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A1WUY5

- UPPP_HALHL

UniProt

A1WUY5 - UPPP_HALHL

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Halorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciHHAL349124:GI3I-735-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:Hhal_0715
    OrganismiHalorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1))
    Taxonomic identifieri349124 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeHalorhodospira
    ProteomesiUP000000647: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 287287Undecaprenyl-diphosphatasePRO_0000290714Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi349124.Hhal_0715.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalUniRule annotationAdd
    BLAST
    Transmembranei49 – 6921HelicalUniRule annotationAdd
    BLAST
    Transmembranei101 – 12121HelicalUniRule annotationAdd
    BLAST
    Transmembranei126 – 14621HelicalUniRule annotationAdd
    BLAST
    Transmembranei160 – 18021HelicalUniRule annotationAdd
    BLAST
    Transmembranei203 – 22321HelicalUniRule annotationAdd
    BLAST
    Transmembranei232 – 25221HelicalUniRule annotationAdd
    BLAST
    Transmembranei267 – 28721HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiFNDAHAK.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1WUY5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALWIAVLLG VVQGIFMFLP VSSTAHMVLL EHWLIGRDHP MPAPESAEMI    50
    LFNLVVHVGT LVSIVVVFAP SLLRFTRYSL RDAYGWARAG RFQGPPLYAR 100
    LFLLGMLSVL FTGVVGLTLK ATFEQVFANP WMIAFTLILT GALLFWTDKL 150
    PPRRRGLRQT GVGTATLIGV AQGFALMPGL SRSAMTIVFG LFAGLKRRWA 200
    AEYSFFLAIP TICAATLLQA IEVYQLGGLE SVSVAALITG FVVAAGVGIV 250
    SLKLVIYFLY RAQLKVFSFY VWALAAAILL GWIDLPI 287
    Length:287
    Mass (Da):31,397
    Last modified:February 6, 2007 - v1
    Checksum:i08AAB8009DA18BF0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000544 Genomic DNA. Translation: ABM61497.1.
    RefSeqiYP_001002299.1. NC_008789.1.

    Genome annotation databases

    EnsemblBacteriaiABM61497; ABM61497; Hhal_0715.
    GeneIDi4711084.
    KEGGihha:Hhal_0715.
    PATRICi22095737. VBIHalHal112047_0724.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000544 Genomic DNA. Translation: ABM61497.1 .
    RefSeqi YP_001002299.1. NC_008789.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349124.Hhal_0715.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM61497 ; ABM61497 ; Hhal_0715 .
    GeneIDi 4711084.
    KEGGi hha:Hhal_0715.
    PATRICi 22095737. VBIHalHal112047_0724.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi FNDAHAK.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci HHAL349124:GI3I-735-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 244 / SL1.

    Entry informationi

    Entry nameiUPPP_HALHL
    AccessioniPrimary (citable) accession number: A1WUY5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 12, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3