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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Halorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.

Cofactori

NAD+Note: Binds 1 NAD+ per subunit.

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (Hhal_0050), Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei56Substrate1
Binding sitei131Substrate1
Binding sitei156Substrate1
Binding sitei186Substrate1
Binding sitei190Substrate1
Binding sitei191NAD1
Binding sitei243NAD1
Binding sitei278NAD1
Binding sitei344NAD1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi157 – 159NAD3
Nucleotide bindingi220 – 225NAD6
Nucleotide bindingi299 – 301NAD3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

BioCyciHHAL349124:GI3I-1718-MONOMER.
UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosylhomocysteinase (EC:3.3.1.1)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolase
Short name:
AdoHcyase
Gene namesi
Name:ahcY
Ordered Locus Names:Hhal_1675
OrganismiHalorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1))
Taxonomic identifieri349124 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeHalorhodospira
Proteomesi
  • UP000000647 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000611251 – 430AdenosylhomocysteinaseAdd BLAST430

Interactioni

Protein-protein interaction databases

STRINGi349124.Hhal_1675.

Structurei

3D structure databases

ProteinModelPortaliA1WXM7.
SMRiA1WXM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.

Phylogenomic databases

eggNOGiENOG4105C3E. Bacteria.
COG0499. LUCA.
HOGENOMiHOG000227987.
KOiK01251.
OMAiTGNRDII.
OrthoDBiPOG091H00W2.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
HAMAPiMF_00563. AdoHcyase. 1 hit.
InterProiView protein in InterPro
IPR034373. Adenosylhomocysteinase.
IPR000043. Adenosylhomocysteinase-like.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiView protein in Pfam
PF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiView protein in SMART
SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiView protein in PROSITE
PS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A1WXM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNQDYKVAD ISLADWGRKE IKIAESEMPG LMETRREFAA QKPLKGARIA
60 70 80 90 100
GCLHMTIQTA VLIETLQELG AEVRWSSCNI FSTQDQAAAA VAANGTPVFA
110 120 130 140 150
WKGETEEEYW WCIEQTINGP DGWKPNMLLD DGGDLTAVIH EQYPDMMKDI
160 170 180 190 200
YGVSEETTTG VHRLYEMSRK GELGMPAFNV NDSVTKSKFD NLYGCRESLV
210 220 230 240 250
DSIKRATDVM IAGKVAVVAG FGDVGKGSAQ SLRGLGAQVW VTEVDPICAL
260 270 280 290 300
QASMDGYKVV TMEEAAPVAD IFVTATGNYN VITHDHMKAM KDEAIVCNIG
310 320 330 340 350
HFDNEIDVAS LKQYKWDEIK PQVDHVEFPD GKKITLLAEG RLVNLGCATG
360 370 380 390 400
HPSFVMSNSF TNQVMAQMEL YNNPGKYEKD VYVLPKHLDE KVAALHLGRV
410 420 430
GANLTRLSEE QAGYIGVSVD GPFKPEWYRY
Length:430
Mass (Da):47,510
Last modified:February 6, 2007 - v1
Checksum:i1B0D75461642D506
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000544 Genomic DNA. Translation: ABM62439.1.
RefSeqiWP_011814461.1. NC_008789.1.

Genome annotation databases

EnsemblBacteriaiABM62439; ABM62439; Hhal_1675.
KEGGihha:Hhal_1675.

Similar proteinsi

Entry informationi

Entry nameiSAHH_HALHL
AccessioniPrimary (citable) accession number: A1WXM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 6, 2007
Last modified: October 25, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families