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Protein

Mitochondrial import inner membrane translocase subunit TIM22-4

Gene

TIM22-4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit TIM22-4
Gene namesi
Name:TIM22-4
Ordered Locus Names:At1g18320
ORF Names:F15H18.28
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G18320
TAIRilocus:2014139 AT1G18320

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Transmembranei70 – 88HelicalSequence analysisAdd BLAST19
Transmembranei97 – 113HelicalSequence analysisAdd BLAST17
Transmembranei120 – 137HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004209371 – 142Mitochondrial import inner membrane translocase subunit TIM22-4Add BLAST142

Proteomic databases

PaxDbiA1XJK0

Expressioni

Gene expression databases

ExpressionAtlasiA1XJK0 baseline and differential
GenevisibleiA1XJK0 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G18320.1

Family & Domainsi

Sequence similaritiesi

Belongs to the Tim17/Tim22/Tim23 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3225 Eukaryota
COG5596 LUCA
HOGENOMiHOG000161169
InParanoidiA1XJK0
OMAiTYAGGIT
OrthoDBiEOG09360R0A

Family and domain databases

InterProiView protein in InterPro
IPR003397 Tim17/Tim22/Tim23/PMP24
PfamiView protein in Pfam
PF02466 Tim17, 1 hit

Sequencei

Sequence statusi: Complete.

A1XJK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTIEEIRAQ EVWNNCAVRA VTSGVMGGGL GLMMGLFLGA LDNPITHDTM
60 70 80 90 100
TARQQFVFTA KQMGQRSWNS CKTFAVMGLV FSAAECIVEK ARAKHDTVNT
110 120 130 140
AIAGCVTGGS MSARGGPKAA CIGCAGFAIF SVLIEKFFDR HT
Length:142
Mass (Da):15,097
Last modified:March 6, 2013 - v3
Checksum:i49B954C61F4A5DB0
GO

Sequence cautioni

The sequence AY089200 differs from that shown. Reason: Frameshift at position 39.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013354 Genomic DNA No translation available.
CP002684 Genomic DNA Translation: AEE29701.1
AY089200 mRNA No translation available.
RefSeqiNP_173268.3, NM_101690.3
UniGeneiAt.41800

Genome annotation databases

GeneIDi838412
KEGGiath:AT1G18320

Similar proteinsi

Entry informationi

Entry nameiTI224_ARATH
AccessioniPrimary (citable) accession number: A1XJK0
Secondary accession number(s): F4IAQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2013
Last sequence update: March 6, 2013
Last modified: April 25, 2018
This is version 60 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health