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A1WYZ7

- SYL_HALHL

UniProt

A1WYZ7 - SYL_HALHL

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Halorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei579 – 5791ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHHAL349124:GI3I-2196-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Hhal_2145
    OrganismiHalorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1))
    Taxonomic identifieri349124 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeHalorhodospira
    ProteomesiUP000000647: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 817817Leucine--tRNA ligasePRO_1000009352Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi349124.Hhal_2145.

    Structurei

    3D structure databases

    ProteinModelPortaliA1WYZ7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi576 – 5805"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1WYZ7-1 [UniParc]FASTAAdd to Basket

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    MDNQYQPKEI EAEAQAYWEQ QQTFQAREDS ARPKYYCLSM FPYPSGRLHM    50
    GHVRNYTIGD VVSRYKRMQG YNVLQPMGWD AFGLPAENAA MERGVPPAAW 100
    TRENIGAMRE QLKGLGFGYD WSRELATCDP EYYRWEQWLF IRLYRKGLVY 150
    RDTAAVNWDP VDQTVLANEQ VIEGRGWRSG ALVERREIPQ WFLRITDYAD 200
    ELLEALDELD GWPEQVRNMQ RNWIGRSEGV ELSFDLAGRD EQLTVFTTRP 250
    DTLYGVTYMG LAPEHPISLE LAEHHPAIAE LVEEARSGGT AEADLATREK 300
    RGADTGLEAI HPLTGERIPV WVANFVLMEY GSGAVMAVPA HDQRDWEFAS 350
    TYGLPIRPVV HPADGTELDI AAGAFSDYGV LADSGPFSGM PSDRAFAAIA 400
    ERLEAEGRGQ RRVQYRLRDW GVSRQRYWGA PIPMIHCADC GPVPVPDDQL 450
    PVTLPEDVEI SGGGSPLKSM PAFYQTACPQ CGADAERETD TFDTFMESSW 500
    YFARFACADQ DGAMLDERAD HWTPVDQYIG GIEHAVLHLL YARFYHKVLR 550
    DEGLVSSDEP FTRLLTQGMV LKDGTKMSKS KGNTVDPQEL VDRFGADTVR 600
    LFTMFAAPPD QSLEWSDSGV EGAYRFLRRL HGLVRDHVAA GPAPALDPQA 650
    LSDTQRDLRR KVHETIAKAS DDVGKRLTFN TAIAAVMELC NALGKAQDDS 700
    AAGRAVMQEG LEAAVLILAP ITPHLCHHLW FQLGHTAPVV EAPWPEADKQ 750
    ALVRDEVELV VQVNGKLRGH VTLPADADQQ QAQEAALAEH NVQRFVADKE 800
    IKKVVFVPGK LINVVAK 817
    Length:817
    Mass (Da):91,337
    Last modified:February 6, 2007 - v1
    Checksum:iEE6BA3B245421A21
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000544 Genomic DNA. Translation: ABM62909.1.
    RefSeqiYP_001003711.1. NC_008789.1.

    Genome annotation databases

    EnsemblBacteriaiABM62909; ABM62909; Hhal_2145.
    GeneIDi4709821.
    KEGGihha:Hhal_2145.
    PATRICi22098591. VBIHalHal112047_2122.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000544 Genomic DNA. Translation: ABM62909.1 .
    RefSeqi YP_001003711.1. NC_008789.1.

    3D structure databases

    ProteinModelPortali A1WYZ7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349124.Hhal_2145.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM62909 ; ABM62909 ; Hhal_2145 .
    GeneIDi 4709821.
    KEGGi hha:Hhal_2145.
    PATRICi 22098591. VBIHalHal112047_2122.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci HHAL349124:GI3I-2196-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 244 / SL1.

    Entry informationi

    Entry nameiSYL_HALHL
    AccessioniPrimary (citable) accession number: A1WYZ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3