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A1X153

- WNT2_ECHTE

UniProt

A1X153 - WNT2_ECHTE

Protein

Protein Wnt-2

Gene

WNT2

Organism
Echinops telfairi (Lesser hedgehog tenrec)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.By similarity

    GO - Biological processi

    1. atrial cardiac muscle tissue morphogenesis Source: Ensembl
    2. canonical Wnt signaling pathway Source: Ensembl
    3. cardiac epithelial to mesenchymal transition Source: Ensembl
    4. cellular response to transforming growth factor beta stimulus Source: Ensembl
    5. labyrinthine layer blood vessel development Source: Ensembl
    6. lung induction Source: Ensembl
    7. mammary gland epithelium development Source: Ensembl
    8. positive regulation of canonical Wnt signaling pathway Source: Ensembl
    9. positive regulation of cardiac muscle cell proliferation Source: Ensembl
    10. positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: Ensembl
    11. positive regulation of fibroblast proliferation Source: Ensembl
    12. positive regulation of mesenchymal cell proliferation Source: Ensembl
    13. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    14. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-2
    Gene namesi
    Name:WNT2
    OrganismiEchinops telfairi (Lesser hedgehog tenrec)
    Taxonomic identifieri9371 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaAfrotheriaTenrecidaeTenrecinaeEchinops

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. plasma membrane Source: Ensembl
    3. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 359334Protein Wnt-2PRO_0000279197Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi75 ↔ 86By similarity
    Disulfide bondi126 ↔ 134By similarity
    Disulfide bondi136 ↔ 156By similarity
    Disulfide bondi205 ↔ 219By similarity
    Disulfide bondi207 ↔ 214By similarity
    Lipidationi211 – 2111O-palmitoyl serine; by PORCNBy similarity
    Disulfide bondi293 ↔ 308By similarity
    Glycosylationi294 – 2941N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi323 ↔ 338By similarity
    Disulfide bondi325 ↔ 335By similarity
    Disulfide bondi330 ↔ 331By similarity

    Post-translational modificationi

    Palmitoylation at Ser-211 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    GeneTreeiENSGT00740000115400.
    HOVERGENiHBG001595.
    OrthoDBiEOG7C8GJ8.
    TreeFamiTF105310.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR009140. Wnt2.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01842. WNT2PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A1X153-1 [UniParc]FASTAAdd to Basket

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    MNAPLAGIWP WLPLLWAWLV PEVSSSWWYM RATGTSRVMC DNVPGLVSRQ    50
    RQLCHRHPDV MRAIGLGVAE WTAECQHQFR QHRWNCDTLD RDHSLFGRLL 100
    LRSSRESAFV YAISSAGVVF AITRACSQGE LKSCSCDPKK KGTAKDSRGT 150
    FDWGGCSDNI DYGVKFARAF VDAKEKKGKD ARALMNLHNN RAGRKAVKRF 200
    LKQECKCHGV SGSCTLRTCW LAMADFRKTG DYLWRKYNGA IQVVMNQDGT 250
    GFTVANKRFK KPTKNDLVYF ENSPDYCIRD RDAGSPGTAG RVCNLTSRGM 300
    DSCEVMCCGR GYDTSRVTRM TKCECKFHWC CAVRCQDCLE ALDVHTCKAP 350
    KSADWAVPT 359
    Length:359
    Mass (Da):40,452
    Last modified:February 6, 2007 - v1
    Checksum:iD872D4D268106543
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DP000274 Genomic DNA. Translation: ABL76169.1.
    RefSeqiXP_004707826.1. XM_004707769.1.

    Genome annotation databases

    EnsembliENSETET00000015802; ENSETEP00000012817; ENSETEG00000015802.
    GeneIDi101651785.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DP000274 Genomic DNA. Translation: ABL76169.1 .
    RefSeqi XP_004707826.1. XM_004707769.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSETET00000015802 ; ENSETEP00000012817 ; ENSETEG00000015802 .
    GeneIDi 101651785.

    Organism-specific databases

    CTDi 7472.

    Phylogenomic databases

    GeneTreei ENSGT00740000115400.
    HOVERGENi HBG001595.
    OrthoDBi EOG7C8GJ8.
    TreeFami TF105310.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR009140. Wnt2.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01842. WNT2PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiWNT2_ECHTE
    AccessioniPrimary (citable) accession number: A1X153
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 6, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3