .
    GeneIDi 838412.
    KEGGi ath:AT1G18320.

    Organism-specific databases

    GeneFarmi 3097. 302.
    TAIRi AT1G18320.

    Phylogenomic databases

    eggNOGi COG5596.
    HOGENOMi HOG000161169.
    OMAi VIDPRIN.

    Gene expression databases

    Genevestigatori A1XJK0.

    Family and domain databases

    InterProi IPR003397. Tim17/Tim22/Tim23/PMP24.
    [Graphical view ]
    Pfami PF02466. Tim17. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Full-length cDNA from Arabidopsis thaliana."
      Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiTI224_ARATH
    AccessioniPrimary (citable) accession number: A1XJK0
    Secondary accession number(s): F4IAQ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2013
    Last sequence update: March 6, 2013
    Last modified: October 1, 2014
    This is version 42 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3