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Protein

Catalase-peroxidase

Gene

katG

Organism
Halorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei93Transition state stabilizerUniRule annotation1
Active sitei97Proton acceptorUniRule annotation1
Metal bindingi266Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciHHAL349124:GI3I-558-MONOMER.

Protein family/group databases

PeroxiBasei3561. HhCP01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Hhal_0547
OrganismiHalorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1))
Taxonomic identifieri349124 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeHalorhodospira
Proteomesi
  • UP000000647 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003548071 – 724Catalase-peroxidaseAdd BLAST724

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki96 ↔ 225Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-251)UniRule annotation
Cross-linki225 ↔ 251Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-96)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiA1WUH1.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi349124.Hhal_0547.

Structurei

3D structure databases

ProteinModelPortaliA1WUH1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiQPEEMML.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1WUH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADQQKAGGC PVMHGAMTQV GESNLDMWPN ALNLDILHQH DRKPDPMGEG
60 70 80 90 100
FNYREEVKKL DLDAVKQDLH QLMTDSQAWW PADWGHYGGL MIRMAWHAAG
110 120 130 140 150
TYRVADGRGG GGTGNQRFAP INSWPDNVNL DKARRLLWPI KKKYGNRLSW
160 170 180 190 200
ADLIILAGNV AYESMGLKTF GFSLGREDIW HPEKDIYWGS EKEWLAPSDS
210 220 230 240 250
EDSRYGEDRA SLENPLAAVM MGLIYVNPEG VDGNPDPLRT AEDVRITFER
260 270 280 290 300
MAMNDEETVA LTAGGHTVGK CHGNGDVENL GPDPESADVE EQGLGWNNKV
310 320 330 340 350
TRGVGRDTVS SGIEGAWTTY PTRWDNGYFH LLLNYEWELT KSPAGAWQWE
360 370 380 390 400
PVDIKEEDKP VDVEDPSIRL NPIMTDADMA MKMDPAYRKI SERFYNDPAY
410 420 430 440 450
FDEVFARAWF KLTHRDLGPR TRYIGPEAPQ EDLIWQDPVP AGRTDYDVEA
460 470 480 490 500
LKAKIADSGL SIGEMVSTAW DSARTFRGSD NRGGANGARI RLAPQKDWEG
510 520 530 540 550
NEPERLSKVL GVLEGIAADA GASLADTIVL AGNVGIEQAA RAAGHDITVP
560 570 580 590 600
FAPGRGDASQ EMTDVDSFQY LEPLADGYRN WVKKEYAVQP EEMMLDRTQL
610 620 630 640 650
MGLTAPEMTV LVGGMRVLGT NHGGTKHGVL TDREGQLTND FFVNLTDMAY
660 670 680 690 700
TWKPVGSNRY EIRQRSSDAV KWTATRVDLV FGSNSILRSY AEVYAQDDNR
710 720
EKFVHDFVAA WTKVMNADRF DLVA
Length:724
Mass (Da):80,764
Last modified:February 6, 2007 - v1
Checksum:i3EADD6749BEC678D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000544 Genomic DNA. Translation: ABM61333.1.
RefSeqiWP_011813356.1. NC_008789.1.

Genome annotation databases

EnsemblBacteriaiABM61333; ABM61333; Hhal_0547.
KEGGihha:Hhal_0547.
PATRICi22095383. VBIHalHal112047_0556.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000544 Genomic DNA. Translation: ABM61333.1.
RefSeqiWP_011813356.1. NC_008789.1.

3D structure databases

ProteinModelPortaliA1WUH1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi349124.Hhal_0547.

Protein family/group databases

PeroxiBasei3561. HhCP01.

Proteomic databases

PRIDEiA1WUH1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM61333; ABM61333; Hhal_0547.
KEGGihha:Hhal_0547.
PATRICi22095383. VBIHalHal112047_0556.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiQPEEMML.
OrthoDBiPOG091H05R1.

Enzyme and pathway databases

BioCyciHHAL349124:GI3I-558-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_HALHL
AccessioniPrimary (citable) accession number: A1WUH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: February 6, 2007
Last modified: October 5, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.