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A1XD93 (TFP11_PANTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Tuftelin-interacting protein 11
Alternative name(s):
Septin and tuftelin-interacting protein 1
Short name=STIP-1
Gene names
Name:TFIP11
Synonyms:STIP
OrganismPan troglodytes (Chimpanzee) [Reference proteome]
Taxonomic identifier9598 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan

Protein attributes

Sequence length837 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix. May also be involved in pre-mRNA splicing By similarity.

Subunit structure

Interacts with TUFT1 By similarity. Identified in the spliceosome C complex By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the TFP11/STIP family.

Contains 1 G-patch domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 837837Tuftelin-interacting protein 11
PRO_0000342274

Regions

Domain149 – 19547G-patch
Compositional bias15 – 195Poly-Asp

Amino acid modifications

Modified residue591Phosphoserine By similarity
Modified residue981Phosphoserine By similarity
Modified residue1441Phosphoserine By similarity
Modified residue2101Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
A1XD93 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 2E27A1ED01EB8525

FASTA83796,848
        10         20         30         40         50         60 
MSLSHLYRDG EGRIDDDDDE RENFEITDWD LQNEFNPNRQ RHWQTKEEAT YGVWAERDSD 

        70         80         90        100        110        120 
DERPSFGGKR ARDYSAPVNF ISAGLKKGAA EEAELEDSDD EEKPVKQDDF PKDFGPRKLK 

       130        140        150        160        170        180 
TGGNFKPSQK GFAGGTKSFM DFGSWERHTK GIGQKLLQKM GYVPGRGLGK NAQGIINPIE 

       190        200        210        220        230        240 
AKQRKGKGAV GAYGSERTTQ SMQDFPVVDS EEEAEEEFQK ELSQWRKDPS GSKKKPKYSY 

       250        260        270        280        290        300 
KTVEELKAKG RISKKLTAPQ KELSQVKVID MTGREQKVYY SYSQISHKHN VPDDGLPLQS 

       310        320        330        340        350        360 
QQLPQSGKEA KAPGFALPEL EHNLQLLIDL TEQEIIQNDR QLQYERDMVV NLFHELEKMT 

       370        380        390        400        410        420 
EVLDHEERVI SNLSKVLEMV EECERRMQPD CSNPLTLDEC ARIFETLQDK YYEEYRMSDR 

       430        440        450        460        470        480 
VDLAVAIVYP LMKEYFKEWD PLRDCTYGTE IISKWKSLLE NDQLLSHGGQ DLSADAFHRL 

       490        500        510        520        530        540 
IWEVWMPFVR NIVTQWQPRN CDPMVDFLDS WVHIIPVWIL DNILDQLIFP KLQKEVENWN 

       550        560        570        580        590        600 
PLTDTVPIHS WIHPWLPLMQ ARLEPLYSPI RSKLSSALQK WHPSDSSAKL ILQPWKDVFT 

       610        620        630        640        650        660 
PGSWEAFMVK NIVPKLGMCL GELVINPHQQ HMDAFYWVID WEGMISVSSL VGLLEKHFFP 

       670        680        690        700        710        720 
KWLQVLCSWL SNSPNYEEIT KWYLGWKSMF SDQVLAHPSV KDKFNEALDI MNRAVSSNVG 

       730        740        750        760        770        780 
AYMQPGAREN IAYLTHTERR KDFQYEAMQE RREAENMAQR GIGVAASSVP MNFKDLIETK 

       790        800        810        820        830 
AEEHNIVFMP VIGKRHEGKQ LYTFGRIVIY IDRGVVFVQG EKTWVPTSLQ SLIDMAK

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References

[1]"Characterization of STIP, a multi-domain nuclear protein, highly conserved in metazoans, and essential for embryogenesis in Caenorhabditis elegans."
Ji Q., Huang C.-H., Peng J., Hashmi S., Ye T., Chen Y.
Exp. Cell Res. 313:1460-1472(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		DQ342026 mRNA. Translation: ABC69918.1.
RefSeqNP_001073621.1. NM_001080152.1.
UniGenePtr.6572.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING9598.ENSPTRP00000055027.

Proteomic databases

PRIDEA1XD93.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSPTRT00000026524; ENSPTRP00000024442; ENSPTRG00000014196.
GeneID458725.
KEGGptr:458725.

Organism-specific databases

CTD24144.

Phylogenomic databases

eggNOGNOG312699.
GeneTreeENSGT00390000012739.
HOGENOMHOG000230470.
HOVERGENHBG055868.
InParanoidA1XD93.
KOK13103.
OMASMSHLYG.
OrthoDBEOG4BRWK2.

Family and domain databases

InterProIPR000467. G_patch_dom.
IPR022783. GCFC_dom.
IPR024933. STIP.
IPR022159. TIP_N.
[Graphical view]
PfamPF01585. G-patch. 1 hit.
PF07842. GCFC. 1 hit.
PF12457. TIP_N. 1 hit.
[Graphical view]
PIRSFPIRSF017706. TFIP11. 1 hit.
SMARTSM00443. G_patch. 1 hit.
[Graphical view]
PROSITEPS50174. G_PATCH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20839105.

Entry information

Entry nameTFP11_PANTR
AccessionPrimary (citable) accession number: A1XD93
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: February 6, 2007
Last modified: April 3, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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