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Protein

Cobalt-precorrin-5B C(1)-methyltransferase

Gene

cbiD

Organism
Halorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.UniRule annotation

Catalytic activityi

Cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route).UniRule annotation
Proteins known to be involved in the 10 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Cobalt-precorrin-5B C(1)-methyltransferase (cbiD)
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. no protein annotated in this organism
  10. no protein annotated in this organism
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route), the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processCobalamin biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00148; UER00227

Names & Taxonomyi

Protein namesi
Recommended name:
Cobalt-precorrin-5B C(1)-methyltransferaseUniRule annotation (EC:2.1.1.195UniRule annotation)
Alternative name(s):
Cobalt-precorrin-6A synthaseUniRule annotation
Gene namesi
Name:cbiDUniRule annotation
Ordered Locus Names:Hhal_1929
OrganismiHalorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1))
Taxonomic identifieri349124 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeHalorhodospira
Proteomesi
  • UP000000647 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000622461 – 373Cobalt-precorrin-5B C(1)-methyltransferaseAdd BLAST373

Interactioni

Protein-protein interaction databases

STRINGi349124.Hhal_1929

Structurei

3D structure databases

ProteinModelPortaliA1WYD1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CbiD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EE8 Bacteria
COG1903 LUCA
HOGENOMiHOG000009126
KOiK02188
OMAiGGIFHTH
OrthoDBiPOG091H02QJ

Family and domain databases

Gene3Di3.30.2110.10, 1 hit
HAMAPiMF_00787 CbiD, 1 hit
InterProiView protein in InterPro
IPR002748 CbiD
IPR036074 CbiD_sf
PANTHERiPTHR35863 PTHR35863, 1 hit
PfamiView protein in Pfam
PF01888 CbiD, 1 hit
PIRSFiPIRSF026782 CbiD, 1 hit
SUPFAMiSSF111342 SSF111342, 1 hit

Sequencei

Sequence statusi: Complete.

A1WYD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEDTSQPTD QQAGTALRRG WTTGACAAAA ARAAFTGLVS GSFPDPVTIR
60 70 80 90 100
LPRDRSPAFA LAVHACGDGW ARAGVIKDAG DDPDVTHGAL VSVTARPGAP
110 120 130 140 150
GRGVQLRAGP GVGTVRRSGL PVAAGEPAIN PGPRGYIEQG IAEAAAALSA
160 170 180 190 200
PTDVTLELAI EDGERLAAQT LNPRLGIEGG LSVLGTTGLL VPFSCAAWID
210 220 230 240 250
AIQRGIDVAR AAGIEHVAGS TGRTSEQAVQ AYHQLPDEAL IDMGDFVGGM
260 270 280 290 300
LKYLRRYPVP RVTIAGGVAK ITKLAQGFLD VHSRRGQADL AALAETAGRL
310 320 330 340 350
GADATCREVM ATANTVAEAF DRAQAAGLPL GDAVAREAQQ TALNLIDPAC
360 370
SEVEVLLFDR RGQRVGRAGW ARD
Length:373
Mass (Da):38,402
Last modified:February 6, 2007 - v1
Checksum:i0A87DE487F26A11E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000544 Genomic DNA Translation: ABM62693.1
RefSeqiWP_011814715.1, NC_008789.1

Genome annotation databases

EnsemblBacteriaiABM62693; ABM62693; Hhal_1929
KEGGihha:Hhal_1929

Similar proteinsi

Entry informationi

Entry nameiCBID_HALHL
AccessioniPrimary (citable) accession number: A1WYD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 6, 2007
Last modified: March 28, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health