A1WZR7 (SYR_HALHL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine--tRNA ligase
EC=6.1.1.19

Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	Hhal_2416

Organism

Halorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1)) [Complete proteome] [HAMAP]

Taxonomic identifier

349124 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Halorhodospira

Protein attributes

Sequence length	584 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP MF_00123
Subunit structure	Monomer By similarity. HAMAP MF_00123
Subcellular location	Cytoplasm HAMAP MF_00123.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW arginine-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 584	584	Arginine--tRNA ligase HAMAP MF_00123		PRO_1000018038
Regions
	Motif	129 – 139	11	"HIGH" region HAMAP MF_00123

Sequences

	Sequence		Length	Mass (Da)
	A1WZR7 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 39FCA2D7DFC580C0	FASTA	584	64,910
	10 20 30 40 50 60 MKRHVASLLA QALKAMREAG ELPADLELPE VQVERARDRA HGDYAANTAM VLAKPARQKP 70 80 90 100 110 120 RDLAETIRSR LPASEAIAGV EIAGPGFLNF TLTTAARQES VRVALRQGAE YGRSDVGAGH 130 140 150 160 170 180 RVHIEFVSAN PTGPLHVGHG RGAAFGDALA SVLEAAGYHV HREYYVNDAG RQMDILAASL 190 200 210 220 230 240 WLRYLEAAGE PVSFPNKGYQ GDYIVTHARE LFEADGREHV RTAAELGAGL PAEDDDPEGY 250 260 270 280 290 300 LDALVARSRE LLGETAYRRV LDFALEAILG DIRADLDAFG VHYHRYFSER QLVDQGRIEH 310 320 330 340 350 360 ALERLDQAGY TYRADGALWF QASVFGDDKD RVLRRDNGLT TYFAADVAYH LDKIERGFDT 370 380 390 400 410 420 LVNVWGADHH GYVPRVQAAL KALGVDAERL DVRLVQFAIL YRGGEKLPMS TRSGEFVTLR 430 440 450 460 470 480 ELRDEVGKDA ARFFYVMRRS EQHMDFDLDL AKSESADNPV YYCQYAHARI CSVFRQLEER 490 500 510 520 530 540 GLACRVTPDE AALERLDAEH EAILLDLLGR YPEVIESAAL AREPHQVAQY LRELAAAFHT 550 560 570 580 YYNAVPFIID DEALRDARLT LVQATRQVLA NGLGLLGVDA PQSM

References

[1]

"Complete sequence of Halorhodospira halophila SL1." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. , Land M., Hauser L., Kyrpides N., Mikhailova N., Hoff W., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 244 / SL1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000544 Genomic DNA. Translation: ABM63179.1.
RefSeq	YP_001003981.1. NC_008789.1.
3D structure databases
ProteinModelPortal	A1WZR7.
ModBase	Search...
Protein-protein interaction databases
STRING	A1WZR7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4710936.
GenomeReviews	Gene locus Hhal_2416 in contig CP000544_GR.
KEGG	hha:Hhal_2416.
PATRIC	22099135. VBIHalHal112047_2391.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0018.
HOGENOM	HBG695395.
OMA	FDVYFHE.
ProtClustDB	PRK01611.
Enzyme and pathway databases
BioCyc	HHAL349124:HHAL_2416-MONOMER.
Family and domain databases
HAMAP	MF_00123. Arg_tRNA_synth. [Tree]
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-synth_Ia. IPR015945. Arg-tRNA-synth_Ia_core. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
Gene3D	G3DSA:3.30.1360.70. Arg-tRNA-synth_Ic_N. 1 hit. G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K01887.
PANTHER	PTHR11956. Arg_tRNA-synt_1c. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 2 hits. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit. [Graphical view]
SUPFAM	SSF55190. Arg-tRNA-synth_Ic_N. 1 hit. SSF47323. tRNAsyn_1a_bind. 1 hit.
TIGRFAMs	TIGR00456. ArgS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_HALHL

Accession

Primary (citable) accession number: A1WZR7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program