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A1WYI8

- GCH4_HALHL

UniProt

A1WYI8 - GCH4_HALHL

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Halorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei145 – 1451May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciHHAL349124:GI3I-2035-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:Hhal_1986
    OrganismiHalorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1))
    Taxonomic identifieri349124 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeHalorhodospira
    ProteomesiUP000000647: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 259259GTP cyclohydrolase FolE2PRO_0000289493Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi349124.Hhal_1986.

    Structurei

    3D structure databases

    ProteinModelPortaliA1WYI8.
    SMRiA1WYI8. Positions 12-256.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000280679.
    KOiK09007.
    OMAiDVQSSRD.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1WYI8-1 [UniParc]FASTAAdd to Basket

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    MEDVQGRADT RQIEINKVGI KDIRHPVRVR DRTGRDQHTV ATFSMYVNLP    50
    QHFKGTHMSR FVSILEGHDR EVTVESFHEM LAEMTDRLEA HSGHIEMAFP 100
    YFVNKQAPVT GVESLMDYEV TFIGEIHGGR HETWVRVAVP ITTLCPCSKE 150
    IAERGAHNQR SLVVVTALMD GFVWLEELID LVEREGSCEL YGLLKRPDEK 200
    HVTERAYDNP KFVEDVVRDI AGRLNDDGRI AAYSVTSENY ESIHNHSAFA 250
    LIEQDKRGR 259
    Length:259
    Mass (Da):29,614
    Last modified:February 6, 2007 - v1
    Checksum:i4E1080D5E833F8AF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000544 Genomic DNA. Translation: ABM62750.1.
    RefSeqiWP_011814772.1. NC_008789.1.
    YP_001003552.1. NC_008789.1.

    Genome annotation databases

    EnsemblBacteriaiABM62750; ABM62750; Hhal_1986.
    GeneIDi4710445.
    KEGGihha:Hhal_1986.
    PATRICi22098269. VBIHalHal112047_1962.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000544 Genomic DNA. Translation: ABM62750.1 .
    RefSeqi WP_011814772.1. NC_008789.1.
    YP_001003552.1. NC_008789.1.

    3D structure databases

    ProteinModelPortali A1WYI8.
    SMRi A1WYI8. Positions 12-256.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349124.Hhal_1986.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM62750 ; ABM62750 ; Hhal_1986 .
    GeneIDi 4710445.
    KEGGi hha:Hhal_1986.
    PATRICi 22098269. VBIHalHal112047_1962.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000280679.
    KOi K09007.
    OMAi DVQSSRD.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci HHAL349124:GI3I-2035-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 244 / SL1.

    Entry informationi

    Entry nameiGCH4_HALHL
    AccessioniPrimary (citable) accession number: A1WYI8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3