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A1WYZ7

- SYL_HALHL

UniProt

A1WYZ7 - SYL_HALHL

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Halorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHHAL349124:GI3I-2196-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Hhal_2145
OrganismiHalorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1))
Taxonomic identifieri349124 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeHalorhodospira
ProteomesiUP000000647: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 817817Leucine--tRNA ligasePRO_1000009352Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349124.Hhal_2145.

Structurei

3D structure databases

ProteinModelPortaliA1WYZ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi576 – 5805"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1WYZ7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDNQYQPKEI EAEAQAYWEQ QQTFQAREDS ARPKYYCLSM FPYPSGRLHM
60 70 80 90 100
GHVRNYTIGD VVSRYKRMQG YNVLQPMGWD AFGLPAENAA MERGVPPAAW
110 120 130 140 150
TRENIGAMRE QLKGLGFGYD WSRELATCDP EYYRWEQWLF IRLYRKGLVY
160 170 180 190 200
RDTAAVNWDP VDQTVLANEQ VIEGRGWRSG ALVERREIPQ WFLRITDYAD
210 220 230 240 250
ELLEALDELD GWPEQVRNMQ RNWIGRSEGV ELSFDLAGRD EQLTVFTTRP
260 270 280 290 300
DTLYGVTYMG LAPEHPISLE LAEHHPAIAE LVEEARSGGT AEADLATREK
310 320 330 340 350
RGADTGLEAI HPLTGERIPV WVANFVLMEY GSGAVMAVPA HDQRDWEFAS
360 370 380 390 400
TYGLPIRPVV HPADGTELDI AAGAFSDYGV LADSGPFSGM PSDRAFAAIA
410 420 430 440 450
ERLEAEGRGQ RRVQYRLRDW GVSRQRYWGA PIPMIHCADC GPVPVPDDQL
460 470 480 490 500
PVTLPEDVEI SGGGSPLKSM PAFYQTACPQ CGADAERETD TFDTFMESSW
510 520 530 540 550
YFARFACADQ DGAMLDERAD HWTPVDQYIG GIEHAVLHLL YARFYHKVLR
560 570 580 590 600
DEGLVSSDEP FTRLLTQGMV LKDGTKMSKS KGNTVDPQEL VDRFGADTVR
610 620 630 640 650
LFTMFAAPPD QSLEWSDSGV EGAYRFLRRL HGLVRDHVAA GPAPALDPQA
660 670 680 690 700
LSDTQRDLRR KVHETIAKAS DDVGKRLTFN TAIAAVMELC NALGKAQDDS
710 720 730 740 750
AAGRAVMQEG LEAAVLILAP ITPHLCHHLW FQLGHTAPVV EAPWPEADKQ
760 770 780 790 800
ALVRDEVELV VQVNGKLRGH VTLPADADQQ QAQEAALAEH NVQRFVADKE
810
IKKVVFVPGK LINVVAK
Length:817
Mass (Da):91,337
Last modified:February 6, 2007 - v1
Checksum:iEE6BA3B245421A21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000544 Genomic DNA. Translation: ABM62909.1.
RefSeqiYP_001003711.1. NC_008789.1.

Genome annotation databases

EnsemblBacteriaiABM62909; ABM62909; Hhal_2145.
GeneIDi4709821.
KEGGihha:Hhal_2145.
PATRICi22098591. VBIHalHal112047_2122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000544 Genomic DNA. Translation: ABM62909.1 .
RefSeqi YP_001003711.1. NC_008789.1.

3D structure databases

ProteinModelPortali A1WYZ7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349124.Hhal_2145.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM62909 ; ABM62909 ; Hhal_2145 .
GeneIDi 4709821.
KEGGi hha:Hhal_2145.
PATRICi 22098591. VBIHalHal112047_2122.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci HHAL349124:GI3I-2196-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 244 / SL1.

Entry informationi

Entry nameiSYL_HALHL
AccessioniPrimary (citable) accession number: A1WYZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: November 26, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3