A1XG10 (NU1C_NUPAD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic
EC=1.6.5.-

Alternative name(s):
NAD(P)H dehydrogenase subunit 1
Short name=NDH subunit 1
NADH-plastoquinone oxidoreductase subunit 1

Gene names

Name:

ndhA

Encoded on

Plastid; Chloroplast

Organism

Nuphar advena (Common spatterdock) (Nuphar lutea subsp. advena)

Taxonomic identifier

77108 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › basal Magnoliophyta › Nymphaeales › Nymphaeaceae › Nuphar

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient By similarity. HAMAP MF_01350
Catalytic activity	NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol. HAMAP MF_01350
Subunit structure	NDH is composed of at least 16 different subunits, 5 of which are encoded in the nucleus By similarity.
Subcellular location	Plastid › chloroplast thylakoid membrane; Multi-pass membrane protein By similarity HAMAP MF_01350.
Sequence similarities	Belongs to the complex I subunit 1 family.

Ontologies

Keywords
Cellular component	Chloroplast Membrane Plastid Thylakoid
Domain	Transmembrane Transmembrane helix
Ligand	NAD NADP Plastoquinone
Molecular function	Oxidoreductase
PTM	Quinone
Gene Ontology (GO)
Cellular component	chloroplast thylakoid membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 361	361	NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic HAMAP MF_01350		PRO_0000298876
Regions
	Transmembrane	25 – 45	21	Helical; Potential
	Transmembrane	102 – 122	21	Helical; Potential
	Transmembrane	125 – 145	21	Helical; Potential
	Transmembrane	251 – 271	21	Helical; Potential
	Transmembrane	298 – 318	21	Helical; Potential
	Transmembrane	334 – 354	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	A1XG10 [UniParc]. Last modified February 20, 2007. Version 2. Checksum: 9182FA4204DA5DC8	FASTA	361	39,751
	10 20 30 40 50 60 MIIEEAQAIN SFFRSESSKE VYGLIWLLVP ILTLVLGITI GVLVIVWLER KISAGIQRRI 70 80 90 100 110 120 GPEYAGPLGI LQALADGVKL LFKEDLLPSR GDIRLFSVGP SIAVVSILLS YSVIPFGHHL 130 140 150 160 170 180 VLTDLSIGVS LWIAISSIAP IGLLMSGYGS NNKYSFSGGL RAAAQSISYE IPLTPCVLSI 190 200 210 220 230 240 SLLSNSSSTV DIVEAQSKYG FWGWNLWRQP IGFIVFIISS LAECERLPFD LPEAEEELVA 250 260 270 280 290 300 GYQTEYSGIK FGLFYVASYL NLLVSSLFVT ILYLGGWNLS IPYIPITELF EKNQTSEVFG 310 320 330 340 350 360 TTISLLITLA KAYLFLFIPI STRWTLPRMR MDQLLNLGWK SLLPIALGNL LLTTSSQLVS L

References

[1]

"Comparative chloroplast genomics: analyses including new sequences from the angiosperms Nuphar advena and Ranunculus macranthus." Raubeson L.A., Peery R., Chumley T.W., Dziubek C., Fourcade H.M., Boore J.L., Jansen R.K. BMC Genomics 8:174-174(2007) [PubMed: 17573971] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ354691 Genomic DNA. Translation: ABC60514.2.
RefSeq	YP_001001589.2. NC_008788.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4699613.
Phylogenomic databases
ProtClustDB	CHL00032.
Family and domain databases
HAMAP	MF_01350. NDH1_NuoH. [Tree]
InterPro	IPR001694. NADH_UbQ_OxRdtase_su1/FPO. IPR018086. NADH_UbQ_OxRdtase_su1_CS. [Graphical view]
PANTHER	PTHR11432. Resp_NADH_DH_1. 1 hit.
Pfam	PF00146. NADHdh. 1 hit. [Graphical view]
PROSITE	PS00667. COMPLEX1_ND1_1. 1 hit. PS00668. COMPLEX1_ND1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NU1C_NUPAD

Accession

Primary (citable) accession number: A1XG10

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	February 20, 2007
Last modified:	June 28, 2011
This is version 28 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program