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Protein

NAD kinase

Gene

nadK

Organism
Halorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei78Proton acceptorUniRule annotation1
Binding sitei83NADUniRule annotation1
Binding sitei165NADUniRule annotation1
Binding sitei182NADUniRule annotation1
Binding sitei184NADUniRule annotation1
Binding sitei255NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi78 – 79NADUniRule annotation2
Nucleotide bindingi154 – 155NADUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Hhal_1479
OrganismiHalorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1))
Taxonomic identifieri349124 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeHalorhodospira
Proteomesi
  • UP000000647 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000054131 – 307NAD kinaseAdd BLAST307

Proteomic databases

PRIDEiA1WX34

Interactioni

Protein-protein interaction databases

STRINGi349124.Hhal_1479

Structurei

3D structure databases

ProteinModelPortaliA1WX34
SMRiA1WX34
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227221
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

A1WX34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEHPPPPFP TVGIIGKPGD PAIAGLVERL LPMLEARGCT ALLDEQSMPE
60 70 80 90 100
TGDDRHPQRV SRETLLDACD LIIAIGGDGT LIHIARAVAG RRDVALMGIN
110 120 130 140 150
RGRLGFLVDI APEHLDEVAQ ILDGQHVVDE RLLLHAEIRS NEDDTLLRED
160 170 180 190 200
VAINEVVLHR WNTARMIELV TRIDGEPLSD HRSDGLILAT PTGSTAYAMA
210 220 230 240 250
GGGPIVHPNL HAMLLVPVCP HTLSNRPLVV DGSSRIEIDV HPRFIEHVRV
260 270 280 290 300
SCDSQNDLTL QAGSRLVVRA HPSPVRLVHP PGYSYFNLLR AKLGWGGPLC

NIEPFGA
Length:307
Mass (Da):33,397
Last modified:February 6, 2007 - v1
Checksum:i3DB2BA703F130177
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000544 Genomic DNA Translation: ABM62246.1
RefSeqiWP_011814268.1, NC_008789.1

Genome annotation databases

EnsemblBacteriaiABM62246; ABM62246; Hhal_1479
KEGGihha:Hhal_1479

Similar proteinsi

Entry informationi

Entry nameiNADK_HALHL
AccessioniPrimary (citable) accession number: A1WX34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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