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Protein

Protein FAM92A1

Gene

FAM92A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM92A1
Gene namesi
Name:FAM92A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:30452. FAM92A1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671823.

Polymorphism and mutation databases

BioMutaiFAM92A1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Protein FAM92A1PRO_0000287080Add
BLAST

Proteomic databases

MaxQBiA1XBS5.
PaxDbiA1XBS5.
PRIDEiA1XBS5.

PTM databases

iPTMnetiA1XBS5.
PhosphoSiteiA1XBS5.

Expressioni

Gene expression databases

BgeeiA1XBS5.
CleanExiHS_FAM92A1.
ExpressionAtlasiA1XBS5. baseline and differential.
GenevisibleiA1XBS5. HS.

Organism-specific databases

HPAiHPA034760.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CBY1Q9Y3M23EBI-2349888,EBI-947308

Protein-protein interaction databases

BioGridi126476. 4 interactions.
IntActiA1XBS5. 2 interactions.
STRINGi9606.ENSP00000429367.

Structurei

3D structure databases

ProteinModelPortaliA1XBS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili107 – 17872Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the FAM92 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IHVX. Eukaryota.
ENOG410Z4I5. LUCA.
GeneTreeiENSGT00390000010285.
HOGENOMiHOG000060253.
HOVERGENiHBG107895.
InParanoidiA1XBS5.
OMAiRNSLYAP.
PhylomeDBiA1XBS5.
TreeFamiTF324316.

Family and domain databases

InterProiIPR009602. FAM92.
[Graphical view]
PANTHERiPTHR21223. PTHR21223. 1 hit.
PfamiPF06730. FAM92. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A1XBS5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMRRTLENRN AQTKQLQTAV SNVEKHFGEL CQIFAAYVRK TARLRDKADL
60 70 80 90 100
LVNEINAYAA TETPHLKLGL MNFADEFAKL QDYRQAEVER LEAKVVEPLK
110 120 130 140 150
TYGTIVKMKR DDLKATLTAR NREAKQLTQL ERTRQRNPSD RHVISQAETE
160 170 180 190 200
LQRAAMDASR TSRHLEETIN NFERQKMKDI KTIFSEFITI EMLFHGKALE
210 220 230 240 250
VYTAAYQNIQ NIDEDEDLEV FRNSLYAPDY SSRLDIVRAN SKSPLQRSLS
260 270 280
AKCVSGTGQV STCRLRKDQQ AEDDEDDELD VTEEENFLK
Length:289
Mass (Da):33,431
Last modified:September 23, 2008 - v2
Checksum:iCC95F1A4217FDCA5
GO
Isoform 2 (identifier: A1XBS5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     182-219: Missing.

Note: No experimental confirmation available.
Show »
Length:251
Mass (Da):28,997
Checksum:iE87B09A3CDE53979
GO
Isoform 3 (identifier: A1XBS5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     260-289: VSTCRLRKDQQAEDDEDDELDVTEEENFLK → EAGWAATCQTLI

Note: No experimental confirmation available.
Show »
Length:271
Mass (Da):31,123
Checksum:iA80C340EF3439A3C
GO
Isoform 4 (identifier: A1XBS5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-289: VFRNSLYAPD...DVTEEENFLK → RWSFAMLPRL...LCMHQIIHLV

Note: No experimental confirmation available.
Show »
Length:262
Mass (Da):30,400
Checksum:i006FEAE8F6F755AC
GO
Isoform 5 (identifier: A1XBS5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-97: ERLEAKVVE → WSEITVSLL
     98-289: Missing.

Note: No experimental confirmation available.
Show »
Length:97
Mass (Da):11,188
Checksum:i80F952E0764B5083
GO

Sequence cautioni

The sequence AAH14598.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI08708.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti137 – 1371N → S in ABC55436 (Ref. 1) Curated
Sequence conflicti150 – 1501E → G in BAC04753 (PubMed:14702039).Curated
Sequence conflicti281 – 2811V → I in ABC55437 (Ref. 1) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti222 – 2221R → Q.
Corresponds to variant rs36117362 [ dbSNP | Ensembl ].
VAR_062190

