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A1WYI8 (GCH4_HALHL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:Hhal_1986
OrganismHalorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1)) [Complete proteome] [HAMAP]
Taxonomic identifier349124 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeHalorhodospira

Protein attributes

Sequence length259 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 259259GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000289493

Sites

Site1451May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
A1WYI8 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 4E1080D5E833F8AF

FASTA25929,614
        10         20         30         40         50         60 
MEDVQGRADT RQIEINKVGI KDIRHPVRVR DRTGRDQHTV ATFSMYVNLP QHFKGTHMSR 

        70         80         90        100        110        120 
FVSILEGHDR EVTVESFHEM LAEMTDRLEA HSGHIEMAFP YFVNKQAPVT GVESLMDYEV 

       130        140        150        160        170        180 
TFIGEIHGGR HETWVRVAVP ITTLCPCSKE IAERGAHNQR SLVVVTALMD GFVWLEELID 

       190        200        210        220        230        240 
LVEREGSCEL YGLLKRPDEK HVTERAYDNP KFVEDVVRDI AGRLNDDGRI AAYSVTSENY 

       250 
ESIHNHSAFA LIEQDKRGR 

« Hide

References

[1]"Complete sequence of Halorhodospira halophila SL1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. expand/collapse author list , Land M., Hauser L., Kyrpides N., Mikhailova N., Hoff W., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 244 / SL1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000544 Genomic DNA. Translation: ABM62750.1.
RefSeqYP_001003552.1. NC_008789.1.

3D structure databases

ProteinModelPortalA1WYI8.
SMRA1WYI8. Positions 12-256.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING349124.Hhal_1986.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABM62750; ABM62750; Hhal_1986.
GeneID4710445.
KEGGhha:Hhal_1986.
PATRIC22098269. VBIHalHal112047_1962.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000280679.
KOK09007.
OMADVQSSRD.
OrthoDBEOG6X6RBH.

Enzyme and pathway databases

BioCycHHAL349124:GI3I-2035-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_HALHL
AccessionPrimary (citable) accession number: A1WYI8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways