A1WVT8 (ARLY_HALHL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1

Alternative name(s):
Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	Hhal_1024

Organism

Halorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1)) [Complete proteome] [HAMAP]

Taxonomic identifier

349124 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Halorhodospira › Halorhodospira halophila

Protein attributes

Sequence length	465 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP-Rule MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP-Rule MF_00006
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	argininosuccinate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 465	465	Argininosuccinate lyase HAMAP-Rule MF_00006		PRO_0000321439

Sequences

	Sequence		Length	Mass (Da)
	A1WVT8 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 870627295BF32374	FASTA	465	51,581
	10 20 30 40 50 60 MSQNDAAPGQ QLWTGRFTEA TDAFVERFSA SVQFDARLAL QDIQGSEAHA RMLAARGVLT 70 80 90 100 110 120 EAERDAILQG LAEIRQEVVE ERFPWSPQLE DVHMNIEHRL TQRIGEAGKK LHTGRSRNDQ 130 140 150 160 170 180 IATDVRLFLR EAIDTIRAEL ARFQHGLVEL AEREADTIMP GFTHLQVAQP VTFGHHMLAW 190 200 210 220 230 240 YEMLERDRDR LADCRRRLNQ CPLGAAALAG TSFPIDREAT ARELGFDAPT RNSLDSVSDR 250 260 270 280 290 300 DFAIEFCADA SLILVHLSRM AEELVLWTSQ QFGFIELPDR FCTGSSIMPQ KKNPDVAELV 310 320 330 340 350 360 RGKAARAQGS LVQLLTLMKG QPLAYNRDNQ EDKEPLFDAV DTARDALTAF ADMVPALSVN 370 380 390 400 410 420 RERCRAAARA GFATATDLAD YLVRQGLAFR DAHEVVGRAV RYATEADRDL AELSLEELQQ 430 440 450 460 FSTAIGDDVF AVLTLDGSVA ARSHVGGTAP EQVRAQAQAA RERLA

References

[1]

"Complete sequence of Halorhodospira halophila SL1." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. , Land M., Hauser L., Kyrpides N., Mikhailova N., Hoff W., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 244 / SL1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000544 Genomic DNA. Translation: ABM61800.1.
RefSeq	YP_001002602.1. NC_008789.1.
3D structure databases
ProteinModelPortal	A1WVT8.
SMR	A1WVT8. Positions 22-465.
ModBase	Search...
Protein-protein interaction databases
STRING	349124.Hhal_1024.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABM61800; ABM61800; Hhal_1024.
GeneID	4709218.
KEGG	hha:Hhal_1024.
PATRIC	22096355. VBIHalHal112047_1019.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0165.
HOGENOM	HOG000242744.
KO	K01755.
OMA	KEGIFDA.
ProtClustDB	PRK00855.
Enzyme and pathway databases
BioCyc	HHAL349124:GI3I-1058-MONOMER.
UniPathway	UPA00068; UER00114.
Family and domain databases
Gene3D	1.10.275.10. 1 hit.
HAMAP	MF_00006. Arg_succ_lyase.
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR024083. Fumarase/histidase_N. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. IPR022761. Fumarate_lyase_N. IPR008948. L-Aspartase-like. [Graphical view]
PANTHER	PTHR11444:SF3. PTHR11444:SF3. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
SUPFAM	SSF48557. L-Aspartase-like. 1 hit.
TIGRFAMs	TIGR00838. argH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_HALHL

Accession

Primary (citable) accession number: A1WVT8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 6, 2007
Last modified:	May 29, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program