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A1X153

- WNT2_ECHTE

UniProt

A1X153 - WNT2_ECHTE

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Protein

Protein Wnt-2

Gene
WNT2
Organism
Echinops telfairi (Lesser hedgehog tenrec)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.

GO - Biological processi

  1. atrial cardiac muscle tissue morphogenesis Source: Ensembl
  2. canonical Wnt signaling pathway Source: Ensembl
  3. cardiac epithelial to mesenchymal transition Source: Ensembl
  4. cellular response to transforming growth factor beta stimulus Source: Ensembl
  5. labyrinthine layer blood vessel development Source: Ensembl
  6. lung induction Source: Ensembl
  7. mammary gland epithelium development Source: Ensembl
  8. positive regulation of canonical Wnt signaling pathway Source: Ensembl
  9. positive regulation of cardiac muscle cell proliferation Source: Ensembl
  10. positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: Ensembl
  11. positive regulation of fibroblast proliferation Source: Ensembl
  12. positive regulation of mesenchymal cell proliferation Source: Ensembl
  13. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  14. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-2
Gene namesi
Name:WNT2
OrganismiEchinops telfairi (Lesser hedgehog tenrec)
Taxonomic identifieri9371 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaAfrotheriaTenrecidaeTenrecinaeEchinops

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. plasma membrane Source: Ensembl
  3. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed predictionAdd
BLAST
Chaini26 – 359334Protein Wnt-2PRO_0000279197Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi75 ↔ 86 By similarity
Disulfide bondi126 ↔ 134 By similarity
Disulfide bondi136 ↔ 156 By similarity
Disulfide bondi205 ↔ 219 By similarity
Disulfide bondi207 ↔ 214 By similarity
Lipidationi211 – 2111O-palmitoyl serine; by PORCN By similarity
Disulfide bondi293 ↔ 308 By similarity
Glycosylationi294 – 2941N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi323 ↔ 338 By similarity
Disulfide bondi325 ↔ 335 By similarity
Disulfide bondi330 ↔ 331 By similarity

Post-translational modificationi

Palmitoylation at Ser-211 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00740000115400.
HOVERGENiHBG001595.
OrthoDBiEOG7C8GJ8.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR009140. Wnt2.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01842. WNT2PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1X153-1 [UniParc]FASTAAdd to Basket

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MNAPLAGIWP WLPLLWAWLV PEVSSSWWYM RATGTSRVMC DNVPGLVSRQ    50
RQLCHRHPDV MRAIGLGVAE WTAECQHQFR QHRWNCDTLD RDHSLFGRLL 100
LRSSRESAFV YAISSAGVVF AITRACSQGE LKSCSCDPKK KGTAKDSRGT 150
FDWGGCSDNI DYGVKFARAF VDAKEKKGKD ARALMNLHNN RAGRKAVKRF 200
LKQECKCHGV SGSCTLRTCW LAMADFRKTG DYLWRKYNGA IQVVMNQDGT 250
GFTVANKRFK KPTKNDLVYF ENSPDYCIRD RDAGSPGTAG RVCNLTSRGM 300
DSCEVMCCGR GYDTSRVTRM TKCECKFHWC CAVRCQDCLE ALDVHTCKAP 350
KSADWAVPT 359
Length:359
Mass (Da):40,452
Last modified:February 6, 2007 - v1
Checksum:iD872D4D268106543
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DP000274 Genomic DNA. Translation: ABL76169.1.
RefSeqiXP_004707826.1. XM_004707769.1.

Genome annotation databases

EnsembliENSETET00000015802; ENSETEP00000012817; ENSETEG00000015802.
GeneIDi101651785.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DP000274 Genomic DNA. Translation: ABL76169.1 .
RefSeqi XP_004707826.1. XM_004707769.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSETET00000015802 ; ENSETEP00000012817 ; ENSETEG00000015802 .
GeneIDi 101651785.

Organism-specific databases

CTDi 7472.

Phylogenomic databases

GeneTreei ENSGT00740000115400.
HOVERGENi HBG001595.
OrthoDBi EOG7C8GJ8.
TreeFami TF105310.

Family and domain databases

InterProi IPR005817. Wnt.
IPR009140. Wnt2.
IPR018161. Wnt_CS.
[Graphical view ]
PANTHERi PTHR12027. PTHR12027. 1 hit.
Pfami PF00110. wnt. 1 hit.
[Graphical view ]
PRINTSi PR01842. WNT2PROTEIN.
PR01349. WNTPROTEIN.
SMARTi SM00097. WNT1. 1 hit.
[Graphical view ]
PROSITEi PS00246. WNT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiWNT2_ECHTE
AccessioniPrimary (citable) accession number: A1X153
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi