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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Halorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Hhal_1192
OrganismiHalorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1))
Taxonomic identifieri349124 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeHalorhodospira
Proteomesi
  • UP000000647 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000456581 – 460Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST460

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi349124.Hhal_1192

Structurei

3D structure databases

ProteinModelPortaliA1WWA5
SMRiA1WWA5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QK8 Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

A1WWA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFVPHTEQE VREMLDAIGV ERIEDLFDEI PESLRKASID AIPAGMNEME
60 70 80 90 100
VTQLMRRRAA QDVQPACFVG AGAYDHHVPA AVWEITTRGE FYSAYTPYQA
110 120 130 140 150
EASQGTLQLL YEFQTMMSEL TGLYASNASL YDGATALAEA VLMAVRANRK
160 170 180 190 200
VKSKRVLMPR SVHPYYRRVV ETIVANQGIE LVEAPLDDTV GRIDPEALGR
210 220 230 240 250
FEDEPFAAVV IPQPNFFGAL EEVDRLTDWA HGLNALVIAV CNPVALALLT
260 270 280 290 300
PPGEWGTEGA DIACGEGQPL GIPLSSGGPY FGYMTTRKQH VRQLPGRIVG
310 320 330 340 350
RTVDADGRTG YTLTLQAREQ HIRRSKATSN ICTNQGLMVT AATVHLSLLG
360 370 380 390 400
AEGLARVAAV SHERTRELVQ KLTAIDGVER LFDGPFFHEV PVRIPAPAEE
410 420 430 440 450
VLPMLANRGV LGGYDLSQEF PEWGPALLIC ATETRTSEEI DRFAAALADA
460
LRNTGQRARA
Length:460
Mass (Da):50,307
Last modified:February 6, 2007 - v1
Checksum:i1C1AEA1151C6B2CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000544 Genomic DNA Translation: ABM61967.1
RefSeqiWP_011813990.1, NC_008789.1

Genome annotation databases

EnsemblBacteriaiABM61967; ABM61967; Hhal_1192
KEGGihha:Hhal_1192

Similar proteinsi

Entry informationi

Entry nameiGCSPA_HALHL
AccessioniPrimary (citable) accession number: A1WWA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: April 25, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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