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A1WYI8

- GCH4_HALHL

UniProt

A1WYI8 - GCH4_HALHL

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Protein
GTP cyclohydrolase FolE2
Gene
folE2, Hhal_1986
Organism
Halorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1))
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei145 – 1451May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciHHAL349124:GI3I-2035-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:Hhal_1986
OrganismiHalorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1))
Taxonomic identifieri349124 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeHalorhodospira
ProteomesiUP000000647: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259GTP cyclohydrolase FolE2UniRule annotation
PRO_0000289493Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349124.Hhal_1986.

Structurei

3D structure databases

ProteinModelPortaliA1WYI8.
SMRiA1WYI8. Positions 12-256.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1WYI8-1 [UniParc]FASTAAdd to Basket

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MEDVQGRADT RQIEINKVGI KDIRHPVRVR DRTGRDQHTV ATFSMYVNLP    50
QHFKGTHMSR FVSILEGHDR EVTVESFHEM LAEMTDRLEA HSGHIEMAFP 100
YFVNKQAPVT GVESLMDYEV TFIGEIHGGR HETWVRVAVP ITTLCPCSKE 150
IAERGAHNQR SLVVVTALMD GFVWLEELID LVEREGSCEL YGLLKRPDEK 200
HVTERAYDNP KFVEDVVRDI AGRLNDDGRI AAYSVTSENY ESIHNHSAFA 250
LIEQDKRGR 259
Length:259
Mass (Da):29,614
Last modified:February 6, 2007 - v1
Checksum:i4E1080D5E833F8AF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000544 Genomic DNA. Translation: ABM62750.1.
RefSeqiWP_011814772.1. NC_008789.1.
YP_001003552.1. NC_008789.1.

Genome annotation databases

EnsemblBacteriaiABM62750; ABM62750; Hhal_1986.
GeneIDi4710445.
KEGGihha:Hhal_1986.
PATRICi22098269. VBIHalHal112047_1962.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000544 Genomic DNA. Translation: ABM62750.1 .
RefSeqi WP_011814772.1. NC_008789.1.
YP_001003552.1. NC_008789.1.

3D structure databases

ProteinModelPortali A1WYI8.
SMRi A1WYI8. Positions 12-256.
ModBasei Search...

Protein-protein interaction databases

STRINGi 349124.Hhal_1986.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM62750 ; ABM62750 ; Hhal_1986 .
GeneIDi 4710445.
KEGGi hha:Hhal_1986.
PATRICi 22098269. VBIHalHal112047_1962.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci HHAL349124:GI3I-2035-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 244 / SL1.

Entry informationi

Entry nameiGCH4_HALHL
AccessioniPrimary (citable) accession number: A1WYI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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