A1WY97 (ACSA_HALHL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase
EC=6.2.1.1

Alternative name(s):
Acetate--CoA ligase
Acyl-activating enzyme

Gene names

Name:	acsA
Ordered Locus Names:	Hhal_1895

Organism

Halorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1)) [Complete proteome] [HAMAP]

Taxonomic identifier

349124 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Halorhodospira

Protein attributes

Sequence length	645 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
PTM	Acetylation
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 645	645	Acetyl-coenzyme A synthetase HAMAP MF_01123		PRO_1000065291
Sites
	Active site	514	1	By similarity
Amino acid modifications
	Modified residue	606	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1WY97 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: A49FA72EB504C8DC	FASTA	645	71,771
	10 20 30 40 50 60 MSETKVYPVP ETIQRDAHLN FEQYQEMYNR SIQDPEGFWS EQADKFLDWF SKWGTTCHWD 70 80 90 100 110 120 LAKGDIRFFE GGTLNVAYNC VDRHLETRGD QTAIIWEGDE PDQDEHITYR DLYERVGRLA 130 140 150 160 170 180 NALKARGVKK GDRVCIYLPM VPEAAVAMLA CARIGAVHSI VFGGFSPEAL RDRIQDADAE 190 200 210 220 230 240 VVITSDEGVR GGRSIPLKAN TDKALEGCPN VKTVFVVRRT GGDIAWNDGR DVWFHEACAE 250 260 270 280 290 300 ASPDCPPEHM DAEDPLFILY TSGSTGKPKG VQHSTAGYLL GTAMTHKYIF DYQDGEVYWC 310 320 330 340 350 360 TADVGWVTGH SYIVYGPLAN GAKTLMFEGV PTYPDAGRFW QVVDKHEVSI FYTAPTAIRA 370 380 390 400 410 420 LMGQGDDHVK KTSRKSLRIL GTVGEPINPE AWEWYYHTIG EDRCPIVDTW WQTETGSILI 430 440 450 460 470 480 APLPGAMDLK PGSATLPFFG VEPQLVDDKG NVLEGATNGN LVINRAWPSM MRTIYGDHER 490 500 510 520 530 540 FFNTYLAAYP GKYFTGDGAR RDEDGYYWIT GRVDDVINVS GHRMGTAEVE SALVLHDKVS 550 560 570 580 590 600 EAAVVGYPHD VKGQGIYAYV TLMAGEEPSD ELKQELVKLC IQEIGPIAKP DIIQFAPGLP 610 620 630 640 KTRSGKIMRR ILRKVASNEL DSLGDTSTLA DPTVVDTLIE DRANQ

References

[1]

"Complete sequence of Halorhodospira halophila SL1." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. , Land M., Hauser L., Kyrpides N., Mikhailova N., Hoff W., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 244 / SL1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000544 Genomic DNA. Translation: ABM62659.1.
RefSeq	YP_001003461.1. NC_008789.1.
3D structure databases
ProteinModelPortal	A1WY97.
ModBase	Search...
Protein-protein interaction databases
STRING	A1WY97.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4710685.
GenomeReviews	Gene locus Hhal_1895 in contig CP000544_GR.
KEGG	hha:Hhal_1895.
PATRIC	22098083. VBIHalHal112047_1869.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0365.
HOGENOM	HBG547964.
OMA	DGFYWIL.
PhylomeDB	A1WY97.
ProtClustDB	PRK00174.
Enzyme and pathway databases
BioCyc	HHAL349124:HHAL_1895-MONOMER.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACSA_HALHL

Accession

Primary (citable) accession number: A1WY97

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	February 6, 2007
Last modified:	January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program