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A1WX34

- NADK_HALHL

UniProt

A1WX34 - NADK_HALHL

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Protein
NAD kinase
Gene
nadK, Hhal_1479
Organism
Halorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei78 – 781Proton acceptor By similarity
Binding sitei83 – 831NAD By similarity
Binding sitei165 – 1651NAD By similarity
Binding sitei182 – 1821NAD By similarity
Binding sitei184 – 1841NAD By similarity
Binding sitei255 – 2551NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi78 – 792NAD By similarity
Nucleotide bindingi154 – 1552NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciHHAL349124:GI3I-1518-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:Hhal_1479
OrganismiHalorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1))
Taxonomic identifieri349124 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeHalorhodospira
ProteomesiUP000000647: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307NAD kinaseUniRule annotation
PRO_1000005413Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349124.Hhal_1479.

Structurei

3D structure databases

ProteinModelPortaliA1WX34.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227221.
KOiK00858.
OMAiTHEMLYH.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

A1WX34-1 [UniParc]FASTAAdd to Basket

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MDEHPPPPFP TVGIIGKPGD PAIAGLVERL LPMLEARGCT ALLDEQSMPE    50
TGDDRHPQRV SRETLLDACD LIIAIGGDGT LIHIARAVAG RRDVALMGIN 100
RGRLGFLVDI APEHLDEVAQ ILDGQHVVDE RLLLHAEIRS NEDDTLLRED 150
VAINEVVLHR WNTARMIELV TRIDGEPLSD HRSDGLILAT PTGSTAYAMA 200
GGGPIVHPNL HAMLLVPVCP HTLSNRPLVV DGSSRIEIDV HPRFIEHVRV 250
SCDSQNDLTL QAGSRLVVRA HPSPVRLVHP PGYSYFNLLR AKLGWGGPLC 300
NIEPFGA 307
Length:307
Mass (Da):33,397
Last modified:February 6, 2007 - v1
Checksum:i3DB2BA703F130177
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000544 Genomic DNA. Translation: ABM62246.1.
RefSeqiWP_011814268.1. NC_008789.1.
YP_001003048.1. NC_008789.1.

Genome annotation databases

EnsemblBacteriaiABM62246; ABM62246; Hhal_1479.
GeneIDi4709260.
KEGGihha:Hhal_1479.
PATRICi22097259. VBIHalHal112047_1466.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000544 Genomic DNA. Translation: ABM62246.1 .
RefSeqi WP_011814268.1. NC_008789.1.
YP_001003048.1. NC_008789.1.

3D structure databases

ProteinModelPortali A1WX34.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349124.Hhal_1479.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM62246 ; ABM62246 ; Hhal_1479 .
GeneIDi 4709260.
KEGGi hha:Hhal_1479.
PATRICi 22097259. VBIHalHal112047_1466.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227221.
KOi K00858.
OMAi THEMLYH.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci HHAL349124:GI3I-1518-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 244 / SL1.

Entry informationi

Entry nameiNADK_HALHL
AccessioniPrimary (citable) accession number: A1WX34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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