A1XD97 (TFP11_CANFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tuftelin-interacting protein 11

Alternative name(s):
Septin and tuftelin-interacting protein 1
Short name=STIP-1

Gene names

Name:	TFIP11
Synonyms:	STIP

Organism

Canis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › Canis lupus

Protein attributes

Sequence length	837 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix. May also be involved in pre-mRNA splicing By similarity.
Subunit structure	Interacts with TUFT1 By similarity. Identified in the spliceosome C complex By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the TFP11/STIP family. Contains 1 G-patch domain.

Ontologies

Keywords
Biological process	Biomineralization mRNA processing mRNA splicing
Cellular component	Cytoplasm Nucleus Spliceosome
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	RNA splicing Inferred from electronic annotation. Source: UniProtKB-KW biomineral tissue development Inferred from electronic annotation. Source: UniProtKB-KW mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell spliceosomal complex Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 837	837	Tuftelin-interacting protein 11		PRO_0000342270
Regions
	Domain	149 – 195	47	G-patch
	Compositional bias	15 – 19	5	Poly-Asp
Amino acid modifications
	Modified residue	59	1	Phosphoserine By similarity
	Modified residue	98	1	Phosphoserine By similarity
	Modified residue	144	1	Phosphoserine By similarity
	Modified residue	210	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1XD97 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: B6CB34E9C14A7AC9	FASTA	837	96,568
	10 20 30 40 50 60 MSLSHLYRDG EGHMDDDDDE RENFEITDWD LQNEFNPNRQ RHWQTKEEAT YGVWAERDSD 70 80 90 100 110 120 EERPSFGGKR ARDYSAPVNF ISAGLKKGAA EEAELEDSED EEKPVKQDDF PKDFGPKKLK 130 140 150 160 170 180 TGGNFKPSQK GFAGGTKSFM DFGSWERHTK GIGQKLLQKM GYVPGRGLGK NAQGIINPIE 190 200 210 220 230 240 AKQRKGKGAV GAYGSERTTQ SLQDFPVVDS EEEAEEEFQK ELSQWRKDPS GSKKKPKYSY 250 260 270 280 290 300 KTVEELKAKG RISKKLAAPQ KELSQVKVID MTGREQKVYY SYSQISHKHN VPDDGLPLPS 310 320 330 340 350 360 QQPPQPGKEA KAPGFALPEL EHNLQLLIDL TEQEIIQSDR QLQYERDMVV NLSHELEKMS 370 380 390 400 410 420 EVLEHEERVI ANLSKVLEMV EECERRLQPS CSNPLTLDEC ARIFETLQDK YYEEYRMSDR 430 440 450 460 470 480 VDLAVAIVYP LMKEYFKEWD PLKDCAYGTQ VISRWKTLLE NDQLLSHGGQ DLSADAFHRL 490 500 510 520 530 540 IWEVWMPFVR NIVTQWQPRN CDPMVDFLDS WVHIIPVWIL DNILDQLIFP KLQKEVENWN 550 560 570 580 590 600 PLTDTVPIHS WVHPWLPLMQ ARLEPLYSPI RSKLSSALQK WHPSDSSAKL ILQPWKDVFT 610 620 630 640 650 660 PGSWEAFMVK NIVPKLGMCL GELVINPHQQ HMDAFYWVID WEGMISVSSL VGLLEKHFFP 670 680 690 700 710 720 KWLQVLCSWL SNSPNYEEIT KWYLGWKSMF SDQVLAHPSV KDKFNEALDI MNRAVSSNVG 730 740 750 760 770 780 AYMQPGAREN IAYLTHTERR KDFQYEAMQE RREAENMAQR GIGVAASSVP MNFKDLIETK 790 800 810 820 830 AEEHNIVFMP VIGKRHEGKQ LYTFGRIVIY IDRGVVFVQG EKTWVPTSLQ SLIDMAK

References

[1]

"Characterization of STIP, a multi-domain nuclear protein, highly conserved in metazoans, and essential for embryogenesis in Caenorhabditis elegans." Ji Q., Huang C.-H., Peng J., Hashmi S., Ye T., Chen Y. Exp. Cell Res. 313:1460-1472(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ342030 mRNA. Translation: ABC69922.1.
RefSeq	NP_001073577.1. NM_001080108.1.
UniGene	Cfa.3209.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9615.ENSCAFP00000017288.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSCAFT00000018663; ENSCAFP00000017288; ENSCAFG00000011741. ENSCAFT00000044117; ENSCAFP00000037958; ENSCAFG00000011741. ENSCAFT00000045711; ENSCAFP00000043052; ENSCAFG00000011741.
GeneID	477530.
KEGG	cfa:477530.
Organism-specific databases
CTD	24144.
Phylogenomic databases
eggNOG	NOG312699.
GeneTree	ENSGT00390000012739.
HOGENOM	HOG000230470.
HOVERGEN	HBG055868.
InParanoid	A1XD97.
KO	K13103.
OMA	SMSHLYG.
OrthoDB	EOG4BRWK2.
Family and domain databases
InterPro	IPR000467. G_patch_dom. IPR022783. GCFC_dom. IPR024933. STIP. IPR022159. TIP_N. [Graphical view]
Pfam	PF01585. G-patch. 1 hit. PF07842. GCFC. 1 hit. PF12457. TIP_N. 1 hit. [Graphical view]
PIRSF	PIRSF017706. TFIP11. 1 hit.
SMART	SM00443. G_patch. 1 hit. [Graphical view]
PROSITE	PS50174. G_PATCH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20852993.

Entry information

Entry name

TFP11_CANFA

Accession

Primary (citable) accession number: A1XD97

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	February 6, 2007
Last modified:	May 29, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program