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Protein

Protein Wnt-2

Gene

WNT2

Organism
Echinops telfairi (Lesser hedgehog tenrec)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-2
Gene namesi
Name:WNT2
OrganismiEchinops telfairi (Lesser hedgehog tenrec)
Taxonomic identifieri9371 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaAfrotheriaTenrecidaeTenrecinaeEchinops

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 359334Protein Wnt-2PRO_0000279197Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi75 ↔ 86By similarity
Disulfide bondi126 ↔ 134By similarity
Disulfide bondi136 ↔ 156By similarity
Disulfide bondi205 ↔ 219By similarity
Disulfide bondi207 ↔ 214By similarity
Lipidationi211 – 2111O-palmitoleyl serine; by PORCNBy similarity
Disulfide bondi293 ↔ 308By similarity
Glycosylationi294 – 2941N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi323 ↔ 338By similarity
Disulfide bondi325 ↔ 335By similarity
Disulfide bondi330 ↔ 331By similarity

Post-translational modificationi

Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Interactioni

Protein-protein interaction databases

STRINGi9371.ENSETEP00000012817.

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG001595.
OrthoDBiEOG7C8GJ8.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR009140. Wnt2.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01842. WNT2PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1X153-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAPLAGIWP WLPLLWAWLV PEVSSSWWYM RATGTSRVMC DNVPGLVSRQ
60 70 80 90 100
RQLCHRHPDV MRAIGLGVAE WTAECQHQFR QHRWNCDTLD RDHSLFGRLL
110 120 130 140 150
LRSSRESAFV YAISSAGVVF AITRACSQGE LKSCSCDPKK KGTAKDSRGT
160 170 180 190 200
FDWGGCSDNI DYGVKFARAF VDAKEKKGKD ARALMNLHNN RAGRKAVKRF
210 220 230 240 250
LKQECKCHGV SGSCTLRTCW LAMADFRKTG DYLWRKYNGA IQVVMNQDGT
260 270 280 290 300
GFTVANKRFK KPTKNDLVYF ENSPDYCIRD RDAGSPGTAG RVCNLTSRGM
310 320 330 340 350
DSCEVMCCGR GYDTSRVTRM TKCECKFHWC CAVRCQDCLE ALDVHTCKAP

KSADWAVPT
Length:359
Mass (Da):40,452
Last modified:February 6, 2007 - v1
Checksum:iD872D4D268106543
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000274 Genomic DNA. Translation: ABL76169.1.
RefSeqiXP_004707826.1. XM_004707769.1.

Genome annotation databases

GeneIDi101651785.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000274 Genomic DNA. Translation: ABL76169.1.
RefSeqiXP_004707826.1. XM_004707769.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9371.ENSETEP00000012817.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101651785.

Organism-specific databases

CTDi7472.

Phylogenomic databases

HOVERGENiHBG001595.
OrthoDBiEOG7C8GJ8.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR009140. Wnt2.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01842. WNT2PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiWNT2_ECHTE
AccessioniPrimary (citable) accession number: A1X153
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: February 6, 2007
Last modified: July 22, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.