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A1WZH3

- FMT_HALHL

UniProt

A1WZH3 - FMT_HALHL

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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Halorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

  1. methionyl-tRNA formyltransferase activity Source: UniProtKB-HAMAP
  2. methyltransferase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

BioCyciHHAL349124:GI3I-2375-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:Hhal_2322
OrganismiHalorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1))
Taxonomic identifieri349124 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeHalorhodospira
ProteomesiUP000000647: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Methionyl-tRNA formyltransferasePRO_1000118482Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349124.Hhal_2322.

Structurei

3D structure databases

ProteinModelPortaliA1WZH3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni110 – 1134Tetrahydrofolate (THF) bindingUniRule annotation

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0223.
HOGENOMiHOG000261177.
KOiK00604.
OMAiRGDWFTP.
OrthoDBiEOG6B09WV.

Family and domain databases

Gene3Di3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPiMF_00182. Formyl_trans.
InterProiIPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR001555. GART_AS.
IPR015518. Met_tRNA_Form_TA-like.
[Graphical view]
PANTHERiPTHR11138. PTHR11138. 1 hit.
PfamiPF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view]
SUPFAMiSSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00460. fmt. 1 hit.
PROSITEiPS00373. GART. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1WZH3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAARIVFAGT PDFAVPGLDA LVEAGVRPVA VFTQPDRPAG RGRRLTPPPV
60 70 80 90 100
KRAAERHGLG VHQPERLGAE EAEQIRALAP DLMVVVAYGQ ILRRNVLDVP
110 120 130 140 150
RFGCVNVHAS LLPRWRGAAP IQRALLAGDE QTGVTLMQMD EGLDTGPMLA
160 170 180 190 200
RKATPISADE TAGSLHDRLA RIGADLLVAH LPEILAGAIT PEPQPDDGVT
210 220 230 240 250
YAAKLTNDES WLDPTEPAEQ LERRVRALAP VPGARLQLGE TPVRVLAARA
260 270 280 290 300
CAGRPEDRAG TVAAVGSGGI EVATGEGRLE ITRLKPAGGR EQTAADYLNG
310
RRLVPGEPVQ
Length:310
Mass (Da):32,830
Last modified:February 6, 2007 - v1
Checksum:i9564D7C54213D643
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000544 Genomic DNA. Translation: ABM63085.1.
RefSeqiWP_011815107.1. NC_008789.1.
YP_001003887.1. NC_008789.1.

Genome annotation databases

EnsemblBacteriaiABM63085; ABM63085; Hhal_2322.
GeneIDi4709354.
KEGGihha:Hhal_2322.
PATRICi22098951. VBIHalHal112047_2300.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000544 Genomic DNA. Translation: ABM63085.1 .
RefSeqi WP_011815107.1. NC_008789.1.
YP_001003887.1. NC_008789.1.

3D structure databases

ProteinModelPortali A1WZH3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349124.Hhal_2322.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM63085 ; ABM63085 ; Hhal_2322 .
GeneIDi 4709354.
KEGGi hha:Hhal_2322.
PATRICi 22098951. VBIHalHal112047_2300.

Phylogenomic databases

eggNOGi COG0223.
HOGENOMi HOG000261177.
KOi K00604.
OMAi RGDWFTP.
OrthoDBi EOG6B09WV.

Enzyme and pathway databases

BioCyci HHAL349124:GI3I-2375-MONOMER.

Family and domain databases

Gene3Di 3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPi MF_00182. Formyl_trans.
InterProi IPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR001555. GART_AS.
IPR015518. Met_tRNA_Form_TA-like.
[Graphical view ]
PANTHERi PTHR11138. PTHR11138. 1 hit.
Pfami PF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsi TIGR00460. fmt. 1 hit.
PROSITEi PS00373. GART. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 244 / SL1.

Entry informationi

Entry nameiFMT_HALHL
AccessioniPrimary (citable) accession number: A1WZH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3