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A1WYZ7 (SYL_HALHL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:Hhal_2145
OrganismHalorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1)) [Complete proteome] [HAMAP]
Taxonomic identifier349124 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeHalorhodospira

Protein attributes

Sequence length817 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 817817Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_1000009352

Regions

Motif42 – 5211"HIGH" region HAMAP-Rule MF_00049
Motif576 – 5805"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site5791ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A1WYZ7 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: EE6BA3B245421A21

FASTA81791,337
        10         20         30         40         50         60 
MDNQYQPKEI EAEAQAYWEQ QQTFQAREDS ARPKYYCLSM FPYPSGRLHM GHVRNYTIGD 

        70         80         90        100        110        120 
VVSRYKRMQG YNVLQPMGWD AFGLPAENAA MERGVPPAAW TRENIGAMRE QLKGLGFGYD 

       130        140        150        160        170        180 
WSRELATCDP EYYRWEQWLF IRLYRKGLVY RDTAAVNWDP VDQTVLANEQ VIEGRGWRSG 

       190        200        210        220        230        240 
ALVERREIPQ WFLRITDYAD ELLEALDELD GWPEQVRNMQ RNWIGRSEGV ELSFDLAGRD 

       250        260        270        280        290        300 
EQLTVFTTRP DTLYGVTYMG LAPEHPISLE LAEHHPAIAE LVEEARSGGT AEADLATREK 

       310        320        330        340        350        360 
RGADTGLEAI HPLTGERIPV WVANFVLMEY GSGAVMAVPA HDQRDWEFAS TYGLPIRPVV 

       370        380        390        400        410        420 
HPADGTELDI AAGAFSDYGV LADSGPFSGM PSDRAFAAIA ERLEAEGRGQ RRVQYRLRDW 

       430        440        450        460        470        480 
GVSRQRYWGA PIPMIHCADC GPVPVPDDQL PVTLPEDVEI SGGGSPLKSM PAFYQTACPQ 

       490        500        510        520        530        540 
CGADAERETD TFDTFMESSW YFARFACADQ DGAMLDERAD HWTPVDQYIG GIEHAVLHLL 

       550        560        570        580        590        600 
YARFYHKVLR DEGLVSSDEP FTRLLTQGMV LKDGTKMSKS KGNTVDPQEL VDRFGADTVR 

       610        620        630        640        650        660 
LFTMFAAPPD QSLEWSDSGV EGAYRFLRRL HGLVRDHVAA GPAPALDPQA LSDTQRDLRR 

       670        680        690        700        710        720 
KVHETIAKAS DDVGKRLTFN TAIAAVMELC NALGKAQDDS AAGRAVMQEG LEAAVLILAP 

       730        740        750        760        770        780 
ITPHLCHHLW FQLGHTAPVV EAPWPEADKQ ALVRDEVELV VQVNGKLRGH VTLPADADQQ 

       790        800        810 
QAQEAALAEH NVQRFVADKE IKKVVFVPGK LINVVAK 

« Hide

References

[1]"Complete sequence of Halorhodospira halophila SL1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. expand/collapse author list , Land M., Hauser L., Kyrpides N., Mikhailova N., Hoff W., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 244 / SL1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000544 Genomic DNA. Translation: ABM62909.1.
RefSeqYP_001003711.1. NC_008789.1.

3D structure databases

ProteinModelPortalA1WYZ7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING349124.Hhal_2145.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABM62909; ABM62909; Hhal_2145.
GeneID4709821.
KEGGhha:Hhal_2145.
PATRIC22098591. VBIHalHal112047_2122.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAGIEHACM.
OrthoDBEOG63Z74X.
ProtClustDBPRK00390.

Enzyme and pathway databases

BioCycHHAL349124:GI3I-2196-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_HALHL
AccessionPrimary (citable) accession number: A1WYZ7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries