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A1WUY5 (UPPP_HALHL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Hhal_0715
OrganismHalorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1)) [Complete proteome] [HAMAP]
Taxonomic identifier349124 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeHalorhodospira

Protein attributes

Sequence length287 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 287287Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000290714

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane49 – 6921Helical; Potential
Transmembrane101 – 12121Helical; Potential
Transmembrane126 – 14621Helical; Potential
Transmembrane160 – 18021Helical; Potential
Transmembrane203 – 22321Helical; Potential
Transmembrane232 – 25221Helical; Potential
Transmembrane267 – 28721Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A1WUY5 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 08AAB8009DA18BF0

FASTA28731,397
        10         20         30         40         50         60 
MALWIAVLLG VVQGIFMFLP VSSTAHMVLL EHWLIGRDHP MPAPESAEMI LFNLVVHVGT 

        70         80         90        100        110        120 
LVSIVVVFAP SLLRFTRYSL RDAYGWARAG RFQGPPLYAR LFLLGMLSVL FTGVVGLTLK 

       130        140        150        160        170        180 
ATFEQVFANP WMIAFTLILT GALLFWTDKL PPRRRGLRQT GVGTATLIGV AQGFALMPGL 

       190        200        210        220        230        240 
SRSAMTIVFG LFAGLKRRWA AEYSFFLAIP TICAATLLQA IEVYQLGGLE SVSVAALITG 

       250        260        270        280 
FVVAAGVGIV SLKLVIYFLY RAQLKVFSFY VWALAAAILL GWIDLPI 

« Hide

References

[1]"Complete sequence of Halorhodospira halophila SL1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. expand/collapse author list , Land M., Hauser L., Kyrpides N., Mikhailova N., Hoff W., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 244 / SL1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000544 Genomic DNA. Translation: ABM61497.1.
RefSeqYP_001002299.1. NC_008789.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING349124.Hhal_0715.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABM61497; ABM61497; Hhal_0715.
GeneID4711084.
KEGGhha:Hhal_0715.
PATRIC22095737. VBIHalHal112047_0724.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAFNDAHAK.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycHHAL349124:GI3I-735-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_HALHL
AccessionPrimary (citable) accession number: A1WUY5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families