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A1WYZ7

- SYL_HALHL

UniProt

A1WYZ7 - SYL_HALHL

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Protein

Leucine--tRNA ligase

Gene
leuS, Hhal_2145
Organism
Halorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHHAL349124:GI3I-2196-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Hhal_2145
OrganismiHalorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1))
Taxonomic identifieri349124 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeHalorhodospira
ProteomesiUP000000647: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 817817Leucine--tRNA ligaseUniRule annotationPRO_1000009352Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349124.Hhal_2145.

Structurei

3D structure databases

ProteinModelPortaliA1WYZ7.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotationAdd
BLAST
Motifi576 – 5805"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1WYZ7-1 [UniParc]FASTAAdd to Basket

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MDNQYQPKEI EAEAQAYWEQ QQTFQAREDS ARPKYYCLSM FPYPSGRLHM    50
GHVRNYTIGD VVSRYKRMQG YNVLQPMGWD AFGLPAENAA MERGVPPAAW 100
TRENIGAMRE QLKGLGFGYD WSRELATCDP EYYRWEQWLF IRLYRKGLVY 150
RDTAAVNWDP VDQTVLANEQ VIEGRGWRSG ALVERREIPQ WFLRITDYAD 200
ELLEALDELD GWPEQVRNMQ RNWIGRSEGV ELSFDLAGRD EQLTVFTTRP 250
DTLYGVTYMG LAPEHPISLE LAEHHPAIAE LVEEARSGGT AEADLATREK 300
RGADTGLEAI HPLTGERIPV WVANFVLMEY GSGAVMAVPA HDQRDWEFAS 350
TYGLPIRPVV HPADGTELDI AAGAFSDYGV LADSGPFSGM PSDRAFAAIA 400
ERLEAEGRGQ RRVQYRLRDW GVSRQRYWGA PIPMIHCADC GPVPVPDDQL 450
PVTLPEDVEI SGGGSPLKSM PAFYQTACPQ CGADAERETD TFDTFMESSW 500
YFARFACADQ DGAMLDERAD HWTPVDQYIG GIEHAVLHLL YARFYHKVLR 550
DEGLVSSDEP FTRLLTQGMV LKDGTKMSKS KGNTVDPQEL VDRFGADTVR 600
LFTMFAAPPD QSLEWSDSGV EGAYRFLRRL HGLVRDHVAA GPAPALDPQA 650
LSDTQRDLRR KVHETIAKAS DDVGKRLTFN TAIAAVMELC NALGKAQDDS 700
AAGRAVMQEG LEAAVLILAP ITPHLCHHLW FQLGHTAPVV EAPWPEADKQ 750
ALVRDEVELV VQVNGKLRGH VTLPADADQQ QAQEAALAEH NVQRFVADKE 800
IKKVVFVPGK LINVVAK 817
Length:817
Mass (Da):91,337
Last modified:February 6, 2007 - v1
Checksum:iEE6BA3B245421A21
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000544 Genomic DNA. Translation: ABM62909.1.
RefSeqiYP_001003711.1. NC_008789.1.

Genome annotation databases

EnsemblBacteriaiABM62909; ABM62909; Hhal_2145.
GeneIDi4709821.
KEGGihha:Hhal_2145.
PATRICi22098591. VBIHalHal112047_2122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000544 Genomic DNA. Translation: ABM62909.1 .
RefSeqi YP_001003711.1. NC_008789.1.

3D structure databases

ProteinModelPortali A1WYZ7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349124.Hhal_2145.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM62909 ; ABM62909 ; Hhal_2145 .
GeneIDi 4709821.
KEGGi hha:Hhal_2145.
PATRICi 22098591. VBIHalHal112047_2122.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci HHAL349124:GI3I-2196-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 244 / SL1.

Entry informationi

Entry nameiSYL_HALHL
AccessioniPrimary (citable) accession number: A1WYZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi