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A1XJK0 (TI224_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial import inner membrane translocase subunit TIM22-4
Gene names
Name:TIM22-4
Ordered Locus Names:At1g18320
ORF Names:F15H18.28
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length142 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane By similarity.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the Tim17/Tim22/Tim23 family.

Sequence caution

The sequence AY089200 differs from that shown. Reason: Frameshift at position 39.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 142142Mitochondrial import inner membrane translocase subunit TIM22-4
PRO_0000420937

Regions

Transmembrane21 – 4121Helical; Potential
Transmembrane70 – 8819Helical; Potential
Transmembrane97 – 11317Helical; Potential
Transmembrane120 – 13718Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A1XJK0 [UniParc].

Last modified March 6, 2013. Version 3.
Checksum: 49B954C61F4A5DB0

FASTA14215,097
        10         20         30         40         50         60 
MPTIEEIRAQ EVWNNCAVRA VTSGVMGGGL GLMMGLFLGA LDNPITHDTM TARQQFVFTA 

        70         80         90        100        110        120 
KQMGQRSWNS CKTFAVMGLV FSAAECIVEK ARAKHDTVNT AIAGCVTGGS MSARGGPKAA 

       130        140 
CIGCAGFAIF SVLIEKFFDR HT 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Full-length cDNA from Arabidopsis thaliana."
Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC013354 Genomic DNA. No translation available.
CP002684 Genomic DNA. Translation: AEE29701.1.
AY089200 mRNA. No translation available.
RefSeqNP_173268.3. NM_101690.3.
UniGeneAt.41800.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING3702.AT3G10110.1-P.

Proteomic databases

PaxDbA1XJK0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT1G18320.1; AT1G18320.1; AT1G18320.
GeneID838412.
KEGGath:AT1G18320.

Organism-specific databases

GeneFarm3097. 302.
TAIRAT1G18320.

Phylogenomic databases

eggNOGCOG5596.
HOGENOMHOG000161169.
OMALITEAPH.

Gene expression databases

GenevestigatorA1XJK0.

Family and domain databases

InterProIPR003397. Tim17/Tim22/Tim23/PMP24.
[Graphical view]
PfamPF02466. Tim17. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTI224_ARATH
AccessionPrimary (citable) accession number: A1XJK0
Secondary accession number(s): F4IAQ1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2013
Last sequence update: March 6, 2013
Last modified: February 19, 2014
This is version 40 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names