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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Halorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciHHAL349124:GI3I-735-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:Hhal_0715
OrganismiHalorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1))
Taxonomic identifieri349124 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeHalorhodospira
Proteomesi
  • UP000000647 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalUniRule annotationAdd BLAST21
Transmembranei49 – 69HelicalUniRule annotationAdd BLAST21
Transmembranei101 – 121HelicalUniRule annotationAdd BLAST21
Transmembranei126 – 146HelicalUniRule annotationAdd BLAST21
Transmembranei160 – 180HelicalUniRule annotationAdd BLAST21
Transmembranei203 – 223HelicalUniRule annotationAdd BLAST21
Transmembranei232 – 252HelicalUniRule annotationAdd BLAST21
Transmembranei267 – 287HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002907141 – 287Undecaprenyl-diphosphataseAdd BLAST287

Interactioni

Protein-protein interaction databases

STRINGi349124.Hhal_0715.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWR. Bacteria.
COG1968. LUCA.
HOGENOMiHOG000218357.
KOiK06153.
OMAiRNDDAHM.
OrthoDBiPOG091H00ZR.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase. 1 hit.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1WUY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALWIAVLLG VVQGIFMFLP VSSTAHMVLL EHWLIGRDHP MPAPESAEMI
60 70 80 90 100
LFNLVVHVGT LVSIVVVFAP SLLRFTRYSL RDAYGWARAG RFQGPPLYAR
110 120 130 140 150
LFLLGMLSVL FTGVVGLTLK ATFEQVFANP WMIAFTLILT GALLFWTDKL
160 170 180 190 200
PPRRRGLRQT GVGTATLIGV AQGFALMPGL SRSAMTIVFG LFAGLKRRWA
210 220 230 240 250
AEYSFFLAIP TICAATLLQA IEVYQLGGLE SVSVAALITG FVVAAGVGIV
260 270 280
SLKLVIYFLY RAQLKVFSFY VWALAAAILL GWIDLPI
Length:287
Mass (Da):31,397
Last modified:February 6, 2007 - v1
Checksum:i08AAB8009DA18BF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000544 Genomic DNA. Translation: ABM61497.1.
RefSeqiWP_011813520.1. NC_008789.1.

Genome annotation databases

EnsemblBacteriaiABM61497; ABM61497; Hhal_0715.
KEGGihha:Hhal_0715.
PATRICi22095737. VBIHalHal112047_0724.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000544 Genomic DNA. Translation: ABM61497.1.
RefSeqiWP_011813520.1. NC_008789.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi349124.Hhal_0715.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM61497; ABM61497; Hhal_0715.
KEGGihha:Hhal_0715.
PATRICi22095737. VBIHalHal112047_0724.

Phylogenomic databases

eggNOGiENOG4105DWR. Bacteria.
COG1968. LUCA.
HOGENOMiHOG000218357.
KOiK06153.
OMAiRNDDAHM.
OrthoDBiPOG091H00ZR.

Enzyme and pathway databases

BioCyciHHAL349124:GI3I-735-MONOMER.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase. 1 hit.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUPPP_HALHL
AccessioniPrimary (citable) accession number: A1WUY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: February 6, 2007
Last modified: September 7, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.