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A1WZP9

- TRMB_HALHL

UniProt

A1WZP9 - TRMB_HALHL

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene
trmB, Hhal_2398
Organism
Halorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei57 – 571S-adenosyl-L-methionine By similarity
Binding sitei82 – 821S-adenosyl-L-methionine By similarity
Binding sitei109 – 1091S-adenosyl-L-methionine By similarity
Active sitei132 – 1321 By similarity
Binding sitei132 – 1321S-adenosyl-L-methionine By similarity
Binding sitei136 – 1361Substrate By similarity
Binding sitei168 – 1681Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciHHAL349124:GI3I-2451-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:Hhal_2398
OrganismiHalorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1))
Taxonomic identifieri349124 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeHalorhodospira
ProteomesiUP000000647: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 231231tRNA (guanine-N(7)-)-methyltransferaseUniRule annotationPRO_0000288156Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349124.Hhal_2398.

Structurei

3D structure databases

ProteinModelPortaliA1WZP9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni205 – 2084Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073968.
KOiK03439.
OMAiHSTLEMA.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1WZP9-1 [UniParc]FASTAAdd to Basket

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MSQPRQTRTF VRREGRLTQG QQRALEGLWP QFGVDVPERG VIDLDGLFGR    50
AAPRVLDIGF GDGEALVEMA AADPERDYLG VEVHRPGVGH CLLCAEQAGL 100
DNLRVATVDA VELVRHHLPG PSLETVQIFF PDPWPKKRHH KRRIIQPAFL 150
DLLAERLVPG GALHLATDWA DYAEWMLDTL EADARFENTC GPRAFVPPPP 200
PRPQTKFERR GLRKGHQVHD LIYRLRPDTA G 231
Length:231
Mass (Da):25,960
Last modified:February 6, 2007 - v1
Checksum:i4AB58A6215A3E687
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000544 Genomic DNA. Translation: ABM63161.1.
RefSeqiWP_011815183.1. NC_008789.1.
YP_001003963.1. NC_008789.1.

Genome annotation databases

EnsemblBacteriaiABM63161; ABM63161; Hhal_2398.
GeneIDi4710033.
KEGGihha:Hhal_2398.
PATRICi22099097. VBIHalHal112047_2373.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000544 Genomic DNA. Translation: ABM63161.1 .
RefSeqi WP_011815183.1. NC_008789.1.
YP_001003963.1. NC_008789.1.

3D structure databases

ProteinModelPortali A1WZP9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349124.Hhal_2398.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM63161 ; ABM63161 ; Hhal_2398 .
GeneIDi 4710033.
KEGGi hha:Hhal_2398.
PATRICi 22099097. VBIHalHal112047_2373.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073968.
KOi K03439.
OMAi HSTLEMA.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci HHAL349124:GI3I-2451-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 244 / SL1.

Entry informationi

Entry nameiTRMB_HALHL
AccessioniPrimary (citable) accession number: A1WZP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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