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei89 – 979ERLEAKVVE → WSEITVSLL in isoform 5. 1 PublicationVSP_025292
Alternative sequencei98 – 289192Missing in isoform 5. 1 PublicationVSP_025293Add
BLAST
Alternative sequencei182 – 21938Missing in isoform 2. 1 PublicationVSP_025294Add
BLAST
Alternative sequencei220 – 28970VFRNS…ENFLK → RWSFAMLPRLVLNSWGSSDP PALASQSVRFSEILCMHQII HLV in isoform 4. 1 PublicationVSP_025295Add
BLAST
Alternative sequencei260 – 28930VSTCR…ENFLK → EAGWAATCQTLI in isoform 3. 1 PublicationVSP_025296Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ327715 mRNA. Translation: ABC55436.1.
DQ327716 mRNA. Translation: ABC55437.1.
AK096298 mRNA. Translation: BAC04753.1.
CR627475 mRNA. Translation: CAH10675.1.
AC010834 Genomic DNA. No translation available.
AC120053 Genomic DNA. No translation available.
BC014598 mRNA. Translation: AAH14598.2. Different initiation.
BC108707 mRNA. Translation: AAI08708.1. Different initiation.
CCDSiCCDS47892.1. [A1XBS5-1]
CCDS64933.1. [A1XBS5-2]
RefSeqiNP_001269963.1. NM_001283034.1. [A1XBS5-2]
NP_660312.2. NM_145269.4. [A1XBS5-1]
UniGeneiHs.125038.

Genome annotation databases

EnsembliENST00000423990; ENSP00000401774; ENSG00000188343. [A1XBS5-2]
ENST00000452913; ENSP00000391671; ENSG00000188343. [A1XBS5-3]
ENST00000518116; ENSP00000428065; ENSG00000188343. [A1XBS5-4]
ENST00000518322; ENSP00000429367; ENSG00000188343. [A1XBS5-1]
GeneIDi137392.
KEGGihsa:137392.
UCSCiuc064onr.1. human. [A1XBS5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ327715 mRNA. Translation: ABC55436.1.
DQ327716 mRNA. Translation: ABC55437.1.
AK096298 mRNA. Translation: BAC04753.1.
CR627475 mRNA. Translation: CAH10675.1.
AC010834 Genomic DNA. No translation available.
AC120053 Genomic DNA. No translation available.
BC014598 mRNA. Translation: AAH14598.2. Different initiation.
BC108707 mRNA. Translation: AAI08708.1. Different initiation.
CCDSiCCDS47892.1. [A1XBS5-1]
CCDS64933.1. [A1XBS5-2]
RefSeqiNP_001269963.1. NM_001283034.1. [A1XBS5-2]
NP_660312.2. NM_145269.4. [A1XBS5-1]
UniGeneiHs.125038.

3D structure databases

ProteinModelPortaliA1XBS5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126476. 4 interactions.
IntActiA1XBS5. 2 interactions.
STRINGi9606.ENSP00000429367.

PTM databases

iPTMnetiA1XBS5.
PhosphoSiteiA1XBS5.

Polymorphism and mutation databases

BioMutaiFAM92A1.

Proteomic databases

MaxQBiA1XBS5.
PaxDbiA1XBS5.
PRIDEiA1XBS5.

Protocols and materials databases

DNASUi137392.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000423990; ENSP00000401774; ENSG00000188343. [A1XBS5-2]
ENST00000452913; ENSP00000391671; ENSG00000188343. [A1XBS5-3]
ENST00000518116; ENSP00000428065; ENSG00000188343. [A1XBS5-4]
ENST00000518322; ENSP00000429367; ENSG00000188343. [A1XBS5-1]
GeneIDi137392.
KEGGihsa:137392.
UCSCiuc064onr.1. human. [A1XBS5-1]

Organism-specific databases

CTDi137392.
GeneCardsiFAM92A1.
H-InvDBHIX0007647.
HIX0024596.
HGNCiHGNC:30452. FAM92A1.
HPAiHPA034760.
neXtProtiNX_A1XBS5.
PharmGKBiPA142671823.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHVX. Eukaryota.
ENOG410Z4I5. LUCA.
GeneTreeiENSGT00390000010285.
HOGENOMiHOG000060253.
HOVERGENiHBG107895.
InParanoidiA1XBS5.
OMAiRNSLYAP.
PhylomeDBiA1XBS5.
TreeFamiTF324316.

Miscellaneous databases

ChiTaRSiFAM92A1. human.
GenomeRNAii137392.
NextBioi83643.
PROiA1XBS5.

Gene expression databases

BgeeiA1XBS5.
CleanExiHS_FAM92A1.
ExpressionAtlasiA1XBS5. baseline and differential.
GenevisibleiA1XBS5. HS.

Family and domain databases

InterProiIPR009602. FAM92.
[Graphical view]
PANTHERiPTHR21223. PTHR21223. 1 hit.
PfamiPF06730. FAM92. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of two novel variants of Hscg6405."
    Ruan X.Z., Yang H.S., Zhao X.Y., Wang C.T., Song M., Lai S., Yan F., Yuan Z., Wei Y.Q.
    Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Ovary tumor.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    Tissue: Brain.
  4. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Testis and Uterus.

Entry informationi

Entry nameiF92A1_HUMAN
AccessioniPrimary (citable) accession number: A1XBS5
Secondary accession number(s): A1XBS4
, Q32ND3, Q6AHW7, Q8N8R1, Q96L09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: September 23, 2008
Last modified: March 16, 2016
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.