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A1X153 (WNT2_ECHTE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein Wnt-2
Gene names
Name:WNT2
OrganismEchinops telfairi (Lesser hedgehog tenrec)
Taxonomic identifier9371 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaAfrotheriaTenrecidaeTenrecinaeEchinops

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity.

Post-translational modification

Palmitoylation at Ser-211 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-75. Palmitoylation is necessary for proper trafficking to cell surface By similarity.

Sequence similarities

Belongs to the Wnt family.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentExtracellular matrix
Secreted
   DomainSignal
   Molecular functionDevelopmental protein
   PTMGlycoprotein
Lipoprotein
Palmitate
Gene Ontology (GO)
   Biological_processatrial cardiac muscle tissue morphogenesis

Inferred from electronic annotation. Source: Ensembl

canonical Wnt signaling pathway

Inferred from electronic annotation. Source: Ensembl

cardiac epithelial to mesenchymal transition

Inferred from electronic annotation. Source: Ensembl

cellular response to transforming growth factor beta stimulus

Inferred from electronic annotation. Source: Ensembl

labyrinthine layer blood vessel development

Inferred from electronic annotation. Source: Ensembl

lung induction

Inferred from electronic annotation. Source: Ensembl

mammary gland epithelium development

Inferred from electronic annotation. Source: Ensembl

positive regulation of canonical Wnt signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of cardiac muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of epithelial cell proliferation involved in lung morphogenesis

Inferred from electronic annotation. Source: Ensembl

positive regulation of fibroblast proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of mesenchymal cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from electronic annotation. Source: Ensembl

proteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 359334Protein Wnt-2
PRO_0000279197

Amino acid modifications

Lipidation751S-palmitoyl cysteine By similarity
Lipidation2111O-palmitoyl serine; by PORCN By similarity
Glycosylation2941N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
A1X153 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: D872D4D268106543

FASTA35940,452
        10         20         30         40         50         60 
MNAPLAGIWP WLPLLWAWLV PEVSSSWWYM RATGTSRVMC DNVPGLVSRQ RQLCHRHPDV 

        70         80         90        100        110        120 
MRAIGLGVAE WTAECQHQFR QHRWNCDTLD RDHSLFGRLL LRSSRESAFV YAISSAGVVF 

       130        140        150        160        170        180 
AITRACSQGE LKSCSCDPKK KGTAKDSRGT FDWGGCSDNI DYGVKFARAF VDAKEKKGKD 

       190        200        210        220        230        240 
ARALMNLHNN RAGRKAVKRF LKQECKCHGV SGSCTLRTCW LAMADFRKTG DYLWRKYNGA 

       250        260        270        280        290        300 
IQVVMNQDGT GFTVANKRFK KPTKNDLVYF ENSPDYCIRD RDAGSPGTAG RVCNLTSRGM 

       310        320        330        340        350 
DSCEVMCCGR GYDTSRVTRM TKCECKFHWC CAVRCQDCLE ALDVHTCKAP KSADWAVPT 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DP000274 Genomic DNA. Translation: ABL76169.1.
RefSeqXP_004707826.1. XM_004707769.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSETET00000015802; ENSETEP00000012817; ENSETEG00000015802.
GeneID101651785.

Organism-specific databases

CTD7472.

Phylogenomic databases

GeneTreeENSGT00740000115400.
HOVERGENHBG001595.
OrthoDBEOG7C8GJ8.
TreeFamTF105310.

Family and domain databases

InterProIPR005817. Wnt.
IPR009140. Wnt2.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERPTHR12027. PTHR12027. 1 hit.
PfamPF00110. wnt. 1 hit.
[Graphical view]
PRINTSPR01842. WNT2PROTEIN.
PR01349. WNTPROTEIN.
SMARTSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameWNT2_ECHTE
AccessionPrimary (citable) accession number: A1X153
Entry history
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: February 6, 2007
Last modified: June 11, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families